Drug Discovery World

NOVEMBER 13, 2023

Researchers at the University of São Paulo (USP) in Brazil and Foresee Pharmaceuticals have tested a synthetic molecule which could increase heart function in patients with heart failure. Heart failure is a condition in which the heart cannot pump enough blood to meet the body’s needs for blood and oxygen. A number of drugs can slow its progression but currently no treatment exists that can reverse it.

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Research Laboratories Pharmaceuticals Science 265

Chemical Biology and Drug Design

NOVEMBER 13, 2023

Developmental formulation of COVID-19 via green technology principles was discussed. Challenges involved in vaccines formulation were also featured. Use of computational methods and models for vaccine development has revolutionized the traditional methods of vaccine development. Main role of mRNA vaccines in the COVID-19 challenge was discussed. Abstract The world has recently experienced one of the biggest and most severe public health disasters with severe acute respiratory syndrome coronaviru

Vaccine 100

Vaccine Laboratories RNA Virus 100

Drug Discovery World

NOVEMBER 13, 2023

Katie Abouzahr is the Vice President and leads the Autoantibody Portfolio Development Team at the Janssen Pharmaceutical Companies of Johnson & Johnson. She speaks with Megan Thomas about the future for Janssen’s investigational medicine nipocalimab and antibody therapeutics at large. A day in the life On a day-to-day basis, Katie Abouzahr is accountable for and leads the development globally of all the assets in Janssen’s Autoantibody portfolio in immunology.

Engineering 148

Engineering Therapies Disease Treatment 148

Chemical Biology and Drug Design

NOVEMBER 13, 2023

TSIIA targeted circ_0000231/miR-590-5p/TXNIP ceRNA network to inactivate the NF-κB signaling pathway to inhibit ox-LDL-aroused endothelial cell dysfunction. Abstract Tanshinone IIA (TSIIA) exhibits inhibitory function in atherosclerosis (AS) progression, and circular RNAs (circRNAs) are pivotal regulators in AS. However, the relation between TSIIA and circ_0000231 in AS pathogenesis remains unknown.

Regulations 100

Regulations Treatment Research 100

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Clinical Trials

Drug Discovery World

NOVEMBER 13, 2023

Genome sequencing has been used to study typhoid fever in a study in Zimbabwe and understand how the disease has evolved to be resistant to treatment. Typhoid fever claims over 135,000 lives annually. Treating it relies on antimicrobials but in the last couple of decades, antimicrobial resistance (AMR) has made controlling it much harder. This has been seen in Zimbabwe, where since 2009 there have been multiple typhoid outbreaks, caused by resistant S.

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Vaccine International Treatment Disease 130

Chemical Biology and Drug Design

NOVEMBER 13, 2023

A series of novel coumarin Mannich base derivatives ( 11a-u ) were obtained by introducing different Mannich bases and furoxan structures into the natural antitumor compound coumarin, compound 11g showed strongest inhibitory activity against HepG2 cancer cells and can lead to apoptosis of HepG2 cells. Abstract Twenty-one new coumarin Mannich base derivatives ( 11a-u ) were synthesized, which exhibited antiproliferation activities in HepG2 (liver cancer), A549 (lung cancer), MCF-7 (breast cancer)

Drugs 100

Drugs Research 100

Chemical Biology and Drug Design

NOVEMBER 13, 2023

Propofol reduced circ_0008898 expression to mediate miR-545-3p/CRKL network, thereby inhibiting the proliferation, migration, and angiogenesis of OSCC. Abstract Propofol has been shown to inhibit oral squamous cell carcinoma (OSCC) progression. However, it is not clear whether propofol mediates OSCC progression through regulating circular RNA (circRNA) network.

RNA 100

RNA Regulations Research 100

Drug Discovery World

NOVEMBER 13, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the first DDW Turning Science into Business Summit taking place next week on the theme of Cancer Research, this dynamic area of drug discovery is this week’s round-up focus again.

Science 130

Science Research Drugs 130

Science Daily: Pharmacology News

NOVEMBER 13, 2023

Researchers aiming to combat rising global temperatures have developed a new 'cooling glass' that can turn down the heat indoors without electricity by drawing on the cold depths of space. The new technology, a microporous glass coating, can lower the temperature of the material beneath it by 3.5 degrees Celsius at noon, and has the potential to reduce a mid-rise apartment building's yearly carbon emissions by 10 percent.

