Practical Cheminformatics

OCTOBER 8, 2024

“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.

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Fragment Screening Packaging Organic Chemistry Small Molecule 130

ASPET

OCTOBER 8, 2024

Amitriptyline, a pleiotropic tricyclic antidepressant, possesses anti-oxidant and anti-inflammatory properties. Despite its diverse benefits, the specific effects of amitriptyline on IBD are not yet well defined. To explore this, we utilized a DSS-induced colitis model to examine the anti-inflammatory effects of amitriptyline and the underlying mechanisms by which it operates.

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RNA Regulations Treatment Research 100

Science Daily: Pharmacology News

OCTOBER 8, 2024

Researchers have developed a novel method of 3D printing that uses acoustic holograms. The process is called holographic direct sound printing (HDSP). It builds on a method introduced in 2022 that described how sonochemical reactions in microscopic cavitations regions -- tiny bubbles -- create extremely high temperatures and pressure for trillionths of a second to harden resin into complex patterns.

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Research 112

ASPET

OCTOBER 8, 2024

Discoidin domain receptor 1 (DDR1) is a collagen receptor with tyrosine kinase activity, and its expression is enhanced in various disease conditions. Although previous research suggests that DDR1 contributes to renal disease progression, DDR1 inhibitors for renal fibrosis have yet to be developed. In this study, we used unilateral ureteral obstruction (UUO) mice to investigate whether CH6824025, a strong and selective DDR1 phosphorylation inhibitor, can improve renal fibrosis.

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Disease Treatment Drugs Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 8, 2024

A research team describes how they engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.

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Engineering DNA Disease Research 110

ASPET

OCTOBER 8, 2024

Progressive multiple sclerosis (PMS) represents the worsening phase of the disease by accumulative neurodegeneration and disability, mainly refractory to current treatments. The therapeutic options remain challenging based partially on the lack of understanding of the pathogenic mechanisms but also because the early dogma was centered on neuroinflammation, overshadowing the critical role of the tissue repair process.

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Disease Treatment 100

ASPET

OCTOBER 8, 2024

Androgen deprivation is the standard treatment for prostate cancer (PCa) patients. However, the disease eventually progresses as castration-resistant PCa (CRPC). Enzalutamide, an AR inhibitor, is a typical drug to treating CRPC and due to continuous reliance on the drug, can lead to Enzalutamide-resistance (ENZ-r). This highlights the necessity for developing novel therapeutic targets to combat the gain of resistance.

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RNA Treatment Therapies Disease 100

Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- As health officials work furiously to stem the spread of Marburg virus in Rwanda, U.S. health officials announced Monday that all passengers flying from that country to the United States will soon be screened for the often.

Virus 101

Virus 101

ASPET

OCTOBER 8, 2024

The objective of this study is to investigate whether PI3kinase (PI3K) and p38 mitogen-activated kinase contributes to the protection of irisin during hemorrhage/resuscitation. Experimental groups were divided by receiving the different treatments during resuscitation: I ) Hemorrhage: Adult male CD-1 mice were subjected to hemorrhage at a mean arterial blood pressure of 35~45 mmHg for 60 min followed by 120 min of resuscitation (n=13); II ) Hemorrhage + Irisin: receiving irisin (5µg/kg) (n=

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Regulations Treatment 100

Science Daily: Pharmacology News

OCTOBER 8, 2024

An international coalition of scientists concludes that the Earth's worsening vital signs indicate a 'critical and unpredictable new phase of the climate crisis' and that 'decisive action is needed, and fast.

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International 104

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

ASPET

OCTOBER 8, 2024

Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL fusion protein, such as imatinib (Gleevec), have revolutionized targeted cancer therapies. However, drug resistance and side effects, particularly those affecting hemostasis, continue to pose significant challenges for TKI therapies. As tyrosine kinases serve pivotal roles in platelet hemostatic function, we investigated the potential impact of both established and emerging ABL TKIs on human platelet activities ex vivo.

Small Molecule 100

Small Molecule Therapies Drugs 100

Science Daily: Pharmacology News

OCTOBER 8, 2024

A new article shares findings from an extensive literature analysis of AI's current trajectory in health care.

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Research 127

Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- The U.S. Environmental Protection Agency on Tuesday finalized a rule that will require the removal of all lead pipes from the country's water systems.“We’ve known for decades that lead exposure has serious long-term impacts.

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Science Daily: Pharmacology News

OCTOBER 8, 2024

Researchers show that for the first time they have achieved atomic-scale observations of grain rotation in polycrystalline materials. Using state-of-the-art microscopy tools, the scientists were able to heat samples of platinum nanocrystalline thin films and observe the mechanism driving grain rotation in unprecedented detail.

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Research 97

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- A recently approved targeted chemotherapy drug can significantly extend the lives of advanced breast cancer patients who have developed tumors in their brains, new clinical trial results show.On average, patients receiving.

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Clinical Trials Trials Drugs 88

Science Daily: Pharmacology News

OCTOBER 8, 2024

Engineers built a solar-powered desalination system that produces large quantities of clean water despite variations in sunlight throughout the day. Because it requires no extra batteries, it offers a much more affordable way to produce drinking water, compared to other solar-driven designs.

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Engineering 83

Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s.

