Tue.Mar 19, 2024

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DDW Spring 2024

Drug Discovery World

The DDW Spring issue looks at where we are in the fight against antimicrobial resistance, explores how structural biology is informing vaccine design, and offers advice on approaching dealmaking in biopharma. It also includes an exclusive cell and gene therapy guide examining the innovation happening in this sector. DDW SPRING 2024 The post DDW Spring 2024 appeared first on Drug Discovery World (DDW).

Vaccine 196
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CDC, AMA Issue Calls to Get Vaccinated Against Measles

Drugs.com

TUESDAY, March 19, 2024 -- Two of America's leading health organizations are highlighting a global rise in measles cases as yet another reason for families to make sure they get the measles vaccine.The U.S. Centers for Disease Control and.

Vaccine 119
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Meet the Researcher: Elaine Duncan, University of Glasgow

Drug Discovery World

DDW’s Diana Spencer speaks to Elaine Duncan, a PhD student on the lifETIME (Engineered Tissues for Discovery, Industry and Medicine) CDT at the University of Glasgow. DS: Can you tell us what you do and what you’re working on at the moment? ED : I’m currently a PhD researcher at the University of Glasgow. My research is focused on developing a 3D in vitro model of adipose tissue which can be used in the lab to help us better understand the complex signalling pathways of metabolic disorders and h

Research 148
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U.S. Abortion Rates Rose After Dobbs Decision, Led by Medication Abortions

Drugs.com

TUESDAY, March 19, 2024 -- Following the historic reversal of Roe v. Wade in June of 2022, the number of abortions in the United States has risen to more than a million per year, with medication abortions representing nearly two-thirds of those.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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€30m raised for first-in-class in vivo cell reprogramming platform

Drug Discovery World

Biotech Asgard Therapeutics has closed a €30 million Series A financing to support the development of its lead programme, AT-108. The company plans to submit an Investigational New Drug (IND) application to the FDA for AT-108 by 2026, expand and reinforce its research and development team, and fuel new reprogramming modalities and delivery platforms to strengthen the pipeline.

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FDA Approves First Drug to Treat Yeast Ear Infections in Dogs, DuOtic

Drugs.com

TUESDAY, March 19, 2024 -- The U.S. Food and Drug Administration has approved the first drug to treat yeast ear infections in dogs. DuOtic is also the first ear infection medication that does not contain an antibiotic, the FDA said in its approval.

More Trending

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Could Intermittent Fasting Diets Raise Heart Risks?

Drugs.com

TUESDAY, March 19, 2024 -- Intermittent fasting might be bad for your heart, a new study warns.People who restricted their eating to an 8-hour window had nearly twice the risk of heart-related death compared to folks who ate freely, results.

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Vitamin A and its role in psychiatric and other disorders

Drug Target Review

Could you describe the potential link between vitamin A levels and altered neuronal connectivity in psychiatric disorders? Vitamin A (retinol and all trans-retinoic acid) is important for brain development because it triggers the differentiation of neural progenitor cells into mature neurons with a complex dendritic arborisation (tree) with many connections with other neurons that collectively form the neural network that organises behaviour.

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Angry? Venting to Others Probably Won't Help You

Drugs.com

TUESDAY, March 19, 2024 -- Grumbling and grousing to others isn’t an effective way of reducing rage, a new review shows.Folks who vent about a source of anger might feel better in the moment, but that won’t diminish their ire, researchers.

Research 105
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Showing Grit When Performing Manual QA

Perficient: Drug Development

Many times, in my career when performing QA, I’ve dealt with many times where I’ve felt uncertain about my efforts. Through my work at Perficient—and with the help of my team—I’ve learned over time how to persist and show grit in testing to be able to ensure the highest quality of work delivered throughout a project. Here are some tips to help your breakthrough any blockers you may have when performing QA.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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FDA Approves First Drug to Treat Yeast Ear Infections in Dogs

Drugs.com

TUESDAY, March 19, 2024 -- The U.S. Food and Drug Administration has approved the first drug to treat yeast ear infections in dogs.DuOtic is also the first ear infection medication that does not contain an antibiotic, the FDA said in its approval.

