Chemical Biology and Drug Design

JANUARY 15, 2024

Sprague–Dawley (SD) rat heart was locally irradiated with 20 Gy absorbent dose x-ray, and 100 mg/kg naringin was given at the same time. Left ventricular function was measured, cardiac tissue pathological changes and myocardial collagen were detected by H&E and Masson staining, pro-inflammatory cytokine activity and lipid peroxidation-related indicators were detected by ELISA and biochemistry, and fibrosis-related proteins were detected by western blot.

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FDA Law Blog: Biosimilars

JANUARY 15, 2024

By David B. Clissold & Sara W. Koblitz — You know a court decision is going to be worth reading when the judges compare FDA’s regulatory governance of flavored e-cigarettes to a Shakespearean gaslighting. To quote the Fifth Circuit: “It was the regulatory equivalent of Romeo sending Mercutio on a wild goose chase—and then admitting there never was a goose while denying he even suggested the chase.

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Chemical Biology and Drug Design

JANUARY 15, 2024

Abstract Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer with a low 5-year survival rate. ANKRD22 is an ankyrin repeat protein capable of promoting tumor progression, and its mechanism in LUAD remains elusive. Our study aims to investigate the mechanisms underlying the involvement of ANKRD22 in the progression of LUAD. The expression of ANKRD22 in LUAD and its enriched pathway were analyzed by bioinformatics analysis.

Bioinformatics 100

Bioinformatics Treatment Research 100

Drug Target Review

JANUARY 15, 2024

Researchers from the Nara Institute of Science and Technology (NAIST) have used the reverse-blastocyst complementation (rBC) method to understand the conditions required to form lungs in rat-mouse chimeric models. They also used the tetraploid-based organ complementation (TOC) method to create a rat-derived lung in their mouse model. Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is the third leading cause of global deaths.

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Immune Response Disease Science Therapies 113

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- Taking nitrates for heart problems alongside erectile dysfunction drugs like Viagra or Cialis could be a prescription for trouble, a new study warns.Men who combine the two types of medications have a higher risk of death.

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Drugs 111

Drug Target Review

JANUARY 15, 2024

Monoclonal antibodies (mAbs) targeting tumour-specific antigens play an essential role in the treatment of many cancers. In general, these agents work by binding to a molecular target on the surface of a tumour cell, and directing destruction of the target cell by chemical, radiological or immunological mechanisms. This approach has produced a broad range of approved and investigational products.

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Engineering DNA Virus Immune Response 110

Drug Target Review

JANUARY 15, 2024

Cancer is a disease driven by variable genetic mutations. Overcoming this variability while sparing normal cells has stymied broad-acting therapeutic development. Our innate immune system evolved to clear genetically diverse pathogens and limit host toxicity, raising the possibility that it can produce similar effects in cancer. Research 1 has shown that neutrophil elastase selectively and potently kills cancer cells irrespective of their genetics and anatomical origin, mobilises adaptive immuni

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Treatment Immune Response Therapies Clinical Trials 105

Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- Stress appears to increase a person’s chances of developing metabolic syndrome, a cluster of unhealthy factors that add up to an increased risk for serious problems, a new study finds.Inflammation driven by a person’s.

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sptlabtech

JANUARY 15, 2024

Every on e of our engineers play s a pivotal role in delivering the highest standards for our firefly customers. Laboratories globally rely on firefly for its liquid handling precision. Our commitment to customers goes beyond just functionality; it's about ensuring robustness and reliability in every instrument we deliver. This dedication is crucial in high-throughput lab operations, where we recognize that any downtime can be costly. firefly: More than a tool, a laboratory partner firefly isn't

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Engineering Laboratories Production Research 90

Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- Snowstorms are blanketing the United States, prompting countless Americans to pick up snow shovels and clear walkways and driveways.Shoveling snow is more than a chore, however -- it can be a health hazard.The exertion of.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Cytel

JANUARY 15, 2024

After explosive and frenetic activity in the clinical trial industry during the COVID era, the past two years have seen challenging market dynamics and a drop-off in activity. Every one of us working in clinical development has felt this slowdown, but as we begin 2024, there is reason for optimism. The future looks promising. Here are some things to consider as you go forward.

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Clinical Development Clinical Trials Trials Marketing 64

Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- Employees at many companies are urged to take advantage of free wellness programs focused on mindfulness, life coaching, better sleep and many other issues. Too bad most won't actually boost their well-being, a new study of.

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Drug Patent Watch

JANUARY 15, 2024

This chart shows the pharmaceutical companies with the most injectable dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most injectable dosed drugs… The post Which pharmaceutical companies have the most injectable dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceutical Companies Pharmaceuticals Drugs 59

Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2023 -- Art therapy has the potential to help women deal with menopause, a new study reports.Creative arts therapies combined with nutrition education significantly improved quality of life, stress, anxiety and body image in a.

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Therapies 73

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Patent Watch

JANUARY 15, 2024

Annual Drug Patent Expirations for PROLENSA Prolensa is a drug marketed by Bausch And Lomb and is included in one NDA. It is available from two suppliers. There are nine… The post New patent expiration for Bausch And drug PROLENSA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- Following weeks of increases in flu activity, the latest U.S. government data shows "a single-week decrease" for the first time in months.But health officials warn that the flu season is far from over, with a surge expected.