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Disease 88

Science Daily: Pharmacology News

OCTOBER 8, 2024

The expectations humans have of a pleasurable sensation asymmetrically shape neuronal responses and subjective experiences to hot sauce, according to a new study.

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Drugs.com

OCTOBER 8, 2024

WEDNESDAY, Oct. 9, 2024 (HealthDay news) -- About 3% of U.S. high school students identify as transgender, according to the first federal attempt to gather national data on trans teens.Another 2% question their gender identity, results from the 2023.

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BioPharma Drive: Drug Pricing

OCTOBER 8, 2024

“The time to re-enter the RNAi revolution is now,” said Robert Nelso=en, the managing director of Arch, which led the Series A funding round for City Therapeutics.

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Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- Any form of breast cancer treatment appears to speed the aging of the recipient's cells, a new study finds.“For the first time, we're showing that the [aging] signals we once thought were driven by chemotherapy are also p.

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Treatment 82

Drug Patent Watch

OCTOBER 8, 2024

A recent study published in Drug Discovery Today highlights the potential of artificial intelligence (AI) in revolutionizing drug discovery and development processes[1]. The research, conducted by a team from the University of Cambridge and AstraZeneca, explores how AI can be leveraged to enhance various aspects of pharmaceutical research, from target identification to clinical trials.

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Clinical Trials Drugs Pharmaceuticals Trials 66

Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- Damage to the brainstem could be behind the physical and psychological effects of Long COVID, a new study suggests.Brain scans of 30 Long COVID patients found they had damage to the region of the brainstem associated with.

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BioPharma Drive: Drug Pricing

OCTOBER 8, 2024

Cumulatively, data showed the shot to be 63% effective across the three-year period. However, efficacy appeared to wane and GSK said it expects revaccination will eventually be needed.

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Vaccine Disease 62

Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- AI isn’t ready to run a hospital’s emergency room just yet, a new study concludes.ChatGPT likely would ask for unnecessary x-rays and antibiotics for some patients, and admit others who don’t really need hospital treatment.

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Hospitals Treatment 69

BioPharma Drive: Drug Pricing

OCTOBER 8, 2024

After a series of setbacks for dalzanemdor, some analysts now expect that Sage won’t reach profitability for awhile — and only if its cost structure undergoes significant changes.

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Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- In a small, preliminary study, piano lessons provided to cancer patients undergoing chemotherapy appeared to help them maintain brain health. "There were a lot of outside stressors contributing to my mood, but piano.

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NIOSH Science Blog: Drugs

OCTOBER 8, 2024

Workers who respond to roadway emergencies, such as vehicle crashes, can face multiple hazards. Working at roadway incidents frequently exposes responders to potentially being struck by passing motor vehicle traffic leading to serious injury or death. These secondary crashes during responses to roadway incidents contribute to about 50 emergency responder fatalities and injuries annually.[1][2] Additionally, crashes during roadway incident responses can cause extensive property damage to agency e

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Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 The recent approval of a new epinephrine nasal spray gives patients a powerful new way to keep life-threatening allergic reactions at bay. But that doesn't mean folks no longer have to worry about anaphylaxis.According to.

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Covalent Modifiers

OCTOBER 8, 2024

Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Brendan G. Dwyer, Katherine A. Donovan, Zixuan Jiang, Hannah M. Jones, Dinah M. Abeja, Meredith N. Nix, Jianing Zhong, Mikołaj Słabicki, Eric S. Fischer, Benjamin L. Ebert, Nathanael S. Gray bioRxiv 2024.09.25.615094; doi: [link] Targeted covalent inhibition (TCI) and targeted protein degradation (TPD) have proven effective in pharmacologically addressing formerly ‘undruggable’ targets.

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Targeted Protein Degradation Small Molecule 57

addgene Blog

OCTOBER 8, 2024

Here at Addgene, we often refer to plasmids as lab or experimental tools. They certainly are very handy in research, but we’re really borrowing these tools from Mother Nature’s toolbox. Natural plasmids, also called environmental plasmids, are all around us!

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Research 55

keypoint

OCTOBER 8, 2024

In honor of National Hispanic Heritage Month, we caught up with Keystone Symposia Fellow Dr. César de la Fuente, Presidential Assistant Professor at the University of Pennsylvania, where he leads the Machine Biology Group. Dr. de la Fuente and colleagues are generating attention for their APEX deep learning model that uses AI to mine ancient organisms’ genomes for therapeutic molecules, dramatically accelerating antibiotics discovery.

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Perficient: Drug Development

OCTOBER 8, 2024

At Dreamforce 2024, Perficient explored the integration of Databricks and Salesforce Data Cloud, focusing on an insurance industry use case. This session showcased data processing, customer engagement, and AI-driven insights, offering real-world value to enterprises. Here’s a comprehensive recap of the session, highlighting the key takeaways and technical depth discussed.

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Drug Target Review

OCTOBER 8, 2024

In the PreTarg-it® system, why is the three-to-five-day interval between ON105 administration and the delivery of the radiolabelled DOTA-di-HSG peptide critical for maximising therapeutic efficacy and minimising off-target effects? Our PreTarg-it® platform enhances the efficacy of radioimmunotherapy (RIT) while reducing off-target radiation by employing a pretargeted approach.

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Pharmacokinetics Engineering Treatment Science 52