Drug Discovery World

FEBRUARY 6, 2024

The first UK patients have received an mRNA cancer therapy – mRNA-4359 – as part of a Phase I/II clinical trial investigating its potential for treating melanoma, lung cancer and other solid tumour cancers. The Mobilize trial is run in partnership between Imperial College London and Imperial College Healthcare NHS Trust, with the first patients in the UK receiving the treatment at the NIHR Imperial Clinical Research Facility at Hammersmith Hospital.

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Therapies Clinical Trials Trials Government 279

Chemical Biology and Drug Design

FEBRUARY 6, 2024

By dint of a relatively high content of glycyrrhetinic acid (GA), radix glycyrrhizae preparata is often adopted to treat atrial fibrillation (AF). Thus, the mechanism of GA was expounded in our study. Our research concludes that GA alleviates AF through suppressing the expression of PIM1. Abstract Glycyrrhetinic acid (GA) is known to exert a cardioprotective effect, while its mechanism in atrial fibrillation (AF) remains poorly defined.

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Treatment Research 100

Drug Discovery World

FEBRUARY 6, 2024

As AI-designed drugs start to enter large-scale clinical trials, DDW’s Diana Spencer investigates how new digital tools are reinventing and reshaping drug discovery for the future. From finding potential active substances and identifying novel targets, to simulating how drugs will function in the human body and optimising laboratory workflows, digital technologies are having a significant impact on drug discovery and development.

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Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- When getting vaccines, switching arms for each dose may produce greater immunity than having the jabs delivered into the same arm.That's the finding from a new study that looked at the first two doses of COVID vaccines.

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Vaccine 111

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 6, 2024

Catherine Brownstein is an Assistant Professor in Pediatrics at Harvard Medical School and the Assistant Director of the Molecular Genetics Core Facility at Boston Children’s Hospital. Her current work focuses on advancing the fields of genome sequencing and analysis, with an emphasis on identifying complex structural variation. She speaks to Megan Thomas on how genomics can advance drug discovery and development.

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Medical Schools Clinical Trials Assay Development Hospitals 148

Drug Target Review

FEBRUARY 6, 2024

Early diagnosis is vital to improving outcomes in any cancer, and a growing number of novel screening options have emerged to address this need. Patients now have more avenues available to understand their cancer risk, from genetic assessments for hereditary forms of cancer to advanced imaging tests. Among American men, prostate cancer is the second leading cause of cancer death and the second most common cancer overall, affecting one in every eight men during his lifetime.

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DNA RNA Science Laboratories 105

Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- The COVID-19 vaccine given to pregnant women does no harm to their unborn babies, and can actually lower the risk of serious complications in newborns, a new study finds.Babies born to women who received the COVID vaccine.

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Vaccine 105

Drug Discovery World

FEBRUARY 6, 2024

For this year’s SLAS2024 conference in Boston (which takes place 3-7 February), DDW’s Megan Thomas narrates articles from the DDW SLAS2024 supplement as part of the DDW Events podcast series. This is episode three, Connecting academia, industry and the public. Erin Welsh, PhD, is a disease ecologist and epidemiologist now working full-time as a science communicator.

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Science Disease Drugs 130

Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- Scientists say they've created the first 3D-printed brain tissue where neurons network and "talk" to each other.The breakthrough could be an advance for studying neurological processes in the lab, say a team from the.

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Research 105

Drug Discovery World

FEBRUARY 6, 2024

The US Food and Drug Administration (FDA) has granted Orphan Drug Designation to Revolo Biotherapeutics’ ‘1104 to treat eosinophilic esophagitis (EoE). EoE is a chronic, allergic inflammatory disease that is characterised by the accumulation of eosinophils in the lining of the esophagus. Inflammation caused by immune cells such as T cells and mast cells results in progressive tissue injury. ‘1104 is a first-in-class peptide that is involved in resetting the immune system.

