Drug Discovery World
AUGUST 2, 2023
Renaissance Pharma has announced its first development programme focused on Hu14.18, a humanised anti-GD2 monoclonal antibody (mAb), licensed from St Jude Children’s Research Hospital for the treatment of newly diagnosed high-risk neuroblastoma. Fifty percent of neuroblastoma patients have high-risk (HRNB) disease which has an overall survival of ~50% over five years.
Chemical Biology and Drug Design
AUGUST 2, 2023
Group 1: the control group, Group 2: STZ-induced diabetes+insulin treatment group, Group 3: STZ-induced diabetes+linagliptin treatment group, Group 4: STZ-induced diabetes+linagliptin+insulin treatment group, Group 5: STZ-induced diabetes+TUDCA treatment group, Group 6: STZ-induced diabetes+TUDCA+insulin treatment group. Abstract The aim of this study is to reveal the effects of the use of linagliptin, a DPP-4 inhibitor due to its beneficial cardiovascular effects, on endoplasmic reticulum stres
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Drug Discovery World
AUGUST 2, 2023
Scientists have unveiled the first and largest encyclopaedia of protein alterations in soft tissue sarcomas – opening the door to a new era of understanding and treatment for this group of rare cancers. The pioneering encyclopaedia, or ‘Rosetta Stone’, of sarcoma biology compiles a wealth of information that could help untangle the protein changes driving sarcomas’ growth, spread and survival.
Chemical Biology and Drug Design
AUGUST 2, 2023
The miRNA-based prognostic signature consisted of hsa-miR-149-5p, hsa-miR-193b-5p, hsa-miR-193a-3p, hsa-miR-3677-3p, hsa-miR-29a-3p, hsa-miR-200c-5p, hsa-miR-200a-5p, hsa-miR-6854-5p, hsa-miR-216a-5p and hsa-miR-891a-5p could properly distinguish the survival difference among CRC patients, suggesting it may be a promising tool for survival prediction.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
AUGUST 2, 2023
Researchers at University of Michigan (U-M) have developed a method to produce human brain organoids without animal cells that could improve the way neurodegenerative conditions are studied and treated. Human brain organoids are derived from embryonic or pluripotent stem cells and more closely model the complex brain structure compared to conventional two-dimensional cultures.
Antidote
AUGUST 2, 2023
At Antidote, our mission is to connect patients with clinical trials is only possible when we understand the individuals that make up the patient population. One way we are able to gain this understanding is by providing our clinical trial search tool, Antidote Match , at no cost to over 300 organizations that we partner with.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- Experts have long recommended breastfeeding for its many benefits for infants, but a new study puts a hard number on breast milk’s lifesaving effects. Breastfeeding is associated with a 33% reduction in infant deaths in.
Drug Patent Watch
AUGUST 2, 2023
In the world of prescription drugs, brand-name manufacturers have employed various strategies to maintain revenue streams in the face of generic competition. One such strategy is the use of “authorized… The post Understanding the Impact of Authorized Generics on Drug Pricing: The Entacapone Case Study appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- While demand for prescription stimulants is surging, a shortage of the drugs persists, so federal officials have stepped in and asked drug companies to ramp up production of the medications. Officials from both the U.S.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
“Our work demonstrates exceptional molecule recognition and separation performance by deliberately organizing the pore geometry, structural flexibility, and molecular-level binding sites within a porous coordination polymer (PCP),” says chemist Susumu Kitagawa, leader of the research team at Kyoto University’s Institute for Integrated Cell-Material Sciences.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- Dr. Jeanne Marrazzo was named on Wednesday to become the next head of the U.S. National Institute of Allergy and Infectious Diseases, a job most recently held by Dr. Anthony Fauci, well known for his work on HIV and the.
BioPharma Drive: Drug Pricing
AUGUST 2, 2023
Intergalactic, a developer of non-viral gene therapies built by ex-Biogen executive Michael Ehlers, is folding less than two years after its launch.
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- First Lady Jill Biden gains at least some of her inner strength by working on her physical strength. Featured in the September issue of Women’s Health magazine, Biden, 72, talks about waking at 5:45 a.m. most days to fit.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
3D light sculptures. Tsunami waves on a beach. Previewing color tattoos. Contributions from the Bickel and Wojtan groups at the Institute of Science and Technology Austria (ISTA) to the 2023 SIGGRAPH conference tackle an impressive variety of classic and novel questions.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- Certain lots of the prescription birth control pill Tydemy may be less effective than expected, potentially resulting in an unintended pregnancy, because the pills do not contain enough of an active ingredient. The U.S.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
The latest issues of three of the American Psychiatric Association’s journals, The American Journal of Psychiatry, Psychiatric Services and Focus are now available online. The August issue of The American Journal of Psychiatry on the neurodevelopmental origins of psychopathology is focused on early-life adversity and genetics as mediators of the risk to develop psychiatric illnesses.
