Drug Discovery World

DECEMBER 18, 2023

University College London (UCL) researchers have developed a new gene therapy to cure focal cortical dysplasia, which a new study shows can significantly reduce seizures in mice. Focal cortical dysplasia is caused by areas of the brain that have developed abnormally and is among the most common causes of drug-resistant epilepsy in children. Epilepsy in focal cortical dysplasia is associated with comorbidities, including learning disabilities.

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Science Daily: Pharmacology News

DECEMBER 18, 2023

An interdisciplinary team consisting of researchers has revealed a striking similarity between the memory processing of artificial intelligence (AI) models and the hippocampus of the human brain. This new finding provides a novel perspective on memory consolidation, which is a process that transforms short-term memories into long-term ones, in AI systems.

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Research 138

Drug Discovery World

DECEMBER 18, 2023

An effective HIV vaccine may need to prompt strong responses from CD8+ T cells to protect people from acquiring HIV, according to a study from the National Institute of Allergy and Infectious Diseases (NIAID). The researchers drew comparisons between the immune system activity of past HIV vaccine study participants and people with HIV who naturally keep the virus from replicating even in the absence of antiretroviral therapy (ART), called ‘long-term non-progressors’ or ‘elite controllers’ (LTNPs

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Vaccine Clinical Trials Laboratories Virus 148

Chemical Biology and Drug Design

DECEMBER 18, 2023

The Buzhong Yiqi decoction can suppress the development and progression of non-small cell lung cancer in vitro. The Buzhong Yiqi decoction could inhibit cell viability and proliferation and induce cell apoptosis of non-small cell lung cancer A549 and H1299 cells. The Buzhong Yiqi decoction regulated the PI3K-AKT signaling pathway in non-small cell lung cancer A549 cells.

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Treatment Clinical Trials Regulations Trials 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

DECEMBER 18, 2023

Digital biomarkers promise to transform preventive medicine and clinical trials, but also raise issues of security, regulation and potential disparities in access. Deepika Khedekar, Clinical Trial Lead at IQVIA, provides an overview of the pros and cons, and suggests a possible solution. The human body, a complex tapestry of over 100 trillion cells 1 and 25,000 genes 2 , remains a biological marvel yet to be fully deciphered.

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Clinical Research Research Clinical Trials Trials 148

Chemical Biology and Drug Design

DECEMBER 18, 2023

Twenty-four new derivatives of natural cinnamic acids were designed and synthesized as promising anti-colorectal cancer agents. Their activity was evaluated against HCT116, SW480, HT29, LoVo, and DLD1 cells, in which they induce apoptosis. Abstract Cinnamic acid and its derivatives represent attractive building blocks for the development of pharmacological tools.

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Research 100

Science Daily: Pharmacology News

DECEMBER 18, 2023

The Earth is a wonderful blue and green dot covered with oceans and life, while Venus is a yellowish sterile sphere that is not only inhospitable but also sterile. However, the difference between the two bears to only a few degrees in temperature. A team of astronomers has achieved a world's first by managing to simulate the entirety of the runaway greenhouse process which can transform the climate of a planet from idyllic and perfect for life, to a place more than harsh and hostile.

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Drug Discovery World

DECEMBER 18, 2023

The European Medicines Agency (EMA) human medicines committee (CHMP) made a number of key recommendations at its December 2023 meeting. Casgevy The committee recommended granting a conditional marketing authorisation for Casgevy (exagamglogene autotemcel), an advanced therapy medicinal product (ATMP) for the treatment of transfusion dependent beta-thalassemia and severe sickle cell disease.

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Drugs Therapies Treatment Disease 130

Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- Add another post-COVID hazard to the list: Research suggests having the illness could raise risks for dangerous irregular heart beats.According to Swedish researchers, the odds a person might develop atrial fibrillation --.

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Research 111

Perficient: Drug Development

DECEMBER 18, 2023

In the fast-paced realm of finance, the significance of regulatory risk and compliance management practices cannot be overstated. This blog post delves into the pivotal role these practices play in ensuring the stability and success of financial institutions and banks. By adopting a proactive stance and leveraging technological advancements, financial entities can navigate the regulatory landscape with greater resilience and efficacy.

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Regulations Compliance 111

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- Cinnamon used in applesauce pouches that have been tied to high lead levels in kids may have been deliberately tainted with the toxic element, a source at the U.S. Food and Drug Administration says."We’re still in the.

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Drugs 111

Drug Patent Watch

DECEMBER 18, 2023

Annual Drug Patent Expirations for VENTOLIN+HFA Ventolin Hfa is a drug marketed by Glaxosmithkline and is included in one NDA. It is available from nine suppliers. There are two patents… The post New patent expiration for Glaxosmithkline drug VENTOLIN HFA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- Much has been made of the effects a pregnant woman's drinking could have on the health of her unborn child.But alcohol consumption by men also increases the risk of birth defects in newborns – and a new study shows that.

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Science Daily: Pharmacology News

DECEMBER 18, 2023

Artificial intelligence can analyze registry data on people's residence, education, income, health and working conditions and, with high accuracy, predict life events.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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SCIENMAG: Medicine & Health

DECEMBER 18, 2023

Antibiotic-resistant “superbugs” that can defeat efforts to kill them are an urgent public health crisis, and according to the Centers for Disease Control, more than 2.8 million antibiotic-resistant infections occur each year. Researchers across the world are scrambling to meet the challenge.

