Drug Discovery World
NOVEMBER 15, 2023
New trial evidence has shown that Kite’s CAR-T cell therapy Yescarta (axicabtagene ciloleucel: axi-cel) reduces the risk of death by 27.4% in patients with relapsed or refractory large B-cell lymphoma (R/R LBCL), corresponding to a 38% improvement in overall survival (OS). It is the only treatment in nearly 30 years to show statistically significant OS, with a median follow-up of 47.2 months.
BioPharma Drive: Drug Pricing
NOVEMBER 15, 2023
Since halting work on a sickle cell treatment early this year, Graphite Bio has laid off staff, shed assets and, now, agreed to be subsumed via a merger with Lenz Therapeutics.
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Drug Discovery World
NOVEMBER 15, 2023
A new compound reversed four types of chronic pain in animal studies, according to research led by New York University (NYU) College of Dentistry’s Pain Research Center. The small molecule, which binds to an inner region of a calcium channel to indirectly regulate it, outperformed gabapentin without troublesome side effects, providing a promising candidate for treating pain.
Broad Institute
NOVEMBER 15, 2023
Fairness, listening, and learning: A conversation with Broad’s chief equity officer By Corie Lok November 15, 2023 Breadcrumb Home Fairness, listening, and learning: A conversation with Broad’s chief equity officer Just a few weeks into his new position, Kedrick Perry spoke about his approach to diversity, equity, inclusion, and belonging, what his goals are, and what motivates him in his work.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
NOVEMBER 15, 2023
The US Food and Drug Administration has approved Zepbound (tirzepatide) injection for chronic weight management alongside a reduced calorie diet and increased physical activity. It is approved in adults with obesity (body mass index of 30 kilograms per square meter (kg/m2) or greater) or overweight (body mass index of 27kg/m2 or greater) with at least one weight-related condition (such as high blood pressure, type 2 diabetes or high cholesterol) for use.
Drug Channels
NOVEMBER 15, 2023
In Medicare Part D in 2024: The Seven Largest Companies' Preferred Pharmacy Networks and the Coming Collapse of the PDP Market , I documented how those networks now dominate stand-alone Medicare Part D prescription drug plans (PDPs) and have become a major presence in Medicare Advantage prescription drug (MA-PD) plans. Today, I examine the seven largest retail chains’ participation in the 20 major 2024 Part D networks that the eight largest plan sponsors will offer.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Perficient: Drug Development
NOVEMBER 15, 2023
Perficient’s Generative AI Lab, part of our larger Generative AI Innovation Group, is consistently exploring and implementing use cases for generative AI and helping clients operationalize it with policies, advocacy, controls, and enablement. One use case organizations can consider is augmented research for sales prospecting, which allows sales professionals to find valuable prospects quickly and generate personalized and effective sales reports and outreach content.
Science Daily: Pharmacology News
NOVEMBER 15, 2023
For the first time, researchers have succeeded in printing a robotic hand with bones, ligaments and tendons made of different polymers using a new laser scanning technique. The new technology makes it possible to 3D print special plastics with elastic qualities in one go. This opens up completely new possibilities for the production of soft robotic structures.
SCIENMAG: Medicine & Health
NOVEMBER 15, 2023
The Department of Biomedicine at the University of Basel and the University Hospital Basel, today announced that it delivered the first surgical procedure to treat Osteoarthritis (OA) in humans.
BioPharma Drive: Drug Pricing
NOVEMBER 15, 2023
The deal gives Gilead an estimated 13% ownership in Arcellx and extends the company’s cash runway into 2027.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
SCIENMAG: Medicine & Health
NOVEMBER 15, 2023
A team led by scientists at Rensselaer Polytechnic Institute has 3D-printed hair follicles in human skin tissue cultured in the lab. This marks the first time researchers have used the technology to generate hair follicles, which play an important role in skin healing and function.
