Drug Discovery World
SEPTEMBER 15, 2023
Advanced Therapies Europe took place from 9-12 September 2023 in Portugal. DDW’s Megan Thomas asked attendees: What is most important to scale from discovery to commercialisation of cell and gene therapies (CGTs)? Joel Eichmann, Co-Founder, Green Elephant Biotech It always comes down to time-to-market and risk minimisation. To cover these, it is critical to choose [.
Chemical Biology and Drug Design
SEPTEMBER 15, 2023
The synthesis of isoindole-1,3-dione analogues bearing halo, hydroxy and acetoxy groups at the 4,5,6-position of the bicyclic imide ring was performed and then the cytotoxic effect and the antimicrobial action of trisubstituted isoindole derivatives were evaluated. Abstract In this study, synthesis of novel isoindole-1,3-dione analogues bearig halo, hydroxy, and acetoxy groups at the position 4,5,6 of the bicyclic imide ring was performed to examine their potential anticancer effects against som
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Drug Discovery World
SEPTEMBER 15, 2023
Replicate Bioscience has dosed the first participant in a Phase I trial of its RBI-4000 vaccine for the prevention of rabies. The trial, which marks the first time a human has been dosed with Replicate’s srRNA technology, will serve as a benchmark for utility in this indication and other complex infectious diseases and provide foundational insights to inform future clinical trials, most notably in oncology and autoimmune disease.
Chemical Biology and Drug Design
SEPTEMBER 15, 2023
In this study, it was suggested that Chemerin or IL-17 were positively correlated with Lund-Mackay and Lund-Kennedy scores of CRS patients, and they showed high predictive values for CRS. In addition, the knockdown of Chemerin was found to alleviate inflammation and bone remodeling in Staphylococcus aureus -induced CRS rabbits. These findings provide reference methods for CRS diagnosis, treatment, and prognosis.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
SEPTEMBER 15, 2023
News round-up for 11-15 September by DDW Digital Content Editor Diana Spencer. Spanning artificial intelligence, theranostics, radiopharmaceuticals, quantum simulation and small regulatory RNA, the top stories this week all cover cutting-edge technologies and techniques making a huge impact on modern drug discovery and development. The headlines: Pharma must embrace an AI future says new report Artificial intelligence (AI) technology has the potential to revolutionise drug discovery and pharma c
Chemical Biology and Drug Design
SEPTEMBER 15, 2023
A radiobiological modelization of 225 Ac-based alpha-emitter radiopharmaceuticals and targeted alpha therapy (TAT). 225 Ac can be considered as best radionuclide because it offers novel therapeutic strategies for advanced and late-stage cancer treatment with a large variety of biomolecules. Abstract In nuclear medicine, cancers that cannot be cured or can only be treated partially by traditional techniques like surgery or chemotherapy are killed by ionizing radiation as a form of therapeutic tre
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
SEPTEMBER 15, 2023
FRIDAY, Sept. 15, 2023 -- Good oral health is one of the keys to healthy aging, but a sobering new study shows that many U.S. nursing home residents have significant dental issues. Close to two in every 10 residents have missing teeth, about 8%.
Drug Discovery World
SEPTEMBER 15, 2023
In this webinar, hosted by DDW and co-sponsored by Benchling and Proscia, you will learn about the key benefits and latest innovations to be aware of in AI and lab automation. You will hear from Jeremy Skillington, CEO of Poolbeg Pharma, as well as sponsor presentations from Helen Liu-Mayo, Product Manager at Benchling, and Nathan Buchbinder, Co-Founder and Chief Strategy Officer at Proscia.
biobide
SEPTEMBER 15, 2023
Pesticides are a vital tool in safeguarding the world’s food supply. The need to protect crops from pests, disease, and weeds has existed for centuries, with the Roman’s having used ash, crushed cypress leaves and diluted urine to protect their crops. Nowadays, pest control methods and the chemicals used are a great deal more sophisticated. It is estimated that without crop protection, which includes the use of pesticides, half of the world’s food crops would be lost.
