Wed.Jul 03, 2024

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How does circVec technology compare to conventional mRNA expression? 

Drug Discovery World

Circio has announced updated in vivo data that demonstrates a substantial durability advantage of Circio’s circVec technology over conventional mRNA expression. In addition, Circio has undertaken sequence optimisation resulting in a new circVec 2.2 design. “The circVec 2.1 design is performing very well in vivo , and Circio has now validated expression for up to five months.

RNA 147
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A breakthrough in inexpensive, clean, fast-charging batteries

Science Daily: Pharmacology News

Scientists have created an anode-free sodium solid-state battery. This brings the reality of inexpensive, fast-charging, high-capacity batteries for electric vehicles and grid storage closer than ever.

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Meet the Researcher: Nicola McCarthy, Milner Therapeutics Institute

Drug Discovery World

DDW’s Megan Thomas talks to Nicola McCarthy, Head of Research at the Milner Therapeutics Institute. MT: Could you start by giving me your name, your job title and what you do? NM: I’m Head of Research at the Milner Therapeutics Institute, which is part of the University of Cambridge, and I oversee both wet and dry labs of the institute. MT: Can you provide a top-line summary of your research?

Research 147
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5 FDA decisions to watch in the third quarter

BioPharma Drive: Drug Pricing

Multibillion-dollar buyouts from Bristol Myers Squibb and Gilead could yield new drugs for brain and liver diseases, while a new cell therapy may reach market.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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UK 2024 election: A vote for drug discovery

Drug Discovery World

By DDW Editor Reece Armstrong The upcoming general election in the UK has placed the priorities of the country into the spotlight and the drug discovery sector should in no way be forgotten. Economic uncertainty, challenging global conditions and a healthcare system facing serious pressures, means that whatever government takes the reigns come 4 July, they’ll be indebted with numerous burdens.

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Supercharge Customer Journeys with Salesforce OmniStudio

Perficient: Drug Development

In today’s digital landscape, delivering exceptional customer experiences is paramount. Salesforce OmniStudio empowers you to create engaging, personalized, and brand-consistent interactions across all touchpoints. This blog post delves into OmniStudio, exploring its capabilities, benefits, and how you can leverage it to elevate your customer journeys.

More Trending

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FDA Bans Food Additive Found in Sports Drinks, Sodas

Drugs.com

WEDNESDAY, July 3, 2024 -- A regulation allowing the use of brominated vegetable oil in food was revoked Tuesday by the U.S. Food and Drug Administration after the agency concluded the additive was unsafe for human consumption.Brominated vegetable.

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Vodcast: Nicola McCarthy, Milner Therapeutics Institute, at SLAS 2024

Drug Discovery World

DDW’s Megan Thomas talks to Nicola McCarthy, Head of Research at the Milner Therapeutics Institute. MT: Could you start by giving me your name, your job title and what you do? NM: I’m Head of Research at the Milner Therapeutics Institute, which is part of the University of Cambridge, and I oversee both wet and dry labs of the institute. MT: Can you provide a top-line summary of your research?

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Extinct humans survived on the Tibetan plateau for 160,000 years

Science Daily: Pharmacology News

Bone remains found in a Tibetan cave 3,280 m above sea level indicate an ancient group of humans survived here for many millennia.

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FDA Warns of 48 Illnesses, One Death Linked to Diamond Shruumz Edibles

Drugs.com

WEDNESDAY, July 3, 2024 -- The U.S. Food and Drug Administration said Tuesday it is now investigating nearly 50 illnesses and one death that may be linked to eating Diamond Shruumz edibles.Of the 48 people in 24 states who said they got sick after.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Blue and great t**s deploy surprisingly powerful memories to find food

Science Daily: Pharmacology News

Blue and great t**s recall what they have eaten in the past, where they found the food and when they found it, a new study shows. In the first experiment of its kind to involve wild animals, blue and great t**s demonstrated 'episodic-like' memory to cope with changes in food availability when foraging. The same study may suggest that humans leaving out seeds and nuts for garden birds could be contributing to the evolution of these memory traits.

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Could Sauna Time Help Curb Weight Gain During Menopause?

Drugs.com

WEDNESDAY, July 3, 2024 — A 30-minute sauna or warm bubble bath every day might help women of a certain age fend off unwanted weight gain.That's the promising takeaway from a study in mice that shows the potential of heat treatments in p.

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Women in Stem with Morgane Rousselot

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? My journey into STEM began at a young age. It was fuelled by my fascination with how the world operates and a deep desire to comprehend scientific phenomena. From high school onwards I chose to pursue studies in science; this passion has guided me throughout my academic journey.

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Florida Keys Issues Dengue Fever Alert After Two Cases Reported There

Drugs.com

WEDNESDAY, July 3, 2024 -- Health officials in the Florida Keys have issued a dengue fever alert after two confirmed cases of the mosquito-borne disease were reported there.In the alert, issued this week by the Monroe County Department of Health.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Giant salamander-like creature was a top predator in the ice age before the dinosaurs

Science Daily: Pharmacology News

Meet Gaiasia jennyae, the swamp creature with a toilet seat-shaped head. It lived 40 million years before the first dinosaurs, and it was the top predator in its ecosystem.

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Why Were Kids Hit Less Hard by COVID? New Study Offers Clues

Drugs.com

WEDNESDAY, July 3, 2024 -- Your children's never-ending colds and sniffles may have protected them from the worst effects of COVID-19, new research suggests.Throughout the pandemic, it was clear that the SARS-CoV-2 virus tends to cause less severe.

