Tue.Aug 13, 2024

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Scientists achieve more than 98% efficiency removing nanoplastics from water

Science Daily: Pharmacology News

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in. Recently, researchers created a new liquid-based solution that eliminates more than 98% of these microscopic plastic particles from water.

Disease 145
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Women Get Worse Pain Management, From Both Male and Female Health Workers

Drugs.com

TUESDAY, Aug. 13, 2024 -- Female patients are consistently less likely to receive painkillers than men with similar complaints, a new study finds.An analysis of more than 21,000 patient records revealed that women across every age group are less.

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Say 'aah' and get a diagnosis on the spot: is this the future of health?

Science Daily: Pharmacology News

A computer algorithm has achieved a 98% accuracy in predicting different diseases by analyzing the color of the human tongue. The proposed imaging system can diagnose diabetes, stroke, anemia, asthma, liver and gallbladder conditions, COVID-19, and a range of vascular and gastrointestinal issues, according to new research.

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Many Nonsmokers Have Lung Nodules Linked to Cancer Risk

Drugs.com

TUESDAY, Aug. 13, 2024 -- Many nonsmokers have lung nodules that have been linked to lung cancer, a new study warns.About 42% of nonsmokers or former smokers have at least one lung nodule, which is a small mass of dense tissue that may be.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Significant link found between heme iron, found in red meat and other animal products, and type 2 diabetes risk

Science Daily: Pharmacology News

Higher intake of heme iron, the type found in red meat and other animal products -- as opposed to non-heme iron, found mostly in plant-based foods -- was associated with a higher risk of developing type 2 diabetes (T2D) in a new study. While the link between heme iron and T2D has been reported previously, the study's findings more clearly establish and explain the link.

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There's No Good Lab Test to Spot Long COVID

Drugs.com

TUESDAY, Aug. 13, 2024 (HealthDay News) -- No lab test can reliably indicate whether or not someone is suffering from Long COVID, a major new study finds. None of 25 standard lab blood and urine tests proved useful in diagnosing Long COVID.

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As Heat Waves Hit U.S., Poll Finds Most Can't Locate Local Cooling Station

Drugs.com

TUESDAY, Aug. 13, 2024 -- It's been a sweltering summer for much of the United States, and a new poll finds many people can recognize the signs of heat sickness if it strikes them or someone else.However, many more don’t know crucial information t.

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Reduce, reuse, 're-fly-cle'

Science Daily: Pharmacology News

Black soldier flies are now commercially used to consume organic waste -- but genetic modifications proposed by bioscientists could see the insects digesting a wider variety of refuse, while also creating raw ingredients for industry.

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Even Light Drinking Harms Health of Older Adults: Study

Drugs.com

TUESDAY, Aug. 13, 2024 -- New research confirms that alcohol is not your friend as you age: Even light drinking was linked to an increase in cancer deaths among older adults, with the raised risk most pronounced in those who had other health.

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Rewriting the evolutionary history of critical components of the nervous system

Science Daily: Pharmacology News

A new study has rewritten the conventionally understood evolutionary history of certain ion channels -- proteins critical for electrical signaling in the nervous system. The study shows that the Shaker family of ion channels were present in microscopic single cell organisms well before the common ancestor of all animals and thus before the origin of the nervous system.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Smoking, Vaping Tied to Similar Unhealthy Changes in DNA

Drugs.com

TUESDAY, Aug. 13, 2024 -- New research suggests that switching from smoking to vaping won't prevent some dangerous changes to a person's genome.A new study conducted in young adults shows similar cancer-linked gene changes in both vapers and.

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SwRI-led team finds evidence of hydration on Asteroid Psyche

Science Daily: Pharmacology News

Using data from NASA's James Webb Space Telescope, astronomers have confirmed hydroxyl molecules on the surface of the metallic asteroid Psyche. The presence of hydrated minerals suggests a complex history for Psyche, important context for the NASA spacecraft en route to this interesting asteroid orbiting the Sun between Mars and Jupiter.

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Anti-Inflammatory Diet Could Lower Your Odds for Dementia

Drugs.com

TUESDAY, Aug. 13, 2024 -- Eating a healthy diet that dampens inflammation in the body could lower your odds for dementia, especially if you already have heart risk factors, a new Swedish study shows.So-called anti-inflammatory diets focus on foods.

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Measuring Martian winds with sound

Science Daily: Pharmacology News

Martian landers have been able capture measurements of wind speeds -- some gauging the cooling rate of heated materials when winds blow over them, others using cameras to image 'tell-tales' that blow in the wind -- but there's still room for improvement. Researchers now demonstrate a novel sonic anemometric system featuring a pair of narrow-band piezoelectric transducers to measure the travel time of sound pulses through Martian air.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Why Red Meat May Be Especially Linked to Diabetes Risk

Drugs.com

TUESDAY, Aug. 13, 2024 -- Red meat contains a type of iron that could increase a person’s risk of type 2 diabetes, a new study warns.People who ate the most foods high in heme iron -- red meat and other animal products, mainly -- had a 26% higher r.

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Antibodies 101: Producing Recombinant Antibodies

addgene Blog

While monoclonal and polyclonal antibodies are readily available from several sources, fewer sources of recombinant antibodies (rAbs) exist (though Addgene has a great collection of ready-to-use rAbs and rAb plasmids !). Since recombinant antibodies conveniently allow for unlimited production, reliable expression, and easy distribution as DNA (Trimmer, 2020), you may be interested in using them in your own experiments.

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Chinese Botanical Medicine Eases a Cancer Treatment Side Effect

Drugs.com

TUESDAY, Aug. 12, 2024 -- An experimental drug based on ancient Chinese herbal medicine can help ease the toxic side effects of chemotherapy and radiation therapy in cancer patients, the results of a small new trial results suggest.A small group of.

