Thu.Dec 05, 2024

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Prevention Outpaced Treatment Advances in Saving Lives From Major Cancers

Drugs.com

THURSDAY, Dec. 5, 2024 -- “An ounce of prevention is worth a pound of cure,” founding father Benjamin Franklin once said.That’s definitely true of cancer, a new study has found.Cancer prevention and screening has saved more people from five types of.

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TRIM16 and PRC1 Are Involved in Pancreatic Cancer Progression and Targeted by Delphinidin

Chemical Biology and Drug Design

Three pancreatic cancer-related microarray datasets (GSE183795, GSE28735, and GSE62452) were integrated. Analysis of differentially expressed genes, WGCNA, and machine learning algorithms (LASSO, XGboost, and random forest) were combined to identify genes associated with the progression of pancreatic cancer. Natural drugs, including delphinidin, which target the core genes, tripartite motif containing 16 (TRIM16), and protein regulator of cytokinesis 1 (PRC1), were then identified.

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'Broken' Sleep Could Be Hallmark of Obesity-Linked Liver Disease

Drugs.com

THURSDAY, Dec. 5, 2024 -- Fatty liver disease may contribute to fragmented sleep patterns, robbing already sick people of good rest, a new study finds.These folks woke up more often in the night, and then lay awake longer waiting for slumber to.

Disease 98
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Design and Development of Novel Hybrids Based on Pyrrolo[2,1‐f][1,2,4]Triazine and 1‐(Methylpiperidin‐4‐yl) Aniline–Based Analogs: Exploring the Utility as Anticancer Agents via MERTK Inhibition

Chemical Biology and Drug Design

A hybrid drug design approach was employed to develop novel leads ( 1K11K5 ). The molecules were synthesized via a multi-step synthetic approach and were assessed for their anticancer potential via cell viability studies, DMPK studies, and MERTK inhibition. Studies were corroborated by in silico studies. ABSTRACT Mer-tyrosine kinase (MERTK), a member of the AXL, TYRO3, and MERTK (TAM) family, is one of the promising targets for cancer treatment.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Molecular zip code draws killer T cells straight to brain tumors

Science Daily: Pharmacology News

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America's Rural Hospitals Are Shutting Down Maternity Wards

Drugs.com

THURSDAY, Dec. 5, 2024 -- Hospitals across America are shuttering their obstetric units, and the issue is most acute for women served by rural hospitals, a new study finds.By 2022, a majority (52%) of rural U.S. hospitals no longer had any.

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California Farm Expands Raw Milk Recall After Bird Flu Virus Found in More Samples

Drugs.com

THURSDAY, Dec. 5, 2024 -- A California dairy farm has expanded a recall of its raw milk and cream after state health officials discovered bird flu virus in more milk samples.In a notice posted Tuesday, Fresno-based Raw Farm LLC said it has now.

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Increases in U.S. life expectancy forecasted to stall by 2050, poorer health expected to cause nation's global ranking to drop

Science Daily: Pharmacology News

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Dark Chocolate Could Help You Ward Off Type 2 Diabetes

Drugs.com

THURSDAY, Dec. 5, 2024 -- The choice may be bittersweet, but the evidence is clear: New research shows that dark chocolate can lower a person’s risk of type 2 diabetes.People who ate at least five servings of dark chocolate a week had a 21% lower r.

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Genetic study of native hazelnut challenges misconceptions about how ancient Indigenous peoples used the land

Science Daily: Pharmacology News

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Most Young People With Long COVID Recover Within 2 Years

Drugs.com

THURSDAY, Dec. 5, 2024 -- Most children and teenagers can shake long COVID within a couple of a years, a new, reassuring study finds.About 70% of children and teens diagnosed with long COVID recover from the disorder within 24 months of their.

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Rapid surge in global warming mainly due to reduced planetary albedo

Science Daily: Pharmacology News

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'Game of Roulette': Flying With Food Allergies Brings Stress, Danger

Drugs.com

THURSDAY, Dec. 5, 2024 -- Holiday travel is always stressful, but particularly so for people with food allergies.Airlines don’t always honor requests to protect the health of people with food allergies during flights, a new study published Dec. 5 i.

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Iberian Neolithic societies had a deep knowledge of archery techniques and materials

Science Daily: Pharmacology News

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Prenatal Blood Tests for Baby Are Spotting Cancers in Moms-to-Be

Drugs.com

FRIDAY, Dec. 6, 2024 -- Could a prenatal blood test designed to find abnormalities in a fetus also detect hidden cancer in the mom-to-be? A new study says yes: Scientists report they discovered cancer in nearly half (48%) of expecting mothers with.

