Wed.Nov 06, 2024

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An RNAi renaissance is creating a new generation of startups

BioPharma Drive: Drug Pricing

Pioneers like Alnylam Pharmaceuticals have led the RNA interference field for years. Now, a crop of young biotechs is building on that foundation by taking the drugmaking technology in new directions.

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Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer

Broad Institute

Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer By Leah Eisenstadt November 6, 2024 Breadcrumb Home Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer Broad and Mass General researcher Alexandra-Chloé Villani and Mass General oncologist Kerry Reynolds describe their pioneering effort to better understand, diagnose, and manage dangerous complications from cancer immunotherapy.

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How gophers brought Mount St. Helens back to life in one day

Science Daily: Pharmacology News

When Mount St. Helens erupted in 1980, lava incinerated anything living for miles around. As an experiment, scientists dropped gophers onto parts of the scorched mountain for only 24 hours. The benefits from that single day were undeniable and still visible 40 years later.

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Study reveals how cancer immunotherapy may cause heart inflammation in some patients

Broad Institute

Study reveals how cancer immunotherapy may cause heart inflammation in some patients By Leah Eisenstadt November 6, 2024 Breadcrumb Home Study reveals how cancer immunotherapy may cause heart inflammation in some patients Myocarditis is driven by a different immune response than the anti-tumor one, suggesting that the serious complication could one day be managed without halting cancer therapy.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Sleepiness during the day may be tied to pre-dementia syndrome

Science Daily: Pharmacology News

Older people who are sleepy during the day or lack enthusiasm for activities due to sleep issues may be more likely to develop a syndrome that can lead to dementia, according to a new study.

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While the Orphan Battles Wages, Jazz Takes a Loss

FDA Law Blog: Biosimilars

By Sara W. Koblitz — The fight between Jazz, Avadel, and FDA over narcolepsy drug sodium oxybate has been a long and arduous one. Starting in 2022 with a patent certification requirement, both Jazz and Avadel have sued FDA over this drug, with Jazz most recently bringing suit challenging FDA’s decision that Avadel’s Lumryz (sodium oxybate) is clinically superior to Jazz’s Xywav (sodium oxybate) in 2023.

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COVID Vaccine Mistrust Levels Aren't Budging, Study Finds

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- More than a third of Americans continue to express mistrust in the science behind COVID vaccines, a new study finds.This level of mistrust has remained relatively consistent, expressed by 36% of people in 2021, 33% in.

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Five minutes of extra exercise a day could lower blood pressure

Science Daily: Pharmacology News

New research suggests that adding a small amount of physical activity -- such as uphill walking or stair-climbing -- into your day may help to lower blood pressure.

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Winter's Onset Brings Mood Changes to Many Americans, Poll Finds

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- Many Americans experience a “winter funk” as the days grow shorter and temperatures turn colder, a new American Psychiatric Association poll reports.Two-fifths of Americans (41%) said their mood declines during the winter.

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The egg or the chicken? An ancient unicellular says egg

Science Daily: Pharmacology News

Chromosphaera perkinsii is a single-celled species discovered in 2017 in marine sediments around Hawaii. The first signs of its presence on Earth have been dated at over a billion years, well before the appearance of the first animals. A team has observed that this species forms multicellular structures that bear striking similarities to animal embryos.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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U.S. Diabetes Rates Rise to Nearly 1 in 6 Adults

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- Nearly 16% of American adults -- that's close to 1 in 6 -- now has diabetes, according to the latest data from the U.S. Centers for Disease Control and Prevention.Increasing age and widening waistlines greatly increase.

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New haptic patch transmits complexity of touch to the skin

Science Daily: Pharmacology News

Thin, flexible device could help people with visual impairments 'feel' surroundings. Device comprises a hexagonal array of 19 actuators encapsulated in soft silicone. Device only uses energy when actuators change position, operating for longer periods of time on a single battery charge.

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PCOS Plus Obesity Can Be Hazardous in Pregnancy

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- Women who are pregnant but who also have the ovarian cyst disorder polycystic ovary syndrome (PCOS) are at higher odds of giving birth to an underweight baby, new Norwegian research shows.The risk rises even higher if the.

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What happens in your brain while you watch a movie

Science Daily: Pharmacology News

By scanning the brains of people while they watched movie clips, neuroscientists have created the most detailed functional map of the brain to date. The fMRI analysis shows how different brain networks light up when participants viewed short clips from a range of independent and Hollywood films including Inception, The Social Network, and Home Alone.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Nasal Swab Might Predict How Severe COVID Will Be

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- A simple nasal swab might help doctors predict the severity of a person’s COVID infection, a new study suggests.More than 70% of people with mild or moderate COVID develop certain antibodies in their nasal cavities that a.

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Scientists calculate predictions for meson measurements

Science Daily: Pharmacology News

Calculations of charge distribution in mesons provide benchmark for experimental measurements and validate widely used 'factorization' method for imaging the building blocks of matter.

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Drowsy Driving: Not Taken as Seriously as Drunk Driving, But It Can Kill

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- Folks are more likely to drive drowsy than drive drunk, even though both raise the risk of a fatal crash, a new survey shows.About 4 in 10 adults say they’ll find alternative transportation when they haven’t gotten enough.

