Wed.Feb 28, 2024

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Optimizing OpenFold Training for Drug Discovery

Nvidia Developer: Drug Discovery

Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep. Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep learning–based computational methods have been emerging and have shown promising results.

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Say Goodbye to PFAS Chemicals in Food Packaging: FDA

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- PFAS "forever" chemicals, increasingly linked to health risks, will no longer be added to food packaging handled by American consumers, the U.S. Food and Drug Administration announced Wednesday."Grease-proofing materials.

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A smartphone app for the self-management of Perthes’ Disease – a blog for Rare Disease Day 2024

On Medicine

What is Perthes’ disease? Perthes’ Disease is a rare condition that affects the developing femoral head (the “ball” of the “ball and socket” hip joint) of a child due to poor blood supply. In this condition, the blood supply to the femoral head is disrupted and this leads to joint deformity. The destruction typically causes the femoral head to flatten and not fit well in the acetabulum (the “socket” of the hip joint).

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What Is Measles, and How Can I Shield Myself & My Family?

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Once thought to be a bygone disease, measles is making a comeback in the United States and globally as folks shun a safe, surefire way to prevent it: The measles vaccine. But what is measles, and how easily does it.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Morgan Stanley Supercharged Its Customer Journey. Learn How at Adobe Summit 2024!

Perficient: Drug Development

Adobe Summit 2024 is right around the corner, and we’re excited to sit down with the executive director of marketing applications at Morgan Stanley Dorothy Joseph on March 27 at 11:30 A.M PST at The Grand Lux Café in The Palazzo. Perficient’s Jay Jackson, director of Adobe Digital Marketing and CDP, will host a fireside chat with Joseph about the global financial services leader’s successful journey to consolidate and optimize the Adobe Experience Platform.

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Is It Allergies or Sinusitis? Many Folks Are Misdiagnosed

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- What if you'd been treated for years for a condition, only to find out that you'd long ago been misdiagnosed?That's what's happening to a sizable number of Americans who are taking allergy meds (to little effect) when in.

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Your Brain Feels Better When Music Is Live, Not Recorded: Study

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Live musical performances speak to the soul, stimulating the brain in ways more powerful than listening to a recorded tune does, new research finds.“Our study showed that pleasant and unpleasant emotions performed as.

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How CDMO Wacker Biotech is inspiring innovation in mRNA therapeutics

Fierce BioTech

mRNA innovation is one of the most exciting and impactful areas of healthcare globally today. | Sitting down with Guido Seidel, Managing Director of Wacker Biotech, we explore some of the key challenges, opportunities and innovations for pharmaceutical companies to consider in mRNA manufacturing.

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Pesticides Linked to Parkinson's Cases in Midwest, Western U.S.

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Pesticides and herbicides used in farming appear to increase people’s risk of Parkinson’s disease, a new, preliminary study finds.People exposed to pesticides and herbicides are 25% to 36% more likely to develop.

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How 40Hz sensory gamma rhythm stimulation clears amyloid in Alzheimer's mice

Science Daily: Pharmacology News

Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer's protein via the brain's glymphatic system, new study suggests.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Daily Marijuana Use Greatly Raises Odds for Heart Attack, Stroke

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Folks who use marijuana have a greater risk of heart attack and stroke, with the odds rising even higher when they partake every day, a new study finds.Both daily and non-daily marijuana users had an increased risk of.

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BRCA1 and BRCA2 in a cohort of ovarian cancer patients from the Salento peninsula

SCIENMAG: Medicine & Health

“Ovarian cancer (OC) is the third most prevalent type of gynecologic cancer affecting women after cervical and uterine cancer [1]. It is also considered the most fatal of all gynecological cancers […]” Credit: 2024 De Matteis et al.

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Radon a Bigger Threat to Rural Homes

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Rural homeowners face a greater threat from odorless, radioactive radon gas than people living in urban areas, and it's likely due to the wells they rely on for their water supply, a new study shows.On average, people.

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Cannabis use linked to increase in heart attack and stroke risk

Science Daily: Pharmacology News

More frequent use of cannabis was associated with higher odds of adverse cardiovascular outcomes, finds new study.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Mom's Grief During Pregnancy Could Pass Heart Trouble to Her Child

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Babies born to mothers who experience profound grief during pregnancy may be vulnerable to heart failure much later in life, new research suggests."If future studies support our findings, the implementation of early.

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'Cosmic lighthouses' that cleared primordial fog identified with JWST

Science Daily: Pharmacology News

Scientists working with data from NASA's James Webb Space Telescope (JWST) have obtained the first full spectra of some of the earliest starlight in the universe. The images provide the clearest picture yet of very low-mass, newborn galaxies, created less than a billion years after the Big Bang, and suggest the tiny galaxies are central to the cosmic origin story.

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Aorta recognised as an independent organ for the first time

SCIENMAG: Medicine & Health

Heart, lungs, brain, aorta: elevated to the highest league as an organ Credit: Medical Center – University of Freiburg / Britt Schilling Heart, lungs, brain, aorta: elevated to the highest league as an organ “Recognising the aorta as an organ puts it on a par with the heart, lungs or brain.

