Drug Discovery World

FEBRUARY 20, 2024

Edinburgh-based PhaSER Biomedical (PhaSER) has received a Bill & Melinda Gates Foundation grant totalling $2.3m to continue its work in accelerating drug discovery and development. PhaSER will provide 8HUM transgenic mouse models, humanised for key pathways involved in the metabolism and disposition of drugs, to all the foundation grantees. These models recapitulate the ways drugs are metabolised in humans and have multiple applications in drug discovery and development: including drug

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Drugs Clinical Trials Trials Disease 130

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Synthesis of 22 novel bistrufluoromethyl-derived hydrazide hydrazones. AChE, hCA I, and hCA II activity evaluation. Compound displayed potent activities against AChE, hCAI, and hCAII. Abstract In this project, non-sulfonamide bistrifluoromethyl-derived hydrazide-hydrazones were synthesized as multi-target-directed ligands to treat Alzheimer's disease and then, the novel derivatives were characterized by diverse spectral methods.

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Disease Research 100

Drug Discovery World

FEBRUARY 20, 2024

A five-year contract totalling up to $31 million including programme options has been awarded to Ginkgo Bioworks to discover and develop next-generation vaccine adjuvants. The contract was awarded by the Defense Threat Reduction Agency’s (DTRA) Joint Science and Technology Office (JSTO) for the Chemical and Biological Defense (CBD) Program, through the Medical Chemical, Biological, Radiological, and Nuclear (CBRN) Defense Consortium (MCDC) requirement 22-05, ‘Adjuvant Activity to Vaccines Protot

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Chemical Biology and Drug Design

FEBRUARY 20, 2024

Hsa_circRNA_103820, downregulated by IGF2BP3, could encode a 188-aa peptide and inhibited lung cancer cell malignant progression by inhibiting the AKT pathway. Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism. Hsa_circRNA_103820 is implicated in the pathogenesis of multiple cancers, including lung cancer (LC).

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Bioinformatics RNA Regulations Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 20, 2024

The drug discovery informatics market is predicted to grow from $3.77 billion in 2024 to $6.06 billion in 2028 at a compound annual growth rate (CAGR) of 12.6%, according to analysts ResearchAndMarkets.com. The recent growth in the market is attributed to advancements in genomics and proteomics, the escalating complexity of drug targets, progress in structural biology, a rise in outsourcing practices, the integration of pharmacogenomics, and the implementation of drug repurposing strategies.

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Marketing Biosimilars Drugs Science 130

BioPharma Drive: Drug Pricing

FEBRUARY 20, 2024

The biotech set a price of roughly $515,000 per patient for its therapy Amtagvi, the first to be approved based on a decades-old technique of using tumor-infiltrating lymphocytes.

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Therapies 120

Science Daily: Pharmacology News

FEBRUARY 20, 2024

The drug finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.

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Disease Drugs 117

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Niacin is an essential B vitamin, but new research reveals that too much of it may harm your heart.Found in many foods that millions of Americans eat, excessive amounts of niacin can trigger inflammation and damage blood.

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Research 116

Science Daily: Pharmacology News

FEBRUARY 20, 2024

Researchers have discovered more than 275 million previously unreported genetic variants, identified from data shared by nearly 250,000 participants of the National Institutes of Health's All of Us Research Program. Half of the genomic data are from participants of non-European genetic ancestry. The unexplored cache of variants provides researchers new pathways to better understand the genetic influences on health and disease, especially in communities who have been left out of research in the p

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Disease Research 107

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Researchers hope a new study will end the debate over the best age to start breast cancer screening and how often to do it. "The biggest takeaway point of our study is that annual screening beginning at 40 and continuing.

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Research 115

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Clinical Trials

ProRelix Research

FEBRUARY 20, 2024

Crafting impactful oncology clinical trial protocols requires a strategic approach to ensure rigorous research, patient safety, and meaningful outcomes. Explore key considerations and best practices for designing effective protocols in […] The post Designing Effective Oncology Clinical Trial Protocols appeared first on ProRelix Research.

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Clinical Trials Trials Research 97

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Americans addicted to opioids who need the anti-addiction med buprenorphine are far more likely to find it if they live in a predominantly white neighborhood, new research finds. “Access is substantially better in.

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Drugs Research 111

Science Daily: Pharmacology News

FEBRUARY 20, 2024

Physicists have used complex computer simulations to develop a new design for significantly more efficient solar cells than previously available. A thin layer of organic material, known as tetracene, is responsible for the increase in efficiency.

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Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Women who carry certain mutations in their BRCA1 or BRCA2 genes know they are at heightened odds for breast cancer.Now, Canadian research suggests that for some patients a "risk-reducing" preventive mastectomy may cut the.

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Research 105

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

SCIENMAG: Medicine & Health

FEBRUARY 20, 2024

For many years, researchers at MPI-EVA have been collecting and analyzing ancient DNA from humans who lived during the past tens of thousands of years. Analyzing these data has allowed the researchers to trace the movement and mixing of people, and even to uncover ancient pathogens that affected their lives.

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DNA Research 88

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Accurate genetic tests for 10 common diseases are nearly ready for everyday use in doctor’s offices, a new study says.Gene scans for 10 common illnesses have been honed to the point that they now are being road-tested in.

