Drug Discovery World
OCTOBER 24, 2023
While attending Life Science Baltics 2023, Diana Spencer spoke to Monika Paule , CEO and Co-founder of Caszyme, about creating a company based on CRISPR gene editing and some of the challenges of operating in this dynamic area of research. DS: What was the motivation for launching Caszyme and what challenges did you face creating a viable business?
Science Daily: Pharmacology News
OCTOBER 24, 2023
An international coalition of climate scientists says that the Earth's vital signs have worsened beyond anything humans have yet seen, to the point that life on the planet is imperiled.
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Drug Discovery World
OCTOBER 24, 2023
The UK TechBio sector is thriving, according to a new report, with a growing number of companies pioneering ground-breaking products and services. A BioIndustry Association (BIA) report lists the widespread adoption of artificial intelligence (AI) and machine learning (ML), the advancement of gene editing technologies, the power of engineering biology, and a growing interest from major pharmaceutical players as key trends driving the sector.
Chemical Biology and Drug Design
OCTOBER 24, 2023
A 4-benzamido-N-benzylphenylacetamide derivative carrying ortho- morpholinocarbonyl substitution was investigated for their kinase activities. The compound also showed good activities against HL60 and HCT116 cancer cell lines. The underlying cytotoxic mechanism involved Src family kinase inhibition and downregulation of Erk1/2 and JNK1/2/3 while it activated Akt1/2/3 and Chk-2.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
OCTOBER 24, 2023
The DDW Turning Science into Business Summit, ‘ Cancer research opportunities and advances ’ will take place online on 16 November at 7AM PST / 10AM EDT / 3PM GMT / 4PM CET. This free summit, sponsored by Taconic, will offer expert thought leadership on cancer research, precision medicine and immunotherapy. One of the key presentations will be given by Dr Qasim Ahmad, Chief Medical Officer of IO Biotech, a Clinical Oncologist with two decades of strategic clinical development, medical affairs, a
Chemical Biology and Drug Design
OCTOBER 24, 2023
Clinical Klebsiella pneumoniae strains express variable colistin-susceptibilities despite deleterious mutations in regulatory protein PmrB. Structural dynamics, free-energy landscapes and backbone flexibilities determined the relative stability of the mutants to be selected by colistin-resistant K. pneumoniae. However, potent FDA-approved inhibitors were identified against druggable PmrB-pocket, bypassing the mutation loci.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- Not all high school injuries happen on the football field or the basketball court. Marching band is also a physically demanding activity and participants can suffer injuries, as seen in a new study that looked at emergency.
addgene Blog
OCTOBER 24, 2023
Addgene has a growing catalogue of viral preps available to request. In this post, we’ll walk you through how we produce both our AAV preps and our lentiviral preps.
Drugs.com
OCTOBER 24, 2023
TUESDAY, Oct. 24, 2023 -- The U.S. Environmental Protection Agency (EPA) proposes to ban a cancer-causing chemical commonly used as a furniture cleaner and degreaser. The ban would prohibit most uses of trichloroethylene (TCE) within one year.
BioPharma Drive: Drug Pricing
OCTOBER 24, 2023
The money will be spread across three investment funds and comes at a time when investment into biotech remains shakier than in years past.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
OCTOBER 24, 2023
TUESDAY, Oct. 24, 2023 -- The party drug ketamine has gotten a lot of notice for its potential to help people with severe and persistent depression who haven't responded to other treatments. But a new study has discovered the drug's effect may be.
SCIENMAG: Medicine & Health
OCTOBER 24, 2023
Osaka, Japan – Everybody knows the importance of warming up your muscles before a workout. But what is actually going on when we warm our muscles up, and are all muscles the same? You might be surprised to find out that the science behind this routine activity hasn’t always been clear.
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- Four years after the state of Georgia approved the distribution of low-dose THC, medical marijuana may be sold at local pharmacies. That will make Georgia the first U.S.
BioPharma Drive: Drug Pricing
OCTOBER 24, 2023
The startup is taking aim at an inflammation-linked protein known as TSLP, which is the target of an approved asthma medicine.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
OCTOBER 24, 2023
TUESDAY, Oct. 24, 2023 -- Heated yoga classes can help some people with depression feel a lot better within a couple months -- even if they practice just once a week, a small clinical trial suggests. The study, of 65 people with moderate-to-severe.
Science Daily: Pharmacology News
OCTOBER 24, 2023
As bitcoin and other cryptocurrencies have grown in market share, they've been criticized for their heavy carbon footprint: Cryptocurrency mining is an energy-intensive endeavor. Mining has massive water and land footprints as well, according to a new study that is the first to detail country-by-country environmental impacts of bitcoin mining.