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CureVac cuts jobs, licenses out vaccines to GSK

BioPharma Drive: Drug Pricing

The mRNA specialist plans to eliminate 30% of its workforce as part of a restructuring that will prioritize “high-value” projects like its cancer vaccines.

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GLP-1 Drugs Ozempic, Wegovy Linked to Rare Blinding Condition

Drugs.com

WEDNESDAY, July 3, 2024 -- Trendy weight-loss drugs appear to increase the risk of a rare and potentially blinding eye condition, a new study warns. People with diabetes prescribed semaglutide (Ozempic, Wegovy) were more than four times more likely.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

Drugs 59
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When It Comes to Weight Gain, Not All Antidepressants Are the Same

Drugs.com

WEDNESDAY, July 3, 2024 -- Weight gain is a common side effect of antidepressants, but some types cause people to pack on pounds more than others, a new study says.Bupropion users are 15% to 20% less likely to gain a significant amount of weight.

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New patent for Janssen Biotech drug AKEEGA

Drug Patent Watch

Annual Drug Patent Expirations for AKEEGA Akeega is a drug marketed by Janssen Biotech and is included in one NDA. It is available from one supplier. There are eight patents protecting this drug.

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Fourth Dairy Worker Infected With Bird Flu, but CDC Says Public Risk Still Low

Drugs.com

WEDNESDAY, July 3, 2024 -- Amid an ongoing outbreak of bird flu in dairy cows, a fourth case of H5N1 avian flu has been confirmed in another dairy worker, U.S. health officials reported Wednesday. The latest case was reported in Colorado, the U.S.

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Moon 'swirls' could be magnetized by unseen magmas

Science Daily: Pharmacology News

Mysterious, light-colored swirls on Moon's surface could be rocks magnetized by magma activity underground, laboratory experiments confirm.

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Gratitude May Bring Longer Life

Drugs.com

WEDNESDAY, July 3, 2024 -- People who are grateful for what they have tend to live longer, a new study reports.Older women who scored highest on a questionnaire measuring gratitude had a 9% lower risk of premature death from any cause, compared to.

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[Podcast] What if You Didn’t Need People To Make Your Technology Work?

Perficient: Drug Development

In this episode of “What If? So What?” Jim talks with Bradie Speller who shares insights from his extensive career, tracing the arc of technological evolution from the dawn of personal computing to today’s high-tech environments. Bradie discusses his early experiences at Mars Group in the 1980s, where he first encountered the transformative power of the IBM PC.

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Just a Few Surgeries Make Up Most Post-Op Opioid Prescriptions

Drugs.com

WEDNESDAY, July 3, 2024 -- Opioid addiction often starts with a prescription for post-surgery pain relief, and two new studies identify a handful of procedures that account for large shares of those prescriptions.The findings were published.

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Beacon raises $170M for eye gene therapy; J&J confirms Carvykti survival benefit

BioPharma Drive: Drug Pricing

Forbion led the startup’s Series B round. Elsewhere, Vertex got an FDA decision date for its “vanza triple” and Dupixent won a marketing green light in Europe for COPD.

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Mediterranean Diet Ups Survival Odds After Cancer

Drugs.com

WEDNESDAY, July 3, 2024 -- The Mediterranean diet can help cancer survivors maintain their heart health and live longer, a new study says.Cancer patients whose eating patterns stuck closely to the Mediterranean diet tended to live longer and have a.

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What’s Now, New, Next in D2C for Manufacturers and Distributors?

Perficient: Drug Development

I was given the opportunity to partner with my colleague David Stallsmith to present at B2B Connect in San Diego, CA. We were thrilled to participate in this invite-only conference and host our session, “How to Prioritize Your Direct-to-Consumer (D2C) Capabilities: What Should I Do Now vs Next?” We summarized why D2C is important to many companies during our workshop and discussed the latest trends.

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Facial Temperatures Might Help Docs Diagnose Diabetes, Fatty Liver Disease

Drugs.com

WEDNESDAY, July 3, 2024 -- Screening for chronic illnesses like diabetes or fatty liver disease could one day be as simple as checking the temperature of your nose, eyes or cheeks.The temperature of different parts of the face are associated with.

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Can Chemistry, Manufacturing, and Controls Consulting Pave the Way for New Tech?

DS in Pharmatics

Developing new pharmaceutical technologies and drugs is a complex and multifaceted process. A critical component that can determine a new drug's success or failure is the Chemistry, Manufacturing, and Controls (CMC) strategy.

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Which pharmaceutical drugs have the most drug patents in Norway?

Drug Patent Watch

This chart shows the drugs with the most patents in Norway. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

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Evidence supports redosing with an in vivo CRISPR-based therapy

Drug Discovery World

Intellia Therapeutics has shared the first-ever clinical data demonstrating the potential for redosing with an investigational in vivo CRISPR-based therapy. The data from the ongoing Phase I study of NTLA-2001, a single-dose treatment in development for transthyretin (ATTR) amyloidosis, were presented at the Peripheral Nerve Society Annual Meeting.

Therapies 147
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Gene therapy halts progression of rare genetic condition

Drug Discovery World

The findings from a single-patient gene therapy trial in Canada show promise in halting the progression of spastic paraplegia type 50 (SPG50). SPG50 is an ultra-rare progressive neurodegenerative disorder that causes developmental delays, speech impairment, seizures, progressive paralysis of all four limbs, and is typically fatal by adulthood. Approximately 80 children around the world are affected by the condition.

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