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Research 123

Antidote

NOVEMBER 13, 2023

Each November is designated as Diabetes Awareness Month , an event that highlights the importance of spreading awareness about diabetes and the health issues it can cause.

Clinical Trials 122

Clinical Trials Trials 122

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Clinical Trials

Broad Institute

NOVEMBER 13, 2023

Gerstner Center for Cancer Diagnostics receives additional commitment from Louis V. Gerstner, Jr., to advance technologies that could transform cancer care By Leah Eisenstadt November 14, 2023 Breadcrumb Home Gerstner Center for Cancer Diagnostics receives additional commitment from Louis V. Gerstner, Jr., to advance technologies that could transform cancer care Commitment of $20 million will propel efforts to develop, optimize, and demonstrate liquid biopsy technology along with other cancer di

DNA 116

DNA Medical Schools Treatment Therapies 116

BioPharma Drive: Drug Pricing

NOVEMBER 13, 2023

Forge Biologics operates a contract manufacturing business as well as develops its own gene therapies, which appears to have attracted the Japan-based food and biotechnology company.

Therapies 113

Therapies 113

NIOSH Science Blog: Drugs

NOVEMBER 13, 2023

One hundred years ago, farmers, loggers, and fishermen turned to their families and communities for advice on safety, health, production, and repairs. They may have even consulted the Farmer’s Almanac or asked a cooperative extension agent. Although family, friends, print media, and extension agents are still great sources of information, the farmers, loggers, and fishermen of this century also began to use smart phones to find answers.

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Production 111

BioPharma Drive: Drug Pricing

NOVEMBER 13, 2023

Trial results add to evidence that so-called Factor XIa inhibitors could have less bleeding risk than currently available oral anticoagulants like Xarelto.

Trials 120

Trials 120

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Clinical Trials

Perficient: Drug Development

NOVEMBER 13, 2023

If you’re in technology, AIs are everywhere nowadays. At work, I use an AI to help me make proofs of concept, sometimes in communicating with other AIs. At home, I use Google’s Bard to help with those day-to-day mental chores such as meal planning. Even at play, when indulging in some Gran Turismo there’s an AI to race against. I can’t do anything about the AIs I use more casually (aside from being aware of them).

Packaging 110

Packaging Production 110

BioPharma Drive: Drug Pricing

NOVEMBER 13, 2023

Regulatory agencies have set the framework and use cases for RWE. How can these increase the probability of success or efficiency in a pre-clinical and clinical drug development program?

Drug Development 109

Drug Development Pharmaceuticals Drugs 109

addgene Blog

NOVEMBER 13, 2023

Every few months, we highlight a subset of the new plasmids, antibodies, and viral preps in the repository through our Hot Plasmids articles. Today, it's time for another edition of Hot Plasmids!

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Drug Target Review

NOVEMBER 13, 2023

Regulatory T cells (Treg) cells are specialised immune cells that are essential for maintaining peripheral tolerance, preventing autoimmune diseases, and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilising immunity and limiting antitumour immunity. 1 Understanding how they work is crucial for determining how they may be manipulated to encourage the destruction of cancer cells or prevent autoimmunity.

Government 104

Government DNA Regulations RNA 104

Science Daily: Pharmacology News

NOVEMBER 13, 2023

A floating, solar-powered device that can turn contaminated water or seawater into clean hydrogen fuel and purified water, anywhere in the world, has been developed by researchers.

Research 101

Research 101

SCIENMAG: Medicine & Health

NOVEMBER 13, 2023

Hepatitis B virus (HBV) is a significant public health problem, with over 296 million people chronically infected worldwide. Despite the availability of a safe and effective vaccine for over 40 years, HBV remains a leading cause of liver disease and death.

Virus 93

Virus Vaccine Disease 93

Science Daily: Pharmacology News

NOVEMBER 13, 2023

A new study has revealed that water from the Earth's surface can penetrate deep into the planet, altering the composition of the outermost region of the metallic liquid core and creating a distinct, thin layer. Illustration of silica crystals coming out from the liquid metal of the Earth's outer core due to a water-induced chemical reaction.

