Drug Discovery World

SEPTEMBER 13, 2023

A Translational Psychiatry publication indicates that SARS-CoV-2 infection, even when unnoticed or asymptomatic, can have an influence on the activation of the Human Endogenous Retrovirus W (W-ENV) protein in psychotic patients, in a context of innate immune inflammation. GeNeuro, a biopharmaceutical company developing treatments for neurodegenerative and autoimmune diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and the severe neuro-cognitive consequences of Cov

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Protein Expression Clinical Trials Hospitals Trials 130

Drug Discovery Today

SEPTEMBER 13, 2023

Taipei, Taiwan, 13th September 2023 / Sciad Newswire / BRIM Biotechnology, Inc. ("BRIM," TPEx 6885), a clinical-stage biotechnology company focusing on developing regenerative peptides for ophthalmology and degenerative joint diseases, announced today that 22,500 shares have been issued at a premium of NT$65 (~US$2.03), raising a total of NT$1.4625 billion (~US$45.8 million).

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Disease 113

Drug Discovery World

SEPTEMBER 13, 2023

Revvity has launched an imaging portfolio designed to drive innovation across diverse applications in preclinical research with the launch of three imaging systems. These systems include the next-generation IVIS Spectrum 2 and the IVIS SpectrumCT 2 imaging systems, as well as the QuantumTM GX3 microCT. Globally, the Vega ultrasound system has been launched, having originally been launched in North America in 2022.

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Chemical Biology and Drug Design

SEPTEMBER 13, 2023

Site specific and targeted delivery leads to reduced toxicity and consequently lower the risk of side effects. This review aims to provide information on cutting-edge Nano particulate-based technologies and Nano therapies for colorectal cancer. Abstract The advancement of colorectal cancer (CRC) prevention, detection, and treatment is essential to ensure that survivors live longer and higher-quality lives.

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Drugs Therapies Science Pharmaceuticals 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- Using both tobacco and marijuana is tied to significantly higher odds for depression and anxiety, a new study suggests. Among nearly 54,000 U.S. adults, those who used both substances experienced anxiety or depression.

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Chemical Biology and Drug Design

SEPTEMBER 13, 2023

Ursolic acid (UA) is a pentacyclic triterpenoid with diverse biological activities, especially in the fields of cardiovascular and diabetes treatment. However, its application is hindered by low bioavailability and poor solubility in water. Consequently, reseacher have focused on designing UA derivatives to address these issues. This paper provides an overview of the development of UA derivatives and their recent advancements as regents for combating cardiovascular diseases and diabetes.

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Chemical Biology and Drug Design

SEPTEMBER 13, 2023

Imiquimod-induced psoriasis-like skin inflammation in BALB/C mice, nutracetical combinations (krill oil, myo-inositol, and canabidiol) significantly ameliorated IMQ-induced psoriasis. Abstract Psoriasis is a chronic inflammatory skin disease that affects both localized and systemic regions of the body. This condition is characterized by the hyperproliferation of keratinocytes, resulting in skin thickening, scaling, and erythema.

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Treatment Therapies Research Production 100

Crown Bioscience

SEPTEMBER 13, 2023

The incidence of pancreatic cancer has been rising by about 1% per year over the past few decades, and it now accounts for ~3% of all cancers and 7% of cancer mortality in the U.S. Pancreatic cancer is now the third leading cause of cancer-related death, and it is exceptionally lethal in part because it is challenging to detect at an early stage. By the time signs and symptoms appear, the disease has often already reached an advanced stage and metastasized.

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Disease 111

Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- A healthy lifestyle -- especially getting enough sleep -- may offer substantial protection against depression, new research suggests. The study, of more than 287,000 British adults, found that several lifestyle factors.

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Research 111

BioPharma Drive: Drug Pricing

SEPTEMBER 13, 2023

The biotech is telling investors it expects to launch as many as 15 new products in five years, a bold goal that will require a lot to go right to pull off.

