Science Daily: Pharmacology News
APRIL 4, 2025
Low vaccination rates for influenza viruses and the lack of an HSV vaccine underscore the need for a new approach to reduce viral transmission. Researchers have now used a clinical-grade antiviral chewing gum to substantially reduce viral loads of two herpes simplex viruses and two influenza A strains in experimental models.
Covalent Modifiers
APRIL 4, 2025
Amanda L. Waterbury, Jonatan Caroli, Olivia Zhang, Paloma R. Tuttle, Chao Liu, Jiaming Li, Ji Sung Park, Samuel M. Hoenig, Marco Barone, Airi Furui, Andrea Mattevi & Brian B. Liau Nat Commun 16 , 3156 (2025). [link] Chromatin modifiers often work in concert with transcription factors (TFs) and other complex members, where they can serve both enzymatic and scaffolding functions.
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Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- Antidepressants appear to increase peoples risk of sudden cardiac death, a new study says.People taking the mood meds are more likely to die suddenly from heart problems, and their risk rises the longer theyre on the dru.
Chemical Biology and Drug Design
APRIL 4, 2025
Isocitrate dehydrogenase (IDH) is a key metabolic enzyme that catalyzes the conversion of isocitrate to -ketoglutaric acid (-KG). At present, there are few studies on the drug resistance of mIDH1 inhibitors. Therefore, this article first summarizes terms of IDH1 function from the molecular mechanism of IDH1, the mechanism of mutation, and the metabolism of substances due to mutations.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- The U.S. Food and Drug Administration (FDA) has delayed the full approval of Novavaxs COVID-19 vaccine. The decision had been expected by April 1, but the agency now says it needs more information before moving forward.The.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- An experimental blood test for Alzheimers disease not only can aid in its diagnosis but also indicate how far the brain condition has progressed, a new study says.The test tracks levels of a protein called MTBR-tau243, w.
Science Daily: Pharmacology News
APRIL 4, 2025
Astronomers have discovered an extremely rare, high mass, compact binary star system only ~150 light years away. These two stars are on a collision course to explode as a type 1a supernova, appearing 10 times brighter than the moon.
Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- Cancer survivors can reduce their ongoing risk of death by sticking to diet and exercise guidelines recommended by the American Cancer Society, a new study suggests.Non-smoking survivors of obesity-related cancers had an.
Science Daily: Pharmacology News
APRIL 4, 2025
Quantum states can only be prepared and observed under highly controlled conditions. A research team has now succeeded in creating so-called hot Schrodinger cat states in a superconducting microwave resonator. The study shows that quantum phenomena can also be observed and used in less perfect, warmer conditions.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- Disrespected by a neighbor or colleague? Eyerolls from servers at a restaurant or store? Denied a job or a mortgage due to skin color?More than half of Americans have experienced some such form of discrimination, and this.
BioPharma Drive: Drug Pricing
APRIL 4, 2025
Sarepta and Roche will share the monitors' findings with EMA to resolve a temporary hold. Elsewhere, Allakos agreed to a buyout and high-dose Ocrevus missed a study goal.
Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- Common chemicals used in plastic and personal care products may interfere with brain development in babies, a new study says.Phthalates are found in many everyday items, like food packaging, shampoo, toys and vinyl.
BioPharma Drive: Drug Pricing
APRIL 4, 2025
Provider groups and health systems warn tariffs will test healthcare’s fragile supply chain, threatening to create disruptions to patient care.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- Hospitals could be short-changing patients if they lean too heavily on nurse staffing agencies or overtime hours, a new study says.Patients are much more likely to develop bedsores at short-staffed hospitals that regularly.
BioPharma Drive: Drug Pricing
APRIL 4, 2025
Just two acquisitions in the first quarter, that of Intra-Cellular Therapies and IDRx, crossed the $1 billion mark, a notable decrease from the six seen during the same period last year.
Drugs.com
APRIL 4, 2025
FRIDAY, April 4, 2025 -- Americans received some protection against death during the COVID-19 pandemic if they lived in a state that had expanded its Medicaid program under the Affordable Care Act (ACA), a new study says.Even though death rates.