Science Daily: Pharmacology News
NOVEMBER 15, 2023
Scientists have 3D-printed hair follicles in human skin tissue cultured in the lab. This marks the first time researchers have used the technology to generate hair follicles, which play an important role in skin healing and function. When it comes to engineering human skin, hair may at first seem superfluous. However, hair follicles are quite important: They produce sweat, helping regulate body temperature, and they contain stem cells that help skin heal.
SCIENMAG: Medicine & Health
NOVEMBER 15, 2023
Media contacts: Emily Gowdey-Backus, director of media relations, Emily_GowdeyBackus@uml.edu Nancy Cicco, assistant director of media relations, Nancy_Cicco@uml.edu Credit: UMass Lowell courtesy photo Media contacts: Emily Gowdey-Backus, director of media relations, Emily_GowdeyBackus@uml.edu Nancy Cicco, assistant director of media relations, Nancy_Cicco@uml.
Science Daily: Pharmacology News
NOVEMBER 15, 2023
A study reports that scattering sunlight-reflecting particles in the atmosphere -- a theoretical form of climate engineering known as 'stratospheric aerosol injection' -- has potential to slow rapid ice melt in Western Antarctica.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
SCIENMAG: Medicine & Health
NOVEMBER 15, 2023
LEXINGTON, Ky. (Nov. 15, 2023) — One University of Kentucky researcher is working to develop new techniques for radiation treatment to improve survival rates of patients with a specific type of cancer. Credit: University of Kentucky LEXINGTON, Ky. (Nov.
BioPharma Drive: Drug Pricing
NOVEMBER 15, 2023
Now independent Mural Oncology will focus on advancing a pipeline of engineered cytokines for cancer, while Alkermes has recast itself as a “pure-play” neuroscience company.
SCIENMAG: Medicine & Health
NOVEMBER 15, 2023
A research team, led by Tokyo Medical and Dental University（TMDU）, identifies disease-associated variants in a rare case of RAD50 deficiency/Nijmegen breakage syndrome-like disorder Credit: Department of Child Health and Development, TMDU A research team, led by Tokyo Medical and Dental University（TMDU）, identifies disease-associated variants in a rare case of RAD50 deficiency/Nijmegen breakage syndrome-like disorder Tokyo, […]
Science Daily: Pharmacology News
NOVEMBER 15, 2023
Astronomers have used recent observations made with the James Webb Space Telescope to study the atmosphere of the nearby exoplanet WASP-107b. Peering deep into the fluffy atmosphere of WASP-107b they discovered not only water vapor and sulfur dioxide, but even silicate sand clouds. These particles reside within a dynamic atmosphere that exhibits vigorous transport of material.
SCIENMAG: Medicine & Health
NOVEMBER 15, 2023
CHAPEL HILL, N.C. – Our DNA is not indestructible. Throughout the course of our lives, DNA can break in response to natural and environmental factors. Thankfully, our bodies have dedicated enzymes and pathways which can glue our broken DNA back together through several different mechanisms, known as DNA repair pathways. Credit: Stroik et al.
Science Daily: Pharmacology News
NOVEMBER 15, 2023
Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles.
Drug Patent Watch
NOVEMBER 15, 2023
Annual Drug Patent Expirations for ZEPZELCA Zepzelca is a drug marketed by Jazz and is included in one NDA. It is available from one supplier. There is one patent protecting… The post New patent for JAZZ drug ZEPZELCA appeared first on DrugPatentWatch - Make Better Decisions.
Science Daily: Pharmacology News
NOVEMBER 15, 2023
In the geological past, several groups of crocodiles evolved towards a morphology adapted to marine life. However, the extent of these adaptations and their evolutionary trajectories remained unknown. An exhaustive study of their morphology has now shed light on the evolutionary mechanisms at work, thanks to three-dimensional reconstructions.
Perficient: Drug Development
NOVEMBER 15, 2023
What makes a consumer buy a product from one brand over another? The answer used to be brand loyalty and quality of product, but the landscape for consumer goods companies has recently flipped upside down. Anymore, consumer goods companies gain and retain loyalty from customers because of the experiences they provide. Thankfully, generative AI has brought about the acceleration of experience creation and allowed companies to dive into new levels of personalization.