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Breakthrough in energy-efficient avalanche-based amorphization could revolutionize data storage

Science Daily: Pharmacology News

Researchers have developed a new method for disrupting the crystal structure of a semiconductor that requires as little as one billion times less power density. This advancement could unlock wider applications for phase-change memory (PCM) -- a promising memory technology that could transform data storage in devices from cell phones to computers.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Scientists Track Brain Function as Folks Watch Movies

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- A person’s brain performs an intricate juggling act while watching a movie, a new study demonstrates. Scans showed that 24 different brain networks and regions engage from scene-to-scene, based on hard it is to.

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Interstellar methane as progenitor of amino acids?

Science Daily: Pharmacology News

Gamma radiation can convert methane into a wide variety of products at room temperature, including hydrocarbons, oxygen-containing molecules, and amino acids, reports a research team. This type of reaction probably plays an important role in the formation of complex organic molecules in the universe -- and possibly in the origin of life. They also open up new strategies for the industrial conversion of methane into high value-added products under mild conditions.

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How a Move Away From Beef Could Help the Planet

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- Eating fewer burgers and steaks could pay big dividends for Mother Earth, and human health, by combatting climate change, a new study suggests.Small cutbacks in beef production among wealthy nations could remove 125.

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Researchers have uncovered the mechanism in the brain that constantly refreshes memory

Science Daily: Pharmacology News

Researchers have discovered a neural mechanism for memory integration that stretches across both time and personal experience.

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How to Develop a Risk Management Plan for Generic Drugs

Drug Patent Watch

Developing a Risk Management Plan (RMP) for generic drugs is a crucial step in ensuring the safety and efficacy of these medications. An RMP provides detailed information on a medicine’s safety profile, measures to prevent or minimize risks, and plans for ongoing safety monitoring and evaluation.

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Use of 'genetic scissors' carries risks

Science Daily: Pharmacology News

The CRISPR tool is capable of repairing the genetic defect responsible for the immune disease chronic granulomatous disease. However, researchers have now shown that there is a risk of inadvertently introducing other defects.

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Remote Work vs Office Work in Software Consulting: What’s the Best Scenario in 2024?

Perficient: Drug Development

The pandemic accelerated the adoption of remote work in the technology sector, especially in software consulting firms. However, now that the situation has changed, what is the most suitable work model for this sector that promotes employee well-being? The Hybrid Model: A Customized Solution for Software Consulting Firms A recent Gartner study: Future of Work reveals that in 2024, companies are more inclined to adopt a hybrid work model.

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Imaging nuclear shapes by smashing them to smithereens

Science Daily: Pharmacology News

Scientists have demonstrated a new way to use high-energy particle smashups at the Relativistic Heavy Ion Collider (RHIC) to reveal subtle details about the shapes of atomic nuclei. The method is complementary to lower energy techniques for determining nuclear structure. It will add depth to scientists' understanding of the nuclei that make up the bulk of visible matter.

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Who You Gonna Email? Digital Health Question Busters!

FDA Law Blog: Biosimilars

By Jennifer D. Newberger — Though digital health is not new, it can still often be difficult to determine with precision the regulatory requirements applicable to a particular software product. Sometimes this is because FDA has not opined on a specific set of facts, but more often it is because FDA seems to take different approaches to the same technology offered by different companies.

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Quantum vortices confirm superfluidity in supersolid

Science Daily: Pharmacology News

Supersolids are a new form of quantum matter that has only recently been demonstrated. The state of matter can be produced artificially in ultracold, dipolar quantum gases. A team has now demonstrated a missing hallmark of superfluidity, namely the existence of quantized vortices as system's response to rotation. They have observed tiny quantum vortices in the supersolid, which also behave differently than previously assumed.

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Moderna said to shuffle sales leadership; Vertex records first Casgevy sale

BioPharma Drive: Drug Pricing

Stephen Hoge will now oversee vaccine sales at Moderna, per a Bloomberg report. Elsewhere, Intra-Cellular unveiled an ambitious sales target and Syndax inked a lucrative royalty deal.

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Asteroid grains shed light on the outer solar system's origins

Science Daily: Pharmacology News

Tiny grains from asteroid Ryugu are revealing clues to the magnetic forces that shaped the far reaches of the solar system over 4.6 billion years ago. The findings suggest the distal solar system harbored a weak magnetic field, which could have played a role in forming the giant planets and other objects.

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Vaccinating Against Cancer Cells and Reprogramming the Tumor Microenvironment That Protects Them

Fierce BioTech

By Ayako Wakatsuki Pedersen, Ph.D., Senior Vice President of Translational Research at IO Biotech | Making the tumor microenvironment hostile to cancer cells and immune-suppressive cells may transform the cancer treatment landscape.

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Mighty radio bursts linked to massive galaxies

Science Daily: Pharmacology News

Researchers have uncovered where FRBs are more likely to occur in the universe -- massive star-forming galaxies rather than low - mass ones.

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Florida Fails to Pass Amendment Legalizing Recreational Weed

Drugs.com

WEDNESDAY, Nov. 6, 2024 -- A ballot measure to legalize the recreational use of marijuana in the state of Florida failed on Tuesday.While 55.9% of Florida voters backed the proposed amendment, it did not reach the 60% threshold needed to make the.

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