Mon.Dec 30, 2024

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Norovirus Cases Are Up in Pockets of the U.S.

Drugs.com

MONDAY, Dec. 30, 2024 -- Norovirus, a highly contagious stomach bug, is surging across the United States this winter, according to the latest data from the U.S. Centers for Disease Control and Prevention (CDC).The data shows 91 outbreaks of.

Disease 116
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Structure‐Based Design of 2‐Aminopyrazolpyrimidopyridone Derivatives as New Rearranged During Transfection (RET) Kinase Inhibitors

Chemical Biology and Drug Design

Compound 8w suppressed BaF3 cells harboring CCDC6-RET V804M mutations with IC 50 values of 0.715M and dose-dependently suppressed the activation of RET and downstream signals. Another compound 8s suppressed BaF3 cells harboring CCDC6-RET G810C mutation with an IC 50 value of 2.91M. Therefore, 8w and 8s might be promising lead compounds. ABSTRACT RET (Rearranged during transfection) kinase is a validated target for non-small cell lung cancer (NSCLC).

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Singapore Is Ready for a Rapidly Aging Society, Study Says. What About the U.S.?

Drugs.com

MONDAY, Dec. 30, 2024 -- The United States is lagging behind dozens of nations in its preparation for dealing with its aging population.The U.S. ranks 24 among 143 countries when it comes to ensuring seniors well-being, productivity and security, a.

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Understanding the Regulatory Environment in Japan for Generic Drug Development

Drug Patent Watch

The regulatory environment in Japan for generic drug development is complex and has undergone significant changes in recent years. This article aims to provide a comprehensive overview of the key aspects of the regulatory framework, highlighting the requirements and challenges faced by pharmaceutical companies seeking to introduce generic drugs into the Japanese market.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Heat Waves Threaten Brain Health, Study Suggests

Drugs.com

MONDAY, Dec. 30, 2024 -- Global warming will increasingly have dire consequences for people with degenerative brain disorders like dementia, Alzheimer’s disease and Parkinson’s disease. Heat waves caused by climate change will.

Disease 94
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CDD Vault 2024 in Review: Celebrating 20 Years of Innovation

Collaborative Drug

2024 was a special year as we celebrated two decades of CDD Vault.

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Building Azure DevOps CD Processes for SPFx

Perficient: Drug Development

This blog provides a detailed explanation of the technical approach for implementing Continuous Deployment (CD) processes within Azure DevOps. It focuses on automating the deployment of solutions to SharePoint environments. This approach not only speeds up the release cycle but also enhances reliability, minimizes errors, and ensures that updates are deployed quickly and effectively.

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Single Peoples' Personalities Differ from Partnered Peoples'

Drugs.com

MONDAY, Dec. 30, 2024 -- Single folks might seem like theyre free to have more fun, but a new study says they may pay the piper in their later years.Lifelong single folks have lower scores on life satisfaction measures than those in long-term r.

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A Beginner’s Perspective on Generative AI

Perficient: Drug Development

Generative AI is rapidly transforming the world around us. From creating stunning artwork to composing music and even writing code, its capabilities are vast and expanding at an unprecedented rate. This blog post will serve as a comprehensive introduction to Generative AI, guiding you through its foundational concepts and exploring the groundbreaking features of ChatGPT.

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The Number of Homeless People in the U.S. Has Increased

Drugs.com

MONDAY Dec. 30, 2024 -- The number of homeless individuals in the U.S. increased by 18% between January 2023 and January 2024, according to the U.S. Department of Housing and Urban Development (HUD).The HUD's 2024 Annual Homelessness Assessment.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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A Beginner’s Guide to Running Selenium Tests on BrowserStack using Pytest

Perficient: Drug Development

In todays world, testing web applications across multiple browsers and devices is essential. One of the best tools for this is BrowserStack , a cloud-based platform that allows you to run Selenium tests on various real browsers and devices. In this blog, we will walk you through the process of integrating BrowserStack with Python Selenium and running tests using Pytest.

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Use Your Freezer to Fight Food Waste, Protect the Planet

Drugs.com

MONDAY, Dec. 30, 2024 -- The bounty of the holidays often leads to loads of leftovers landing in the garbage after they go bad.A freezer can prevent such food waste by preserving edible food for later meals, a new study suggests.Discarded frozen.

