Fri.Dec 22, 2023

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Parthenolide as a therapeutic for disseminated canine neoplasms [Drug Discovery and Translational Medicine]

ASPET

This study provides a unique translational research opportunity to help both humans and dogs diagnosed with diseases that carry dismal prognoses in both species: histiocytic sarcoma (HS), hemangiosarcoma (HSA), and disseminated mastocytosis/mast cell tumor (MCT). While exceedingly rare in humans, these so called "orphan diseases" are relatively more common in dogs.

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FDA Warns of Counterfeit Ozempic

Drugs.com

FRIDAY, Dec. 22, 2023 -- The U.S. Food and Drug Administration has uncovered counterfeit Ozempic shots in the legitimate U.S. drug supply chain, and is warning patients to be on their guard. The FDA said Thursday that it has seized thousands of.

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Cognitive-enhancing effects of acetylcholine receptor agonists in group-housed cynomolgus monkeys who drink ethanol [Behavioral Pharmacology]

ASPET

The cognitive impairments that are often observed in patients with alcohol use disorder (AUD) partially contribute to the extremely low rates of treatment initiation and adherence. Brain acetylcholine receptors (AChR) mediate and modulate cognitive and reward-related behavior and their distribution can be altered by long-term heavy drinking. Therefore, AChRs are promising pharmacotherapeutic targets for treating the cognitive symptoms of AUD.

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Patient perspectives: From public relations executive to chronic pain patient

Antidote

Because Antidote’s key focus is connecting patients to clinical trials , hearing directly from individuals serves as a great reminder of why we do what we do. One patient we’ve had the pleasure of speaking with is Linda VandeVrede, a former high-tech PR executive who shared her story of chronic pain, clinical trials, and personal experience.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Investigating the mechanisms underlying U46619-induced contraction on porcine lower esophageal sphincter [Gastrointestinal, Hepatic, Pulmonary, and Renal]

ASPET

Gastroesophageal reflux disease (GERD) is associated with an incompetent lower esophageal sphincter (LES), resulting in the reflux of gastric contents into the esophagus. U46619, a thromboxane A2 (TXA2) receptor agonist, induces contractions in various smooth muscles. Therefore, this study aimed to investigate the effects and mechanisms of action of U46619 on the porcine LES.

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Scent of a Woman's Tears Could Lower Anger Levels in Men

Drugs.com

FRIDAY, Dec. 22, 2023 -- A man becoming incredibly uncomfortable when a woman starts crying – to the point he’ll do anything to make her stop – is a reliable old chestnut in TV and movies.But there appears to be a biochemical truth to that.

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Researchers study a million galaxies to find out how the universe began

Science Daily: Pharmacology News

Researchers have analyzed more than one million galaxies to explore primordial fluctuations that seeded the formation of the structure of the entire universe.

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A Vibrating Capsule You Swallow Might Keep Weight Gain at Bay

Drugs.com

FRIDAY, Dec. 22, 2023 -- Can’t afford Ozempic?You might soon have another weight-loss option, in the form of an ingestible vibrating capsule that tricks the body into thinking the stomach is full.Animals given the multivitamin-sized pill 20.

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How jellyfish regenerate functional tentacles in days

Science Daily: Pharmacology News

At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage.

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Record Number of Americans Choose Obamacare

Drugs.com

FRIDAY, Dec. 22, 2023 -- Over 15 million Americans have signed up for health insurance using the Affordable Care Act's federal marketplace, a 33% increase from the year before, preliminary government data shows.On Dec. 15, the deadline for coverage.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Target Review Proteomics eBook 2023

Drug Target Review

In this eBook, Drug Target Review breaks down the potential of stem cells for personalised regenerative medicine, offering practical insights into their role in healthcare. Simultaneously, Ellen Capon reveals new biomarkers for diabetic kidney disease, reshaping diagnostics and treatment approaches.

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Polymers that can kill bacteria

Science Daily: Pharmacology News

Scientists have created a new family of polymers capable of killing bacteria without inducing antibiotic resistance -- a major step in the fight against superbugs like E. coli and MRSA.

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Women in STEM with Dr Catherine Sheehan

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? My journey and interest in STEM began initially because of my secondary school Biology and Chemistry teachers. Both were woman teachers who were passionate about science and very good teachers to boot. I attended an all-girls secondary school in Ireland which strongly encouraged us to study STEM in both secondary and third-level education.

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Hazardous Exposures to Silica in Metal and Nonmetal Mining Indicate the Need for Better Prevention

NIOSH Science Blog: Drugs

Mined raw materials, or products produced from them, are essential for all industries. Mining will remain an essential industry even with the shift to sustainable energy as critical minerals that will support the needs for zero-emission vehicles, carbon-free energy, and production of energy resources and everyday products must be mined. Respirable crystalline silica (RCS) is one of the most prevalent and severe health hazards in mining – one that has been well-known since the Hawks Nest Tunnel D

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Unapproved 'Fat-Dissolving' Injections Are Leaving Patients Maimed, FDA Warns

Drugs.com

FRIDAY, Dec. 22, 2023 -- People are being maimed by unauthorized fat-dissolving injections meant to tighten up double chins and dissipate flab along the arms, thighs and stomach, the U.S. Food and Drug Administration warns.The shots are supposed to.

