Drug Discovery World

AUGUST 13, 2024

Professor Andy Whiting , CEO of Nevrargenics, asks whether animal models should be used as the default regulatory requirement and explores the times to use them. Animal models (AMs) have generally been seen as useful for drug development and biomedical research for many years. They are assumed to closely mimic human disease progression and act as a good testing ground for toxicology studies and pharmacokinetics 1.

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Science Daily: Pharmacology News

AUGUST 13, 2024

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in. Recently, researchers created a new liquid-based solution that eliminates more than 98% of these microscopic plastic particles from water.

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Drug Discovery World

AUGUST 13, 2024

The Memorial Sloan Kettering Cancer Center (MSK) will be collaborating with Absci Corporation to discover and develop novel cancer therapeutics using generative artificial intelligence (AI) for up to six programmes. Under the terms of the collaboration, Absci and MSK’s cancer research teams will co-develop therapeutics using Absci’s platform. “At MSK, we are committed to continuous innovation as we strive toward our mission of ending cancer for life, and we expect cancer care AI to play an incre

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Science Daily: Pharmacology News

AUGUST 13, 2024

A computer algorithm has achieved a 98% accuracy in predicting different diseases by analyzing the color of the human tongue. The proposed imaging system can diagnose diabetes, stroke, anemia, asthma, liver and gallbladder conditions, COVID-19, and a range of vascular and gastrointestinal issues, according to new research.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 13, 2024

Researchers at Tokyo University of Science have successfully developed a new method to synthesise eutyscoparol A and violaceoid C, two naturally occurring compounds with promising antimalarial and antibacterial properties. The new approach involves the synthesis of these compounds using readily available dinitriles. This method requires fewer steps and produces the bioactive compounds in higher yields compared to previous approaches, opening up new avenues for drug development.

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Science Daily: Pharmacology News

AUGUST 13, 2024

Higher intake of heme iron, the type found in red meat and other animal products -- as opposed to non-heme iron, found mostly in plant-based foods -- was associated with a higher risk of developing type 2 diabetes (T2D) in a new study. While the link between heme iron and T2D has been reported previously, the study's findings more clearly establish and explain the link.

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Production 127

Science Daily: Pharmacology News

AUGUST 13, 2024

A new interpretation of the runic inscription on the Forsa Ring (Forsaringen in Swedish), provides fresh insights into the Viking Age monetary system and represents the oldest documented value record in Scandinavia. The inscription describes how the Vikings handled fines in a flexible and practical manner.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- Many nonsmokers have lung nodules that have been linked to lung cancer, a new study warns.About 42% of nonsmokers or former smokers have at least one lung nodule, which is a small mass of dense tissue that may be.

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Science Daily: Pharmacology News

AUGUST 13, 2024

Black soldier flies are now commercially used to consume organic waste -- but genetic modifications proposed by bioscientists could see the insects digesting a wider variety of refuse, while also creating raw ingredients for industry.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 (HealthDay News) -- No lab test can reliably indicate whether or not someone is suffering from Long COVID, a major new study finds. None of 25 standard lab blood and urine tests proved useful in diagnosing Long COVID.

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Clinical Trials

Science Daily: Pharmacology News

AUGUST 13, 2024

Unprecedented wildfires in Canada and parts of Amazonia last year were at least three times more likely due to climate change and contributed to high levels of CO2 emissions from burning globally, according to the a new systematic review. The State of Wildfires report takes stock of extreme wildfires of the 2023-2024 fire season (March 2023-February 2024), explains their causes, and assesses whether events could have been predicted.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- It's been a sweltering summer for much of the United States, and a new poll finds many people can recognize the signs of heat sickness if it strikes them or someone else.However, many more don’t know crucial information t.

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Science Daily: Pharmacology News

AUGUST 13, 2024

Using data from NASA's James Webb Space Telescope, astronomers have confirmed hydroxyl molecules on the surface of the metallic asteroid Psyche. The presence of hydrated minerals suggests a complex history for Psyche, important context for the NASA spacecraft en route to this interesting asteroid orbiting the Sun between Mars and Jupiter.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- New research confirms that alcohol is not your friend as you age: Even light drinking was linked to an increase in cancer deaths among older adults, with the raised risk most pronounced in those who had other health.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Channels

AUGUST 13, 2024

Last fall, poor ol’ Rite Aid finally succumbed to bankruptcy. It was pretty much the definition of an expected surprise. To get a comprehensive look at the company’s ever-declining fortunes, DCI rummaged around the compnay's numerous bankruptcy filings. Below, you’ll find our review of Rite Aid’s current financial situation, shrinking store footprint, changing relationship with key wholesaler McKesson, surprisingly optimistic projections, and more.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- New research suggests that switching from smoking to vaping won't prevent some dangerous changes to a person's genome.A new study conducted in young adults shows similar cancer-linked gene changes in both vapers and.