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- The President’s Emergency Program for AIDS Relief (PEPFAR), a program that's long successfully provided relief to people with AIDS around the world, will now be housed within the U.S. State Department. The move comes.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
Singapore, 02 Aug 2023 — A team led by scientists from the National University of Singapore’s (NUS) Department of Biological Sciences in collaboration with the French Centre for Scientific Research (CNRS) has successfully synthesised a special protein-mimic that can self-assemble into a pore structure.
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- Actress Suzanne Somers, who first battled breast cancer in her 50s, announced on Instagram this week that the disease recently returned. Somers, now 76, has been fighting cancer for decades. But she says she follows a.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
The cardiovascular polypill, developed by the Spanish National Centre for Cardiovascular Research (CNIC) and the pharmaceutical company Ferrer, has been included by the World Health Organization (WHO) in its List of Essential Medicines.
BioPharma Drive: Drug Pricing
AUGUST 2, 2023
Yosemite is one of a new class of biotech venture funds that also includes the recently launched Dimension and Cure Ventures.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
Researchers have found that robots can have a ‘U-shaped’ effect on profits: causing profit margins to fall at first, before eventually rising again.
Drugs.com
AUGUST 2, 2023
WEDNESDAY, Aug. 2, 2023 -- More U.S. women are living in areas with little or no maternity care, raising concern about their ability to have a healthy pregnancy and birth. New research from the March of Dimes shows a 4% drop in birthing hospitals.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
HAMILTON, ON (August 2, 2023) – Steroids commonly offered to pregnant people with increased risk of preterm birth may be unnecessary and may leadto long-term health issues for the infants, according to new research led by McMaster University.
NIOSH Science Blog: Drugs
AUGUST 2, 2023
A recently published research article explored patterns and characteristics of workers’ compensation injury claims over a 17-year period among firefighters in Ohio. Researchers from the National Institute for Occupational Safety and Health (NIOSH) collaborated with the Ohio Bureau of Workers Compensation (OHBWC) to conduct the study, which provided valuable insights into the occupational health and safety challenges faced by firefighters.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
Northern muriquis, which live in the Atlantic forest of Brazil, are one of the most endangered species of monkey in the world. Choosing good mates and rearing thriving offspring are key to the species’ long-term survival.
Science Daily: Pharmacology News
AUGUST 2, 2023
A new image of the galaxy cluster known as 'El Gordo' is revealing distant and dusty objects never seen before, and providing a bounty of fresh science. The infrared image displays a variety of unusual, distorted background galaxies that were only hinted at in previous Hubble Space Telescope images.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
CLEVELAND—What if there was a more effective way to coach and inspire your employees? Athletes? Students? Even your kids? Credit: Case Western Reserve University CLEVELAND—What if there was a more effective way to coach and inspire your employees? Athletes? Students? Even your kids?
BioPharma Drive: Drug Pricing
AUGUST 2, 2023
The biotech, which has struggled to grow sales of its medicine Xpovio, is laying off 20% of its staff and focusing on late-stage studies in endometrial cancer and myelofibrosis.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
Two new studies published by The BMJ today examine the potential health risks for infants of giving steroid drugs to women who are at risk of giving birth early. Taken together, the results highlight the need for doctors to be aware of the potential risks and to exercise caution when considering antenatal steroid treatment.
Drug Patent Watch
AUGUST 2, 2023
Obeticholic acid is the generic ingredient in one branded drug marketed by Intercept Pharms Inc and is included in one NDA. There are ten patents protecting this compound. Drug patent… The post New tentative approval for Optimus Pharma drug obeticholic acid appeared first on DrugPatentWatch - Make Better Decisions.
SCIENMAG: Medicine & Health
AUGUST 2, 2023
PROVIDENCE, R.I. [Brown University] — While mRNA vaccines against COVID-19 have been found to be safe and effective for the general population, in-depth evidence about safety and effectiveness for older adults and individuals with chronic health conditions is more limited.
Perficient: Drug Development
AUGUST 2, 2023
Introduction Coveo Enterprise Search is a strong search solution that helps organizations enhance information management and offers users a hassle-free search experience. In order to accomplish this, Coveo establishes connections with numerous data and content sources, indexing the data to make it simple to find using its search interface. Two essential elements of this procedure are “Sources” and “Mapping.” Organizations can create a thorough and unified search experienc
SCIENMAG: Medicine & Health
AUGUST 2, 2023
Individuals who have been cured of hepatitis C infection still face a substantially greater risk of death compared with the general population – between 3 and 14 times higher depending on liver disease stage, finds the largest study of its kind published by The BMJ today.
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