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Reindeer sleep while chewing their cud

Science Daily: Pharmacology News

Researchers report that the more time reindeer spend ruminating, the less time they spend in non-rapid eye movement (non-REM) sleep. EEG recordings revealed that reindeer's brainwaves during rumination resemble the brain waves present during non-REM sleep, and these brainwave patterns suggest that the reindeer are more 'rested' after ruminating. The researchers speculate that this multitasking might help reindeer get enough sleep during the summer months, when food is abundant and reindeer feed

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Spinal Cord Injury Triggers Muscle Wasting, Study Finds

Drugs.com

FRIDAY, Dec. 22, 2023 -- A spinal cord injury can trigger muscle wasting in patients, causing them to drop more weight and muscle mass than can be explained solely by their paralysis, a new study in mice warns.This muscle wasting is rapid and.

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Light color is less important for the internal clock than originally thought

Science Daily: Pharmacology News

Light in the evening is thought to be bad for sleep. However, does the color of the light play a role? Researchers compared the influence of different light colors on the human body. The researchers' findings contradict the results of a previous study in mice.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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America's School Counselors Say Vaping, Gaming Are Tough Issues for Kids

Drugs.com

FRIDAY, Dec. 22, 2023 -- Online gaming and vaping to the point of addiction have become widespread enough that most high school counselors regularly confront these behaviors in today’s teens, a new survey shows.Four out of five counselors.

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Like kids in a candy store 

SCIENMAG: Medicine & Health

Kyoto, Japan – A non-prescription drug abuse crisis in Japan seems only one overdose away. The demand for a particular anti-cough drug has been rising, along with the social impact of its abuse due to its psychosomatic effects.

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Losing Sleep Makes for Unhappy, Anxious Days

Drugs.com

FRIDAY, Dec. 22, 2023 — An exhaustive review of sleep research spanning five decades underscores the importance of getting your Zzzzzs.Sleep loss undermines emotional functioning and increases a person's risk for anxiety and depression, the study.

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Malta Targeting Phage Therapy 2024: The next clinical revolution

SCIENMAG: Medicine & Health

Building on the momentum of the 6th World Congress on Targeting Phage Therapy, that gathered more than 150 attendees from over 30 countries and featured over 71 presentations, the highly anticipated Targeting Phage Therapy 2024 is set to unfold.

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Bristol Myers to acquire brain drug developer Karuna for $14B

BioPharma Drive: Drug Pricing

The deal would hand Bristol Myers, which has newly made neuroscience a therapeutic focus, an experimental treatment for schizophrenia.

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Predicting Alzheimer’s dementia in oldest of the old

SCIENMAG: Medicine & Health

PITTSBURGH, Dec. 22, 2023 – A new study indicates that severity of amyloid deposition in the brain — not just age — may be key to determining who will benefit from new anti-amyloid therapies to delay the progression of Alzheimer’s disease. Credit: UPMC PITTSBURGH, Dec.

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Sarepta tests FDA flexibility with bid to expand Duchenne gene therapy’s approval

BioPharma Drive: Drug Pricing

The biotech is asking the agency to clear its treatment Elevidys in more patients with the disease, despite a confirmatory trial that missed its main goal.

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Fewer hospital admissions when people are fitter

SCIENMAG: Medicine & Health

People who maintain or increase their aerobic fitness are at less risk of being hospitalized in future, particularly if they were hospitalized previously. These are the findings of a study conducted at the University of Gothenburg. Credit: Photo by Johan Wingborg.

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Justin Racine Named A 2023 CMSWire Contributor of the Year

Perficient: Drug Development

Perficient’s Principal of Unified Commerce Justin Racine was recently named one of CMSWire’s Contributors of the Year. CMSWire is a leading community of CX professionals, whose goal is to advance its members via high-impact knowledge and quality content. The Contributor of the Year recognition is awarded to authors whose articles greatly resonated with the CMSWire community this year.

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Screens Are Everywhere: Resolve to Protect Your Vision

Drugs.com

FRIDAY, Dec. 22, 2023 -- Screens are everywhere -- on desks, in laps, on the wall -- and eye strain is a temporary but uncomfortable condition that comes with overuse.

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Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells

Covalent Modifiers

Sobinoff, Alexander P.; Di Maro, Salvatore; Low, Ronnie R.J.; Benedetti, Rosaria; Tomassi, Stefano; D'Aniello, Antonia; Russo, Rosita; Baglivo, Ilaria; Chianese, Ugo; Pedone, Paolo V.; Chambery, Angela; Cesare, Anthony J.; Altucci, Lucia; Pickett, Hilda A.,; Cosconati, Sandro Cell Chemical Biology , 2023 doi: 10.1016/j.chembiol.2023.11.008 The TRF2 shelterin component is an essential regulator of telomere homeostasis and genomic stability.

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Ionis, Astrazeneca win FDA approval of competitor to Alnylam drug

BioPharma Drive: Drug Pricing

The clearance of Wainua for transthyretin amyloidosis opens up a new front in a long-running commercial battle between Ionis and Alnylam.

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Ease Up on Drinking to Cut Your Risk for 'Holiday Heart'

Drugs.com

FRIDAY, Dec. 22, 2023 -- Rum-laced eggnog, mulled wine, or a hot toddy all sound good around the holidays, but too much imbibing can increase your risk of “holiday heart syndrome,” doctors warn.Holiday heart syndrome is the unofficial name for.

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Which pharmaceutical drugs have the most drug patents in Cyprus?

Drug Patent Watch

This chart shows the drugs with the most patents in Cyprus. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.… The post Which pharmaceutical drugs have the most drug patents in Cyprus? appeared first on DrugPatentWatch - Make Better Decisions.

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Top Therapeutics Development Topics of 2023

Cytel

Perspectives covers a wide range of topics within therapeutics development from advice on regulatory submission to adaptive clinical trial design to aligning your trial with investment priorities, and much more.