Tue.Feb 13, 2024

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A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease

Chemical Biology and Drug Design

Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions. Although there is currently no successful pharmacotherapy for AD, and researchers are continuously exploring the various pathogenesis of AD to develop potential therapeutic drugs. Abstract Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions.

Disease 100
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Scientists Develop Sensor That Tests Saliva for Breast Cancer

Drugs.com

TUESDAY, Feb. 13, 2024 -- Mammograms are a lifesaving misery for middle-aged women, but a new tool could make getting a breast cancer screening as easy as spitting.Literally.A new hand-held biosensor can detect breast cancer biomarkers from a tiny.

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Scaling Phage Therapy

Codon

Tom Ireland writes about the companies and technologies that are reimagining phage therapy. Read it on our website here. Illustration by David S. Goodsell, RCSB Protein Data Bank and Scripps Research. doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of u

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Great apes playfully tease each other

Science Daily: Pharmacology News

Babies playfully tease others as young as eight months of age. Since language is not required for this behavior, similar kinds of playful teasing might be present in non-human animals. Now cognitive biologists and primatologists have documented playful teasing in four species of great apes. Like joking behavior in humans, ape teasing is provocative, persistent, and includes elements of surprise and play.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Syphilis Rates Among Pregnant Women Have Tripled, CDC Data Shows

Drugs.com

TUESDAY, Feb. 13, 2024 -- Maternal syphilis rates have tripled in recent years, putting thousands of newborns at risk for infection, a new U.S. government report shows.

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Microservices Architectural Design by using Spring Boot

Perficient: Drug Development

What is Microservices Architecture? Microservices Architecture Software development follows an architectural and organizational approach where small independent services communicate with each other through well-defined APIs. Overview of Microservices Architecture Microservices architecture provides a set of rules and guidelines to develop a project as a set of loosely coupled/de-coupled services, and this can be implemented using Spring Boot + Spring Cloud + Netflix and many other tools.

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Helping a Loved One With Dementia Enjoy Valentine's Day

Drugs.com

TUESDAY, Feb. 13, 2024 -- When a loved one has dementia, Valentine's Day can be bittersweet."When dementia enters someone's life, it can change many things, including the dynamic of their relationships," said Jennifer Reeder, director of.

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Are you depressed? Scents might help

Science Daily: Pharmacology News

Smelling a familiar scent can help depressed individuals recall specific autobiographical memories and potentially assist in their recovery.

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A Quarter of Americans Breathe 'Unhealthy Air,' Report Shows

Drugs.com

TUESDAY, Feb. 13, 2024 -- Few can forget the haunting images of New York City bathed in a thick orange smog after smoke from Canadian wildfires swept southward last summer.Now, a new report from the First Street Foundation suggests these alarming.

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Two GV partners on biotech’s reset and building their next drug startups

BioPharma Drive: Drug Pricing

Newly named partner Anthony Philippakis and managing partner Krishna Yeshwant spoke with BioPharma Dive about biotech’s newfound optimism and their investing “North Star.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Blood Test to Predict Schizophrenia Shows Promise

Drugs.com

TUESDAY, Feb. 13, 2024 — Researchers say they have developed a blood test for schizophrenia.More than 3 million people in the United States have schizophrenia, a disorder marked by hallucinations and delusions, or a related psychotic.

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Neural prosthetic device can help humans restore memory

Science Daily: Pharmacology News

A team of scientists have demonstrated the first successful use of a neural prosthetic device to recall specific memories.

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Salt Substitutes Help Prevent High Blood Pressure

Drugs.com

TUESDAY, Feb. 13, 2024 -- Replacing regular salt with a salt substitute can reduce high blood pressure in older adults, a new study has found.Older adults who use a salt substitute are 40% less likely to develop high blood pressure compared to.

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Pediatric sickle cell disease team uses pain screening to improve care

SCIENMAG: Medicine & Health

CLEVELAND — A recent study from researchers at University Hospitals (UH) Connor Whole Health and UH Rainbow Babies & Children’s Hospital describes a quality improvement project where pain screening procedures were embedded within an outpatient pediatric sickle cell disease (SCD) clinic.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Research With a Bang: Science Reveals How Loud Noise Damages Hearing

Drugs.com

TUESDAY, Feb. 13, 2024 -- Preventing noise-related hearing loss from a loud concert, a banging jackhammer or a rifle blast could be as simple as managing levels of zinc within the inner ear, a new study reports.Such hearing loss stems from cellular.

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BioAge raises $170M to back Phase 2-ready obesity drug

BioPharma Drive: Drug Pricing

BioAge’s Series D will fund a study combining its medicine with Eli Lilly’s Zepbound, a strategy the company hopes could help people lose weight while maintaining muscle mass.

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Pregnancy Complications May Harm Child's Heart Health Long-Term

Drugs.com

TUESDAY, Feb. 13 -- Two of the most common pregnancy complications for women, high blood pressure and gestational diabetes, could jeopardize the future heart health of their children, a new study suggests. Researchers found that the children.