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Drug Development Production Drugs 116

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- California is on track to become the first state to ban four food additives that some experts have linked to health issues ranging from behavioral problems in children to reproductive issues to cancer in lab animals. On.

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Perficient: Drug Development

SEPTEMBER 13, 2023

Introduction The Content Recommendations add-on for Optimizely CMS dynamically recommends content from your site tailored to the interests of each user. Installing the NuGet Package will give you access to Optimizely’s Content Recommendations Block which uses Mustache Templating to render the data from the Content Recommendations API on a page. Although Mustache Templates provide a great way of inserting recommendation data into a webpage, content authors who don’t have prior experience wi

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Packaging 105

Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- When some U.S. states made abortion illegal after the Supreme Court overturned the longstanding Roe v Wade in June 2022, women in those areas increased their searches for self-managed abortions. To come to that.

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Antidote

SEPTEMBER 13, 2023

Globally, there are thousands of research studies and clinical trials conducted each year, all with the shared goal of bringing new treatment options and medical devices to the market. However, approximately 80% of clinical trials are delayed or closed because of problems with recruitment.

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Clinical Trials Trials Treatment Marketing 98

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Channels

SEPTEMBER 13, 2023

Time for our annual update on the channels for provider-administered drugs. For 2023, specialty pharmacies—via white, brown, and clear bagging—retained a meaningful share of the distribution channels for provider-administered oncology drugs. Despite the concerted efforts of insurers such as UnitedHealthcare and Elevance Health, however, buy-and-bill remains the most common channel for these products.

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Science Daily: Pharmacology News

SEPTEMBER 13, 2023

A new study updates the planetary boundary framework and shows human activities are increasingly impacting the planet and, thereby, increasing the risk of triggering dramatic changes in overall Earth conditions.

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BioPharma Drive: Drug Pricing

SEPTEMBER 13, 2023

“There is a light wind for benefit, and no wind for risk,” said one adviser who voted with eight others to recommend the biotech’s drug Onpattro for cardiomyopathy of ATTR amyloidosis.

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FDA Drugs 76

Science Daily: Pharmacology News

SEPTEMBER 13, 2023

Researchers have developed an artificial intelligence (AI) system that has the potential to not only identify sight-threatening eye diseases but also predict general health, including heart attacks, stroke, and Parkinson's disease.

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Disease Research 99

Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- Air pollution has long been known to harm the heart and lungs, but new research suggests it might also raise the risk of breast cancer. Researchers at the U.S. National Institute of Environmental Health Sciences (NIEHS).

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Science Daily: Pharmacology News

SEPTEMBER 13, 2023

Researchers have developed small robotic devices that can change how they move through the air by 'snapping' into a folded position during their descent. Each device has an onboard battery-free actuator, a solar power-harvesting circuit and controller to trigger these shape changes in mid-air.

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Research 94

Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- It's now been possible to buy a hearing aid over-the-counter for nearly a year, but few Americans are doing so. More education is needed about just who these over-the-counter (OTC) hearing aids can help, according to the.

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Science Daily: Pharmacology News

SEPTEMBER 13, 2023

One of the most interesting and important questions in cosmology is, 'How much matter exists in the universe?' An international team has now succeeded in measuring the total amount of matter for the second time. The team determined that matter makes up 31% of the total amount of matter and energy in the universe, with the remainder consisting of dark energy.

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International 88

Covalent Modifiers

SEPTEMBER 13, 2023

Leonard Barasa, Sauradip Chaudhuri, Jeffrey Y. Zhou, Zhaozhao Jiang, Shruti Choudhary, Robert Madison Green, Elenore Wiggin, Michael Cameron, Fiachra Humphries, Katherine A. Fitzgerald, and Paul R. Thompson Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.3c03637 The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust inflammatory response.

