Tue.Oct 08, 2024

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Climate report warns of escalating crisis, urges immediate action as UN summit nears

Science Daily: Pharmacology News

An international coalition of scientists concludes that the Earth's worsening vital signs indicate a 'critical and unpredictable new phase of the climate crisis' and that 'decisive action is needed, and fast.

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Were FDA's 'Black Box' Warnings on Antidepressants a Mistake? Youth Suicides Rose Afterwards

Drugs.com

TUESDAY, Oct. 8, 2024 -- "Black Box” warnings added to antidepressants might have contributed to an increase in suicide attempts and deaths among young people, a new evidence review claims.The warnings say that antidepressants might be associated w.

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Will AI tools revolutionize public health? Not if they continue following old patterns, researchers argue

Science Daily: Pharmacology News

A new article shares findings from an extensive literature analysis of AI's current trajectory in health care.

Research 327
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Scientists Discover the Brain's Waste-Disposal System, With Clues to Alzheimer's Disease

Drugs.com

TUESDAY, Oct. 8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Team engineers new enzyme to produce synthetic genetic material

Science Daily: Pharmacology News

A research team describes how they engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.

More Trending

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Solar-powered desalination system requires no extra batteries

Science Daily: Pharmacology News

Engineers built a solar-powered desalination system that produces large quantities of clean water despite variations in sunlight throughout the day. Because it requires no extra batteries, it offers a much more affordable way to produce drinking water, compared to other solar-driven designs.

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CDC Will Test Travelers From Rwanda for Ebola-Like Marburg Virus

Drugs.com

TUESDAY, Oct. 8, 2024 -- As health officials work furiously to stem the spread of Marburg virus in Rwanda, U.S. health officials announced Monday that all passengers flying from that country to the United States will soon be screened for the often.

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Asymmetric placebo effect in response to spicy food

Science Daily: Pharmacology News

The expectations humans have of a pleasurable sensation asymmetrically shape neuronal responses and subjective experiences to hot sauce, according to a new study.

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Damage to Brainstem Could Be Driving Long COVID

Drugs.com

TUESDAY, Oct. 8, 2024 -- Damage to the brainstem could be behind the physical and psychological effects of Long COVID, a new study suggests.Brain scans of 30 Long COVID patients found they had damage to the region of the brainstem associated with.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Atomic-level mechanism in polycrystalline materials

Science Daily: Pharmacology News

Researchers show that for the first time they have achieved atomic-scale observations of grain rotation in polycrystalline materials. Using state-of-the-art microscopy tools, the scientists were able to heat samples of platinum nanocrystalline thin films and observe the mechanism driving grain rotation in unprecedented detail.

Research 300
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Could Music Lessons Help Clear the 'Brain Fog' of Chemotherapy?

Drugs.com

TUESDAY, Oct. 8, 2024 -- In a small, preliminary study, piano lessons provided to cancer patients undergoing chemotherapy appeared to help them maintain brain health. "There were a lot of outside stressors contributing to my mood, but piano.

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Holographic 3D printing has the potential to revolutionize multiple industries

Science Daily: Pharmacology News

Researchers have developed a novel method of 3D printing that uses acoustic holograms. The process is called holographic direct sound printing (HDSP). It builds on a method introduced in 2022 that described how sonochemical reactions in microscopic cavitations regions -- tiny bubbles -- create extremely high temperatures and pressure for trillionths of a second to harden resin into complex patterns.

Research 290
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Breast Cancer Treatments Might Speed Aging, Study Finds

Drugs.com

TUESDAY, Oct. 8, 2024 -- Any form of breast cancer treatment appears to speed the aging of the recipient's cells, a new study finds.“For the first time, we're showing that the [aging] signals we once thought were driven by chemotherapy are also p.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Ice cream-inspired physics: Team uncovers a quantum Mpemba effect, with a host of 'cool' implications

Science Daily: Pharmacology News

Researchers have just described the existence of the paradoxical Mpemba effect within quantum systems. Initially investigating out of pure curiosity, the discovery has bridged the gap between Aristotle's observations two millennia ago and modern-day understanding, and opened the door to a whole host of 'cool' -- and 'cooling' -- implications.