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Disease 105

Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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DNA International Research 90

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Being an angry hard-charger won’t win you any points in the workplace, new research has found.Prior evidence had suggested that workers who express anger are judged to be competent and hold a higher status, the.

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Research 102

Science Daily: Pharmacology News

FEBRUARY 20, 2024

Smiling for just a split second makes people more likely to see happiness in expressionless faces, new research has revealed. The study shows that even a brief weak grin makes faces appear more joyful. The pioneering experiment used electrical stimulation to spark smiles and was inspired by photographs made famous by Charles Darwin.

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Research 89

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Folks can lose weight even if they pack all their weekly exercise into one or two days, a new study finds.Guidelines recommend that people get at least 150 minutes a week of moderate physical activity or 75 minutes a week.

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SCIENMAG: Medicine & Health

FEBRUARY 20, 2024

A team led by scientists at the Case Western Reserve University School of Medicine has identified a new therapeutic approach for combating neurodegenerative diseases, offering hope of improved treatments for Alzheimer’s disease, Parkinson’s disease, Vanishing White Matter disease and multiple sclerosis, among others.

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Disease Treatment 83

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Americans addicted to opioids who need the anti-addiction med buprenorphine are far more likely to find it if they live in a predominantly white neighborhood, new research finds.“Access is substantially better in areas.

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Drugs Research 97

SCIENMAG: Medicine & Health

FEBRUARY 20, 2024

Abigail Lewis traveled all across the United States for college and graduate school, and she ended up researching lakes in her own hometown. Credit: Courtesy Virginia Tech Abigail Lewis traveled all across the United States for college and graduate school, and she ended up researching lakes in her own hometown.

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Research 71

Science Daily: Pharmacology News

FEBRUARY 20, 2024

A team of scientists on location with a film crew in the remote Amazon has uncovered a previously undocumented species of giant anaconda.

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SCIENMAG: Medicine & Health

FEBRUARY 20, 2024

CLEVELAND–For the past 38 years, Case Western Reserve University (CWRU) and University Hospitals (UH) have worked closely with a variety of institutions in Uganda to advance medical research and education across a range of fields.

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Research Hospitals 70

Science Daily: Pharmacology News

FEBRUARY 20, 2024

A few years ago, astronomers uncovered one of the Milky Way's greatest secrets: an enormous, wave-shaped chain of gaseous clouds in our sun's backyard, giving birth to clusters of stars along the spiral arm of the galaxy we call home. Naming this astonishing new structure the Radcliffe Wave, the team now reports that the Radcliffe Wave not only looks like a wave, but also moves like one -- oscillating through space-time much like 'the wave' moving through a stadium full of fans.

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BioPharma Drive: Drug Pricing

FEBRUARY 20, 2024

Rapt reported one case of liver failure in a study participant who received the biotech’s drug, which is seen by analysts as a possible competitor to Dupixent.

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Trials FDA Drugs 62

Drug Patent Watch

FEBRUARY 20, 2024

Annual Drug Patent Expirations for LUMRYZ Lumryz is a drug marketed by Avadel Cns and is included in one NDA. It is available from one supplier. There are seventeen patents… The post New patent for Avadel Cns drug LUMRYZ appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Perficient: Drug Development

FEBRUARY 20, 2024

Leveraging Your CDP In today’s dynamic business landscape, harnessing the power of customer data is non-negotiable for success. Companies around the globe are increasingly turning to Customer Data Platforms (CDPs) to consolidate and manage their customer information effectively. While many organizations have already invested in a CDP, the addition of Salesforce Data Cloud can elevate their data strategy to new heights.

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Compliance Regulations Marketing Production 59

Drug Patent Watch

FEBRUARY 20, 2024

Annual Drug Patent Expirations for EPSOLAY Epsolay is a drug marketed by Galderma Labs Lp and is included in one NDA. It is available from one supplier. There are seven… The post New patent for Galderma Labs drug EPSOLAY appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Cytel

FEBRUARY 20, 2024

In clinical trials based on count data, the aim is to compare independent treatment groups in terms of the rate of occurrence of a particular outcome, such as number of times a subject responds to a therapy, develops a certain adverse experience, requires specialized care, or takes medication to achieve a particular response — for example, the number of migraines, seizures, recurrent infections, hospitalizations, episodes of diarrhea, and so on.

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Clinical Trials Hospitals Trials Therapies 59

Drug Patent Watch

FEBRUARY 20, 2024

Annual Drug Patent Expirations for AUVELITY Auvelity is a drug marketed by Axsome and is included in one NDA. It is available from one supplier. There are one hundred and… The post New patent for Axsome drug AUVELITY appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Immigration has become a contentious topic in America, but new research shows the heated debate on the issue may be stressing out Hispanics across the country, whether they are citizens or not.After analyzing data from.

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Research 59

Drug Patent Watch

FEBRUARY 20, 2024

Annual Drug Patent Expirations for OFEV Ofev is a drug marketed by Boehringer Ingelheim and is included in one NDA. It is available from one supplier. There are five patents… The post New patent expiration for Boehringer Ingelheim drug OFEV appeared first on DrugPatentWatch - Make Better Decisions.

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