Tue.Aug 08, 2023

article thumbnail

UK biotech financing up 29% on last quarter

Drug Discovery World

The second quarter of 2023 has seen steady growth in financing activity for the UK’s life sciences sector, according to new data released by the BioIndustry Association (BIA) and Clarivate. The positive news comes soon after industry figures welcomed recent announcements to unlock new sources of capital in the City of London. Last month, the UK Chancellor and the Lord Mayor of London launched Mansion House Compact, which is an agreement by pension providers to allocate a minimum 5% to unlisted e

Science 246
article thumbnail

Novo Nordisk’s Huge Financial Bet On Obesity Drug Wegovy Wins Big

Forbes: Drug Truths

The SELECT trial is a game changer. Yes, Novo Nordisk achieved winning results. But obesity patients with heart disease now have a major new drug to extend their lives – and that’s an even bigger win.

Drugs 171
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Astex and MSD expand cancer drug discovery collaboration

Drug Discovery World

Astex Pharmaceuticals and MSD (Merck & Co) have announced an exclusive worldwide research collaboration to identify small molecule candidates with activity towards a tumour suppressor protein for the treatment of cancer. Under the terms of the agreement, Astex will apply its fragment-based drug discovery platform to develop compounds targeting multiple forms of the p53 tumour suppressor protein and provide MSD with lead compounds for further optimisation and preclinical development.

article thumbnail

Emergent to lay off around 400 in pivot away from contract manufacturing

BioPharma Drive: Drug Pricing

The job cuts will affect “all areas of the company” and, combined with other cost-reduction efforts, lead to annualized savings of over $100 million, Emergent said.

98
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Astellas invests in CAR-T cell therapy for solid tumours

Drug Discovery World

Astellas Pharma will invest $50 million into Poseida Therapeutics to secure the rights to the company’s cancer CAR-T cell therapy for solid tumours, which is currently in Phase I trials. The total $50 million will include $25 million to acquire 8,333,333 shares of common stock of Poseida and a one-time $25 million payment for first refusal to license allogeneic CAR-T cell therapy P-MUC1C-ALLO1.

Therapies 130
article thumbnail

New COVID Variant EG.5 Now Dominant in U.S., CDC Says

Drugs.com

TUESDAY, Aug. 8, 2023 – A variant nicknamed Eris now accounts for the largest proportion of new COVID infections across America. About 17.3% of U.S. COVID cases are believed to have been caused by the variant, formally known as EG.5, in early.

98

More Trending

article thumbnail

Lilly market value soars on higher sales, obesity drug potential

BioPharma Drive: Drug Pricing

The Indianapolis drugmaker is now worth more than $500 billion, higher than any other pharmaceutical company, as analysts project lucrative markets for its obesity and Alzheimer's drugs.

article thumbnail

Bella Hadid Opens Up About Lyme Disease Battle

Drugs.com

TUESDAY, Aug. 8, 2023 -- Top model Bella Hadid is talking about being "finally healthy" and feeling well after more than a decade of health issues, including Lyme disease. Hadid shared her struggle on Instagram after what she described as "almost.

Disease 98
article thumbnail

What to know about persistent corneal epithelial defects

Antidote

Persistent corneal epithelial defects are more than just an eye injury. The corneal epithelium is an integral part of the eye , tasked with guarding against infection and structural damage. While most injuries to the corneal epithelium are able to heal within a week , these persistent injuries will continue well past the seven-day mark. If they remain unresponsive to standard treatments, the condition is referred to as a persistent corneal epithelial defect.

article thumbnail

'Walking Miracles': Born With Lungs Reversed, They Suffered Until Getting Double-Organ Transplants

Drugs.com

TUESDAY, Aug. 8, 2023 -- Dennis Deer woke from surgery in utter disbelief that he was breathing normally. He’d been on supplemental oxygen for two years, and “I didn’t know what it was like not to have something on my face,” said Deer, 51, a.

98
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Integrate Sitecore Form into a JSS app (React/Next.js) in Headless Architecture.