Science Daily: Pharmacology News
NOVEMBER 15, 2023
After a distant star's explosive death, an active stellar corpse was the likely source of repeated energetic flares observed over several months -- a phenomenon astronomers had never seen before, astronomers report.
Drug Patent Watch
NOVEMBER 15, 2023
Annual Drug Patent Expirations for MEKTOVI Mektovi is a drug marketed by Array Biopharma Inc and is included in one NDA. It is available from one supplier. There are ten… The post New patent for Array Biopharma drug MEKTOVI appeared first on DrugPatentWatch - Make Better Decisions.
H1 Blog
NOVEMBER 15, 2023
How to Create an Effective KOL Engagement Plan That Complies with Anti-Kickback Laws In medical affairs, building and managing relationships with key opinion leaders (KOLs) is a critical component of successful product launches and long-term growth. But in today’s highly regulated environment, it is more important than ever to make sure that HCP engagement plans are compliant with anti-kickback laws.
Drug Patent Watch
NOVEMBER 15, 2023
Annual Drug Patent Expirations for BIJUVA Bijuva is a drug marketed by Mayne Pharma and is included in one NDA. It is available from one supplier. There are twenty-two patents… The post New patent for Mayne Pharma drug BIJUVA appeared first on DrugPatentWatch - Make Better Decisions.
SCIENMAG: Medicine & Health
NOVEMBER 15, 2023
Nov. 15, 2023 Credit: UMass Lowell courtesy photo Nov.
Drug Patent Watch
NOVEMBER 15, 2023
Annual Drug Patent Expirations for VELTASSA Veltassa is a drug marketed by Vifor Pharma and is included in one NDA. It is available from one supplier. There are thirteen patents… The post New patent for Vifor Pharma drug VELTASSA appeared first on DrugPatentWatch - Make Better Decisions.
Broad Institute
NOVEMBER 15, 2023
MIA: Dynamics of colonization and transmission in the human gut microbiome By Rose Circeo November 15, 2023 Breadcrumb Home MIA: Dynamics of colonization and transmission in the human gut microbiome Katherine Xue David Relman lab and Dmitri Petrov lab, Stanford University Primer: Tracking strains in the human gut microbiome The human gut microbiome is a diverse, complex ecosystem that has important impacts on human health.
Drug Patent Watch
NOVEMBER 15, 2023
Acetylcysteine is the generic ingredient in seven branded drugs marketed by Cumberland Pharms, Aspen, Eugia Pharma, Exela Pharma, Fresenius Kabi Usa, Indoco, Rising, Sagent Pharms Inc, Steriscience, Zydus Pharms, Alvogen,… The post New tentative approval for Rising drug acetylcysteine appeared first on DrugPatentWatch - Make Better Decisions.
ACTO
NOVEMBER 15, 2023
Breaking Down Data Silos to Offer Robust Real-time Analytics, Provide Meaningful Insight, and Impact Commercial Success TORONTO, Nov. 16, 2023 — ACTO , the #1 Learning Platform in Life Sciences, today announced OmniSight dashboards, which enable pharmaceutical, biotech, and medical device companies to leverage commercial learning and development in a targeted manner to positively impact sales performance.
Drug Patent Watch
NOVEMBER 15, 2023
Annual Drug Patent Expirations for EXFORGE+HCT Exforge Hct is a drug marketed by Novartis and is included in one NDA. It is available from one supplier. There are two patents… The post New patent expiration for Novartis drug EXFORGE HCT appeared first on DrugPatentWatch - Make Better Decisions.
ACTO
NOVEMBER 15, 2023
Everyone has always wanted big-picture insight to guide decisions and strategy, so why has it taken us this long to finally get it? As I reflected on this question, I thought about a favorite pastime of mine. I have always been a reader… I love books, magazines, newspapers - anything I can get my hands on. As a kid, I couldn’t get enough of Judy Blume and Sweet Valley High, and as a high school and college student, I moved on (thankfully!
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