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Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells [@EvertNjomen]

Covalent Modifiers

Njomen, E., Hayward, R.E., DeMeester, K.E. et al. Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells. Nat. Chem. 2024 DOI [link] Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with broadly reactive probes.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Three reflections from David Hulcoop's first year as Executive Director

The Open Targets Blog

This month marks my first anniversary in the Executive Director role at Open Targets. This, plus the 10-year anniversary of Open Targets and onboarding our latest partner MSD , has been a great chance to step back and see our research programme with fresh eyes, to think about how we tell the story of Open Targets, generating and working with data to build knowledge, therapeutic hypotheses, and ultimately aid decision making in target discovery.

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Acelyrin shifts from main drug, lays off staff

BioPharma Drive: Drug Pricing

The company will no longer develop its medicine izokibep in two immune conditions, prioritizing instead another treatment it’s developing for thyroid eye disease.

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Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story

Covalent Modifiers

Ruxandra Moraru, Beatriz Valle-Argos, Annabel Minton, Lara Buermann, Suyin Pan, Thomas E. Wales, Raji E. Joseph, Amy H. Andreotti, Jonathan C. Strefford, Graham Packham, and Matthias G. J. Baud Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01927 Targeted covalent inhibitors (TCIs) directing cysteine have historically relied on a narrow set of electrophilic “warheads”.

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Can Rite Aid Recover?

Drug Channels

Last fall, poor ol’ Rite Aid finally succumbed to bankruptcy. It was pretty much the definition of an expected surprise. To get a comprehensive look at the company’s ever-declining fortunes, DCI rummaged around the compnay's numerous bankruptcy filings. Below, you’ll find our review of Rite Aid’s current financial situation, shrinking store footprint, changing relationship with key wholesaler McKesson, surprisingly optimistic projections, and more.

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Galderma wins FDA approval for skin condition treatment

BioPharma Drive: Drug Pricing

Nemluvio is now cleared for adults with the chronic itching condition prurigo nodularis, making it a competitor to Sanofi and Regeneron’s Dupixent.

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Brain Health Scientific Community

Broad Institute

Brain Health Scientific Community By Rose Circeo August 13, 2024 Breadcrumb Home Brain Health Brain Health Scientific Community PI Topic Paola Arlotta (Harvard) 3D cerebral organoid culture technologies to assess the molecular laws that govern the birth, differentiation, and assembly of the human cerebral cortex in health and disease. Human Stem Cells, Neurodevelopmental Disorders, Autism Jason Buenrostro (Broad, Harvard) Developing new technologies and computational approaches that advance ou

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[Podcast] What if Your Mobile Provider Could Predict When Your Car Would Break Down?

Perficient: Drug Development

In the latest episode of our podcast, we dive into the world of communications, media, and technology (CMT). Our guest, Kevin Colletti, director of digital strategy and consulting at Perficient, sheds light on how these once-distinct industries are rapidly converging in the digital age. The lines between telecom providers, media companies, and tech giants are blurring.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Salesforce “Flow” and Debug Importance

Perficient: Drug Development

What Is a Salesforce Flow? Salesforce flow is an application inside Salesforce that will help you automate your business process easily using point-and-click or a declarative approach without writing a single line of code. Flow empowers you to build complex business solutions using clicks, not by code, and reduces repetitive tasks. Flow builder is the most powerful tool that a salesforce admin has at their disposal, giving you similar powers to that of salesforce developers.

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Men Face Much Higher Risk for Hernias Than Women, and Age Matters

Drugs.com

TUESDAY, Aug. 12, 2024 -- At least 20 million hernia surgeries are performed globally each year, making it one of the most common medical procedures in the world. But does gender matter when it comes to hernia risk?New Australian research says yes.

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[Podcast] What if Your Assembly Line Was Replaced by Lines of Code? An interview with Kevin Espinosa

Perficient: Drug Development

In our latest “What If? So What? episode, we sit down with Kevin Espinosa, a seasoned digital strategist with a rich background in the industry, to look at how technology is impacting the manufacturing industry. Kevin’s journey from an electrical engineer to a digital marketing expert provides a unique perspective on the evolving landscape of the industry.

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Tougher State Insurance Laws Get Kids Needed Mental Health Care

Drugs.com

TUESDAY, Aug. 13, 2024 -- Kids more often get the psychiatric care they need if they live in states that mandate insurance coverage for child mental health care, a new study confirms.Parents and caregivers were 20% less likely to say they'd had.

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Securing Application with Custom Headers Using AWS CloudFront and WAF

Perficient: Drug Development

Securing Application with Custom Headers Using AWS CloudFront and WAF Background Your company runs a website that is hosted on AWS. To ensure high availability and low latency for users worldwide, you used AWS CloudFront as the Content Delivery Network (CDN) in front of your web servers. To enhance security and protect against web threats, you decided to integrate AWS WAF with your CloudFront distribution.

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Men's Cancer Deaths to Rise 93% Globally by 2050

Drugs.com

TUESDAY, Aug. 13, 2024 -- Men, take note: Cancer cases and deaths among males will jump globally by 84% and 93%, respectively, by 2050, new research predicts.Published Monday in the journal Cancer, the study found the increases were greater among.

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How to Navigate the VMware License Cost Increase

Perficient: Drug Development

VMware (Broadcom) has discontinued their VMware partner resell program. This announcement forces customers to move forward with one of three options: Buy directly from VMware, Migrate workloads to another hypervisor, or Make a platform change. For many VMware customers, the price changes were abrupt, while others have the luxury of taking a little more time to explore their options.