Fri.Feb 16, 2024

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Lessons from Monte Carlo Models: Why Drug Development is Hard

DrugBaron

“There is more than one way to skin a cat” is a rather gruesome British idiom, but its sentiment surely applies to running a successful pharmaceutical portfolio. It is now more than a decade since Francesco De Rubertis, together with Kevin Johnson and Michele Olier, coined the term “asset-centric” investing to describe the approach to portfolio creation that still underpins the strategy at Medicxi.

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Study finds youth-onset diabetes is a genetically distinct form of the disorder

Broad Institute

Study finds youth-onset diabetes is a genetically distinct form of the disorder By Claire Hendershot February 16, 2024 Breadcrumb Home Study finds youth-onset diabetes is a genetically distinct form of the disorder Researchers suggest diabetes exists in multiple forms on a spectrum of varying genetic factors and symptoms. By Claire Hendershot February 16, 2024 Image by Ricardo Job-Reese, Broad Communications.

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Drug That Treats Cocaine Addiction May Curb Colon Cancer

Drugs.com

FRIDAY, Feb. 16, 2024 (HealthDay news) -- A drug first developed to treat cocaine addiction might also help slow the spread of advanced colon cancer, a new study suggests.The drug vanoxerine appears to suppress cancer stem cell activity by.

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Advanced artificial photosynthesis catalyst uses CO2 more efficiently to create biodegradable plastics

Science Daily: Pharmacology News

A research team that had previously succeeded in synthesizing fumaric acid using bicarbonate and pyruvic acid, and carbon dioxide collected directly from the gas phase as one of the raw materials, has now created a new photosensitizer and developed a new artificial photosynthesis technology, effectively doubling the yield of fumaric acid production compared to the previous method.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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CDC May Recommend COVID Boosters for Some This Spring

Drugs.com

FRIDAY, Feb. 16, 2024 -- The U.S. Centers for Disease Control and Prevention is weighing whether to recommend another COVID booster shot this spring, most likely for those who are vulnerable to severe illness.An advisory panel to the CDC is.

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A new genetic biomarker to predict immunotherapy success

Drug Target Review

Scientists at the University of Pittsburgh have discovered that tumours with a greater intragenic rearrangement (IGR) burden may respond better to immune checkpoint blockades (ICB). This could lead to more precise treatment for patients with cancers like oesophageal, breast, ovarian and endometrial, which solves an unmet need to discover genetic abnormalities that predict ICB responses in these tumour types.

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ALS drug from Denali, Sanofi falls short in mid-stage study

BioPharma Drive: Drug Pricing

The disclosure the experimental therapy missed its trial goal comes after Sanofi had earmarked the drug for advancement into Phase 3.

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FDA Expands Use of Asthma Med Xolair to Treat Food Allergies

Drugs.com

FRIDAY, Feb. 16, 2024 -- People threatened by accidental exposure to foods they're allergic to may have a new weapon of defense: On Friday, the U.S. Food and Drug Administration expanded the use of the asthma drug Xolair to help prevent.

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Astellas teams up with startup Kelonia to make ‘in vivo’ cell therapies

BioPharma Drive: Drug Pricing

Kelonia will receive $40 million upfront through a partnership to develop “off-the-shelf” cell therapies for cancer.

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Most People Have Been Exposed to Little-Known Pesticide: Study

Drugs.com

FRIDAY, Feb. 16, 2024 -- A little-known pesticide is likely present in the bodies of most U.S. residents, raising concerns of potential reproductive and developmental problems, researchers report.In the study, the pesticide chlormequat was found in.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Rare case of opossum infected by rabies sounds alarm regarding circulation of this virus in urban environments

SCIENMAG: Medicine & Health

A female White-eared opossum (Didelphis albiventris) found dead in 2021 in Bosque dos Jequitibás Park in the center of Campinas, one of the largest cities in São Paulo state, Brazil, died from rabies meningoencephalitis, according to a group of researchers at the University of São Paulo (USP) and Adolfo Lutz Institute (IAL), the regional reference […]

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Brain Cancer Risk Rises in Vets After Serious Head Injury

Drugs.com

FRIDAY, Feb. 16, 2024 -- People who’ve suffered a moderate to severe traumatic brain injury have a greatly increased risk of brain cancer, a new study of military service members finds.Brain cancer is relatively uncommon, occurring in fewer than.

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Brain waves are part of memory

SCIENMAG: Medicine & Health

Spatial navigation and spatial memory play a central role in our lives. Without these abilities, we would hardly be able to find our way around our surroundings and would find it difficult to remember past events. However, the neuronal basis of spatial memory is far from being fully understood. A research group led by Prof.

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Smoking Now Fuels More Drug Overdoses than Injecting Does

Drugs.com

FRIDAY, Feb. 16, 2024 -- Despite stereotypical images of addicts injecting heroin and then dying, new government research finds that smoking drugs such as fentanyl is now the leading cause of fatal overdoses.In the new research, published Thursday.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Self-monitoring improves physical activity of care-needing elderly

SCIENMAG: Medicine & Health

Self-monitoring of physical activity with an accelerometer and feedback is an effective tool to improve physical activity in elderly people requiring long-term support.

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Women With HIV Age Faster, Study Shows

Drugs.com

FRIDAY, Feb. 16, 2024 -- Women with HIV experience accelerated DNA aging, potentially leading to poorer physical function sooner in life than expected, a new study says.Markers of aging measured in blood revealed that women with HIV age faster than.