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Change in gene code may explain how human ancestors lost tails

Science Daily: Pharmacology News

A genetic change in our ancient ancestors may partly explain why humans don't have tails like monkeys.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Sedentary behavior increases mortality risk

SCIENMAG: Medicine & Health

Based on decades-long observations of centenarians, author Dan Buettner (Blue Zones) conjectures that people live longer when they get up and move around after sitting for twenty minutes. Now, a rigorous new study published in the Journal of the American Heart Association (JAHA) has data showing that older women who sat for 11.

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Feature Engineering with Databricks and Unity Catalog

Perficient: Drug Development

Feature Engineering is the preprocessing step used to make raw data usable as input to an ML model through transformation, aggregation, enrichment, joining, normalization and other processes. Sometimes feature engineering is used against the output of another model rather than the raw data (transfer learning). At a high level, feature engineering has a lot in common with data engineering; we use these same steps going from the Bronze to Silver to Gold layers in a Databricks medallion architectur

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Medical University of South Carolina neuroscientist honored for trailblazing pain management research

SCIENMAG: Medicine & Health

Medical University of South Carolina neuroscientist Bashar Badran, Ph.D., was one of only 10 investigators nationwide recognized for their research at the fifth annual scientific meeting of the National Institutes of Health – Helping to End Addiction Long-Term (NIH HEAL) Initiative in Bethesda, Maryland. Badran received an honorable mention for the NIH HEAL Initiative Trailblazer Award.

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How Is Autism Diagnosed?

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- According to the advocacy group Autism Speaks, one in every 36 U.S. children has an autism spectrum disorder (ASD). Early diagnosis is crucial to helping to treat the condition, but how is a diagnosis done? The U.S.

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Ai finds key signs that predict patient survival across dementia types

SCIENMAG: Medicine & Health

New York, NY [February 28, 2024]—Researchers at the Icahn School of Medicine at Mount Sinai and others have harnessed the power of machine learning to identify key predictors of mortality in dementia patients. Credit: Zhang & Song et al.

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Ginkgo adds gene editing tools in buyout of Feng Zhang-founded startup

BioPharma Drive: Drug Pricing

The acquisition of Proof Diagnostics, which was formed to develop a COVID-19 test, gives Ginkgo a library of novel enzymes that can be used to make genetic medicines.

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How 40Hz sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice

SCIENMAG: Medicine & Health

Studies at MIT and elsewhere are producing mounting evidence that light flickering and sound clicking at the gamma brain rhythm frequency of 40 Hz can reduce Alzheimer’s disease (AD) progression and treat symptoms in human volunteers as well as lab mice.

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Incannex says psilocybin therapy lowered anxiety in small study

BioPharma Drive: Drug Pricing

Shares of the Australian biotech rocketed up about 55% after the company announced results from a mid-stage study in generalized anxiety disorder.

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Research shows continued cocaine use disrupts communication between major brain networks

SCIENMAG: Medicine & Health

A collaborative research endeavor by scientists in the Departments of Radiology, Neurology, and Psychology and Neuroscience at the UNC School of Medicine have demonstrated the deleterious effects of chronic cocaine use on the functional networks in the brain.

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Most drug patent challenges last year

Drug Patent Watch

This chart shows the generic firms that had the most successful drug patent challenges last year. Companies that successfully challenge patents on branded drugs are granted six months of generic… The post Most drug patent challenges last year appeared first on DrugPatentWatch - Make Better Decisions.

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FDA Flexes its New FDORA Muscles in Withdrawing an Accelerated Approval

FDA Law Blog: Drug Discovery

By Mark A. Tobolowsky & Michelle L. Butler — On Friday, February 23, 2024, FDA announced its final decision to withdraw the approval of Pepaxto (melphalan flufenamide), which was approved in February 2021 in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior lines of therapy and whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and one CD38-dir

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New patent expiration for Mylan Speciality drug DYMISTA

Drug Patent Watch

Annual Drug Patent Expirations for DYMISTA Dymista is a drug marketed by Mylan Speciality Lp and is included in one NDA. It is available from two suppliers. There are four… The post New patent expiration for Mylan Speciality drug DYMISTA appeared first on DrugPatentWatch - Make Better Decisions.

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Perficient Interviewed for Forrester: The Future Of Insurance

Perficient: Drug Development

With new risks, shifting market dynamics, and the unstoppable march of technology, the insurance industry finds itself at a crossroads. The imperative for transformation has never been clearer, and this is highlighted in Forrester’s report, The Future Of Insurance. Embracing Change The report states, “The business of insurance is in a heightened state of transformation…,” and insurance leaders must proactively “…change their business models, products, and processes over the com

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New patent for Pfizer drug VELSIPITY

Drug Patent Watch

Annual Drug Patent Expirations for VELSIPITY Velsipity is a drug marketed by Pfizer and is included in one NDA. It is available from two suppliers. There are six patents protecting… The post New patent for Pfizer drug VELSIPITY appeared first on DrugPatentWatch - Make Better Decisions.

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How molecular 'handedness' emerged in early biology

Science Daily: Pharmacology News

Chemists fill a major gap in origin-of-life theories.

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