ASPET

JANUARY 25, 2024

3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic stress disorder (PTSD). However, MDMA is also used in non-medical contexts that pose risk for cardiovascular and neurological complications. It is well established that MDMA exerts its effects by stimulating transporter-mediated release of the monoamines, 5-hydroxytryptamine (5-HT), norepinephrine, and dopamine.

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Drugs Research 184

Science Daily: Pharmacology News

JANUARY 25, 2024

An international group of leading scientists call for an urgent change in the governance of urban expansion as the world's cities continue to grow at unprecedented rates.

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Government International 129

Broad Institute

JANUARY 25, 2024

With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks By Tom Ulrich January 25, 2024 Breadcrumb Home With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks Images commonly taken as part of eye care may provide valuable information about patients' ocular and systemic health By Liana Wait January 25, 2024 Credit: Pete/Flickr Related news #WhyIScience Q&A: An aspiring physician-scientist inv

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Disease Research Science Medical Schools 124

Science Daily: Pharmacology News

JANUARY 25, 2024

Data gathered through years of observation reveal an innocuous-seeming ant is disrupting an ecosystem in East Africa, illustrating the complex web of interactions among ants, trees, lions, zebras and buffaloes.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Antidote

JANUARY 25, 2024

Recruiting patients for clinical trials is a common challenge for study sponsors conducting research. For this reason, it is often a wise strategy to work with an agency that specializes in outreach. These agencies excel at helping sponsors achieve their research goals within defined timelines and budgets.

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Clinical Trials Trials Research 120

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- The maker of Robitussin has recalled eight lots of Robitussin Honey CF Max Day Adult and Robitussin Honey CF Max Nighttime Adult cough syrups.The products, which are made by Haleon, may be contaminated with a.

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Production 119

Drug Target Review

JANUARY 25, 2024

Researchers from the Cleveland Clinic, led by Dr Ofer Reizes and Dr Justin Lathia, have developed a therapeutic peptide that disrupts the molecular processes behind aggressive cancer cell growth. These findings offer a novel strategy for developing targeted treatments for triple-negative breast cancer, which currently has no approved options. Dr Reizes, the Laura J Fogarty Endowed Chair for Uterine Cancer Research, commented: “It’s devastating that we currently have such limited options to help

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Treatment Clinical Trials Research Science 105

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- Reiterating a warning first issued in November, the U.S. Food and Drug Administration is urging Americans to stay away from supplements containing tianeptine, known on the street as "gas station heroin.

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Production FDA Drugs 111

Science Daily: Pharmacology News

JANUARY 25, 2024

Chemists have developed an autonomous chemical synthesis robot with an integrated AI-driven machine learning unit. Dubbed 'RoboChem', the benchtop device can outperform a human chemist in terms of speed and accuracy while also displaying a high level of ingenuity. As the first of its kind, it could significantly accelerate chemical discovery of molecules for pharmaceutical and many other applications.

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Pharmaceuticals 104

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 (HealthDay news) -- It’s been said that closing the toilet lid before flushing can prevent the spread of all germs, by keeping any flush-produced mist in the bowl.But a new study refutes that, showing that tiny viral.

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ASPET

JANUARY 25, 2024

Abuse of novel arylcyclohexylamines (ACX) poses risks for toxicities including adverse neurocognitive effects. In vivo effects of ring-substituted analogs of phencyclidine (PCP), eticyclidine (PCE), and ketamine are understudied. Adult male NIH Swiss mice were used to assess locomotor effects of PCP and its 3-OH, 3-MeO, 3-Cl and 4-MeO analogs; PCE and its 3-OH and 3-MeO analogs; and ketamine and its deschloro and 2F-deschloro analogs, in comparison to those of methamphetamine (METH), 3,4-methyle

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Government Drugs Marketing 100

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- Factors like sleep, energy levels and stress can predict the onset of a migraine headache, a new study finds.Those factors differed from the morning to the afternoon and evening, however.

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ASPET

JANUARY 25, 2024

Therapeutic vaccines containing aluminum adjuvants have been widely used in the treatment of tumors due to their powerful immune-enhancing effects. However, the neurotoxicity of aluminum adjuvants with different physicochemical properties have not been completely elucidated. In this study, a library of engineered aluminum oxyhydroxide (EAOs) and aluminum hydroxyphosphate (EAHPs) nanoparticles was synthesized to determine their neurotoxicity in vitro.