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There are large accumulations of plastics in the ocean, even outside so-called garbage patch

Science Daily: Pharmacology News

When plastic ends up in the ocean, it gradually weathers and disintegrates into small particles. If marine animals ingest these particles, their health can be severely affected. Large accumulations of plastic can therefore disrupt the biological balance of marine ecosystems. But which areas are particularly affected?

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Staying Social Vital for People With Alzheimer's, Caregivers

Drugs.com

TUESDAY, March 19, 2024 -- People with dementia -- and their caregivers -- need active social lives to stay healthy, a new study reports.However, researchers found that both dementia patients and their caregivers had declining social connections as.

Research 104
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NOW AVAILABLE: The 2024 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers

Drug Channels

I am pleased to announce our new 2024 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers , available for purchase and immediate download. Download a free report overview (including key industry trends, the Table of Contents, and a List of Exhibits) HMP Global’s Drug Channels Institute releases ‘2024 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers’ (press release) Review pricing/license options and download the full 2024 report We’re offering special discounted pric

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Blood Test Might Spot Lung Damage Risk After Long COVID

Drugs.com

TUESDAY, March 19, 2024 -- Fears that Long COVID patients might end up with long-term, potentially deadly lung scarring are unfounded, a new study concludes.The same team have come up with a blood test that could potentially spot those Long COVID.

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Artificial nanofluidic synapses can store computational memory

Science Daily: Pharmacology News

In a step toward nanofluidic-based neuromorphic -- or brain-inspired -- computing, engineers have succeeded in executing a logic operation by connecting two chips that use ions, rather than electrons, to process data.

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Mass General Brigham researchers develop AI foundation models to advance pathology

SCIENMAG: Medicine & Health

Foundation models, advanced artificial intelligence systems trained on large-scale datasets, hold the potential to provide unprecedented advancements for the medical field. In computational pathology (CPath), these models may excel in diagnostic accuracy, prognostic insights, and predicting therapeutic responses.

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Fairy circles: Plant water stress causes Namibia's gaps in grass

Science Daily: Pharmacology News

Namibia's legendary fairy circles are mysterious, circular, bald patches in the dry grasslands on the edge of the Namib Desert. Their formation has been researched for decades and has recently been the subject of much debate. With extensive fieldwork, researchers investigated how freshly germinated grass dies inside the fairy circle. Their results show that the grass withers due to a lack of water inside the fairy circle.

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Exercise helps patients with advanced breast cancer, especially if they are suffering with pain

SCIENMAG: Medicine & Health

Milan, Italy: Taking part in an exercise programme reduced pain and fatigue, and improved quality of life for people with metastatic breast cancer, according to new results of a trial presented at the 14th European Breast Cancer Conference today (Wednesday).

Trials 83
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Brain recordings in people before surgery reveal how all minds plan what to say prior to speaking

Science Daily: Pharmacology News

A new study in people undergoing surgery to treat seizures related to epilepsy shows that pauses in speech reveal information about how people's brains plan and produce speech.

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Antibodies 101 Series on TikTok

addgene Blog

Our popular Antibodies 101 animation is becoming a TikTok series! Follow @addgene on TikTok for bite-sized portions of antibody concepts. Each short video answers an Antibodies 101 question, like "what is an antibody?" or "what is an IgE isotype?

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Swallowable sensors could pinpoint gut movement problems for patients

SCIENMAG: Medicine & Health

Scientists have developed an ingestible capsule dotted with sensors that can detect pressure in a patient’s guts and detect points of failure. Credit: Credit Gerard Cummins, University of Birmingham. Scientists have developed an ingestible capsule dotted with sensors that can detect pressure in a patient’s guts and detect points of failure.

