Fri.Oct 25, 2024

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CDC Says Some People May Need Extra Dose of COVID Vaccine

Drugs.com

FRIDAY, Oct. 25, 2024 -- Some Americans should get more than one shot of the updated COVID vaccines because their age or certain health conditions make them more vulnerable to severe infections, U.S. health officials advised this week.Six months.

Vaccine 314
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Watershed moment: Engineers invent high-yield atmospheric water capture device for arid regions

Science Daily: Pharmacology News

As a megadrought stresses the water supply throughout the Southwest, revolutionary research is answering this problem with a groundbreaking technology that pulls large amounts of water from the air in low humidities.

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Weight-Loss Surgeries Decline 25% as More Americans Turn to GLP-1 Meds

Drugs.com

FRIDAY, Oct. 25, 2024 -- As the popularity of GLP-1 meds like Wegovy and Zepbound grows, fewer Americans are turning to weight-loss surgeries to trim their waistlines, a new report finds.Prescriptions of this GLP-1 class of diabetes and weight-loss.

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'Well-man' thrown from castle identified from 800-year-old Norse saga

Science Daily: Pharmacology News

A passage in the Norse Sverris Saga, the 800-year-old story of King Sverre Sigurdsson, describes a military raid that occurred in AD 1197, during which a body was thrown into a well at Sverresborg Castle, outside Trondheim in central Norway, likely as an attempt to poison the main water source for the local inhabitants. A new study describes how researchers used ancient DNA to corroborate the events of the saga and discover details about the 'Well-man,' blending history and archaeology with scie

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Antibiotics Reveal Links Between Gut Microbes, Parkinson's

Drugs.com

FRIDAY, Oct. 24, 2024 -- Certain gut microbes might be linked to a person’s risk of developing Parkinson’s disease, a new study suggests.People prescribed multiple courses of penicillin antibiotics have a modestly lower risk of developing Par.

Disease 278

More Trending

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Burger King, Other Fast Food Chains Also Pulling Onions Tied to E. Coli Outbreak

Drugs.com

FRIDAY, Oct. 25, 2024 -- With onions from one supplier implicated as the source of E. coli illness linked to McDonald's Quarter Pounders, other fast food chains are now pulling the onions from their menus.Representatives for Burger King, Taco Bell.

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Saturn's moon Titan has insulating methane-rich crust up to six miles thick

Science Daily: Pharmacology News

A new study has revealed that methane gas may be trapped within the icy surface of Saturn's moon Titan, forming a distinct crust up to six miles thick, which warms the underlying ice shell and may also explain Titan's methane-rich atmosphere.

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There's Still Confusion on How to Spot, Treat Severe Allergic Reactions

Drugs.com

FRIDAY, Oct. 25, 2024 -- Anaphylaxis involves a sudden, potentially life-threatening reaction to an allergen, including even very small amounts of food allergens such as egg or peanut. Now, two studies find that people with allergies, as well as.

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How mammals got their stride

Science Daily: Pharmacology News

Researchers reveal new insights into the complex evolutionary history behind the distinctive upright posture of modern placental and marsupial mammals, showing the transition was surprisingly complex and nonlinear, and occurred much later than previously believed.

Research 259
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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CDC Confirms Second Human Bird Flu Case in Missouri With No Known Exposure to Farm Animals

Drugs.com

FRIDAY, Oct. 25, 2024 -- A second person in Missouri who wasn't exposed to either poultry or dairy cows has been infected with bird flu, U.S. health officials reported Thursday.This person shared a home with a patient who was first hospitalized.

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Sanofi earnings boosted by Beyfortus, earlier vaccine sales

BioPharma Drive: Drug Pricing

Sanofi and partner AstraZeneca recently increased production capacity for their RSV antibody shot, sales of which jumped during the third quarter.

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E. Coli Outbreak Linked to McDonald's Quarter Pounders Widens to 75 Cases in 13 States; 22 Hospitalized

Drugs.com

FRIDAY, Oct. 25, 2024 -- An outbreak of E. coli illness linked to onions used in McDonald's Quarter Pounders has expanded to now include 75 cases across 13 states, U.S. health officials announced Friday.That's up from 49 cases in 10 states reported.

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GSK invests $800M in manufacturing; Amgen sets small discount for Eylea biosimilar

BioPharma Drive: Drug Pricing

The British pharma is making what it calls its largest U.S. manufacturing investment. Elsewhere, AbbVie expanded a longstanding partnership and Marinus said it would lay off staff.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Will Injury Pain Become Chronic? Brain Scans Might Tell

Drugs.com

FRIDAY, Oct. 25, 2024 -- Brain scans can provide early warning of who will develop chronic pain following a whiplash injury, a new study finds.Higher levels of “cross talk” between two specific brain regions within one to three days of the injury in.

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CovalentInDB 2.0: an updated comprehensive database for structure-based and ligand-based covalent inhibitor design and screening

Covalent Modifiers

Hongyan Du, Xujun Zhang, Zhenxing Wu, Odin Zhang, Shukai Gu, Mingyang Wang, Feng Zhu, Dan Li, Tingjun Hou, Peichen Pan Nucleic Acids Research , 2024 , gkae946 [link] The rational design of targeted covalent inhibitors (TCIs) has emerged as a powerful strategy in drug discovery, known for its ability to achieve strong binding affinity and prolonged target engagement.