Drug Discovery World
SEPTEMBER 15, 2023
In this Application Note, multi-parallel screening of binding conditions on CIM ® Oligo dT 96-well plates was performed to optimise the dynamic binding capacity (DBC) in the shortest time possible. What you will learn: How to effectively use Monolithic 96-well plates when developing methods. They are unique on the market in combining the standard well-plate design with monolithic technology and Oligo dT for high throughput of mRNA purification.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
SEPTEMBER 15, 2023
FRIDAY, Sept. 15, 2023 – Kids are back in school and it’s time to think about viruses, for both yourself and them. It could be an early flu season in the United States, if what happened in the Southern Hemisphere offers any insight, according to.
Drug Discovery World
SEPTEMBER 15, 2023
A new Application Note is now available to download from Sartorius BIA Separations. In this App Note, multi-parallel screening of binding conditions on CIM ® Oligo dT 96-well plates was performed to optimise the dynamic binding capacity (DBC) in the shortest time possible. What you will learn: How to effectively use Monolithic 96-well plates when developing methods.
Drugs.com
SEPTEMBER 15, 2023
FRIDAY, Sept. 15, 2023 – If you have a Chuckle & Roar Ultimate Water Beads Activity Kit, a child’s toy made by Buffalo Games and sold exclusively at Target, throw it out. The toy is being recalled due to serious ingestion, choking and.
Drug Discovery World
SEPTEMBER 15, 2023
What you will learn: Researchers from ChromoTek discuss the differences between affinity and avidity as measured on the Octet ® BLI platform Measuring affinity in avidity driven assay orientations Why assay orientation, valency, ligand surface density and non-specific binding matter Recognise and resolve issues arising from interactions that contain a bivalent or multivalent component The post Optimising kinetic assays to avoid avidity effects appeared first on Drug Discovery World (DDW).
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
SEPTEMBER 15, 2023
FRIDAY, Sept. 15, 2023 -- That beautiful park you walk through could be hiding dangerous levels of lead. So, too, could the soil under the play equipment where your children slide and swing. New research in the United States finds that urban parks.
Drug Discovery World
SEPTEMBER 15, 2023
Specialist pharmaceutical company Norgine has appointed Saulo Martiniano as its new Chief Operating Officer (COO). Martiniano previously worked at L’Oréal and was responsible for leading Global Manufacturing Excellence across 38 plants that included more than 10,000 employees. Martiniano will now be based in the UK and takes on the responsibility of overseeing Norgine’s global operations and driving growth across the business to further strengthen the company’s position as a leade
Drugs.com
SEPTEMBER 15, 2023
FRIDAY, Sept. 15, 2023 -- The American Stroke Association is promoting the acronym R.Á.P.I.D.O. as a way to raise awareness among Hispanic Americans about stroke symptoms and the need for quick action. Every second counts when someone has had a.
Perficient: Drug Development
SEPTEMBER 15, 2023
Mark Your Calendars Date: Wednesday, October 25th | Time: 11:00 AM – 12:00 PM CT Are you ready to take your e-commerce game to the next level? Join us for an illuminating session hosted by Perficient’s seasoned commerce experts. We’re here to demystify complexities, share real-world success stories, and provide you with actionable advice to steer your migration to SAP Commerce Cloud.
Drug Channels
SEPTEMBER 15, 2023
Today’s guest post comes from Nicole Mayer, Senior Analyst at MMIT. Nicole summarizes MMIT’s research on payers’ views of two crucial market changes: (1) the Inflation Reduction Act of 2022’s requirement to cap insulin prices at $35 for Medicare beneficiaries, and (2) manufacturers’ reduction in list prices for certain insulin products. She also discusses MMIT’s research on such glucagon-like peptide 1 (GLP-1) drugs as Ozempic and Mounjaro.
Science Daily: Pharmacology News
SEPTEMBER 15, 2023
Researchers have achieved a significant breakthrough in identifying the primary cause and potential treatment for preeclampsia, a severe pregnancy complication. Experts pinpointed a toxic protein named cis P-tau in the blood and placenta of individuals with preeclampsia. The study describes cis P-tau as a pivotal circulating instigator of preeclampsia.
Collaborative Drug
SEPTEMBER 15, 2023
Recorded Webinar: Drug Design Trends in the Age of AI. fragment-based drug design and full molecule-based drug design.
