Wed.May 01, 2024

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Scientists work out the effects of exercise at the cellular level

Science Daily: Pharmacology News

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought. In a study on rats, a team of scientists has found that physical activity causes many cellular and molecular changes in all 19 of the organs they studied in the animals.

Research 139
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Major Women's Health Study Supports Hormone Replacement Therapy in Early Menopause

Drugs.com

WEDNESDAY, May 1, 2024 -- Hormone replacement therapy can safely ease middle-aged women’s symptoms during early menopause, data from a major women’s health study show. Women younger than 60 can use hormone replacement to treat symptoms.

Therapies 116
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Earth-like environment likely on ancient Mars

Science Daily: Pharmacology News

A research team using the ChemCam instrument onboard NASA's Curiosity rover discovered higher-than-usual amounts of manganese in lakebed rocks within Gale Crater on Mars, which indicates that the sediments were formed in a river, delta, or near the shoreline of an ancient lake.

Research 128
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GSK raises forecasts on strong vaccine, HIV drug sales

BioPharma Drive: Drug Pricing

Sales of the shingles vaccine Shingrix and the RSV shot Arexvy helped fuel quarterly revenue totals that surpassed analyst expectations, though the company warned momentum could slow in the months ahead.

Vaccine 114
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Every breath you take: Study models the journey of inhaled plastic particle pollution

Science Daily: Pharmacology News

With recent studies having established the presence of nano and microplastic particles in the respiratory systems of both human and bird populations, new research has modeled what happens when people breathe in different kinds of plastic particles and where they end up.

Research 127
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FTC targets ‘junk patents’ on Ozempic, other top drugs

BioPharma Drive: Drug Pricing

The move broadens the antitrust regulator’s campaign against allegedly “improper or inaccurate” patent listings by drugmakers to include top-selling medicines for weight loss, diabetes, asthma and COPD.

More Trending

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Avoid Raw Milk to Cut Risk of Bird Flu, Officials Urge

Drugs.com

WEDNESDAY, May 1, 2024 -- People drinking raw unpasteurized milk are at risk for potentially contracting bird flu, the U.S. Food and Drug Administration warned Wednesday.“We continue to strongly advise against the consumption of raw milk,” Dr.

Drugs 114
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Scientists identify new brain circuit in mice that controls body's inflammatory reactions

Science Daily: Pharmacology News

The brain can direct the immune system to an unexpected degree, capable of detecting, ramping up and tamping down inflammation, shows a new study in mice.

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Pfizer’s strong Vyndaqel sales draw attention to rare disease drug’s patent life

BioPharma Drive: Drug Pricing

Sales of the transthyretin amyloidosis treatment widely beat Wall Street forecasts in the first quarter. The company aims to extend its patent exclusivity.

Disease 117
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Time zones and tiredness strongly influence NBA results, study of 25,000 matches shows

Science Daily: Pharmacology News

The body clock has a significant impact on the performance of NBA players. Data shows vastly better win ratio for home teams from the Western Time Zone Area (PDT) when playing an EDT team, compared to vice versa.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Perficient Awarded as HCL Software’s Gold Reseller Award

Perficient: Drug Development

We are proud to announce Perficient has been awarded HCL Software’s Gold Reseller Award! This award comes as recognition for our continued collaboration and outstanding performance in regard to sales and delivery in 2023. As an HCL Software strategic partner, we actively drive innovation into HCL’s roadmap and collaborate closely from a product innovation and support perspective.

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New strategy could lead to universal, long-lasting flu shot

Science Daily: Pharmacology News

An experimental influenza vaccine carrying more than 80,000 variations of hemagglutinin antigens caused the immune system of mice and ferrets to respond more strongly to less variable portions of the virus. This is a big step forward in efforts at the Duke Human Vaccine Institute to develop a universal, long-lasting flu shot.

Vaccine 110
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Using Optimizely Content Delivery API for data migration

Perficient: Drug Development

Optimizely Content Delivery API is very well known for building headless CMS, to connect to Single Page Apps, mobile apps, etc. However I also found that come in handy in terms of data migration. With the Content Delivery API, you can easily retrieve detailed information of source content in JSON format and map it to your target application. In this article, I will give a brief instruction on how to migrate data between Optimizely Content Cloud applications using the API.

Packaging 105
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Sleep resets brain connections -- but only for first few hours

Science Daily: Pharmacology News

During sleep, the brain weakens the new connections between neurons that had been forged while awake -- but only during the first half of a night's sleep, according to a new study.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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More Than Half of Cats on Farm Where Bird Flu Infected Cows Died After Drinking Milk

Drugs.com

WEDNESDAY, May 1, 2024 -- In yet another sign that bird flu is spreading widely among mammals, a new report finds more than half of cats at the first Texas dairy farm to have cows test positive for bird flu this spring died after drinking raw.

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75,000-year-old female Neanderthal from cave where species buried their dead

Science Daily: Pharmacology News

A new documentary has recreated the face of a 75,000-year-old female Neanderthal whose flattened skull was discovered and rebuilt from hundreds of bone fragments by a team of archaeologists and conservators.

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How Anger Could Raise Your Heart Risks

Drugs.com

WEDNESDAY, May 1, 2024 -- Feeling angry constricts blood vessels in unhealthy ways and could raise a person's long-term odds for heart disease, new research warns.“If you’re a person who gets angry all the time, you’re having chronic injuries.

Disease 98
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A 'cosmic glitch' in gravity

Science Daily: Pharmacology News

Researchers have discovered a potential 'cosmic glitch' in the universe's gravity, explaining its strange behavior on a cosmic scale.