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Are 'Elimination Diets' Much Help Against Child Eczema?

Drugs.com

FRIDAY, Oct. 25, 2024 -- Cutting certain foods from a child’s diet isn’t likely to improve their eczema symptoms, a new study finds.Eczema, also known as atopic dermatitis, results from an overactive immune response and has been linked to an inc.

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Tuning isatoic anhydrides’ lysine ligation chemistry for bioconjugation and drug delivery

Covalent Modifiers

Tiwari, Sona, Senthil, Sathyapriya, Khanna, Shweta, Duraisamy, Santhosh, Vechalapu, Sai Kumari, Mallojjala, Sharath Chandra, Allimuthu, Dharmaraja, Cell Reports Physical Science , 2024 DOI: [link] The discovery of new chemical entities for the selective modification of protein lysines is a recent interest in the development of unique covalent chemical probes.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Vigorous Workouts Suppress Hunger, Especially for Women

Drugs.com

FRIDAY, Oct. 25, 2024 -- A heart-pounding workout suppresses a person’s hunger levels better than less strenuous exercises like a brisk walk or active yoga, a new study shows.Running, swimming laps or taking a fast-paced spin class is more e.

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Molecular mechanisms underlying amyloid beta peptide mediated upregulation of vascular cell adhesion molecule-1 in Alzheimer's disease. [Cellular and Molecular]

ASPET

Amyloid beta (Aβ) deposition and neurofibrillary tangles are widely considered as the primary pathological hallmarks of familial and sporadic forms of Alzheimer's disease (AD). However, cerebrovascular inflammation, which is prevalent in 70% of AD patients is emerging as another core feature of AD pathology. In addition, activation of inflammatory signaling pathways have been observed in AD patients; specifically, cerebrovascular inflammation was found to be augmented in Alzheimer's patient

Disease 100
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What Works Best to Ease MS-Linked Fatigue? New Study Finds Out

Drugs.com

FRIDAY, Oct. 25, 2024 -- Medication and behavioral therapy are both effective in combatting fatigue caused by multiple sclerosis (MS), either separately or together, a new study finds.MS patients felt significantly less fatigue after they were.

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Alzheimer’s disease: driving advancements with precision medicine

Drug Target Review

How does precision neuroscience differ from traditional approaches in the treatment of neurodegenerative diseases, and what advantages does it offer? Traditionally, Alzheimer’s disease is diagnosed by clinical examination, medical history and cognitive testing. 1 While these approaches have been the basis of Alzheimer’s disease diagnosis for many decades, they are based on evaluating clinical symptoms, not disease pathology.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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People's Brains Now Process Texts Almost as Quickly as Pictures

Drugs.com

FRIDAY, Oct. 25, 2024 -- Texts deliver rapid-fire messages, but a new study indicates human brains can keep up with the barrage.The brain can detect the basic linguistic structure of a brief sentence in roughly 150 milliseconds -- about the speed.

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Advancements in Protein Design - Shaping the Future of Nanodevices

Fierce BioTech

Advancements in Protein Design - Shaping the Future of Nanodevices swheeler Fri, 10/25/2024 - 16:29 Wed, 12/04/2024 - 11:00 Resource Type Webinar Arvind Pillai Promotion Start Thu, 10/31/2024 - 12:20 Promotion End Mon, 04/28/2025 - 10:00 Duration 60 minutes Creating nanodevices that can change shape and function in response to molecular signals is a key objective in protein design.

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Wildfires Are Gaining Speed in Western U.S., Upping Threat to People

Drugs.com

FRIDAY, Oct. 25, 2024 -- Wildfires that spread so fast they outrun the efforts of fire crews trying to contain them: These types of conflagrations are becoming far more common across the Western United States, a new study warns.A fire's velocity.

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De Novo Design of Allosterically Switchable Protein Assemblies

Fierce BioTech

De Novo Design of Allosterically Switchable Protein Assemblies swheeler Fri, 10/25/2024 - 16:29 Wed, 12/04/2024 - 11:00 Resource Type Webinar Arvind Pillai Promotion Start Thu, 10/31/2024 - 12:20 Promotion End Mon, 04/28/2025 - 10:00 Duration 60 minutes Designing nanodevices that can change shape and function in response to molecular signals is a key objective in protein design, paving the way for the development of switchable nanomaterials, triggerable drug-delivery systems, and molecular motor

Drugs 52
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Autoimmune Disease ML Challenge - Lecture 1, Part D - Biology - Catching Cancer Early

Broad Institute

Autoimmune Disease ML Challenge - Lecture 1, Part D - Biology - Catching Cancer Early By Rose Circeo October 25, 2024 Breadcrumb Home Autoimmune Disease ML Challenge - Lecture 1, Part D - Biology - Catching Cancer Early The Eric and Wendy Schmidt Center and Klarman Cell Observatory at the Broad Institute of MIT and Harvard invite you to join this year’s three-part ML challenge to design algorithms that will enable a more accurate diagnosis of inflammatory bowel disease (IBD), affecting millions

Disease 52