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- Many college kids are depressed and anxious, especially when they are a minority on campus or the first in their family to go to a university, a new study finds. These feelings may be particularly pronounced among.
BioPharma Drive: Drug Pricing
OCTOBER 24, 2023
Rampart Biosciences closed a Series A round that will fund its goal to develop more potent DNA-based medicines that avoid immune responses.
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- As scientists try to learn more about the impact of the gut microbiome on physical and mental health, a new study finds the Mediterranean diet may prevent PTSD symptoms. “There is a very intriguing relationship.
Science Daily: Pharmacology News
OCTOBER 24, 2023
Primatologists are using genetic analysis to determine the geographic origin of ancient mummified baboons found in Egypt. The team finds evidence that the two legendary trading regions of Punt and Adulis may have been the same place separated by a thousand years of history.
Drugs.com
OCTOBER 24, 2023
TUESDAY, Oct. 24, 2023 -- Research has shown that older Black adults are more likely to have poor heart health when compared with white adults and other minority groups. Now, a new study finds that chronic stress from racism and impoverished.
Science Daily: Pharmacology News
OCTOBER 24, 2023
Newly published research proves that it's possible to treat high blood pressure by using specially engineered Lactobacillus paracasei to produce a protein called ACE2 in the gut, reducing gut angiotensin II and, in turn, lowering blood pressure. The study, done in lab rats that are predisposed to hypertension and unable to naturally produce ACE2, opens new doors in the pursuit of harnessing our body's own microbiome to regulate blood pressure.
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- New research suggests a link between middle school students being disciplined for marijuana use and legalization of recreational weed, particularly when schools are close to dispensaries that sell the drug. Researchers.
Science Daily: Pharmacology News
OCTOBER 24, 2023
Researchers have proposed a new way of using quantum light to 'see' quantum sound. A new paper reveals the quantum-mechanical interplay between vibrations and particles of light, known as photons, in molecules. It is hoped that the discovery may help scientists better understand the interactions between light and matter on molecular scales. And it potentially paves the way for addressing fundamental questions about the importance of quantum effects in applications ranging from new quantum techno
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- A virtual reality program helped hoarders clear out their clutter, researchers report. Hoarding disorder, which strikes more than 2.5% of Americans, has only been defined as a mental health condition for 10 years, and.
Science Daily: Pharmacology News
OCTOBER 24, 2023
Scientists studied the genomes of 30 kingfisher species to try to identify the genes that allow kingfishers to dive headfirst into water without huring their brains. The researchers found that the diving birds have unusual mutations to the genes that produce tau: a protein that helps stabilize tiny structures in the brain, but which can build up in humans with traumatic brain injuries or Alzheimer's disease.
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- The expression "you snooze, you lose” may have given reluctant morning risers a bad rap. New research suggests folks who hit the snooze button on their alarm clock may actually reap a rise-and-shine gain. Snoozing.
Science Daily: Pharmacology News
OCTOBER 24, 2023
A team has identified several factors to help answer a fundamental ecological question: why is there a ridiculous abundance of species some places on earth and a scarcity in others? What factors, exactly, drive animal diversity? They discovered that what an animal eats (and how that interacts with climate) shapes Earth's diversity.
Drugs.com
OCTOBER 24, 2023
MONDAY, Oct. 23, 2023 -- More than 60,000 gun safes have been recalled following the death of a 12-year-old boy and dozens of reports that unauthorized people can open the Fortress Safe devices. The U.S. Consumer Product Safety Commission said a.
Science Daily: Pharmacology News
OCTOBER 24, 2023
Next-generation solar materials are cheaper and more sustainable to produce than traditional silicon solar cells, but hurdles remain in making the devices durable enough to withstand real-world conditions. A new technique could simplify the development of efficient and stable perovskite solar cells, named for their unique crystalline structure that excels at absorbing visible light.
Drugs.com
OCTOBER 24, 2023
TUESDAY, Oct. 24, 2023 -- Mid-life isn't too late to make a dietary change to preserve brain health. Women who started following the diet known as DASH (Dietary Approaches to Stop Hypertension) to lower their blood pressure were about 17% less.
Science Daily: Pharmacology News
OCTOBER 24, 2023
New analysis of data from the Curiosity rover reveals that much of the craters on Mars today could have once been habitable rivers.
Drugs.com
OCTOBER 24, 2023
TUESDAY, Oct. 24, 2023 -- Nurse practitioners are just as good as primary care doctors at avoiding potentially harmful prescriptions for older patients -- but both need to do better, a large, new study suggests. Nurse practitioners (NPs) are.
Science Daily: Pharmacology News
OCTOBER 24, 2023
It's viable to produce low-cost, lightweight solar panels that can generate energy in space, according to new research.
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