Broad Institute

SEPTEMBER 10, 2023

New machine learning techniques boost predictions for virtual drug screening with less data By Corie Lok September 10, 2023 Breadcrumb Home New machine learning techniques boost predictions for virtual drug screening with less data Schmidt Center researchers have found a way to improve kernel methods, which are a simpler alternative to neural networks, for biomedical applications.

Drugs 130

Drugs Engineering Science Research 130

Chemical Biology and Drug Design

SEPTEMBER 10, 2023

Astragalus radix (AR) acted on Akt1 targets through its main active component quercetin, and promoted the osteogenic differentiation of BM-MSCs by activating the PI3K/Akt signaling pathway. Abstract The present study used network pharmacology and molecular docking to predict the active ingredients and mechanisms of action of Astragalus radix (AR) to promote osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs), and cell experiments were conducted for verification.

Regulations 100

Regulations Research 100

Broad Institute

SEPTEMBER 10, 2023

Broad Institute welcomes Kedrick Perry as new Chief Equity Officer By Corie Lok September 11, 2023 Breadcrumb Home Broad Institute welcomes Kedrick Perry as new Chief Equity Officer A proven leader in diversity, equity, and inclusion in research and higher education, Perry joined Broad in September. By Broad Communications September 11, 2023 Kedrick Perry leads the Inclusion, Diversity, Equity, and Allyship Office at Broad.

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Doctors Science Research 111

FDA Law Blog: Drug Discovery

SEPTEMBER 10, 2023

By Mark A. Tobolowsky — CDER, CBER, and the Oncology Center of Excellence recently published a final guidance document titled “ Considerations for the Use of Real-World Data and Real-World Evidence to Support Regulatory Decision-Making for Drug and Biological Products ” as another part of its real-world evidence (“RWE”) Program. This finalized a draft guidance issued in December 2021, largely similar in substance.

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FDA Production Laboratories Drugs 108

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

SEPTEMBER 10, 2023

September 8, 2023 -- Lotronex (alosetron hydrochloride) and approved generics are FDA approved for the treatment of irritable bowel syndrome in women whose predominant bowel symptom is diarrhea. Although safety risks for Lotronex (alosetron.

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FDA FDA Approval Treatment 64

Drug Patent Watch

SEPTEMBER 10, 2023

Annual Drug Patent Expirations for VIBATIV Vibativ is a drug marketed by Cumberland Pharms and is included in one NDA. It is available from one supplier. There are two patents… The post New patent expiration for Cumberland Pharms drug VIBATIV appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Drug Patent Watch

SEPTEMBER 10, 2023

Annual Drug Patent Expirations for TYZEKA Tyzeka is a drug marketed by Novartis and is included in two NDAs. There are two patents protecting this drug. This drug has eleven… The post New patent expiration for Novartis drug TYZEKA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59

Drugs Marketing 59

SCIENMAG: Medicine & Health

SEPTEMBER 10, 2023

Milan, Italy: Young children growing up in towns and cities suffer from more respiratory infections than those who grow up in the countryside, according to research presented at the European Respiratory Society International Congress in Milan, Italy [1].

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International Research 52

Drug Patent Watch

SEPTEMBER 10, 2023

Annual Drug Patent Expirations for LONSURF Lonsurf is a drug marketed by Taiho Oncology and is included in one NDA. It is available from one supplier. There are six patents… The post New patent for Taiho Oncology drug LONSURF appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59

Drugs Marketing 59

Drugs.com

SEPTEMBER 10, 2023

SUNDAY, Sept. 10, 2023 -- When someone has surgery, pain may be top of mind. An expert in managing post-op pain offers three tips for keeping it under control, safely. “Pain can inhibit recovery, but good pain control can be an accelerator of a.

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Clinical Trials

Drug Patent Watch

SEPTEMBER 10, 2023

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Sweden. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Sweden? appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceutical Companies Pharmaceuticals 59