Mon.Aug 12, 2024

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AI poses no existential threat to humanity, new study finds

Science Daily: Pharmacology News

Large Language Models (LLMs) are entirely controllable through human prompts and lack 'emergent abilities'; that is, the means to form their own insights or conclusions. Increasing model size does not lead LLMs to gain emergent reasoning abilities, meaning they will not develop hazardous abilities and therefore do not pose an existential threat. A new study sheds light on the (until now unexplained) capabilities and shortcomings of LLMs, including the need for carefully engineered prompts to exh

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KLS-13019, a novel structural analogue of cannabidiol (CBD) and GPR55 receptor antagonist, Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats. [Behavioral Pharmacology]

ASPET

Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential.

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Scientists find oceans of water on Mars: It's just too deep to tap

Science Daily: Pharmacology News

Quakes and meteor impacts on Mars generate seismic waves that can help map the interior. A new study analyzed seismic waves detected by the Insight lander and concludes that 11-20 kilometers beneath the surface, a zone of pores and fractures is filled with liquid water -- more than was thought to fill Mars' surface oceans before they disappeared 3 billion years ago.

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Following FDA rejection, a journal retracts papers on MDMA-assisted therapy

BioPharma Drive: Drug Pricing

Editors at Psychopharmacology cited "unethical conduct" that the study authors didn't disclose when submitting the papers. Lykos Therapeutics says it filed a complaint with a third party to review the way the journal came to its decision.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Parents who use humor have better relationships with their children, study finds

Science Daily: Pharmacology News

In a pilot study, most people viewed humor as an effective parenting tool and that a parent or caregiver's use of humor affected the quality of their relationship with their children, according to new research. Among those whose parents used humor, the majority viewed their relationship with their parents and the way they were parented in a positive light.

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FDA Says No to MDMA as Therapy for PTSD

Drugs.com

MONDAY, Aug. 12, 2024 -- Advocates for the use of the psychedelic drug MDMA (midomafetamine) to treat mental health conditions were delivered a setback on Friday after the U.S. Food and Drug Administration declined to approve it as treatment for.

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FDA approves Ascendis drug for rare endocrine condition

BioPharma Drive: Drug Pricing

The clearance of Yorvipath for hypoparathyroidism was some time coming for Ascendis, which had resubmitted after receiving a rejection last year.

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Even Moderate Drinking Ups Risk for Brain Bleeds After a Fall

Drugs.com

MONDAY, Aug. 12, 2024 -- Drinking can increase a senior’s risk of a brain bleed following a fall, even if they only occasionally imbibe, a new study finds.In fact, the risk of a brain bleed increases with a senior’s level of drinking, researchers fo.

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Pfizer builds case for RSV shot with data from immunocompromised adults

BioPharma Drive: Drug Pricing

Results from a Phase 3 study could help Pfizer broaden use of its vaccine Abrysvo to younger adults whose medical history puts them at higher risk.

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Fruits, Vegetables Lower Your Body's Acid Levels, Boosting Health

Drugs.com

MONDAY, Aug. 12, 2024 -- An apple a day, along with a healthy serving of vegetables, could become a first line of treatment for hypertension, new research suggests.Diet plays a large role in overall health, and the study confirmed that a diet high.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New genetically engineered wood can store carbon and reduce emissions

Science Daily: Pharmacology News

Researchers genetically modified poplar trees to produce high-performance, structural wood without the use of chemicals or energy intensive processing.

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Could More Men With Early Prostate Cancers Keep Their Lymph Nodes?

Drugs.com

MONDAY, Aug. 12, 2024 -- For years, the treatment of early-stage prostate cancers that haven't spread beyond the organ have often included the removal of nearby lymph nodes in the pelvis. It's done as a precaution and as a means of "staging" the.

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Engineers bring efficient optical neural networks into focus

Science Daily: Pharmacology News

Researchers have published a programmable framework that overcomes a key computational bottleneck of optics-based artificial intelligence systems. In a series of image classification experiments, they used scattered light from a low-power laser to perform accurate, scalable computations using a fraction of the energy of electronics.

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Getting Fats From Plants Vs. Animals Boosts Your Life Span

Drugs.com

MONDAY, Aug. 12, 2024 -- A study of more than 400,000 people tracked for up to 24 years finds that those who got their dietary fat from plants versus animals had significantly lower odds of dying during the study period.Plant-based fats' benefit.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Ships now spew less sulfur, but warming has sped up

Science Daily: Pharmacology News

New findings document fewer ship tracks, reduced cloud cover, and boosted warming after ship emissions regulations took effect in 2020.

