Drug Target Review

DECEMBER 13, 2023

Why has it been challenging to identify genetic risk factors for long COVID? There is an extensive array of symptoms associated with long COVID, with the most common being fatigue and post-exertional malaise, cognitive dysfunction, mood disturbances and respiratory problems. This is likely indicative of the heterogeneous nature of the disorder, and it is this complexity and diversity of clinical presentation and effects across multiple organ systems, that has made efforts to identify genetic ris

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Bioinformatics Disease Regulations Immune Response 145

Broad Institute

DECEMBER 13, 2023

New method tags cells with location coordinates for single-cell studies By Corie Lok December 13, 2023 Breadcrumb Home New method tags cells with location coordinates for single-cell studies The technique, called Slide-tags, allows scientists to map the location of cells within tissues in standard single-cell experiments. By Sarah C.P. Williams December 13, 2023 Credit: Andrew Russell Different cell types (each represented by a different color) are mapped to their native location in human brain

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RNA DNA Research Hospitals 145

The ChEMBL-og

DECEMBER 13, 2023

Credit: Science biotech, CC BY-SA 4.0 Assays des cribe the experimental set-up when testing the activity of drug-like compounds against biological targets; they provide useful context for researchers interested in drug-target relationships. Ver sion 33 of ChEMBL contains 1.6 million diverse assays spanning ADMET, physicochemical, binding, functional and toxicity experiments.

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Pharmacokinetics Drugs Drug Development Science 125

Broad Institute

DECEMBER 13, 2023

Scientists map the locations of hundreds to thousands of cell types across a mammalian brain By Leah Eisenstadt December 13, 2023 Breadcrumb Home Scientists map the locations of hundreds to thousands of cell types across a mammalian brain Two Broad research teams use spatial transcriptomics to create detailed atlases of the mouse nervous system, paving the way for similar efforts in humans.

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DNA Virus Research Engineering 140

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Chemical Biology and Drug Design

DECEMBER 13, 2023

This up-to-date commentary/perspective article sheds light on the revolutionary approaches designed to target the principal viral weapon “RNA” used by RNA viruses (e.g., SARS-CoV-2) to infect humans and spread infections. These tactics depend on exploiting the weaknesses of this bioweapon to disable or attack it, stop viral reproduction, and terminate microbial infection (e.g., COVID-19).

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RNA Disease Virus Drugs 100

Science Daily: Pharmacology News

DECEMBER 13, 2023

During quiet waking, brain activity in mice suggests the animals are daydreaming about a recent image. Having daydreams about a recently viewed image predicted how the brain would respond to the image in the future. The findings provide a clue that daydreams may play a role in brain plasticity.

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Science Daily: Pharmacology News

DECEMBER 13, 2023

Researchers have created a complete cell atlas of a whole mammalian brain. This atlas serves as a map for the mouse brain, describing the type, location, and molecular information of more than 32 million cells and providing information on connectivity between these cells.

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Research 113

Perficient: Drug Development

DECEMBER 13, 2023

WordPress, which began as a blogging platform, is now one of the most popular content management systems on the web. Its popularity is largely due to its being free and familiar for most digital marketers and IT professionals. However, as a DXP (Digital Experience Platform) consultant, I believe that WordPress is not the best choice for marketing sites of businesses making close to and over $1 billion in annual revenue.

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Marketing Engineering Production 111

Science Daily: Pharmacology News

DECEMBER 13, 2023

Scientists show that breathing may be used to control a wearable extra robotic arm in healthy individuals, without hindering control of other parts of the body.

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BioPharma Drive: Drug Pricing

DECEMBER 13, 2023

The company is now expecting to save $4 billion by the end of 2024, with a majority of the spending cuts coming from drug research and development.

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Drug Research Research Drugs 114

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

DECEMBER 13, 2023

WEDNESDAY, Dec. 13, 2023 -- A healthy plant-based diet can reduce a person’s risk of type 2 diabetes by 24%, a new study has found.Eating plenty of fresh fruits, vegetables and whole grains has this protective effect even in people with a genetic.

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BioPharma Drive: Drug Pricing

DECEMBER 13, 2023

The closely watched medicine showed promise treating a form of chronic nerve pain, with the results suggesting comparable effects to an available therapy.

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Therapies Drugs 111

Drugs.com

DECEMBER 13, 2023

WEDNESDAY, Dec. 13, 2023 -- Connor Heinz started experiencing periods of a racing heartbeat at age 12, but doctors were having a hard time pinning down the problem.The heart monitor Connor wore was too irritating, and his irregular heart rhythms.

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Doctors 98

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

About 40 percent of people over age 65 suffer some form of age-related memory loss, which puts them at higher risk for developing dementia and Alzheimer’s disease. However, there are currently no approved methods for preventing memory loss with age. Credit: Photo by Max Esterhuizen for Virginia Tech.

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Clinical Trials

Drugs.com

DECEMBER 13, 2023

WEDNESDAY, Dec. 13, 2023 -- Teens who avidly use weed typically use it either for enjoyment or to cope, but both uses have a dark side to them, new research finds.Teenagers who use marijuana for enjoyment or to forget their problems have more.

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Research 98

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

NEW ORLEANS, La. – Ochsner Health announces plans for The Gayle and Tom Benson Ochsner Children’s Hospital, made possible through a transformational gift from Mrs. Gayle Benson. Credit: HOK, Houston NEW ORLEANS, La. – Ochsner Health announces plans for The Gayle and Tom Benson Ochsner Children’s Hospital, made possible through a transformational gift from Mrs.