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From Code to Cloud: AWS Lambda CI/CD with GitHub Actions

Perficient: Drug Development

Introduction: Integrating GitHub Actions for Continuous Integration and Continuous Deployment (CI/CD) in AWS Lambda deployments is a modern approach to automating the software development lifecycle. GitHub Actions provides a platform for automating workflows directly from your GitHub repository, making it a powerful tool for managing AWS Lambda functions.

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Moms Take on 70% of 'Mental Load' for Household Tasks: Study

Drugs.com

MONDAY, Dec. 30, 2024 -- If you're a mom right now, you are likely tearing your hair out as you juggle the sizable scheduling demands of the holiday season. Maybe you feel like you are carrying the load alone.New research suggests you are not.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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How to Build a Component Library in next with Storybook

Perficient: Drug Development

Building a component library in Next.js with Storybook involves creating reusable UI components in Next.js and using Storybook to visualize and document them. Here’s a step-by-step guide on how to set up a component library in Next.js and integrate it with Storybook: 1) Set Up a Next.js Project If you dont have a Next.js project yet, you can create one: npx create-next-app@latest my-component-library cd my-component-library This will create a basic Next.js project with the default settings

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Weight-Loss Drugs, Wily Viruses, Abortion Pill Under Attack: The Top Health Stories of 2024

Drugs.com

MONDAY, Dec. 30, 2024 -- It was a year in health news that will be hard to forget.As blockbuster weight-loss drugs known as GLP-1s made a sizable dent in the obesity epidemic, study after study revealed other ways in which these powerful.

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Acquia Cloud Site Review – A Crucial Step for Success

Perficient: Drug Development

In the dynamic world of digital experiences, maintaining a high-performing and secure website is paramount. For organizations leveraging the power of Acquia Cloud, proactive site reviews are essential for optimizing performance, identifying potential risks, and ensuring a smooth and successful digital journey. This blog post will delve into the significance of Acquia Cloud Site Reviews, outlining their purpose, key components, and the invaluable insights they provide.

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Engineering researchers develop deep-UV microLED display chips for maskless photolithography

Science Daily: Pharmacology News

In a breakthrough set to revolutionize the semiconductor industry, engineers have developed the world's first-of-its-kind deep-ultraviolet (UVC) microLED display array for lithography machines. This enhanced efficiency UVC microLED has showcased the viability of a lowered cost maskless photolithography through the provision of adequate light output power density, enabling exposure of photoresist films in a shorter time.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Building Azure DevOps CI Pipelines for SPFx

Perficient: Drug Development

This blog offers a comprehensive guide to setting up Continuous Integration (CI) in Azure DevOps to automate the integration of SharePoint Framework (SPFx) code by leveraging Azure DevOps pipelines. This process aims to streamline development workflows, improve code quality, and ensure quicker code validation before deployment without any manual processing.

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Brain structure differences are associated with early use of substances among adolescents

Science Daily: Pharmacology News

A study of nearly 10,000 adolescents has identified distinct differences in the brain structures of those who used substances before age 15 compared to those who did not. Many of these structural brain differences appeared to exist in childhood before any substance use, suggesting they may play a role in the risk of substance use initiation later in life, in tandem with genetic, environmental, and other neurological factors.

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Malvika Malviya’s Experience With Perficient’s People-First Culture

Perficient: Drug Development

Perficient takes pride in its people and believes each colleague makes a difference in shaping our success. Every colleague brings a unique perspective to our organization, which is why Perficient promises to challenge, champion, and celebrate every colleague. Malvika Malviya is a lead technical consultant based in Nagpur, India, and she has experienced first-hand how Perficient prioritizes colleagues and fosters a collaborative work environment.

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Preclinical study finds surges in estrogen promote binge drinking in females

Science Daily: Pharmacology News

The hormone estrogen regulates binge drinking in females, causing them to 'pregame' -- consume large quantities of alcohol in the first 30 minutes after it's offered, according to a preclinical study. The study establishes -- for what is thought to be the first time -- that circulating estrogen increases binge alcohol consumption in females and contributes to known sex differences in this behavior.

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Leadership Summit: A Day of Vision & Growth

Perficient: Drug Development

On a memorable day, the Hyderabad team had the privilege of hosting our esteemed leadership: Tom Hogan (President and CEO -), Kevin Sheen (Senior Vice President), Prakash Chembai (Vice President India), and other influential Directors and Managing Directors. It was a remarkable and enriching experience, filled with interactions, learning, and camaraderie.