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Every Day Counts for PTE: Court Finds FDA’s Reinterpretation of Testing Phase Arbitrary and Capricious

FDA Law Blog: Biosimilars

By Sara W. Koblitz — In the world of patent term extensions, every day considered part of the regulatory review period is important, as that day—either in whole or in part—gets added back to the patent upon approval of the product. In the veterinary world, where rolling applications are common, the testing phase is usually particularly important because the review phase, which starts only when the last component of the rolling New Animal Drug Application (NADA)—called the Administrative NADA—is

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TikTok Craze 'Extra Hard' Gum Won't Chisel Your Jawline. It Might Even Hurt You

Drugs.com

MONDAY, Aug. 12, 2024 -- “Extra-hard” chewing gum is being touted on social media as a means of developing a chiseled jawline.This sort of gum is promoted as a gym for “facial fitness,” toning and tightening the muscles around the jaw.But experts sa.

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Startup Halda raises $126M to advance new type of targeted cancer therapy

BioPharma Drive: Drug Pricing

Technology emerging from Yale researcher Craig Crews’ labs will be used to target prostate and breast cancer in early clinical trials.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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More Toddler Screen Time Brings More Tantrums, Study Finds

Drugs.com

MONDAY, Aug. 12, 2024 -- Using tablets as 'e-babysitters' for toddlers could lead to more tantrums, which in turn can have harried parents trying to calm a child by handing them a tablet, new research shows.This type of "vicious cycle" played out.

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Perficient Insights: Dreamforce 2024 with Kristen Quick

Perficient: Drug Development

At Perficient, we take pride in our talented and dedicated team members who bring their unique expertise and energy to everything they do. This month, we’re spotlighting Kristen Quick, a Director within our Salesforce practice, as she prepares to attend her very first Dreamforce in 2024. Introducing Kristen Quick Kristen comes to Perficient with a robust background in healthcare, having worked on both the payer and provider sides of the industry.

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Brain Study Shows How Classical Music Lifts Your Mood

Drugs.com

MONDAY, Aug. 12, 2024 -- Does listening to classical music make you feel sublime?A new study suggests there might be a scientific reason for that: Researchers discovered that the music lifts a person’s mood by improving connections between brain r.

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Perficient Insights: Dreamforce 2024 with Megan Glasow

Perficient: Drug Development

As we eagerly anticipate Dreamforce 2024, the Perficient team is excited to come together with Salesforce and our valued clients to collaborate on the innovations that will shape the future. Dreamforce provides a unique opportunity to connect great minds, tackle complex business challenges, and harness the power of cutting-edge technologies. Megan Glasow’s Enthusiasm for AI and Collaborative Innovation Megan Glasow, Managing Director of Perficient’s Global Salesforce Practice, shared

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Blood Test Can Predict a Dangerous Lung Issue for Preemie Babies

Drugs.com

MONDAY, Aug. 12, 2024 -- Simantha Nation’s son, Atticus, struggled to breathe from his very first gasp for air.Born very preterm at 26 weeks’ gestation, Atticus was rushed to the NICU, where he was intubated and connected to a ventilator.The first t.

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The Importance of Pharmacovigilance in Generic Drugs: Ensuring Patient Safety and Effective Surveillance

Drug Patent Watch

Pharmacovigilance is a crucial aspect of ensuring patient safety and maintaining the effectiveness of medications.

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Obamacare Boosted New Moms' Access to Mental Health Care

Drugs.com

MONDAY, Aug. 12, 2024 -- Pregnant women and new moms have better access to treatment for mood disorders, thanks to Obamacare, a new study finds.More women received treatment for their pregnancy-related depression or anxiety after the Affordable.

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Implementing AI Technology in Medical Information: Risks to Consider

thought leadership

AI is a highly praised tool to implement across industries and service lines and Medical Information (MI) is no exception. In Medical Information, AI is embedded in a workflow for patients and healthcare providers to access the services more swiftly, and for the MI team to deliver timely and accurate information with elevated quality. When integrating AI into MI workflow, several risks should be carefully considered for patient privacy and safety.

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Some Cases of Recurrent Wheeze in Kids May Need New Treatment

Drugs.com

MONDAY, Aug. 12, 2024 -- Does your kid suffer from wheezing that returns again and again?They might be suffering from a “silent” viral lung infection that would be better treated by changing up their medications, a new study finds.Nearly a quarter o.

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Which pharmaceutical companies have the most SPCs in Italy?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Italy.

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5 Major Benefits of Azure Integration Services Over MuleSoft

Perficient: Drug Development

In the realm of enterprise integration, choosing the right platform is crucial for ensuring seamless connectivity between diverse applications and systems. Azure Integration Services (AIS) and MuleSoft are two prominent players in this field. Azure Integration Services is a cloud-based integration platform provided by Microsoft, while MuleSoft is an integration platform that allows developers to connect applications, data, and devices.

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Metabolic Drug Development: A to Z Solutions

Alta Sciences

Metabolic Drug Development: A to Z Solutions blussier Mon, 08/12/2024 - 18:07 HTML In the complex and dynamic field of metabolic drug development, partnering with an accomplished contract research organization is essential. Altasciences has over 25 years of experience in metabolic diseases and supports every stage of the development process, from the initial discovery phase and preclinical studies to clinical trials and beyond.