Fierce BioTech
APRIL 4, 2025
AI-Powered Market Intelligence: Transforming Critical Decision-Making and Strategies in Global Healthcare pesurya Fri, 04/04/2025 - 10:55 Tue, 05/06/2025 - 09:00 Resource Type Webinar Promotion End Tue, 05/06/2025 - 12:01 In a rapidly evolving healthcare landscape, business strategies are becoming increasingly complex due to shifting payer expectations and market demographics, regulatory pressures, and dynamic market conditions.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
DS in Pharmatics
APRIL 4, 2025
The Prescription Drug User Fee Act (PDUFA) has been a cornerstone of the U.S. Food and Drug Administrations (FDA) drug approval process since its inception in 1992.
thought leadership
APRIL 4, 2025
The US Government recently modified their policy to utilize tariffs to in an effort to support the US economy. Pharmaceutical tariffs have been announced causing many global organizations to investigate the consequences of the tariffs on their overall product portfolio. Companies need to know the facts and have data to support their decisions.
DS in Pharmatics
APRIL 4, 2025
Navigating the regulatory pathways for drug approvals in the U.S. can be complex, especially when determining whether a Biologics License Application (BLA) or a New Drug Application (NDA) is the appropriate route.
thought leadership
APRIL 4, 2025
The US Government recently modified their policy to utilize tariffs to in an effort to support the US economy. Pharmaceutical tariffs of 25% have been forecasted causing many global organizations to investigate the consequences of the tariffs on their overall product portfolio. Companies need to know the facts and have data to support their decisions.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
DS in Pharmatics
APRIL 4, 2025
The Center for Biologics Evaluation and Research (CBER) plays a critical role in overseeing the approval of innovative biologic products, including gene therapies, cell-based treatments, and vaccines.
Science Daily: Pharmacology News
APRIL 4, 2025
A team of researchers led by a physics graduate student recently made the surprising discovery of what they call a 'shape-recovering liquid,' which defies some long-held expectations derived from the laws of thermodynamics. The research details a mixture of oil, water and magnetized particles that, when shaken, always quickly separates into what looks like the classically curvaceous lines of a Grecian urn.
DS in Pharmatics
APRIL 4, 2025
For early-stage drug developers, engaging with the FDA at the right time can be critical to success. One such opportunity is the INitial Targeted Engagement for Regulatory Advice on CBER/CDER ProducTs (INTERACT) meeting.
Chemical Biology and Drug Design
APRIL 4, 2025
Our deep learning framework, combining ProtTrans and multiwindow convolutional neural networks (CNNs), achieved high predictive accuracy for NAD-binding sites, with area under the curves (AUCs) of 0.9733 for human sirtuin proteins and 0.9701 for other NAD-dependent deacylation enzymes. This approach advances the understanding of sirtuin roles in aging and therapeutic potential.
DS in Pharmatics
APRIL 4, 2025
The path to FDA drug approval involves several critical milestones, one of the most important being the Pre-New Drug Application (Pre-NDA) meeting. This crucial step provides pharmaceutical companies with an opportunity to engage with the FDA before submitting a New Drug Application (NDA).
Codon
APRIL 4, 2025
By Kamal Nahas James Phipps , the son of a poor, landless gardener, was only eight years old when his father signed him up for a risky experimental procedure to be performed by his employer, the British physician Edward Jenner. It’s unclear whether his father fully understood what he was consenting to or whether he had been persuaded by a payment.
Perficient: Drug Development
APRIL 4, 2025
My dad generally does not have a very strong opinion about anything. His best reaction was when we went to see the Taj Mahal in Agra, India and he said “its good” Not someone who will applaud anything vociferously. When he heard about the whole manifestation spiel from my sister, he recommended us to read Psycho-Cybernetics by Dr Maxwell Maltz , a 1960s book he read as a young man that he says was amazing.
New Drug Approvals
APRIL 4, 2025
Bevemipretide, CAS 2356106-71-1 FREE BASE CAS SBT-272 Trihydrochloride, 2589640-11-7 607.7 g/mol, C 31 H 45 N 9 O 4 F553HAL9V8 SBT-272 (2R)-2-amino-N-[(2S)-1-[[(1S)-5-amino-1-(3-benzyl-1,2,4-oxadiazol-5-yl)pentyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide L-Tyrosinamide, D-arginyl-N-[(1S)-5-amino-1-[3-(phenylmethyl)-1,2,4-oxadiazol-5-yl]pentyl]-2,6-dimethyl- (2R)-2-amino-N-[(2S)-1-[[(1S)-5-amino-1-(3-benzyl-1,2,4-oxadiazol-5-yl)pentyl]amino]-
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