Vaccine 100

Vaccine Engineering Treatment 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Perficient: Drug Development

JANUARY 25, 2024

This past week was one to celebrate for the Perficient DXP team, as Sitecore awarded us their Order Cloud Specialization. Sitecore takes certification seriously and only recognizes partners with a Specialization if they have proven a deep understanding of the products and a track record of success on relevant projects. The Order Cloud Specialization is the fourth that Perficient has earned in addition to badges for CDP & Personalize , Content Hub and Sitecore XP.

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Production Marketing 98

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- Folks think of big city life as an ear-blasting festival of noise -- taxi horns honking, jackhammers pounding, police sirens wailing and jet planes roaring overhead.But rural residents actually have a higher rate of.

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PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA. Human remains also harbor bits of DNA that can reveal how people lived long ago.

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Disease DNA Science Virus 95

SCIENMAG: Medicine & Health

JANUARY 25, 2024

The anti-acne medicine isotretinoin, which can cause defects in a developing fetus, is now used by almost 2 in 1,000 girls and women of childbearing age, according to analysis of German database of 25 million Credit: Reinold J, et al., 2024, PLOS Medicine, CC-BY 4.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Covalent Modifiers

JANUARY 25, 2024

Guanghui Tang , Wei Wang , Chengjun Zhu , Huisi Huang , Peng Chen , Xuan Wang , Manyi Xu , Jie Sun , Chong-Jing Zhang , Qicai Xiao , Liqian Gao , Zhi-Min Zhang , Shao Q. Yao , Angew. Chem. Int. Ed. 2024 , e202316394. [link] Advances in targeted covalent inhibitors (TCIs) have been made by using lysine-reactive chemistries. Few aminophiles possessing balanced reactivity/stability for the development of cell-active TCIs are however available.

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Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- Five of six Chinese children born deaf due to a rare genetic defect now have the ability to hear, thanks to an experimental gene therapy.The therapy involved a hollowed-out virus loaded with a healthy version of the gene.

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Therapies Virus 85

SCIENMAG: Medicine & Health

JANUARY 25, 2024

AMSTERDAM and TUCSON, Ariz., January 25, 2024 — Critical Path Institute (C-Path) today announced the promotion of Cécile Ollivier, M.S., from Managing Director, Europe to Vice President of Global Affairs. Credit: C-Path AMSTERDAM and TUCSON, Ariz., January 25, 2024 — Critical Path Institute (C-Path) today announced the promotion of Cécile Ollivier, M.S., from Managing Director, Europe to Vice President of Global Affairs.

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Drug Development Drugs 85

addgene Blog

JANUARY 25, 2024

Once upon a time, not so long ago, spCas9 was the only Cas enzyme widely available and applied by researchers for gene targeting. Fast forward a decade, and the CRISPR field has exploded with dozens of Cas enzymes and variants available. Without a comprehensive resource, it can be overwhelming to choose a Cas for your experiment. Even worse, you may end up missing an enzyme that is a better experimental fit due to this.

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Research 83

Science Daily: Pharmacology News

JANUARY 25, 2024

'Hidden' stars including a new type of elderly giant nicknamed an 'old smoker' have been spotted for the first time by astronomers. The mystery objects exist at the heart of our Milky Way galaxy and can sit quietly for decades -- fading almost to invisibility -- before suddenly puffing out clouds of smoke, according to a new study.

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SCIENMAG: Medicine & Health

JANUARY 25, 2024

WHAT: Scientists have unexpectedly discovered that the weakened form of the bacteria Coxiella burnetii (C. burnetii) not typically known to cause disease, naturally acquired an ability to do so. C. burnetii causes Q Fever in humans and its weakened forms are those used for scientific purposes.

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Research Disease 83

Science Daily: Pharmacology News

JANUARY 25, 2024

Researchers were able to control the growth of thin, branching networks that support cellular structure and help cells function. The networks, called microtubules, can exert force and precisely transport chemicals at a subcellular level.

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Research 83

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- A sampling of the last three years of life spent by people who died in 2018 is giving a picture of what dying looks like in the United States.The analysis was conducted by a team at Rutgers University in New Jersey.

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SCIENMAG: Medicine & Health

JANUARY 25, 2024

A single dose of the typhoid conjugate vaccine, Typbar TCV®, provides lasting efficacy in preventing typhoid fever in children ages 9 months to 12 years old, according to a new study conducted by researchers at University of Maryland School of Medicine’s (UMSOM) Center for Vaccine Development and Global Health (CVD) and led by in-country partners […]

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Vaccine Research 76

BioPharma Drive: Drug Pricing

JANUARY 25, 2024

The company is developing an oral alternative to J&J’s lung cancer medicine Rybrevant, and adds to a trend of late-stage drugmakers finding investor demand on Wall Street.

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