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The Drug Discount Ecosystem Needs Clarity in 2024 and Beyond

Drug Channels

Today’s guest post comes from Gavin Magaha, Senior Director of Value Delivery at Kalderos. Gavin discusses the problems manufacturers face in accessing and standardizing drug discount data. These data are necessary to avoid duplicate discounts and comply with regulatory requirements. To learn more about how the Inflation Reduction Act adds to challenges of drug discount programs, download Kalderos’ whitepaper: Operational Complexity and Evolving Challenges: What Drug Manufacturers Need to Know N

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Big Cats Can Tell Familiar Voices From Strangers

Drugs.com

FRIDAY, Feb. 16, 2024 -- Big cats may be more attuned to humans than you think: New research shows that lions, tigers and cheetahs can recognize familiar human voices and tell them apart from strangers.Investigators found consistent evidence of.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New chip opens door to AI computing at light speed

Science Daily: Pharmacology News

Engineers have developed a new chip that uses light waves, rather than electricity, to perform the complex math essential to training AI. The chip has the potential to radically accelerate the processing speed of computers while also reducing their energy consumption.

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Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Covalent Modifiers

Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan M. Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto & Alessio Ciulli Nat Commun 14 , 6345 (2023). [link] The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signaling.

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Mystery solved: The oldest fossil reptile from the alps is an historical forgery

Science Daily: Pharmacology News

Palaeontological analysis shows renowned fossil thought to show soft tissue preservation is in fact just paint. Fossil discovered in 1931 was thought to be an important specimen for understanding early reptile evolution. While not all of the celebrated fossil is a forgery, scientists urge caution in how the fossil is utilized in future.

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Despite the Evidence, Nearly 15% of Americans Deny Climate Change

Drugs.com

FRIDAY, Feb. 15, 2024 -- Nearly 15% of Americans still deny that climate change is real, according to a new national assessment from the University of Michigan.Evidence of climate change has been mounting, including science which has shown that.

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FDA to consider expanding use of Sarepta Duchenne gene therapy

BioPharma Drive: Drug Pricing

The agency will decide by June 21 whether to enable more patients with the disease to receive Elevidys, and won’t convene a group of outside experts beforehand.

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More Kids, Teens May Be Taking Multiple Psychiatric Meds

Drugs.com

FRIDAY, Feb. 16, 2024 -- A study of mental health care in Maryland finds an increasing number of children and teens covered by Medicaid are taking multiple psychiatric meds.This trend towards "polypharmacy" might be happening elsewhere, prior.

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Perficient Launches LiveWell Employee Resource Group

Perficient: Drug Development

New ERG Will Assist in Delivering On Our People Promise At Perficient, our success is defined by our colleagues. Because of this, Perficient has promised to challenge, champion, and celebrate its people, and that includes empowering their personal health and well-being. Today, we proudly announce the launch of the LiveWell Employee Resource Group (ERG), a community of Perficient colleagues passionate about health and wellness that aims to support everyone in achieving better overall well-being.

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When Grandparents Support Mom, Antidepressant Use Drops: Study

Drugs.com

FRIDAY, Feb. 16, 2024 —When grandparents can lend a hand with little ones, moms are less likely to battle depression.And, in turn, they are less likely to take antidepressants, Finnish researchers report in the Feb. 15 issue of the journal.

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Measuring neutrons to reduce nuclear waste

Science Daily: Pharmacology News

Nuclear power is considered one of the ways to reduce dependence on fossil fuels, but how to deal with nuclear waste products is a concern. Radioactive waste products can be turned into more stable elements, but this process is not yet viable at scale. New research reveals a method to more accurately measure, predict and model a key part of the process to make nuclear waste more stable.

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Gilead reviewing drug acquired in $5B buyout after latest setback

BioPharma Drive: Drug Pricing

The FDA paused enrollment in the only remaining tests of the drug, as Gilead reviews the program it acquired through a buyout of biotech Forty Seven.

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Greater Than The Sum Of The Parts: A Framework For Leading Enterprises In Non-Traditional Ways

LifeSciVC

By Ankit Mahadevia, former CEO of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC The right leaders in the right structure can power companies to great things. The general consensus is that all companies need a CEO and full team at the helm (see here for several posts we’ve written on this topic) to thrive. However, many emerging companies do not have a traditional structure, as I’ve noticed across my Board, venture, and company building experience.

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Which pharmaceutical companies have the most drug patents in Lithuania?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Lithuania. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Lithuania? appeared first on DrugPatentWatch - Make Better Decisions.

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Breaking Down Barriers – Creating Inclusive Public Spaces Through Universal Design

Perficient: Drug Development

In our rapidly evolving world, the importance of inclusive public spaces cannot be overstated. Designing spaces that are accessible to everyone, regardless of their abilities or disabilities, is at the core of universal design. This concept aims to break down barriers and create environments that promote equal participation for all. In this blog post, we’ll explore how to enhance inclusivity in public spaces through universal design principles.

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New patent expiration for Sage Prods drug CHLORHEXIDINE GLUCONATE

Drug Patent Watch

Annual Drug Patent Expirations for CHLORHEXIDINE+GLUCONATE Chlorhexidine Gluconate is a drug marketed by Sage Prods, Akorn, Bajaj, Chartwell Rx, Lyne, Pharm Assoc, Xttrium, Becton Dickinson, and Kendall Il and, and… The post New patent expiration for Sage Prods drug CHLORHEXIDINE GLUCONATE appeared first on DrugPatentWatch - Make Better Decisions.

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Opening Doors to Inclusion: Universal Design in Public Spaces

Perficient: Drug Development

In the quest for a more inclusive society, the significance of universal design in public spaces cannot be overstated. By incorporating thoughtful features, such as ramps, elevators, and automatic doors, we can break down physical barriers and create environments that cater to the diverse needs of individuals, especially those facing mobility challenges.