Drug Discovery World

OCTOBER 31, 2023

Professor Andy Whiting and Dr Tony Lockett discuss how specific levels of a protein could be used to advance drug development in neurodegenerative diseases. Neurofilament light (NfL) analysis is a potential biomarker for damage to both the central and peripheral nervous system. It has been used experimentally in international trials 1 , but researchers are hopeful that further use and evaluation in the UK will accelerate drug development for hard-to-treat neurodegenerative diseases.

Drug Development 148

Drug Development Disease Drugs Clinical Trials 148

BioPharma Drive: Drug Pricing

OCTOBER 31, 2023

The high-profile meeting focused on the theoretical risks of CRISPR gene editing, as both the FDA and its advisory committee appeared convinced by the efficacy of the companies’ exa-cel treatment.

FDA 135

FDA Therapies Treatment 135

Drug Discovery World

OCTOBER 31, 2023

UK regulatory authorities have approved the first trial of a gene therapy for young children with Hunter syndrome. The UK Medicines and Healthcare Products Regulatory Agency (MHRA), Research Ethics Committee (REC), and Health Research Authority (HRA) have all approved the clinical trial application that was submitted by The University of Manchester in August 2022.

Therapies 130

Therapies Trials Clinical Trials Hospitals 130

Science Daily: Pharmacology News

OCTOBER 31, 2023

A new paper revealed that human activities are making Earth's air, soil and freshwater saltier, which could pose an 'existential threat' if current trends continue. Geologic and hydrologic processes bring salts to Earth's surface over time, but human activities such as mining and land development are rapidly accelerating this natural 'salt cycle.

133

133

Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

OCTOBER 31, 2023

The DDW Turning Science into Business Summit, ‘ Cancer research opportunities and advances ’ will take place online on 16 November at 7AM PDT / 10AM EDT / 3PM GMT / 4PM CET and will be available on-demand after that date. The free summit, sponsored by Taconic, will offer expert thought leadership on cancer research, precision medicine and immunotherapy.

Science 130

Science Research Drugs 130

BioPharma Drive: Drug Pricing

OCTOBER 31, 2023

Expert advisers are reviewing the companies’ case for approval of what could be the first medicine based on the gene editing technology. Follow their discussion here.

Therapies 133

Therapies 133

Chemical Biology and Drug Design

OCTOBER 31, 2023

This study revealed that paclitaxel inhibits SNU-16 cell migration and invasion via activating the NLRP3/caspase-1/GSDME mediated pyroptosis pathway when used to treat Gastric cancer (GC). This finding provides a theoretical basis for the potential of paclitaxel in GC treatment. Abstract Gastric cancer (GC) is a gastric epithelium-derived malignancy insensitive to post-surgical radiotherapy.

Treatment 100

Treatment Drugs Research 100

Drug Discovery World

OCTOBER 31, 2023

PwC has published a new report on the UK life sciences industry ‘The Life Sciences Future50’, highlighting companies that illustrate world-class science and innovation, including 32 in the therapeutics space. According to the report, the life science industry represents a £43.4 ($52.7) billion annual contribution to GVA and supports 646,000 job every year and.

Science 130

Science Drugs Research Drug Development 130

Drug Target Review

OCTOBER 31, 2023

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? What inspired you to pursue a career in STEM, and how did you overcome any obstacles or biases you may have faced? Someone with a fighter spirit and FDA regulatory experience had to fight for it and I decided to take on that role. I always knew I wanted to study biology.

Cell Biology 107

Cell Biology Pharmaceuticals Science International 107

Drugs.com

OCTOBER 31, 2023

MONDAY, Oct. 30, 2023 -- A cheap, do-it-yourself air purifier is powerful enough to effectively protect a home from free-floating flu and COVID-19 viruses, according to test results from the U.S. Environmental Protection Agency. The filter, crafted.

Virus 105

Virus 105

Advertisement

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Patent Watch

OCTOBER 31, 2023

Annual Drug Patent Expirations for CALQUENCE Calquence is a drug marketed by Astrazeneca and is included in two NDAs. It is available from one supplier. There are eight patents protecting… The post New patent for Astrazeneca drug CALQUENCE appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 104

Drugs Marketing 104

Drugs.com

OCTOBER 31, 2023

TUESDAY, Oct. 31, 2023 – Certain pureed fruit pouches from WanaBana may contain dangerous levels of lead, the U.S. Food and Drug Administration has warned. Parents and caregivers should not buy or serve WanaBana apple cinnamon fruit puree.

FDA 105

FDA Drugs 105

Drug Channels

OCTOBER 31, 2023

Zoinks! It's time for a super-sized Halloween roundup of wicked Drug Channels ’ tales. This month’s tricks and treats: Spooky! CVS Health frightens all but one Humira biosimilar maker away from its formulary. Creepy! The gross-to-net bubble for anti-obesity GLP-1 drugs walks among us. Grotesque! Penn Medicine gorges on the 340B program. Vampiric!

Biosimilars 98

Biosimilars Pharmacy Drugs 98

Drugs.com

OCTOBER 31, 2023

MONDAY, Oct. 30, 2023 -- Federal regulators are warning consumers to stop using eyedrops and gels from several major brands after finding unsanitary conditions in a manufacturing plant. Twenty-six eye care products are part of the alert.

FDA 105

FDA Regulations Production 105

Advertisement

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

CHAPEL HILL, N.C. – The lungs were once at the forefront of SARS-Cov-2 research, but as reports of organ failure and other serious complications poured in, scientists set out to discover how and why the respiratory virus was causing serious damage to the body’s major organs, including the lungs.

