Mon.May 06, 2024

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Participants of pioneering CRISPR gene editing trial see vision improve

Science Daily: Pharmacology News

About 79% of clinical trial participants experienced measurable improvement after receiving experimental, CRISPR-based gene editing that is designed to fix a rare form of blindness, according to a new article.

Trials 361
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Bluebird preps for first commercial use of sickle cell gene therapy

BioPharma Drive: Drug Pricing

A 12-year-old boy in the Washington, D.C., area is set become the first patient treated with Lyfgenia since its U.S. approval last December.

Therapies 294
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Caterbot? Robatapillar? It crawls with ease through loops and bends

Science Daily: Pharmacology News

Engineers created a catapillar-shaped robot that splits into segments and reassembles, hauls cargo, and crawls through twisting courses.

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Scientists Developing Vaccine Against Present and Future COVID Viruses

Drugs.com

MONDAY, May 6, 2024 -- Scientists are busy working on a vaccine that might fight strains of the COVID virus SARS-CoV-2 that haven't even emerged yet.The effort from a British team at the University of Cambridge is already showing promise in mouse.

Virus 290
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Venus has almost no water: A new study may reveal why

Science Daily: Pharmacology News

Billions of years ago, Venus may have harbored as much water as Earth. Today, almost all of it has disappeared. A new study may help to explain why.

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Astronomers observe elusive stellar light surrounding ancient quasars

Science Daily: Pharmacology News

Astronomers observed the elusive starlight surrounding some of the earliest quasars in the universe. The findings may shed light on how the earliest supermassive black holes became so massive despite having a relatively short amount of cosmic time in which to grow.

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Combo Therapy May Be Advance Against Liver Cancer

Drugs.com

MONDAY, May 6, 2024 -- A new combination therapy appears to boost the response rate for liver cancer patients receiving immunotherapy, according to results from a phase 2 clinical trial.The combo therapy involves bavituximab, a drug that.

Therapies 281
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New discoveries about Jupiter's magnetosphere

Science Daily: Pharmacology News

New discoveries about Jupiter could lead to a better understanding of Earth's own space environment and influence a long-running scientific debate about the solar system's largest planet.

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Money Worries Top Seniors' List of Health-Related Concerns: Poll

Drugs.com

MONDAY, May 6, 2024 -- Worries over health-related costs are plaguing the minds of older Americans of all backgrounds, a new poll suggests.Five of the six health-related issues that most people found very concerning had to do with health care.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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As drug shortages reach record highs, regulators weigh next steps

BioPharma Drive: Drug Pricing

With many chemotherapy and ADHD drugs stuck in stubbornly short supply, several agencies are looking for new solutions.

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New Test Might Alert Pregnant Women to Preeclampsia Danger

Drugs.com

MONDAY, May 6, 2024 -- A potentially dangerous spike in blood pressure known as preeclampsia can occur in 1 in every 25 pregnancies, but an accurate test to spot those women at highest risk has remained elusive.Now, Canadian researchers at.

Research 246
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AstraZeneca ups stake in Cellectis in latest cell therapy bet

BioPharma Drive: Drug Pricing

The British drugmaker, which has made genetic medicine a larger priority of late, added $140 million to a deal to develop up to 10 gene and cell therapies.

Therapies 171
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Avoid Some 'Project Watson' Dog Eye Wipes Due to Infection Danger

Drugs.com

MONDAY, May 6, 2024 -- Pets and pet owners who come into contact with Bausch & Lomb's "Project Watson" dog eye wipes could be at risk for infection if the products come from certain lots.The wipes are used to clean a dog's eyelids, but two.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Gossamer sells rights to drug it hopes can rival a new Merck therapy

BioPharma Drive: Drug Pricing

One analyst thinks the collaboration “bodes well” for Gossamer, which has had trouble convincing investors its drug seralutinib can compete on the market.

Therapies 164
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How 'Unruly' Sports Parents Harm Their Kids' Mental Health

Drugs.com

MONDAY, May 6, 2024 -- Everyone knows that specific type of sports parent – the over-the-top dad or mom who curses, shouts and even becomes physically aggressive during their kid’s match.While they might think they’re cheering their kid to.

