Drugs.com

DECEMBER 21, 2024

SATURDAY, Dec. 21, 2024 -- The holiday spirit is infectious, even for people suffering from dementia.But family and friends might need to make some slight adjustments to help a dementia patient better enjoy the holidays, the Alzheimers Foundation o.

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Covalent Modifiers

DECEMBER 21, 2024

Nir London Chemical Reviews Article ASAP DOI: 10.1021/acs.chemrev.4c00570 Molecules that are able to induce proximity between two proteins are finding ever increasing applications in chemical biology and drug discovery. The ability to introduce an electrophile and make such proximity inducers covalent can offer improved properties such as selectivity, potency, duration of action, and reduced molecular size.

Drugs 64

Drugs 64

Covalent Modifiers

DECEMBER 21, 2024

Jung-Chun Chu, Keng-Chang Tsai, Ting-Yu Wang, Tzu-Yin Chen, Ju-Ying Tsai, Tien Lee, Mei-Hsiang Lin, Yves S.Y. Hsieh, Chin-Chung Wu, Wei-Jan Huang, European Journal of Medicinal Chemistry , 283, 2025 , 117169 [link] Protein disulfide isomerase (PDI) regulates multiple protein functions by catalyzing the oxidation, reduction, and isomerization of disulfide bonds.

Metabolic Stability 52

Metabolic Stability Regulations 52