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Hospitals 95

Drugs.com

DECEMBER 13, 2023

WEDNESDAY, Dec. 13, 2023 -- An overwhelming majority of older Americans think health insurers and Medicare should cover the cost of weight-loss medications like Ozempic, Wegovy or Zepbound, a new survey has found.More than four out of five older.

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SCIENMAG: Medicine & Health

DECEMBER 13, 2023

The methane and nitrous oxide we exhale might contribute – in a very small way – to greenhouse gas emissions, with breath analysis indicating this may comprise up to 0.

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Clinical Trials

Drugs.com

DECEMBER 13, 2023

WEDNESDAY, Dec. 13, 2023 -- While rates of a deadly heart infection are dropping generally across the United States, a new report finds one exception: Young adults.In that group, rates of infective endocarditis are rising, probably fueled by a.

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SCIENMAG: Medicine & Health

DECEMBER 13, 2023

Practicing yoga nidra—a kind of mindfulness training— might improve sleep, cognition, learning, and memory, even in novices, according to a pilot study publishing in the open-access journal PLOS ONE on December 13 by Karuna Datta of the Armed Forces Medical College in India, and colleagues.

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Science Daily: Pharmacology News

DECEMBER 13, 2023

Scientists have solved a decades-long puzzle and unveiled a near unbreakable substance that could rival diamond, as the hardest material on earth, a study says. Researchers found that when carbon and nitrogen precursors were subjected to extreme heat and pressure, the resulting materials -- known as carbon nitrides -- were tougher than cubic boron nitride, the second hardest material after diamond.

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Research 91

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

Research led by Professor John McGrath from the University of Queensland found that the concentration of the C4 protein, an important part of the immune system, was not associated with risk of mental disorders.

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Research 91

Science Daily: Pharmacology News

DECEMBER 13, 2023

A new study expands the search for life beyond our solar system by indicating that 17 exoplanets (worlds outside our solar system) could have oceans of liquid water, an essential ingredient for life, beneath icy shells. Water from these oceans could occasionally erupt through the ice crust as geysers. The science team calculated the amount of geyser activity on these exoplanets, the first time these estimates have been made.

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Science 90

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

Flat-faced dog breeds are popular all over the world. In the USA and in Hungary, the French Bulldog is currently the most common breed. However, their popularity comes at a high cost in terms of health: shortened skulls are associated with deteriorative brain morphology changes, breathing difficulties and sleep problems.

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Research 90

Science Daily: Pharmacology News

DECEMBER 13, 2023

In a study of historic scale, scientists have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing. Their findings uncover detailed information that could help overcome the limitations of today's immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer.

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Immune Response Government Disease Drugs 84

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

Alone at home, your bones creaky due to old age, you crave a cool beverage. Credit: Sontakke et al Alone at home, your bones creaky due to old age, you crave a cool beverage. You turn to your robot and say, “Please get me a tall glass of water from the refrigerator.

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Drug Channels

DECEMBER 13, 2023

This week, I’m rerunning some popular posts while I prepare for Fiday's Drug Channels Outlook 2024 live video webinar. Click here to see the original post from September 2023. Time for our annual update on the channels for provider-administered drugs. For 2023, specialty pharmacies—via white, brown, and clear bagging—retained a meaningful share of the distribution channels for provider-administered oncology drugs.

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Specialty Pharmacies Pharmacy Pharmaceuticals Drugs 81

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

DETROIT (December 13, 2023) – Published results of a large, national heart attack study show that patients with a life-threatening complication known as cardiogenic shock survived at a significantly higher rate when treated with a protocol developed by cardiologists at Henry Ford Health, in collaboration with 80 hospitals nationwide. Credit: Dr.

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Hospitals 89

Drugs.com

DECEMBER 13, 2023

WEDNESDAY, Dec. 13, 2023 -- A California company has asked the U.S. Food and Drug Administration to approve MDMA, the active ingredient in party drugs like molly and ecstasy, as a treatment for post-traumatic stress disorder (PTSD).When announcing.

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Treatment FDA Drugs 85

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

University of Pittsburgh researchers have developed a new embryo-like model derived from adult cells that replicates key features of early human development, including the generation of blood cells.

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Production Research 88

Science Daily: Pharmacology News

DECEMBER 13, 2023

Breastfeeding, even partially alongside formula feeding, changes the chemical makeup -- or metabolome -- of an infant's gut in ways that positively influence brain development and may boost test scores years later, suggests new research.

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Research 81

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

It’s a hidden cause of diarrhea and the development of the disease is poorly understood. Multiple factors work against the diagnosis of microscopic colitis, an inflammatory digestive disease, because the symptom distress compared to patients with other causes of chronic diarrhea remains unknown.

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Covalent Modifiers

DECEMBER 13, 2023

Tianyang Yan, Lisa M. Boatner, Liujuan Cui, Peter J. Tontonoz, and Keriann M. Backus JACS Au 2023 DOI: 10.1021/jacsau.3c00707 The plasma membrane proteome is a rich resource of functionally important and therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy glycosylation, disulfide-rich sequences, and low overall abundance, the cell surface proteome remains undersampled in established proteomic pipelines, including our own cysteine chemoproteomics platforms.

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