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Science Daily: Pharmacology News

AUGUST 13, 2024

Martian landers have been able capture measurements of wind speeds -- some gauging the cooling rate of heated materials when winds blow over them, others using cameras to image 'tell-tales' that blow in the wind -- but there's still room for improvement. Researchers now demonstrate a novel sonic anemometric system featuring a pair of narrow-band piezoelectric transducers to measure the travel time of sound pulses through Martian air.

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Research 104

Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- Eating a healthy diet that dampens inflammation in the body could lower your odds for dementia, especially if you already have heart risk factors, a new Swedish study shows.So-called anti-inflammatory diets focus on foods.

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addgene Blog

AUGUST 13, 2024

While monoclonal and polyclonal antibodies are readily available from several sources, fewer sources of recombinant antibodies (rAbs) exist (though Addgene has a great collection of ready-to-use rAbs and rAb plasmids !). Since recombinant antibodies conveniently allow for unlimited production, reliable expression, and easy distribution as DNA (Trimmer, 2020), you may be interested in using them in your own experiments.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- Red meat contains a type of iron that could increase a person’s risk of type 2 diabetes, a new study warns.People who ate the most foods high in heme iron -- red meat and other animal products, mainly -- had a 26% higher r.

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The Open Targets Blog

AUGUST 13, 2024

This month marks my first anniversary in the Executive Director role at Open Targets. This, plus the 10-year anniversary of Open Targets and onboarding our latest partner MSD , has been a great chance to step back and see our research programme with fresh eyes, to think about how we tell the story of Open Targets, generating and working with data to build knowledge, therapeutic hypotheses, and ultimately aid decision making in target discovery.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 12, 2024 -- An experimental drug based on ancient Chinese herbal medicine can help ease the toxic side effects of chemotherapy and radiation therapy in cancer patients, the results of a small new trial results suggest.A small group of.

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BioPharma Drive: Drug Pricing

AUGUST 13, 2024

The company will no longer develop its medicine izokibep in two immune conditions, prioritizing instead another treatment it’s developing for thyroid eye disease.

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Covalent Modifiers

AUGUST 13, 2024

Njomen, E., Hayward, R.E., DeMeester, K.E. et al. Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells. Nat. Chem. 2024 DOI [link] Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with broadly reactive probes.

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BioPharma Drive: Drug Pricing

AUGUST 13, 2024

Nemluvio is now cleared for adults with the chronic itching condition prurigo nodularis, making it a competitor to Sanofi and Regeneron’s Dupixent.

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Covalent Modifiers

AUGUST 13, 2024

Ruxandra Moraru, Beatriz Valle-Argos, Annabel Minton, Lara Buermann, Suyin Pan, Thomas E. Wales, Raji E. Joseph, Amy H. Andreotti, Jonathan C. Strefford, Graham Packham, and Matthias G. J. Baud Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01927 Targeted covalent inhibitors (TCIs) directing cysteine have historically relied on a narrow set of electrophilic “warheads”.

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Broad Institute

AUGUST 13, 2024

Brain Health Scientific Community By Rose Circeo August 13, 2024 Breadcrumb Home Brain Health Brain Health Scientific Community PI Topic Paola Arlotta (Harvard) 3D cerebral organoid culture technologies to assess the molecular laws that govern the birth, differentiation, and assembly of the human cerebral cortex in health and disease. Human Stem Cells, Neurodevelopmental Disorders, Autism Jason Buenrostro (Broad, Harvard) Developing new technologies and computational approaches that advance ou

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Perficient: Drug Development

AUGUST 13, 2024

In the latest episode of our podcast, we dive into the world of communications, media, and technology (CMT). Our guest, Kevin Colletti, director of digital strategy and consulting at Perficient, sheds light on how these once-distinct industries are rapidly converging in the digital age. The lines between telecom providers, media companies, and tech giants are blurring.

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Drug Patent Watch

AUGUST 13, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 12, 2024 -- At least 20 million hernia surgeries are performed globally each year, making it one of the most common medical procedures in the world. But does gender matter when it comes to hernia risk?New Australian research says yes.

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Perficient: Drug Development

AUGUST 13, 2024

In our latest “What If? So What? episode, we sit down with Kevin Espinosa, a seasoned digital strategist with a rich background in the industry, to look at how technology is impacting the manufacturing industry. Kevin’s journey from an electrical engineer to a digital marketing expert provides a unique perspective on the evolving landscape of the industry.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- Kids more often get the psychiatric care they need if they live in states that mandate insurance coverage for child mental health care, a new study confirms.Parents and caregivers were 20% less likely to say they'd had.

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Perficient: Drug Development

AUGUST 13, 2024

Securing Application with Custom Headers Using AWS CloudFront and WAF Background Your company runs a website that is hosted on AWS. To ensure high availability and low latency for users worldwide, you used AWS CloudFront as the Content Delivery Network (CDN) in front of your web servers. To enhance security and protect against web threats, you decided to integrate AWS WAF with your CloudFront distribution.

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Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- Men, take note: Cancer cases and deaths among males will jump globally by 84% and 93%, respectively, by 2050, new research predicts.Published Monday in the journal Cancer, the study found the increases were greater among.

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