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Disease 68

Science Daily: Pharmacology News

SEPTEMBER 13, 2023

Maritime archaeologists have studied what might be Europe's oldest shipboard cannon. The cannon was found in the sea off Marstrand on the Swedish west coast and dates back to the 14th century. The findings from the interdisciplinary study contribute new knowledge about the early development of artillery on land and at sea, but also bears witness to a troubled period for seafarers as well as coastal populations.

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Cytel

SEPTEMBER 13, 2023

Independent data monitoring committees (IDMCs) review ongoing clinical trial data to make recommendations regarding trial conduct based on risk-benefit. Formal interim analyses (IAs) include pre-specified statistical boundaries for demonstrating efficacy and/or futility. These boundaries often do not consider other scenarios that may be present such as apparent futility in the absence of a formal boundary, discrepant trends in endpoints, limited other endpoint data, and external factors impactin

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Clinical Trials Trials Clinical Development 59

Science Daily: Pharmacology News

SEPTEMBER 13, 2023

Most coastal communities will encounter '100-year floods' annually by the end of the century, even under a moderate scenario where carbon dioxide emissions peak by 2040, according to a new study. And as early as 2050, regions worldwide could experience 100-year floods every nine to fifteen years on average.

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SCIENMAG: Medicine & Health

SEPTEMBER 13, 2023

New research published in the scientific journal Addiction has found that the proportion of US overdose deaths involving both fentanyl and stimulants has increased more than 50-fold since 2010, from 0.6% (235 deaths) in 2010 to 32.3% (34,429 deaths) in 2021.

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Research Drugs 52

Science Daily: Pharmacology News

SEPTEMBER 13, 2023

A research team has achieved a groundbreaking advancement in nanomaterials by successfully developing a highly efficient electrocatalyst which can enhance the generation of hydrogen significantly through electrochemical water splitting. This major breakthrough has great application potential for the clean energy industry.

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Research 80

SCIENMAG: Medicine & Health

SEPTEMBER 13, 2023

New UCLA-led research has found that the proportion of US overdose deaths involving both fentanyl and stimulants has increased more than 50-fold since 2010, from 0.6% (235 deaths) in 2010 to 32.3% (34,429 deaths) in 2021. Credit: Friedman and Shover, 2023, doi: 10.1111/add.

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Research 52

Science Daily: Pharmacology News

SEPTEMBER 13, 2023

Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.

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Research 74

SCIENMAG: Medicine & Health

SEPTEMBER 13, 2023

In a study involving several wolves and dogs, both animals performed better at finding hidden food if they had observed the food being hidden by a person—suggesting that they remembered where the food was, and did not rely solely on scent to find it.

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Broad Institute

SEPTEMBER 13, 2023

Developing diagnostics and treatments By Rose Circeo September 13, 2023 Breadcrumb Home Developing diagnostics and treatments At the Broad Institute, researchers are revealing deep biological insights about the causes of disease, which are leading to new ways to monitor, diagnose, and treat patients with greater precision. These include new tools that help predict diseases well before symptoms appear, and more effective therapeutics that reduce the chance of relapse or drug resistance.

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SCIENMAG: Medicine & Health

SEPTEMBER 13, 2023

The brain is perhaps the most sensitive organ with respect to changes in blood flow and oxygen supply. Even brief interruptions in capillary flow (or “stalling”) can indicate acute neurological issues; evidence suggests that chronic conditions like Alzheimer’s and Parkinson’s diseases are closely related to stalling events.

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Disease 52

Alta Sciences

SEPTEMBER 13, 2023

Four Pain Models Altasciences Uses to Assess Treatments During Clinical Trials pmjackson Wed, 09/13/2023 - 17:01 September is pain awareness month, and the importance of pain management and continued research into effective analgesics is integral to helping patients suffering from various pain conditions. At Altasciences, we are driven to help sponsors improve and develop safe treatments for acute and chronic pain, as summarized by Beatrice Setnik, Chief Scientific Officer of Altasciences, and e

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