Drug Discovery World

FEBRUARY 12, 2024

DDW’s Megan Thomas spoke to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. This is part of a series of predictions based on different themes. Here, experts weigh in on the impact of artificial intelligence (AI), machine learning (ML) and automation in the sector. Updesh Dosanjh, Practice Leader for Pharmacovigilance Technology Solutions, IQVIA “In 2024, the traditional pain points of the pharmacovigilance (PV) space will not disappear.

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Small Molecule Regulations Clinical Trials Therapies 349

Chemical Biology and Drug Design

FEBRUARY 12, 2024

Schematic diagram of the mechanism of sophoridine-induced apoptosis and cycle arrest in BLCA. Abstract Bladder cancer (BLCA), a common primary malignancy, exhibits resistance to conventional chemotherapeutic agents. Sophoridine (SR) is a quinoline alkaloid derived from the traditional Chinese herb Sophora alopecuroides L., which belongs to the legume family Sophoraceae.

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Research 100

Drug Discovery World

FEBRUARY 12, 2024

A team from Aston University and the University of Warwick has secured a £1.8 ($2.2) million grant to engineer microbial cell factories to produce membrane proteins which will support future drug screening and sustainable chemical production. The Engineering Biology Mission Award was given by UK Research and Innovation (UKRI). Membrane proteins are crucial molecules on the surface of cells with numerous biological functions, such as sensing hormones or cell communication.

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Research Engineering Molecular Biology Protein Production 264

Science Daily: Pharmacology News

FEBRUARY 12, 2024

You can mend a broken heart this valentine s day now that researchers invented a new hydrogel that can be used to heal damaged heart tissue and improve cancer treatments.

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Treatment Research 120

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 12, 2024

Dr Pandora Pound , Fellow Oxford Centre for Animal Ethics explores the hinderances of animal testing in pharma and why new technologies such AI, genomics and synthetic biology c an further drug development. There was great fanfare recently for a new Alzheimer’s drug, lecanemab (brand name Leqembi), which was shown in a trial to reduce the rate of cognitive decline in people with mild impairment.

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Animal Testing Disease Trials Research 148

Science Daily: Pharmacology News

FEBRUARY 12, 2024

Growing cartilage tissue in the lab could help patiens with injuries, but it is very hard to make the tissue grow in exactly the right shape. A new approach could solve this problem: Tiny spherical containers are created with a high-resolution 3D printer. These containers are then filled with cells and assembled into the desired shape. The cells from different containers connect, the container itself is degradable and eventually disappears.

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Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- Weight loss drugs like Ozempic and Zepbound can lead to better heart health for people struggling with excess weight or diabetes, a University of Michigan cardiologist says. However, these medications help the heart best.

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Drugs 111

Drug Target Review

FEBRUARY 12, 2024

Denise, could you share some insights into your journey at Onyx Scientific, highlighting key milestones and challenges you’ve faced during your nearly 25 years with the company? At the turn of the millennium in early 2000, I was approached by the founders of Onyx Scientific to join the company as their Business Development Manager. I considered this to be an exciting opportunity and became part of the original team that established the company.

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International Science Laboratories Pharmaceuticals 111

National Drug & Alcohol Research Centre Blog

FEBRUARY 12, 2024

Who’s most likely to die from alcohol poisoning, and what do they drink? A new study led by researchers at the National Drug and Alcohol Research Centre (NDARC), UNSW Sydney, has explored the circumstances of death and characteristics of fatal alcohol poisoning cases. The study, published in Drug and Alcohol Review, examined deaths from acute alcohol poisoning in Australia, 2011–2022.

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Disease Treatment Research Drugs 110

Science Daily: Pharmacology News

FEBRUARY 12, 2024

This study reports widespread mineral carbonation of mantle rocks in an oceanic transform fueled by magmatic degassing of CO2. The findings describe a previously unknown part of the geological carbon cycle in transform faults that represent one of the three principal plate boundaries on Earth. The confluence of tectonically exhumed mantle rocks and CO2-rich alkaline basalt formed through limited extents of melting characteristic of the St.

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Research 106

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- Being active may help ease ongoing cancer pain.That's the key takeaway from a study of more 10,600 people with a history of cancer and over 51,000 without the disease.A team led by Erika Rees-Punia of the American Cancer.

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Science Daily: Pharmacology News

FEBRUARY 12, 2024

The replacement of regular salt with a salt substitute can reduce incidences of hypertension, or high blood pressure, in older adults without increasing their risk of low blood pressure episodes, according to a recent study. People who used a salt substitute had a 40% lower incidence and likelihood of experiencing hypertension compared to those who used regular salt.

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Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- Dutch researchers have developed a new stool test that appears to detect colon polyps better than the current test does."The current test performs well, but leaves room for improvement," said Dr. Gerrit Meijer, principle.

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Research 105

BioPharma Drive: Drug Pricing

FEBRUARY 12, 2024

The proposed acquisition is a bet on CymaBay’s drug seladelpar, which is now under FDA review in a chronic liver disease called primary biliary cholangitis.

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Disease FDA Drugs 123

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- A new pair of earrings have joined the plethora of wearable technology that can help track wellness, researchers report.The Thermal Earring continuously monitors a user’s earlobe temperature, according to the University.

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Research 98

SCIENMAG: Medicine & Health

FEBRUARY 12, 2024

LOS ANGELES (February 9, 2024)—Up to 5.8 million children and youth in the U.S. have experienced symptoms of COVID-19 that persisted long after initial infection.