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Clinical Trials FDA Drugs Trials 130

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- Two people have died and 23 have been hospitalized in a years-long outbreak of listeria illness that's finally been traced to one company's cheeses, yogurts and other dairy products.That's the message from a U.S. Centers.

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Hospitals 98

Drug Discovery World

FEBRUARY 6, 2024

The Association of the British Pharmaceutical Industry (ABPI) has published a manifesto outlining what a UK government must do to make the country a great place to research and develop the medicines and vaccines of the future. The ABPI manifesto for investment, health and growth sets out a vision for how the UK can overtake its global competitors and create a virtuous cycle, where investment in medicines and research accelerates future waves of innovation and attracts an increased UK share of gl

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Science Government Vaccine Pharmaceuticals 130

Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- They say money can’t buy happiness – and now a new study of Indigenous peoples around the world backs up that assertion.People living in small-scale societies on the fringes of the modern world lead lives as happy and.

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Science Daily: Pharmacology News

FEBRUARY 6, 2024

China's Chang'e-5, the first lunar sample return mission since the Soviet Union's Luna 24 in 1976, delivered 1.73 kilograms of regolith from the Oceanus Procellarum, a plane named for its vast size. The sample landed with CE-5 in late 2020 and included a new mineral, Changesite-(Y), as well as a perplexing combination of silica minerals. Researchers now compare CE-5's material composition to other lunar and Martian regolith samples and examine potential causes and origins for the lunar sample's

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Research 94

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- Age-related macular degeneration can lead to vision loss in seniors, but new therapies have offered fresh hope for preserving eyesight later in life, eye experts say.These cutting-edge therapies benefit both the dry and wet.

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Therapies 97

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

Law enforcement seizures of “magic mushrooms” or “shrooms” containing the psychoactive component psilocybin increased dramatically in the United States between January 2017 and December 2022, according to a new study funded by the National Institute on Drug Abuse, part of the National Institutes of Health.

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Drugs 93

Science Daily: Pharmacology News

FEBRUARY 6, 2024

Black holes not only existed at the dawn of time, they birthed new stars and supercharged galaxy formation, a new analysis of James Webb Space Telescope data suggests.

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addgene Blog

FEBRUARY 6, 2024

If you’re interested in studying immunology or subpopulations of cells, you’ll soon find yourself encountering flow data in the literature. Data reported from flow cytometry experiments can be a little challenging to understand if you’ve never done any flow. But in order to plan a flow experiment, you’ll need to first read papers with flow data, but to…which can send you in an endless loop.

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Science Daily: Pharmacology News

FEBRUARY 6, 2024

Most women agree that menopause has its advantages and disadvantages. Some relish the end of menstruation and concerns about unplanned pregnancies, while others dread the possibililty of hot flashes, moodiness, and other unpleasant symptoms. What some women consider a brief and barely noticeable phase in their lives can evolve into lasting changes and discomfort for others.

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Covalent Modifiers

FEBRUARY 6, 2024

Schönherr, H.; Ayaz, P.; Taylor, A. M.; Casaletto, J. B.; Touré, B. B.; Moustakas, D. T.; Hudson, B. M.; Valverde, R.; Zhao, S.; O’Hearn, P. J.; Foster, L.; Sharon, D. A.; Garfinkle, S.; Giordanetto, F.; Lescarbeau, A.; Kurukulasuriya, R.; Gerami-Moayed, N.; Maglic, D.; Bruderek, K.; Naik, G.; Gunaydin, H.; Mader, M. M.; Boezio, A. A.; McLean, T. H.; Chen, R.; Wang, Y.; Shaw, D.

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Small Molecule Treatment Science Therapies 86

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

In the human body, the lungs and their vasculature can be likened to a building with an intricate plumbing system. The lungs’ blood vessels are the pipes essential for transporting blood and nutrients for oxygen delivery and carbon dioxide removal.