Perficient: Drug Development

Everyone is moving toward headless architecture these days and wants to take advantage of the new approach in the CMS industry to improve the CMS experience. However, in a few cases, it does not support a CMS functionality like Sitecore Form. Sitecore does not have any out of the box (OOB) component to implement Sitecore Form. Although Sitecore has provided different approaches and advice on how to integrate Sitecore Form in JSS app.

article thumbnail

Menstrual Discs Could Help Women With Heavy Periods, Study Finds

Drugs.com

TUESDAY, Aug. 8, 2023 -- For women with heavy periods, some newer menstrual products may offer more security than old-fashioned pads and tampons. That's among the findings of a new study that tested the absorbency levels of a range of period.

article thumbnail

What I (and Others) Told the Senate about the 340B Drug Pricing Program

Drug Channels

Recently, a bipartisan group of six U.S. senators issued a request for information (RFI) for “input on bipartisan policy solutions that would provide stability and appropriate transparency to ensure the 340B program can continue to achieve its original intent of supporting entities serving eligible patients.” Click here to read the full letter. I submitted a 14-page letter, which you can read below.

article thumbnail

AHA News: Salty-Tasting Water Turned Out to Be a Warning Sign

Drugs.com

TUESDAY, Aug. 8, 2023 (American Heart Association News) -- Donnese Tyler's schedule was chock-full. With a husband, two sons, a demanding job in contracts management and a reluctance to say no to anyone, she rarely made time for herself. On an.

98
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Novo obesity drug protects heart health in large trial

BioPharma Drive: Drug Pricing

Treatment with Wegovy led to a 20% reduction in the relative risk of cardiovascular complications or death, a finding that could further shift how doctors treat obesity.

Doctors 98
article thumbnail

Understanding the Stages of Breast Cancer: 0, 1, 2, 3 & 4

Drugs.com

A diagnosis of breast cancer comes with many tough questions, but one of the biggest is what stage your cancer is. Millions of women struggle with such questions every year: Breast cancer is the most common cancer in women in the United States, with.

98
article thumbnail

Prevalence and timing of authorized generics in the US market

Drug Patent Watch

A recent study explores the landscape of authorized generics in the United States pharmaceutical market. Authorized generics are brand-name drugs that are marketed without their original branding. The article sheds… The post Prevalence and timing of authorized generics in the US market appeared first on DrugPatentWatch - Make Better Decisions.

article thumbnail

How the COVID Vaccine Is Keeping Folks Out of the Hospital

Drugs.com

TUESDAY, Aug. 8, 2023 -- Most people know that even though vaccination doesn't eliminate their risk of getting COVID-19, it does lower their odds for severe illness -- including their risk for hospitalization and death. Now scientists believe they.

article thumbnail

The Use of Zebrafish as New Alternative Model in Eye Disease.

biobide

The observation of the Zebrafish’s (Danio rerio) innate capacity to regenerate retinal cells has resulted in its identification as an ideal New Alternative Model (NAM) for ocular disease research. As a result of the negative impact on the person’s quality of life that visual impairment causes and the high amount of people suffering from this condition, an estimated 295 million people are believed to suffer from moderate to severe visual impairment worldwide, the study of eye diseases is of high

Disease 94
article thumbnail

U.S. Heart Disease Death Rates Have Fallen Sharply in Past 30 Years

Drugs.com

TUESDAY, Aug. 8, 2023 -- Fatal heart disease in the United States dropped about 4% a year between 1990 and 2019, but Americans need to quit smoking, drinking and overeating or those gains could be wiped out, according to new research. The declining.

Disease 96
article thumbnail

The voices of indigenous peoples and local communities as an important part of the climate fight

SCIENMAG: Medicine & Health

Coinciding with the International Day of Indigenous Peoples, an ICTA-UAB study calls for indigenous peoples’ in-depth knowledge of climate change to be considered. Credit: Author Mouna Chambon Coinciding with the International Day of Indigenous Peoples, an ICTA-UAB study calls for indigenous peoples’ in-depth knowledge of climate change to be considered.

article thumbnail

Wegovy Lowered Users' Heart Risks in New Trial

Drugs.com

TUESDAY, Aug. 8, 2023 -- A large clinical trial weighing the medical merits of the obesity drug Wegovy has unearthed a significant positive side effect. Taking the medication cut the risk of serious heart problems by 20%, drug maker Novo Nordisk.

Trials 75
article thumbnail

Theory meets practice

SCIENMAG: Medicine & Health

(Santa Barbara, Calif.) — Scientific findings don’t always translate neatly into actions, especially in conservation and resource management. The disconnect can leave academics and practitioners disheartened and a bit frustrated.