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Brain-inspired wireless system to gather data from salt-sized sensors

Science Daily: Pharmacology News

In a new study, researchers describe a novel approach for a wireless communication network that can efficiently transmit, receive and decode data from thousands of microelectronic chips that are each no larger than a grain of salt.

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AstraZeneca buys into radiopharmaceuticals with $2.4B deal for Fusion Pharma

BioPharma Drive: Drug Pricing

The deal hands AstraZeneca a prostate cancer drug that’s designed differently than Novartis’ fast-selling Pluvicto and currently in mid-stage testing.

Drugs 76
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When words make you sick

SCIENMAG: Medicine & Health

In a new book, experts in a variety of fields explore nocebo effects – how negative expectations concerning health can make a person sick. It is the first time a book has been written on this subject. “I think it’s the idea that words really matter.

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Orchard follows buyout with FDA approval of rare disease gene therapy

BioPharma Drive: Drug Pricing

The U.S. clearance of Lenmeldy, for a rare and inherited metabolic disease, triggers an additional payout related to Kyowa Kirin’s recent deal to acquire the once high-flying gene therapy developer.

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IVI starts technology transfer to Biological E. Limited to manufacture oral cholera vaccine for India and global markets

SCIENMAG: Medicine & Health

Credit: IVI IVI will complete the technology transfer by 2025 Oral Cholera Vaccine to be manufactured by Biological E.

Vaccine 82
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Engrail’s precision psychiatry drugs get more buy in from venture investors

BioPharma Drive: Drug Pricing

The San Diego-based startup added $157 million in new funding to back a drug for generalized anxiety order that’s now in human testing.

Drugs 76
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HP&M Director, Allyson Mullen, Appointed to the Association of Medical Diagnostic Manufacturers 2024-2026 Board of Directors

FDA Law Blog: Biosimilars

Hyman, Phelps & McNamara, P.C. (HP&M), the largest dedicated food and drug law firm in the U.S., is pleased to announce that Director Allyson Mullen has been appointed to the Board of Directors of the Association of Medical Diagnostic Manufacturers (AMDM). This prestigious appointment recognizes Ms. Mullen’s extensive experience and contributions to the field of in vitro diagnostic (IVD) regulation.

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With new data, Bayer readies rival to Astellas menopause drug

BioPharma Drive: Drug Pricing

Following a third successful Phase 3 trial, the company is planning approval filings for the medicine, which it acquired in a $425 million deal four years ago.

Trials 67
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AI Can Help or Hinder a Radiologist's Accuracy, Study Finds

Drugs.com

TUESDAY, March 19, 2024 -- Artificial intelligence tools don’t always help radiologists better review a patient’s X-rays or CT scans, a new study claims.AI has been touted as a potential means of improving doctors’ ability to interpret.

Doctors 59
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Feeling the Heat (or Cold) – New Draft Guidance Addresses Requirements for Devices that Produce Thermal Effects

FDA Law Blog: Biosimilars

By Adrienne R. Lenz, Principal Medical Device Regulation Expert — FDA recently issued a draft guidance, Evaluation of Thermal Effects of Medical Devices that Produce Tissue Heating and/or Cooling ( link ), which describes information to include in a marketing application to support the evaluation of thermal effects of medical devices that produce local, regional, and/or systemic changes in tissue temperature due to their use, either by heating or cooling.

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No Brain Injuries Seen Among 'Havana Syndrome' Patients

Drugs.com

TUESDAY, March 19, 2024 -- “Havana Syndrome” appears to cause real and severe symptoms among federal employees suffering from the mystery illness, but there’s no evidence of brain injury or biological abnormalities among them, a new report.

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Elevance to buy Kroger’s specialty pharmacy

BioPharma Drive: Drug Pricing

Major pharmacy benefit managers continue to double down on specialty as a reliable source of business amid a growing crop of pharmacy upstarts.