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Government 59

Drug Patent Watch

JANUARY 15, 2024

Annual Drug Patent Expirations for IGALMI Igalmi is a drug marketed by Bioxcel and is included in one NDA. It is available from one supplier. There are six patents protecting… The post New patent for Bioxcel drug IGALMI appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Covalent Modifiers

JANUARY 15, 2024

D. Yadav, S. Tiwari, S. Senthil, S. K. Vechalapu, S. Duraisamy, V. Rawat, M. I. Rahman, S. Khanna and D. Allimuthu, Chem. Commun. , 2024 DOI: 10.1039/D3CC06215E Developing new chemotherapeutics that are structurally and mechanistically unique is a need due to the rapid rise of cancer incidences across the globe. Here we report the identification of irreversible, thiol-reactive diazepam derivatives as GPX4 modifiers and nanomolar inducers of ferroptosis in liver cancer cells.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Patent Watch

JANUARY 15, 2024

Annual Drug Patent Expirations for LAZANDA Lazanda is a drug marketed by Btcp Pharma and is included in one NDA. There are five patents protecting this drug. This drug has… The post New patent expiration for Btcp Pharma drug LAZANDA appeared first on DrugPatentWatch - Make Better Decisions.

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Science Daily: Pharmacology News

JANUARY 15, 2024

New research has cracked a vital process in the creation of a unique rock type from the Moon. The discovery explains its signature composition and very presence on the lunar surface at all, unraveling a mystery which has long-eluded scientists.

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Research 66

Drug Patent Watch

JANUARY 15, 2024

Annual Drug Patent Expirations for ORGOVYX Orgovyx is a drug marketed by Sumitomo Pharma and is included in one NDA. It is available from one supplier. There are eight patents… The post New patent for Sumitomo Pharma drug ORGOVYX appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Alta Sciences

JANUARY 15, 2024

How Is Your CRO Handling Your Trial Data? blussier Mon, 01/15/2024 - 22:39 HTML Best Practices for a Successful, Multi-Step Data Journey In this issue of The Altascientist , we guide you through the complex, multi-step data journey for Phase I clinical trials, from study conceptualization and protocol development, to data collection and analysis, through to final regulatory submission.

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Drug Patent Watch

JANUARY 15, 2024

Annual Drug Patent Expirations for GALAFOLD Galafold is a drug marketed by Amicus Therap Us and is included in one NDA. It is available from one supplier. There are fifty-four… The post New patent for Amicus Therap drug GALAFOLD appeared first on DrugPatentWatch - Make Better Decisions.

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Perficient: Drug Development

JANUARY 15, 2024

Welcome back to our ongoing exploration of inclusive design! In this installment, we’re delving into the intersection of Universal Design and Web Accessibility, unraveling the crucial role these principles play in making the digital realm an inclusive space for everyone. As we navigate through the digital landscape, it becomes evident that the principles of Universal Design seamlessly extend to the online world, ensuring that websites and digital content are accessible to users of all abil

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Drug Patent Watch

JANUARY 15, 2024

Annual Drug Patent Expirations for LUMIFY Lumify is a drug marketed by Bausch And Lomb Inc and is included in one NDA. It is available from one supplier. There are… The post New patent for Bausch And drug LUMIFY appeared first on DrugPatentWatch - Make Better Decisions.

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Perficient: Drug Development

JANUARY 15, 2024

In the world of ASP.NET development, logging is a crucial aspect of building robust and reliable applications. With the right logging tool, developers can easily track and analyze errors, exceptions, and other critical information that can help improve application performance and maintainability. One such tool that stands out is ELMAH (Error Logging Modules and Handlers), known for its powerful features and easy integration.

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Packaging 52

Drug Patent Watch

JANUARY 15, 2024

Annual Drug Patent Expirations for MYFEMBREE Myfembree is a drug marketed by Myovant Sciences and is included in one NDA. It is available from one supplier. There are six patents… The post New patent for Myovant Sciences drug MYFEMBREE appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- Trendy bottled water marketed as “alkaline water” isn’t likely to prevent kidney stones in a person plagued by them, a new study reports.These products tend to have contain less alkali than is needed to alter urine pH.

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Production Marketing 52

Science Daily: Pharmacology News

JANUARY 15, 2024

New research has precisely dated some of the oldest fossils of complex multicellular life in the world, helping to track a pivotal moment in the history of Earth when the seas began teeming with new lifeforms -- after four billion years of containing only single-celled microbes.

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Research 57

Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- New research in mice is pointing to a surprising connection: Gum disease could exacerbate chronic obstructive pulmonary disease (COPD).Because gum disease (periodontitis) is a chronic, inflammatory infection, it's long been.

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Disease Research 52

Alta Sciences

JANUARY 15, 2024

Webinar—Sinclair Nanopig™: The Next Generation, Non-Rodent Model for (Bio)Pharmaceuticals Safety Assessment lperez Mon, 01/15/2024 - 15:58 Image Website_Webinar_Minipig Sinclair_v3.

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Drugs.com

JANUARY 15, 2024

MONDAY, Jan. 15, 2024 -- Online-only health care services have become a trendy way for people to receive low-cost medical attention.These websites don’t require a referral or health insurance, and offer a flat fee for services. The online.

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Doctors 52

Drug & Device Law

JANUARY 15, 2024

As we discussed at length in this post, since the 1940s, the Pennsylvania Supreme Court and other courts applying Pennsylvania law have refused to subject prescription medical products to strict liability. That is significant because, unlike (now) every other state in the country, since 1987 Pennsylvania precedent prohibited defendants from introducing evidence of their compliance with government and/or industry standards (“standards compliance” or “compliance” evidence, for short) in strict li

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