Drug Discovery World
JANUARY 25, 2024
Japan-based pharma company Kyowa Kirin has successfully completed the acquisition of gene therapy developer Orchard Therapeutics. Orchard Therapeutics’ portfolio comprises Libmeldy (atidarsagene autotemcel), which is intended for the treatment of eligible patients with early-onset metachromatic leukodystrophy (MLD), a rare and life-threatening inherited disease of the body’s metabolic system.
Broad Institute
JANUARY 25, 2024
With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks By Tom Ulrich January 25, 2024 Breadcrumb Home With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks Images commonly taken as part of eye care may provide valuable information about patients' ocular and systemic health By Liana Wait January 25, 2024 Credit: Pete/Flickr Related news #WhyIScience Q&A: An aspiring physician-scientist inv
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Drug Discovery World
JANUARY 25, 2024
The UK’s life sciences and biotech sector showed resilience in 2023, securing £1.8 ($2.2) billion in equity investment despite a challenging global economic climate, according to a report by the UK BioIndustry Association (BIA). This follows another BIA report in January 2024, which showed that the UK is a global leader in cell and gene therapy (CGT), with significant investment and the highest number of clinical trials in Europe.
Antidote
JANUARY 25, 2024
Recruiting patients for clinical trials is a common challenge for study sponsors conducting research. For this reason, it is often a wise strategy to work with an agency that specializes in outreach. These agencies excel at helping sponsors achieve their research goals within defined timelines and budgets.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JANUARY 25, 2024
US company Vaxxinity and the University of Central Florida (UCF) have announced plans to work together to advance space medicine research. The research, funded by a grant from the State of Florida, aims to develop Vaxxinity’s active immunotherapies to prevent and mitigate muscle and bone wasting. These are well known health challenges related to long-term spaceflight, and share biological mechanisms implicated in highly prevalent age-related diseases.
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 -- The maker of Robitussin has recalled eight lots of Robitussin Honey CF Max Day Adult and Robitussin Honey CF Max Nighttime Adult cough syrups.The products, which are made by Haleon, may be contaminated with a.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
JANUARY 25, 2024
An international group of leading scientists call for an urgent change in the governance of urban expansion as the world's cities continue to grow at unprecedented rates.
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 (HealthDayNews) -- In the 14 states with abortion bans, there have been nearly 65,000 pregnancies resulting from rape during the time since those bans went into place, a new study estimates. To arrive at that troubling.
Science Daily: Pharmacology News
JANUARY 25, 2024
The intricate dance of nature often unfolds in mysterious ways, hidden from the naked eye. At the heart of this enigmatic tango lies a vital partnership: the symbiosis between plants and a type of fungi known as arbuscular mycorrhizal (AM) fungi. New groundbreaking research delves into this partnership, revealing key insights that deepen our understanding of plant-AM fungi interactions and could lead to advances in sustainable agriculture.
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 -- Reiterating a warning first issued in November, the U.S. Food and Drug Administration is urging Americans to stay away from supplements containing tianeptine, known on the street as "gas station heroin.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
JANUARY 25, 2024
Data gathered through years of observation reveal an innocuous-seeming ant is disrupting an ecosystem in East Africa, illustrating the complex web of interactions among ants, trees, lions, zebras and buffaloes.
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 (HealthDay news) -- It’s been said that closing the toilet lid before flushing can prevent the spread of all germs, by keeping any flush-produced mist in the bowl.But a new study refutes that, showing that tiny viral.
Drug Target Review
JANUARY 25, 2024
Researchers from the Cleveland Clinic, led by Dr Ofer Reizes and Dr Justin Lathia, have developed a therapeutic peptide that disrupts the molecular processes behind aggressive cancer cell growth. These findings offer a novel strategy for developing targeted treatments for triple-negative breast cancer, which currently has no approved options. Dr Reizes, the Laura J Fogarty Endowed Chair for Uterine Cancer Research, commented: “It’s devastating that we currently have such limited options to help
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 -- Women are suffering more anxiety and depression in states that banned abortion after the Supreme Court overturned Roe v. Wade, a new study shows.The court’s Dobbs decision in June 2022 triggered laws banning abortion in.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Perficient: Drug Development
JANUARY 25, 2024
This past week was one to celebrate for the Perficient DXP team, as Sitecore awarded us their Order Cloud Specialization. Sitecore takes certification seriously and only recognizes partners with a Specialization if they have proven a deep understanding of the products and a track record of success on relevant projects. The Order Cloud Specialization is the fourth that Perficient has earned in addition to badges for CDP & Personalize , Content Hub and Sitecore XP.
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 -- Factors like sleep, energy levels and stress can predict the onset of a migraine headache, a new study finds.Those factors differed from the morning to the afternoon and evening, however.
Science Daily: Pharmacology News
JANUARY 25, 2024
Chemists have developed an autonomous chemical synthesis robot with an integrated AI-driven machine learning unit. Dubbed 'RoboChem', the benchtop device can outperform a human chemist in terms of speed and accuracy while also displaying a high level of ingenuity. As the first of its kind, it could significantly accelerate chemical discovery of molecules for pharmaceutical and many other applications.
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 -- Folks think of big city life as an ear-blasting festival of noise -- taxi horns honking, jackhammers pounding, police sirens wailing and jet planes roaring overhead.But rural residents actually have a higher rate of.