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Disease Research 91

Collaborative Drug

DECEMBER 18, 2023

Discover the impact of 'junk DNA' on cancer, teen obesity treatments, Neanderthal genes on sleep patterns, and Nobel discoveries shaping medicine

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DNA Treatment Drugs 101

SCIENMAG: Medicine & Health

DECEMBER 18, 2023

Research pioneer Dr. Daniel Drucker has much to be proud of, as the GLP-1-based diabetes drugs hailing from his early research are named 2023 breakthrough of the year by the Science Magazine. Credit: please credit Colin Dewar Research pioneer Dr.

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Science Research Drugs 90

Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- Severe obesity appears to be on the rise among young U.S. children, based on data from a federal supplemental nutrition program.About 2% of children between 2 and 4 years of age in the Women, Infants and Children (WIC).

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SCIENMAG: Medicine & Health

DECEMBER 18, 2023

“[…] murine models proved to be valuable and, in some cases, indispensable for advancing melatonin applications in oncology […].” Credit: 2023 Anisimov and Golubev “[…] murine models proved to be valuable and, in some cases, indispensable for advancing melatonin applications in oncology […].

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Research 88

BioPharma Drive: Drug Pricing

DECEMBER 18, 2023

The firm is tracking startups that launched during the biotechnology sector’s peak a few years ago but now need fresh funds to move their programs forward, one of its investors said.

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Science 78

SCIENMAG: Medicine & Health

DECEMBER 18, 2023

Led by Aoxing Liu and senior authors Melinda Mills, Andrea Ganna and an international team, the study examined the link between 414 early-life diseases and lifetime childlessness in over 2.5 million individuals born in Finland and Sweden.

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Drug Patent Watch

DECEMBER 18, 2023

Annual Drug Patent Expirations for ADVAIR+HFA Advair Hfa is a drug marketed by Glaxo Grp Ltd and is included in one NDA. It is available from three suppliers. There are… The post New patent expiration for Glaxo Grp drug ADVAIR HFA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 81

SCIENMAG: Medicine & Health

DECEMBER 18, 2023

– Insights from Professor Sakorn Pornprasert, Dean, Faculty of Associated Medical Sciences at Chiang Mai University, on raising thalassemia awareness in Thailand. Credit: BGI Genomics – Insights from Professor Sakorn Pornprasert, Dean, Faculty of Associated Medical Sciences at Chiang Mai University, on raising thalassemia awareness in Thailand.

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Science Daily: Pharmacology News

DECEMBER 18, 2023

Apes recognize photos of groupmates they haven't seen for more than 25 years and respond even more enthusiastically to pictures of their friends, a new study finds. The work, which demonstrates the longest-lasting social memory ever documented outside of humans, and underscores how human culture evolved from the common ancestors we share with apes, our closest relatives.

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Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- If you're one of the 50 million Americans with asthma or allergies, 2024 is another year to redouble efforts to manage them.But how?“It’s not always easy to get allergies and asthma under control,” allergist Dr.

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BioPharma Drive: Drug Pricing

DECEMBER 18, 2023

While the study met its goal, the drug’s benefit was less than analysts had predicted, an outcome that could hasten a planned takeover by Eli Lilly.

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Drugs 73

Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- Most parents plan to have their kids vaccinated against influenza and respiratory syncytial virus (RSV), even as COVID-19 vaccine acceptance flags, a new poll finds.Seven in 10 parents (71%) plan to have their children get.

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Vaccine Virus 69

Drug Patent Watch

DECEMBER 18, 2023

Annual Drug Patent Expirations for XTANDI Xtandi is a drug marketed by Astellas and is included in two NDAs. It is available from one supplier. There are three patents protecting… The post New patent for Astellas drug XTANDI appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- French Bulldogs might be the most widespread breed in the world, but the fancy, flat-faced pooches pay a high price for their popularity, a new study warns.The shortened skulls and large, round heads that make Frenchies so.

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H1 Blog

DECEMBER 18, 2023

How will AI impact clinical trials? Will FDA legislation improve diversity? What platforms will key opinion leaders adopt? Every year, we take a look at annual predictions to help life sciences, pharmaceutical, and healthcare companies understand larger industry trends and dynamics to prepare for the new year. These forecasts, curated by our own experts and thought leaders, shed light on the changes set to reshape the healthcare and pharmaceutical sectors.

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Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 15, 2023 -- Heart failure is a major killer. However, a new study finds that heart failure patients living in poorer neighborhoods are much less likely to pick up lifesaving meds from local pharmacies, compared to patients living in.

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Pharmacy 64

BioPharma Drive: Drug Pricing

DECEMBER 18, 2023

Results from a Phase 2 trial fell short of what’s been seen with a similar Eli Lilly medicine, causing the closely watched biotech’s shares to plummet.

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Trials 67

Drugs.com

DECEMBER 18, 2023

MONDAY, Dec. 18, 2023 -- Dandruff becomes more common in the cold winter months, when the chilly air and dry heat causes a person’s scalp to flake and itch.But while it might be an annoying and unattractive condition, dandruff doesn’t mean you.

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BioPharma Drive: Drug Pricing

DECEMBER 18, 2023

The newly established initiative, which consists of a research center and an accelerator, will focus on developing vaccines for tuberculosis, influenza and group A streptococcus.

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