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Research 86

Science Daily: Pharmacology News

FEBRUARY 6, 2024

Employing massive data sets collected through NASA's James Webb Space Telescope, astronomers are unearthing clues to conditions existing in the early universe. The team has catalogued the ages of stars in the Wolf--Lundmark--Melotte (WLM) galaxy, constructing the most detailed picture of it yet, according to the researchers. WLM, a neighbor of the Milky Way, is an active center of star formation that includes ancient stars formed 13 billion years ago.

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Research 82

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

For the first time, researchers including those at the University of Tokyo discovered a way to improve the durability of gold catalysts by creating a protective layer of metal oxide clusters. The enhanced gold catalysts can withstand a greater range of physical environments compared to unprotected equivalent materials.

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Research 84

Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb 6, 2024 -- The former 'party drug' ketamine has gotten some good press recently, with clinical trials suggesting it might be a powerful and fast-acting antidepressant.Now, one of the first "real-world" studies of ketamine against.

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Clinical Trials Trials Drugs 81

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

Evanston, IL—The International Society for Stem Cell Research (ISSCR) is honoring Jun Wu, Ph.D. with the 2024 ISSCR Outstanding Young Investigator Award. Dr. Wu is an associate professor in the Department of Molecular Biology at the University of Texas Southwestern Medical Center, U.S.A. and a New York Stem Cell Foundation–Robertson Investigator.

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Molecular Biology International Research 83

BioPharma Drive: Drug Pricing

FEBRUARY 6, 2024

The life sciences investor has backed a number of startups working on technologies for delivering and manufacturing cell and gene medicines.

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Science Drugs 85

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

BIRMINGHAM, Ala. – Fran Lund, Ph.D., a professor of microbiology at the University of Alabama at Birmingham and the Endowed Chair in Immunology in the UAB Immunology Institute, has been named a 2024 Distinguished Fellow of the American Association of Immunologists. Credit: UAB BIRMINGHAM, Ala. – Fran Lund, Ph.D.

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BioPharma Drive: Drug Pricing

FEBRUARY 6, 2024

The Alzheimer’s drug was administered to a total of 2,000 U.S. patients as of Jan. 26, signaling to analysts that an earlier goal of 10,000 may take longer than expected to hit.

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Drugs 73

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

Sepsis is a life-threatening condition triggered by a severe infection. Severe sepsis and septic shock are progressive stages of sepsis, associated with multi-organ failure and death. Mortality for pediatric sepsis ranges from 4% to 50%, depending on illness severity, risk factors, and geographic location.

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Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- New guidelines from the American Dental Association (ADA) are cracking down on the use of opioids for tooth pain.The guidelines say that non-steroidal anti-inflammatory drugs (NSAIDs) taken alone or alongside acetaminophen.

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Drugs 72

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

The Brain & Behavior Research Foundation (BBRF) is hosting a free webinar, “Developing Biological Markers to Improve Clinical Care in Autism” on Tuesday, February 13, 2024, at 2:00 pm ET. The presenter will be James McPartland, Ph.D.

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Research Clinical Development 77

Science Daily: Pharmacology News

FEBRUARY 6, 2024

Daily exposure to chemicals used in the manufacture of plastic food containers and many cosmetics may be tied to nearly 56,600 preterm births in the U.S. in 2018, a new study shows. The resulting medical costs, the authors of the report say, were estimated to reach a minimum of $1.6 billion and as much as $8.1 billion over the lifetime of the children.

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SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

EL PASO, Texas (Feb. 6, 2024) – A group of researchers at The University of Texas at El Paso are behind an emerging lithium extraction technology that won the inaugural Hill Prize from the Texas Academies of Medicine, Engineering, Science and Technology (TAMEST) on Monday.

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BioPharma Drive: Drug Pricing

FEBRUARY 6, 2024

The company also reported trial results suggesting tirzepatide, the drug Lilly now sells as Mounjaro and Zepbound, could treat a common liver disease.

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