BioPharma Drive: Drug Pricing
SEPTEMBER 15, 2023
The antitrust regulator is examining what it describes as abuse of the FDA “Orange Book” — another step in its scrutiny of pharma business practices.
Drugs.com
SEPTEMBER 15, 2023
FRIDAY, Sept 15, 2023 — Rebutting conventional wisdom, a large Swedish study finds that most people with chronic acid reflux, or GERD, do not have a higher risk for developing cancer of the esophagus. “Previous studies have shown that.
FDA Law Blog: Biosimilars
SEPTEMBER 15, 2023
On September 18-20, Informa Connect will hold its annual #MDRPSummit in Chicago (and via livestream) to discuss the complex, ever-evolving laws and regulations in the government pricing and price reporting space. This three-day summit will feature numerous presentations, workshops and networking opportunities featuring government officials, drug pricing and reimbursement lawyers and experts and industry leaders.
Drug Patent Watch
SEPTEMBER 15, 2023
Annual Drug Patent Expirations for INGREZZA Ingrezza is a drug marketed by Neurocrine and is included in one NDA. It is available from one supplier. There are twenty patents protecting… The post New patent for Neurocrine drug INGREZZA appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
SEPTEMBER 15, 2023
FDA’s nonprescription advisors find no efficacy for phenylephrine This week, FDA’s Nonprescription Drugs Advisory Committee (NDAC) voted unanimously that current scientific data do not support the efficacy of oral phenylephrine as a nasal decongestant, aligning with FDA analysis — and re-analysis — of data. The change, if adopted by FDA, will have huge implications for consumer options and will challenge the FDA to execute a clear communications rollout.
Drug Patent Watch
SEPTEMBER 15, 2023
Annual Drug Patent Expirations for SUNOSI Sunosi is a drug marketed by Axsome Malta and is included in one NDA. It is available from two suppliers. There are thirteen patents… The post New patent for Axsome Malta drug SUNOSI appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
SEPTEMBER 15, 2023
FRIDAY, Sept. 15, 2023 -- Parents who drink too much, too often, may be influencing their teens to do the same, a new study finds. "Adolescents whose parents binge drink had a four times greater chance of drinking alcohol themselves compared to.
Drug Patent Watch
SEPTEMBER 15, 2023
Annual Drug Patent Expirations for AUVELITY Auvelity is a drug marketed by Axsome and is included in one NDA. It is available from one supplier. There are one hundred and… The post New patent for Axsome drug AUVELITY appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
SEPTEMBER 15, 2023
For first time, FDA releases OTC drug user fees prior to start of government fiscal year The FDA today unexpectedly unveiled certain user fees under its OTC Monograph User Fee Program (OMUFA), its nonprescription drug funding and performance mechanism. While fees payable for OTC Monograph Order Request (OMOR) submissions have previously been published in March, six months after the start of the fiscal year, the fees are now being published prior to the start of the 2024 fiscal year.
Drug Patent Watch
SEPTEMBER 15, 2023
Annual Drug Patent Expirations for FERRIPROX Ferriprox is a drug marketed by Chiesi and is included in three NDAs. It is available from two suppliers. There are six patents protecting… The post New patent for Chiesi drug FERRIPROX appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
SEPTEMBER 15, 2023
California set to ban an additional 26 chemicals from cosmetics California’s assembly passed a bill prohibiting the manufacture and sale of cosmetics containing 26 discrete chemical substances. The bill was passed by a bipartisan vote and is expected to be sent to Gov. Gavin Newsom for signature. Once it becomes law, California will have banned the intentional addition of a total of 50 chemicals in cosmetics.
Drug Patent Watch
SEPTEMBER 15, 2023
Annual Drug Patent Expirations for REZLIDHIA Rezlidhia is a drug marketed by Rigel Pharms Inc and is included in one NDA. It is available from one supplier. There are ten… The post New patent for Rigel Pharms drug REZLIDHIA appeared first on DrugPatentWatch - Make Better Decisions.
BioPharma Drive: Drug Pricing
SEPTEMBER 15, 2023
Janssen will be recast as Johnson & Johnson Innovative Medicine, melding the drugs division’s identity more closely with its parent.
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