Science 90
article thumbnail

Carcinogens Found at Montana Nuclear Missile Base as Cancer Cases Rise Nearby

Drugs.com

TUESDAY, Aug. 8, 2023 -- An investigation into a high number of cancers at a Montana nuclear missile base has led to the discovery of unsafe levels of a likely carcinogen. The hundreds of cancer cases appear to be connected to underground launch.

75
article thumbnail

Remission from HIV-1 infection: discovery of broadly neutralizing antibodies that contribute to virus control

SCIENMAG: Medicine & Health

Some HIV-1 carriers who have received an early antiretroviral treatment during several years are able to control the virus for a long term after treatment interruption. However, the mechanisms enabling this post-treatment control have not been fully elucidated.

Virus 89
article thumbnail

Women who consumed sugar sweetened beverage daily had higher risk of developing liver cancer and chronic liver disease

Science Daily: Pharmacology News

Approximately 65% of adults in the United States consume sugar sweetened beverages daily. Chronic liver disease is a major cause of morbidity and mortality worldwide and can result in liver cancer and liver disease-related mortality. Researchers looked at the association between intake of sugar-sweetened beverages, artificially sweetened beverages, and incidence of liver cancer and chronic liver disease mortality.

Disease 75
article thumbnail

Association of radiation facility volume with survival for men with very high-risk prostate cancer

SCIENMAG: Medicine & Health

About The Study: The findings of this study suggest that the expertise and resources that accompany high-volume treatment facilities are associated with improved outcomes for men with very high-risk prostate cancer, but further investigation is needed to identify the specific causes for this association. Authors: Sagar A. Patel, M.

article thumbnail

Step Up to a New School Year: Tips for Buying Shoes for Your Kids

Drugs.com

TUESDAY, Aug. 8, 2023 -- Buying back-to-school shoes should be more about the right fit than the right look — but with luck you can combine the two. Shoes play a big part in how kids’ feet function and should be selected with care, say.

75
article thumbnail

Ancient DNA reveals an early African origin of Cattle in the Americas

SCIENMAG: Medicine & Health

Cattle may seem like uniquely American animals, steeped in the lore of cowboys, cattle drives and sprawling ranches. But cattle didn’t exist on the American continents prior to the arrival of the Spanish, who brought livestock with them from Europe by way of the Canary Islands.

DNA 89
article thumbnail

Polluted Air Linked to Dangerous Antibiotic Resistance

Drugs.com

TUESDAY, Aug. 8, 2023 -- Doctors who overprescribe antibiotics are often blamed for medication-resistant illnesses, but new research points to another potential culprit: air pollution.

Doctors 75
article thumbnail

Prestigious NSF grants awarded to UTEP early-career faculty

SCIENMAG: Medicine & Health

EL PASO, Texas (Aug. 8, 2023) – Two University of Texas at El Paso researchers have earned one of the nation’s highest awards for early-career faculty in 2023. Credit: The University of Texas at El Paso. EL PASO, Texas (Aug.

article thumbnail

Nurses, Other Health Care Workers at High Risk of Drug Overdose

Drugs.com

TUESDAY, Aug. 8, 2023 -- As the United States wrestles with soaring drug overdose deaths, new research finds that nurses, social and behavioral health care workers and health care support workers are at particularly high risk. Compared with employed.

Nurses 75
article thumbnail

How to increase acceptance of an RSV vaccine? Explain the FDA’s vaccine approval process

SCIENMAG: Medicine & Health

PHILADELPHIA – A new study finds that people are more likely to recommend that a pregnant family member or friend get vaccinated to protect the infant from RSV illness if they are shown a chart outlining the rigorous process a vaccine undergoes to be approved by the Food and Drug Administration (FDA).

Vaccine 88
article thumbnail

FDA Sets a Recommended Framework for Predicting the Mutagenic and Carcinogenic Potential of Nitrosamine Drug Substance-Related Impurities

FDA Law Blog: Biosimilars

By Douglas B. Farquhar & Richard A. Lewis, Senior Regulatory Device & Biologics Expert — Please sing to the tune of “ Honesty ,” by Billy Joel: Nitrosamines, it’s such an ugly word, In pharmaceuticals’ impurity. Nitrosamines are hardly ever good, Now FDA has issued policy. Failure to detect nitrosamines, failure to notify FDA when nitrosamines appear in finished drug products, failure to identify impurities in drugs that may be nitrosamines, even having a deviation in pH of an Active Pha

FDA 74