Research 114
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Organic Walnuts Tied to Serious E. Coli Illnesses

Drugs.com

WEDNESDAY, May 1, 2024 -- Organic walnuts from a California grower that were distributed to health food and co-op stores in 19 states have been linked to serious cases of E. coli illness, federal officials reported Tuesday.So far, 12 people have.

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Revised dating of the Liujiang skeleton renews understanding of human occupation of China

Science Daily: Pharmacology News

Researchers have provided new age estimates and revised provenance information for the Liujiang human fossils, shedding light on the presence of Homo sapiens in the region. Using advanced dating techniques including U-series dating on human fossils, and radiocarbon and optically stimulated luminescence dating on fossil-bearing sediments, the study revealed new ages ranging from approximately 33,000 to 23,000 years ago.

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EPA Clamps Down on Deadly Toxin Found in Paint Strippers

Drugs.com

WEDNESDAY, May 1, 2024 -- A toxin found in paint strippers that's responsible for 85 U.S. deaths over the past five decades will be phased out for many uses, under an Environmental Protection Agency rule finalized Tuesday. The cancer-causing.

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NIOSH Science Blog: The Problem of Falls from Elevation in Construction and Prevention Resources

NIOSH Science Blog: Drugs

The Current Situation with Falls In 2022 falls from elevation represented approximately 81% of all fatal and 20% of all nonfatal slips, trips, and falls for all industry workers (BLS 2023a, BLS 2023b). Many of these falls occurred in the construction industry, and significantly impact construction employers, workers, and their families. In fact, construction workers made up nearly half (49%) of all fatal occupational slips, trips, and falls (BLS 2023).

Science 93
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Years Prior to Menopause Are Danger Zone for Depression

Drugs.com

WEDNESDAY, May 1, 2024 -- Women approaching menopause appear to be at higher risk of depression, a new review indicates.

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Sitecore 10.4 is out and here’s all you need to know about it

Perficient: Drug Development

That was a decent gap since 1.5 years ago Sitecore previously released a feature-full version of their XM/XP platform, namely 10.3 was released on December 1st of 2022. That is why I was very excited to look through the newest release of the vendor’s self-hosted platforms and familiarize myself with its changes. First and foremost, the 10.4 platforms could be exclusively obtained from a new download page which has moved to its new home at Sitecore Developer Portal.

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Unlocking the potential of antibody drug conjugates

Drug Target Review

How have advancements in antibody-drug conjugates (ADCs) expanded treatment options for different types of cancer? The design of ADCs has advanced considerably since initial efforts in the 1980’s, when using polyclonal antibodies and unoptimised payloads, linkers and conjugation strategies failed to provide patient benefit. The advent of monoclonal antibodies paired with improvements in each ADC design component has led to the approval of 11 ADCs with more than 180 ADCs currently in clinical dev

Drugs 69
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Novel genetic plant regeneration approach without the application of phytohormones

Science Daily: Pharmacology News

Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. However, optimizing culture conditions can be laborious. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation.

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School Entry Rules Boost Kids' HPV Vaccination Rates

Drugs.com

WEDNESDAY, May 1, 2024 -- Getting the HPV shot in adolescence can spare kids a lifetime of risk for cervical and other cancers related to the virus, but only half of American kids are up-to-date on these shots.Now, a new review suggests that if.

Vaccine 64
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Astellas adds to ‘off-the-shelf’ cell therapy capabilities with Poseida deal

BioPharma Drive: Drug Pricing

The partnership follows Astellas’ investment in the biotech last year and adds to its portfolio of donor-derived cellular medicines.

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Spring 2024 Salesforce Release Brings Important Changes for Healthcare

Perficient: Drug Development

As of mid-February 2024, the Spring ‘24 release was generally available across all instances of Health Cloud bringing with it a host of improvements and added functionality for healthcare organizations. The new features and enhancements offer opportunities for efficiency, security, and insights. Home Health Advanced visit scheduling enables healthcare organizations to proactively manage care delivery, optimizing resource allocation and enhancing patient outcomes.

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New patent for Mayne Pharma drug NEXTSTELLIS

Drug Patent Watch

Annual Drug Patent Expirations for NEXTSTELLIS Nextstellis is a drug marketed by Mayne Pharma and is included in one NDA. It is available from one supplier.

Drugs 59
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New modality - Peptides Innovations and A Comprehensive Synthetic Peptide Drug Discovery Platform

Fierce BioTech

New modality - Peptides Innovations and A Comprehensive Synthetic Peptide Drug Discovery Platform dwunderlin Wed, 05/01/2024 - 17:28 Wed, 06/19/2024 - 10:00 Resource Type Webinar Yuyan Chen Wanyong Feng Jingjing Zhu Promotion Start Thu, 05/02/2024 - 16:00 Promotion End Sat, 11/02/2024 - 16:00 Duration 60 Minutes Peptides emerge as a new promising modality in different area, such as GLP-1 analogues, PDC, PPI inhibitors etc.

Drugs 52
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New patent for Eli Lilly drug ZEPBOUND

Drug Patent Watch

Annual Drug Patent Expirations for ZEPBOUND Zepbound is a drug marketed by Eli Lilly And Co and is included in one NDA. It is available from one supplier.

Drugs 59
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Process Perfect Peptide Synthesis Combines Peptide and Normal Chemistry

Fierce BioTech

Process Perfect Peptide Synthesis Combines Peptide and Normal Chemistry dwunderlin Wed, 05/01/2024 - 17:28 Wed, 06/19/2024 - 10:00 Resource Type Webinar Yuyan Chen Wanyong Feng Jingjing Zhu Promotion Start Thu, 05/02/2024 - 16:00 Promotion End Sat, 11/02/2024 - 16:00 Duration 60 Minutes Peptide drugs demonstrate promising patient safety and stable biological activity, with industry interest to treat a variety of conditions, including cancer, obesity, and microbial infections.