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SCIENMAG: Medicine & Health

NOVEMBER 13, 2023

New findings from the University of Houston Department of Health and Human Performance reveal a significant association between a lower number of positive childhood experiences and a higher prevalence of binge-eating disorder characteristics, as well as lower scores for intuitive eating.

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Science Daily: Pharmacology News

NOVEMBER 13, 2023

Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process. Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms.

Drugs 94

Drugs Disease Research 94

SCIENMAG: Medicine & Health

NOVEMBER 13, 2023

In 1986, John Watson’s finger was bitten off by a crocodile. A Nyikina Mangala man from the Jarlmadangah Burru Aboriginal Community of the Kimberley, John turned to the bark of the Mudjala mangrove tree seeking pain relief. He chewed on a strip of bark and applied it as a dressing to his wound.

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Science Daily: Pharmacology News

NOVEMBER 13, 2023

Humankind risks getting stuck in 14 evolutionary dead ends, ranging from global climate tipping points to misaligned artificial intelligence, chemical pollution, and accelerating infectious diseases, finds a new major assessment by scientists from multiple different disciplines. To break these trends, humans must become self-aware of our common futures.

Research 92

Research Disease 92

SCIENMAG: Medicine & Health

NOVEMBER 13, 2023

What is glare? Simply put, glare is visual discomfort often leading to annoyance, fatigue or even headaches. Perception of glare varies from person to person, and one set of lighting conditions may be comfortable for one person yet uncomfortable for another. But why?

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Science Daily: Pharmacology News

NOVEMBER 13, 2023

An international team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer's and Parkinson's Diseases. The biosensor can also transmit the results wirelessly to a laptop or smartphone. The team tested the device on in vitro samples from patients and showed that it is as accurate as the state of the art method.

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International Disease Research 92

Cytel

NOVEMBER 13, 2023

For nonclinical studies that precede Phase I, a drug formulation in high doses and concentrations is required. While entering Phase I, high flexibility is needed, often covering a wide dose range. In addition, the quality and stability of the drug formulation should be adequate for the purpose. Are there differences in what level of quality is expected for the active drug substance in each phase?

Drugs 64

Drugs Production Clinical Development 64

Science Daily: Pharmacology News

NOVEMBER 13, 2023

The second- and fourth-most distant galaxies ever observed have been discovered in a region of space known as Pandora's Cluster, or Abell 2744, using data from NASA's James Webb Space Telescope.

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New Drug Approvals

NOVEMBER 13, 2023

VODOBATINIB 1388803-90-4 Molecular Weight 453.92 Appearance Solid Formula C 27 H 20 ClN 3 O 2 SCO-088 K0706 K-0706 2-chloro-6-methyl- N ‘-[4-methyl-3-(2-quinolin-3-ylethynyl)benzoyl]benzohydrazide Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC 50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I.

Treatment 63

Treatment Disease Therapies Production 63

Science Daily: Pharmacology News

NOVEMBER 13, 2023

Researchers have shown that a previously demonstrated ability to turn on superconductivity with a laser beam can be integrated on a chip, opening up a route toward opto-electronic applications.

Research 86

Research 86

BioPharma Drive: Drug Pricing

NOVEMBER 13, 2023

With the deal, the Swiss pharma is exploring a tumor target, DLL3, that’s thwarted past drugmaker efforts to attack it.

Licensing 78

Licensing Licensing Therapies 78

Science Daily: Pharmacology News

NOVEMBER 13, 2023

A compound -- one of 27 million screened in a library of potential new drugs -- reversed four types of chronic pain in animal studies, according to new research. The small molecule, which binds to an inner region of a calcium channel to indirectly regulate it, outperformed gabapentin without troublesome side effects, providing a promising candidate for treating pain.

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Small Molecule Regulations Drugs Research 85

BioPharma Drive: Drug Pricing

NOVEMBER 13, 2023

Shares in several heart device makers, which have been battered over the perceived impact of obesity medicines, rose this week following AHA data on Novo’s therapy.

Therapies 62

Therapies 62