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Free pathway analysis: How much do you really save?

BioPharma Drive: Drug Pricing

Can free bioinformatics tools get the job done?

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Parental Deaths to Guns, Drugs Harmed Nearly 100,000 U.S. Kids in 2020

Drugs.com

MONDAY, May 6, 2024 -- Nearly 100,000 U.S. children lost a parent in 2020 to gun violence or drug overdose, a three-fold rise since 1999, according to a new study.

Drugs 242
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Maximizing efficiency in translational medicine with an on-site pharmacy

BioPharma Drive: Drug Pricing

The ability to modify drug formulations in real time and dosage strengths is crucial, while adhering to all regulatory standards and maintaining cGMP standards.

Pharmacy 139
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ERs Often Missing Epilepsy in Kids With 'Non-Motor' Seizures

Drugs.com

MONDAY, May 6, 2024 — Two-thirds of kids who suffer a subtle type of epileptic seizure go undiagnosed when they seek emergency room treatment, new research shows.“We do not know how many people are walking around with seizures that they are.

Treatment 240
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Optimized trials are the easiest way to meet the FDA’s latest diversity requirements

BioPharma Drive: Drug Pricing

Optimized clinical trials will help sponsors align with new FDORA diversity requirements.

Trials 130
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Parents of Infants With Cystic Fibrosis Often Feel Confused, Unsupported: Survey

Drugs.com

MONDAY, May 6, 2024 -- Parents of newborns diagnosed with cystic fibrosis often are confused about both the disease and their next steps, a new national survey has found.In fact, about half of new parents don’t even know that newborns are.

Disease 130
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Can a Device Be Found Not Substantially Equivalent Because of Cybersecurity Risks? A Review of FDA’s Draft Guidance on Cybersecurity in Medical Devices

FDA Law Blog: Biosimilars

By Lisa M. Baumhardt, Senior Medical Device Regulation Expert & Adrienne R. Lenz, Principal Medical Device Regulation Expert — FDA recently issued a draft guidance which would update the agency’s Cybersecurity in Medical Devices: Quality System Considerations and Content of Premarket Submissions guidance. The draft guidance provides recommendations on what is required to meet cybersecurity obligations under section 524B of the Food, Drug and Cosmetic Act (FD&C).

FDA 105
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Women in Stem with Stefanie Flückiger-Mangual

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? My journey in STEM has been both challenging and immensely fulfilling. Early in my career, I had a bad experience in one of my first jobs, helping in the lab as a young student. My professor’s seeming support of my work quickly shifted into a more personal interest in me.

Therapies 105
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Rapid-onset, short-duration induction of colorectal contractions in anesthetized, adult, male rats. [Gastrointestinal, Hepatic, Pulmonary, and Renal]

ASPET

Substantial clinical and preclinical evidence indicates that transient receptor potential vanilloid 1 (TRPV1) receptors are expressed on terminals of colorectal chemoreceptors and mechanoreceptors and are involved in various rectal hypersensitivity disorders with common features of colorectal overactivity. These stimulatory properties of TRPV1 receptors on colorectal function suggested that brief stimulation of TRPV1 might provide a means of pharmacologically activating the colorectum to induce

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Biologics: Innovations, Challenges, and the Road Ahead

DrugBank

Biologics are revolutionizing modern healthcare. Unlike conventional chemical-based medicines, biologics offer targeted therapies derived from living cells, which can result in more effective and personalized treatments. This category encompasses a broad spectrum of treatments including vaccines, blood components, gene therapies, and more, each tailored to combat diseases in highly specific ways.

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CAR and PPAR{alpha} do not perform liquid-liquid phase separation in cells [Cellular and Molecular]

ASPET

Constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor α (PPARα) are members of the nuclear receptor superfamily, which regulates various physiological and pathological processes. Phase separation is a dynamic biophysical process that biomacromolecules form liquid-like condensates, which have been identified as a contributor to many cellular functions, such as signal transduction and transcription regulation.