Virus 98

Virus Research 98

Drugs.com

OCTOBER 31, 2023

MONDAY, Oct. 30, 2023 -- Americans have been getting COVID treatments such as Paxlovid for free, but that’s about to end. The medications will enter the private market this week, the Associated Press reported. The price for a five-day course.

Treatment 111

Treatment Marketing 111

Drug Discovery Today

OCTOBER 31, 2023

The topic of this month’s newsletter from Drug Discovery Today is “Drug Delivery”.

Drugs 113

Drugs 113

Drugs.com

OCTOBER 31, 2023

MONDAY, Oct. 30, 2023 -- Kids with a genetic risk for autism spectrum disorder (ASD) are likely to spend hours a day glued to their screens, but researchers say it doesn't mean screen time causes ASD. The investigators also found that children with.

Research 103

Research 103

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

New York, NY (October 30, 2023)—The Icahn School of Medicine at Mount Sinai will award its 2023 Maria I. New International Prize for Biomedical Research to Jean-Laurent Casanova, MD, PhD, for revolutionizing our understanding of human infectious diseases through the discovery of genetic and immunological determinants that underpin both rare and common infectious illnesses.

International 93

International Research Disease 93

Drugs.com

OCTOBER 31, 2023

TUESDAY, Oct. 31, 2023 -- In some big cities, mobile stroke units can deliver a powerful clot-busting drug to patients as these specialized ambulances speed to the hospital. Now, a new study shows these units deliver anti-clotting treatment a.

Hospitals 98

Hospitals Treatment Drugs 98

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

When, where, and why do diseases jump from animals to people? A new project will monitor how changing seasons, land use, and human behavior influence viral outbreaks in wild rodent populations, to identify hotspots with high potential for spillover into people.

Disease 87

Disease 87

BioPharma Drive: Drug Pricing

OCTOBER 31, 2023

Already a partner to Verve, the pharma is paying $200 million upfront and investing another $50 million in Beam to acquire option rights to several gene editing programs.

Drugs 86

Drugs 86

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

AMES, Iowa – Since 2011, roughly 10,000 people in the U.S. have turned 65 every day. The Baby Boomer generation and those born before 1946 make up the country’s fastest growing age group, which is on track to outnumber children by 2035.

84

84

addgene Blog

OCTOBER 31, 2023

Looking for a fast and inexpensive way to determine your antibody's purity? Check out our latest protocol video, "Coomassie Purity Stain of Recombinant Antibodies.

87

87

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

BINGHAMTON, N.Y. — A new drug developed by professors from the School of Pharmacy and Pharmaceutical Sciences at Binghamton University has received Food and Drug Administration (FDA) approval for the treatment of patients with Duchenne muscular dystrophy (DMD), a common genetic disease that mostly affects young boys.

FDA Approval 83

FDA Approval FDA Disease Pharmacy 83

Drugs.com

OCTOBER 31, 2023

TUESDAY, Oct. 31, 2023 -- Taking the drug metformin – typically used for type 2 diabetes – can help counter weight gain in young people who are taking medication for bipolar disorder, according to a new trial. While second-generation.

Trials 81

Trials Drugs 81

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

Researchers at the University of Wisconsin–Madison and Academia Sinica of Taiwan have harnessed a combination of lab-grown cells to regenerate damaged heart muscle. Credit: Yu-Che Cheng Researchers at the University of Wisconsin–Madison and Academia Sinica of Taiwan have harnessed a combination of lab-grown cells to regenerate damaged heart muscle.

Therapies 77

Therapies Research 77

Drugs.com

OCTOBER 31, 2023

TUESDAY, Oct. 31, 2023 -- The Biden administration is encouraging schools throughout the United States to carry naloxone to help prevent fatal drug overdoses in students. The medication (Narcan) was approved earlier this year as an over-the-counter.

Treatment 81

Treatment Drugs 81

Science Daily: Pharmacology News

OCTOBER 31, 2023

Sunflowers famously turn their faces to follow the sun as it crosses the sky. But how do sunflowers 'see' the sun to follow it? Plant biologists show that they use a different, novel mechanism from that previously thought.

80

80

Drugs.com

OCTOBER 31, 2023

MONDAY, Oct. 30, 2023 -- Time-restricted dieting may be a better way for people with type 2 diabetes to lose weight than counting calories, a new study suggests. Researchers found that people who only ate between noon and 8 p.m. each day lost more.

Research 81

Research 81

BioPharma Drive: Drug Pricing

OCTOBER 31, 2023

The pharma’s shot Abrysvo made over $300 million in sales during the first few months of its launch, and will be an important product to help offset declining COVID vaccine sales.

Vaccine 73

Vaccine Marketing Production 73

The Open Targets Blog

OCTOBER 31, 2023

This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users. The National Cancer Institute (NCI)’s Childhood Cancer Data Initiative (CCDI) is supporting the development of an instance of the Open Targets Platform specific to childhood cancers for systematic drug target identification and prioritisation.

Bioinformatics 69

Bioinformatics Engineering FDA Clinical Trials 69

Drugs.com

OCTOBER 31, 2023

MONDAY, Oct. 30, 2023 -- Many law enforcement officers own firearms but fail to store them properly, claims a study that points to an increased risk of suicide. Police officers are also more likely to have suicidal thoughts, according to research.

Research 64

Research 64

BioPharma Drive: Drug Pricing

OCTOBER 31, 2023

The acquisition of Telavant and its TL1A drug was born out of a J.P. Morgan conference meeting, Roivant chief executive Matt Gline said, and reflects the biotech’s flexible business strategy.

Drugs 62

Drugs 62