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Hand-held biosensor makes breast cancer screening fast, affordable, and accurate

Science Daily: Pharmacology News

Researchers report successful results from a hand-held breast cancer screening device that can detect breast cancer biomarkers from a tiny sample of saliva. Their design uses common components, such as widely available glucose testing strips and the open-source hardware-software platform Arduino. A saliva sample is placed on the paper strip, which has been treated with specific antibodies that interact with the targeted cancer biomarkers.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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One in 10 Pregnant Women With COVID Will Develop Long COVID

Drugs.com

TUESDAY, Feb. 13, 2024 -- Nearly 1 in every 10 women infected with COVID during pregnancy will go on to develop long COVID, a new study says.A little more than 9% of pregnant women developed long COVID six or more months after their initial.

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Predicting Adverse Reactions to Monoclonal Antibody Drugs

addgene Blog

Monoclonal antibody drugs are popular therapeutics for a plethora of disease conditions, from cancer to autoimmune disorders. Antibodies administered as drugs are still immunogenic, meaning that they elicit an immune response from the body. Several factors contribute to the immunogenicity of a drug including the product origin; purity, mechanism, and stability; and sequence of biologic product, mode of administration, and dose (Lu et.al., 2020).

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Quality of EMS Care Across the Country Varies Widely

Drugs.com

TUESDAY, Feb. 13, 2024 -- The care you receive in a medical emergency may hinge strongly on where you are when you need it.That's a key takeaway from a comprehensive review of the nation's emergency medical service (EMS) systems by researchers at.

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Virginia Tech researchers discover that blocking an essential nutrient inhibits malaria parasite growth

SCIENMAG: Medicine & Health

Living organisms often create what is needed for life from scratch. Credit: Photo by Max Esterhuizen for Virginia Tech. Living organisms often create what is needed for life from scratch. For humans, this process means the creation of most essential compounds needed to survive.

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Avoiding Meat Can Help Men Cope With Prostate Cancer Treatments

Drugs.com

TUESDAY, Feb. 13, 2024 -- The red meat diet associated with masculinity could be the worst thing for men dealing with prostate cancer, a new study says.Prostate cancer patients who limit meat and dairy but eat lots of plant-based foods tend to.

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Kalvista pill succeeds in late-stage study for rare swelling disorder

BioPharma Drive: Drug Pricing

The biotech's drug quickly alleviated symptoms of the swelling attacks associated with hereditary angioedema, supporting the idea it could be an oral alternative to existing medicines.

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Treatment options for corneal epithelial defects

Antidote

In the human eye, the cornea's function is to refract light onto the lens and retina to maintain vision function — but this role is dependent on the corneal epithelium’s ability to renew itself continually. The corneal epithelium provides a barrier to protect the interior of the cornea from damage, but when it becomes injured, this function becomes impaired.

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Road features that predict crash sites identified in new machine-learning model

Science Daily: Pharmacology News

Issues such as abrupt changes in speed limits and incomplete lane markings are among the most influential factors that can predict road crashes, finds new research. The study then used machine learning to predict which roads may be the most dangerous based on these features.

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Strategies to Overcome Limited Patient Population Challenges in Rare Disease Studies

Cytel

Written by Boaz N. Adler, MPA, Director, Global Product Engagement, and Valeria Mazzanti, MPH, Associate Director, Customer Success Rare disease studies come with their own unique challenges, particularly limited patient populations. However, there are a number of adaptive clinical trial design strategies that can be used to mitigate the challenge of hard-to-recruit patient populations and associated trial risks.

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ADC startup ProfoundBio, led by Seagen veterans, raises $112M

BioPharma Drive: Drug Pricing

The Series B round will fund development of antibody-drug conjugates now in clinical testing, among them a rival to AbbVie’s ovarian cancer drug Elahere.

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Dr. Jeanne Lackamp to lead university hospitals’ behavioral health efforts

SCIENMAG: Medicine & Health

CLEVELAND – Jeanne Lackamp, MD, DFAPA, FACLP, has been selected to serve as Chair of Department of Psychiatry, Psychiatrist in Chief for University Hospitals (UH), and Director of the UH Behavioral Health Institute.

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Automating the Survey Invitations with Flows

Perficient: Drug Development

Hello Trailblazers! With Salesforce Survey, gaining valuable insights and feedback from your audience becomes a seamless and insightful experience. In this blog post, we’ll learn how we can Automate Survey Invitations with the help of Flows. This innovative capability empowers you to integrate surveys into your Salesforce Flows effortlessly, ensuring timely and targeted feedback collection.

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Which pharmaceutical companies have the most drug patents in Lithuania?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Lithuania. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Lithuania? appeared first on DrugPatentWatch - Make Better Decisions.

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Large Data Volumes: Mitigation Techniques

Perficient: Drug Development

Aloha Trailblazers! In the last blog, we discussed Large Data Volume in Salesforce and its impact on our business and efficiency. Continuing from that, let’s now look at different ways to handle the challenges of dealing with a large amount of data. Large Data Volume Mitigation Techniques When looking at Large Data Volumes below are the mitigation techniques Indexing Skinny Tables Divisioning What is Data Indexing?

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New patent expiration for Pf Prism drug ZMAX

Drug Patent Watch

Annual Drug Patent Expirations for ZMAX Zmax is a drug marketed by Pf Prism Cv and is included in one NDA. There are two patents protecting this drug. This drug… The post New patent expiration for Pf Prism drug ZMAX appeared first on DrugPatentWatch - Make Better Decisions.

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