Research 267
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3% of U.S. High School Students Identify as Transgender, First National Survey Finds

Drugs.com

WEDNESDAY, Oct. 9, 2024 (HealthDay news) -- About 3% of U.S. high school students identify as transgender, according to the first federal attempt to gather national data on trans teens.Another 2% question their gender identity, results from the 2023.

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Rates of a tick-borne parasitic disease are on the rise

Science Daily: Pharmacology News

Rates of babesiosis, a tick-borne parasitic disease, increased an average of 9% per year in the United States between 2015 and 2022 and four in 10 patients were found to be co-infected with another tick-borne illness such as Lyme disease, according to a new study.

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EPA Finalizes Rule to Require Removal of Lead Pipes in U.S. Water System

Drugs.com

TUESDAY, Oct. 8, 2024 -- The U.S. Environmental Protection Agency on Tuesday finalized a rule that will require the removal of all lead pipes from the country's water systems.“We’ve known for decades that lead exposure has serious long-term impacts.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Breakthrough in soft robotics: First toroidal micro-robot to swim autonomously in viscous liquids

Science Daily: Pharmacology News

Researchers introduces the first toroidal, light-driven micro-robot that can move autonomously in viscous liquids, such as mucus. This innovation marks a major step forward in developing micro-robots capable of navigating complex environments, with promising applications in fields such as medicine and environmental monitoring.

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AI May Not Be Ready to Run Emergency Rooms

Drugs.com

TUESDAY, Oct. 8, 2024 -- AI isn’t ready to run a hospital’s emergency room just yet, a new study concludes.ChatGPT likely would ask for unnecessary x-rays and antibiotics for some patients, and admit others who don’t really need hospital treatment.

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Startup led by John Maraganore raises $135M to build ‘future of RNAi’

BioPharma Drive: Drug Pricing

“The time to re-enter the RNAi revolution is now,” said Robert Nelso=en, the managing director of Arch, which led the Series A funding round for City Therapeutics.

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New Hope Against Breast Cancers That Spread to the Brain

Drugs.com

TUESDAY, Oct. 8, 2024 -- A recently approved targeted chemotherapy drug can significantly extend the lives of advanced breast cancer patients who have developed tumors in their brains, new clinical trial results show.On average, patients receiving.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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GSK says RSV vaccine protects against disease over three seasons

BioPharma Drive: Drug Pricing

Cumulatively, data showed the shot to be 63% effective across the three-year period. However, efficacy appeared to wane and GSK said it expects revaccination will eventually be needed.

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Discovery of electrophilic degraders that exploit SNAr chemistry

Covalent Modifiers

Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Brendan G. Dwyer, Katherine A. Donovan, Zixuan Jiang, Hannah M. Jones, Dinah M. Abeja, Meredith N. Nix, Jianing Zhong, Mikołaj Słabicki, Eric S. Fischer, Benjamin L. Ebert, Nathanael S. Gray bioRxiv 2024.09.25.615094; doi: [link] Targeted covalent inhibition (TCI) and targeted protein degradation (TPD) have proven effective in pharmacologically addressing formerly ‘undruggable’ targets.

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Sage continues downslide as Alzheimer’s study fails

BioPharma Drive: Drug Pricing

After a series of setbacks for dalzanemdor, some analysts now expect that Sage won’t reach profitability for awhile — and only if its cost structure undergoes significant changes.

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Silly Things Large Language Models Do With Molecules

Practical Cheminformatics

“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.

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AI in Action: Accelerating the Drug Discovery Pipeline

Drug Patent Watch

A recent study published in Drug Discovery Today highlights the potential of artificial intelligence (AI) in revolutionizing drug discovery and development processes[1]. The research, conducted by a team from the University of Cambridge and AstraZeneca, explores how AI can be leveraged to enhance various aspects of pharmaceutical research, from target identification to clinical trials.