SCIENMAG: Medicine & Health
JANUARY 25, 2024
The anti-acne medicine isotretinoin, which can cause defects in a developing fetus, is now used by almost 2 in 1,000 girls and women of childbearing age, according to analysis of German database of 25 million Credit: Reinold J, et al., 2024, PLOS Medicine, CC-BY 4.
addgene Blog
JANUARY 25, 2024
Once upon a time, not so long ago, spCas9 was the only Cas enzyme widely available and applied by researchers for gene targeting. Fast forward a decade, and the CRISPR field has exploded with dozens of Cas enzymes and variants available. Without a comprehensive resource, it can be overwhelming to choose a Cas for your experiment. Even worse, you may end up missing an enzyme that is a better experimental fit due to this.
SCIENMAG: Medicine & Health
JANUARY 25, 2024
AMSTERDAM and TUCSON, Ariz., January 25, 2024 — Critical Path Institute (C-Path) today announced the promotion of Cécile Ollivier, M.S., from Managing Director, Europe to Vice President of Global Affairs. Credit: C-Path AMSTERDAM and TUCSON, Ariz., January 25, 2024 — Critical Path Institute (C-Path) today announced the promotion of Cécile Ollivier, M.S., from Managing Director, Europe to Vice President of Global Affairs.
Covalent Modifiers
JANUARY 25, 2024
Guanghui Tang , Wei Wang , Chengjun Zhu , Huisi Huang , Peng Chen , Xuan Wang , Manyi Xu , Jie Sun , Chong-Jing Zhang , Qicai Xiao , Liqian Gao , Zhi-Min Zhang , Shao Q. Yao , Angew. Chem. Int. Ed. 2024 , e202316394. [link] Advances in targeted covalent inhibitors (TCIs) have been made by using lysine-reactive chemistries. Few aminophiles possessing balanced reactivity/stability for the development of cell-active TCIs are however available.
SCIENMAG: Medicine & Health
JANUARY 25, 2024
WHAT: Scientists have unexpectedly discovered that the weakened form of the bacteria Coxiella burnetii (C. burnetii) not typically known to cause disease, naturally acquired an ability to do so. C. burnetii causes Q Fever in humans and its weakened forms are those used for scientific purposes.
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 -- Five of six Chinese children born deaf due to a rare genetic defect now have the ability to hear, thanks to an experimental gene therapy.The therapy involved a hollowed-out virus loaded with a healthy version of the gene.
SCIENMAG: Medicine & Health
JANUARY 25, 2024
A single dose of the typhoid conjugate vaccine, Typbar TCV®, provides lasting efficacy in preventing typhoid fever in children ages 9 months to 12 years old, according to a new study conducted by researchers at University of Maryland School of Medicine’s (UMSOM) Center for Vaccine Development and Global Health (CVD) and led by in-country partners […]
Drugs.com
JANUARY 25, 2024
THURSDAY, Jan. 25, 2024 -- A sampling of the last three years of life spent by people who died in 2018 is giving a picture of what dying looks like in the United States.The analysis was conducted by a team at Rutgers University in New Jersey.
BioPharma Drive: Drug Pricing
JANUARY 25, 2024
The company is developing an oral alternative to J&J’s lung cancer medicine Rybrevant, and adds to a trend of late-stage drugmakers finding investor demand on Wall Street.
Science Daily: Pharmacology News
JANUARY 25, 2024
'Hidden' stars including a new type of elderly giant nicknamed an 'old smoker' have been spotted for the first time by astronomers. The mystery objects exist at the heart of our Milky Way galaxy and can sit quietly for decades -- fading almost to invisibility -- before suddenly puffing out clouds of smoke, according to a new study.
BioPharma Drive: Drug Pricing
JANUARY 25, 2024
Two “global biopharmaceutical companies” made bids to buy the radiopharma specialist, but lost out to Bristol Myers, which negotiated aggressively to secure a $4.1 billion buyout.
Science Daily: Pharmacology News
JANUARY 25, 2024
Researchers were able to control the growth of thin, branching networks that support cellular structure and help cells function. The networks, called microtubules, can exert force and precisely transport chemicals at a subcellular level.
BioPharma Drive: Drug Pricing
JANUARY 25, 2024
A two-day workshop highlighted the lack of investment and inadequate understanding of what causes early births, making development efforts more challenging.
ASPET
JANUARY 25, 2024
3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic stress disorder (PTSD). However, MDMA is also used in non-medical contexts that pose risk for cardiovascular and neurological complications. It is well established that MDMA exerts its effects by stimulating transporter-mediated release of the monoamines, 5-hydroxytryptamine (5-HT), norepinephrine, and dopamine.
LifeSciVC
JANUARY 25, 2024
By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From the Trenches feature of LifeSciVC Well, this is a first… while I have read and enjoyed the the LifeSci VC blog for years, being asked to contribute for the first time yielded a ‘holy crap’ moment in the ‘be careful what you wish for’ category. For those of you out there who know me, you know that I am not afraid to share my view and opinion.
Perficient: Drug Development
JANUARY 25, 2024
Perficient is excited to announce we’ve won Coveo’s exclusive partner award! The Accelerator Award commemorates a Coveo partner that exhibited deep knowledge and technical expertise, understands a customers’ business challenges, and clearly delivers value-driven business outcomes. Perficient is a trusted Coveo Platinum Partner with expertise in modern intelligent search solutions.
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