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Hospitals 86

Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- Think twice if you're pregnant and craving a packaged pastry or a take-out burger and shake.That indulgence can do more than cause unwanted weight gain.

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Packaging 97

Science Daily: Pharmacology News

FEBRUARY 12, 2024

Scientists examined hundreds of birds in museum collections and discovered a suite of feather characteristics that all flying birds have in common. These 'rules' provide clues as to how the dinosaur ancestors of modern birds first evolved the ability to fly, and which dinosaurs were capable of flight.

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Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- The doctor tapped at his computer, ordering a routine prostate exam for an 80-year-old man, when a dramatic yellow alert popped up on the patient’s electronic health record.“You are ordering a test that no guideline.

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Doctors 98

SCIENMAG: Medicine & Health

FEBRUARY 12, 2024

Ultra-processed foods make up more than half the food average Americans eat. Including frozen and prepared meals, most packaged snacks, desserts and carbonated soft drinks—but also including more innocuous foods—they are often considered the bane of healthy eating, containing little to no nutrition to fuel healthy bodies.

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Packaging 76

Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- Don’t expect to sweat away the heart risks posed by sugary sodas and drinks, a new study warns.Canadian researchers found that even if the recommended 150 minutes of weekly physical activity protects against.

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Research 97

BioPharma Drive: Drug Pricing

FEBRUARY 12, 2024

Explore how companies are optimizing efficiency, enhancing customer experiences and embracing AI.

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Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- Pickleball has become the darling of older folks trying to stay in shape, but new research shows that with that popularity has come a surge in serious injuries.Bone fractures related to pickleball have increased 90-fold.

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Research 75

SCIENMAG: Medicine & Health

FEBRUARY 12, 2024

Anyone who has ever been to a loud concert knows the feeling of ringing ears. Some people experience temporary or even permanent hearing loss or drastic changes in their perception of sound after the loud noises stop. Thanos Tzounopoulos, Ph.D.

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Research 66

Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 — Novo Nordisk has settled lawsuits against two Florida businesses that claimed to sell copycat versions of its popular weight-loss drugs Ozempic and Wegovy.The Danish drugmaker announced the settlements Friday, according to.

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Drugs 69

Science Daily: Pharmacology News

FEBRUARY 12, 2024

Charles Darwin -- arguably the most influential man of science in history, accumulated a vast personal library throughout his working life. Until now, 85 per cent of its contents were unknown or unpublished. This year, coinciding with Darwin's 215th birthday, The Complete Work of Charles Darwin Online, a scholarly project, has released an online 300-page catalogue detailing Darwin's complete personal library, with 7,400 titles across 13,000 volumes and items including books, pamphlets and journa

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Science 70

Drugs.com

FEBRUARY 12, 2024

MONDAY, Feb. 12, 2024 -- Kids are more likely to lie to their parents if their parents have been lying to them -- even with positive “white” lies, a new study shows.But researchers found a difference between encouraging white lies and.

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Research 73

SCIENMAG: Medicine & Health

FEBRUARY 12, 2024

Your morning cereal, a jar of nuts, the sands of distant planets, and even the concrete in your city are all examples of granular systems surrounding us. And such systems are harboring secrets that could change the way we mix things up.

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BioPharma Drive: Drug Pricing

FEBRUARY 12, 2024

European venture firm Medicxi built the startup by combining six of its portolio companies, similar to when it merged 10 startups to form Centessa Pharmaceuticals in 2021.

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Disease Pharmaceuticals Drugs 62

SCIENMAG: Medicine & Health

FEBRUARY 12, 2024

October 19, 2024 – Corinthia Palace, Malta Credit: International Society of Microbiota (ISM) October 19, 2024 – Corinthia Palace, Malta The International Society of Microbiota (ISM) invites academics, companies, startups, and industrial players in the field of probiotics to participate in the upcoming workshop titled “Probiotic Prescribing Practices: Empowering Medical Doctors for Improved Patient Health.

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Production Doctors International 67

Drug Patent Watch

FEBRUARY 12, 2024

Annual Drug Patent Expirations for FLONASE+SENSIMIST+ALLERGY+RELIEF Flonase Sensimist Allergy Relief is a drug marketed by Glaxosmithkline Cons and is included in one NDA. It is available from two suppliers. There… The post New patent for Glaxosmithkline Cons drug FLONASE SENSIMIST ALLERGY RELIEF appeared first on DrugPatentWatch - Make Better Decisions.

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Agency IQ

FEBRUARY 12, 2024

BY RACHEL COE, MSC Yesterday, the Bespoke Gene Therapy Consortium, a public-private partnership focused on creating resources to streamline the process for moving AAV-based gene therapies from the lab to the clinic, published a comprehensive summary of the lessons the group has learned so far. The regulatory playbook acts as a comprehensive resource – especially for those not well-versed in how the FDA’s regulatory processes function.

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Therapies FDA 59

Drug Patent Watch

FEBRUARY 12, 2024

Annual Drug Patent Expirations for SUNOSI Sunosi is a drug marketed by Axsome Malta and is included in one NDA. It is available from two suppliers. There are twenty-three patents… The post New patent for Axsome Malta drug SUNOSI appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Agency IQ

FEBRUARY 12, 2024

BY AMANDA CONTI The path to market for complex generics and hybrid products is complicated, and regulatory harmonization efforts in this space are lacking. FDA and EMA launched the Parallel Scientific Advice (PSA) Pilot Program for Complex Generic/Hybrid Products in September 2021. With just two takers going through the program in over two years, the FDA is again encouraging participation and addressing industry concerns.

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