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Scientists identify mutation that could facilitate H5N1 'bird flu' virus infection and potential transmission in humans

Science Daily: Pharmacology News

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U.S. Overdose Deaths Linked to Fentanyl May Be Declining

Drugs.com

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Mothers massively change their intestines during pregnancy and nursing

Science Daily: Pharmacology News

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Atlas doubles down on ‘disciplined’ biotech investing with latest fundraise

BioPharma Drive: Drug Pricing

The venture firm’s “modest” $450 million fund, a lower total than some of its peers recently raised, reflects lessons learned after Atlas grew too quickly, partner Bruce Booth wrote in a blog post.

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Chimpanzees perform the same complex behaviors that have brought humans success

Science Daily: Pharmacology News

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GSK taps a startup for shot at Alzheimer’s drug

BioPharma Drive: Drug Pricing

The collaboration deal, which could be worth hundreds of millions of dollars, is a “pivotal moment” for Muna Therapeutics, a startup that launched less than four years ago.

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That's no straw: Hummingbirds evolved surprisingly flexible bills to help them drink nectar

Science Daily: Pharmacology News

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Nuvig pulls in $161M to make better immune drugs

BioPharma Drive: Drug Pricing

The company is developing treatments to rebalance, rather than suppress, immune function in people with inflammatory conditions, starting with an antibody near Phase 2 testing.

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Researchers use data from citizen scientists to uncover the mysteries of a blue low-latitude aurora

Science Daily: Pharmacology News

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Atlas XIV And Reflections On The VC Math Problem

LifeSciVC

Today we announced the closing of Atlas Venture Fund XIV , a $450M investment vehicle focused exclusively on early stage biotech investing. With the closing of Fund XIV, we’re privileged to be able to continue backing innovative new biotech companies for another fund cycle, reinforcing our science-first and seed-led venture creation model for novel therapeutics – and delivering on our mission of doing well by doing good.

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Particle research gets closer to answering why we're here

Science Daily: Pharmacology News

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CTE Rates Rise Year-by-Year in Pro Hockey Players

Drugs.com

THURSDAY, Dec. 5, 2024. Hockey players’ chances of developing concussion-related brain injury increase with every year they spend on the ice, a new study finds. The odds of having chronic traumatic encephalopathy (CTE) increase among hockey.

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Product lifecycle management: why it matters for the In Vitro Diagnostics industry

Tecan

By David Keller Developing an effective product lifecycle management (LCM) process is no longer just a ‘nice to have’ for manufacturers in the medical and diagnostics equipment industry, but an essential ‘must have’ to ensure long-term business growth. From managing the total cost of ownership (TCO) to accomplishing product updates without disruptions in regulatory compliance, a holistic view of product LCM during new product development can help you to increase operational efficiency and mainta

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Multi-Omics and its Application in Personalised Medicine Studies

Quanticate

Advances in multi-omics are driving significant breakthroughs in biomedical research. By integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics, researchers can achieve a comprehensive view of complex biological processes. This in turn is aiding personalised disease prevention, diagnosis, and treatment​. However, handling and interpreting vast, heterogeneous data present unique challenges, requiring advanced computational methods and data integration techniques.

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Product lifecycle management: why it matters for the In Vitro Diagnostics industry

Tecan

By David Keller Developing an effective product lifecycle management (LCM) process is no longer just a ‘nice to have’ for manufacturers in the medical and diagnostics equipment industry, but an essential ‘must have’ to ensure long-term business growth. From managing the total cost of ownership (TCO) to accomplishing product updates without disruptions in regulatory compliance, a holistic view of product LCM during new product development can help you to increase operational efficiency and mainta

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New insights into the role of viral capsids in gene therapy safety

Drug Target Review

Viral vectors have been crucial in transforming the gene therapy landscape due to their natural ability to infect cells. Among them, adeno-associated viruses (AAVs) stand out due to their small size, high efficiency in gene delivery, low immunogenicity, and potential for customisable tissue targeting, making them the leading tool in gene expression research. 1 In 2017, the US Food and Drug Administration (FDA) approved the first AAV-based gene replacement therapy (Luxturna), for Leber congenital

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Understanding the Lifecycle of Generic Drugs: From Development to Market Impact

Drug Patent Watch

In the ever-evolving landscape of healthcare, generic drugs play a crucial role in providing affordable and accessible medication to millions of people worldwide. But have you ever wondered about the journey these drugs take from conception to your local pharmacy shelf?

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Pre-Approval Inspection (PAI) Readiness is Easy, Isn't It?

thought leadership

Facing a  pending filing and subsequent PAI  can feel overwhelming, no matter if you are a young firm or an established company. You're balancing the excitement of bringing a new product to market with the reality of limited resources. For many companies, regardless of size and tenure, the culmination of fund raising, planning, and execution has led you to this – the need for a solid filing and a successful inspection.