Fri.Feb 02, 2024

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Scammed! Animals 'led by the nose' to leave plants alone

Science Daily: Pharmacology News

Fake news works for wallabies and elephants. Herbivores can cause substantial damage to crops or endangered or protected plants, with traditional methods to deter foraging lethal, expensive or ineffective. Biologists are now using aromas from plants naturally repellent with remarkable success to deter the animals.

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Could natural terpenes be an alternative for the treatment of neglected tropical diseases?

Chemical Biology and Drug Design

Terpenes are compounds that inhibit the growth of Leishmania spp, Schistosoma spp, and Echinococcus spp, cause changes in parasite ultrastructure, inhibit enzyme activity, and modulate the immune response. Their use in combination therapy decreases the concentration of the reference drug used. Abstract Existing chemotherapy for neglected tropical diseases (NTDs) can often be toxic and ineffective, highlighting the necessity for new treatments.

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An overview of endometrial cancer

Antidote

Endometrial cancer, also known as endometrial carcinoma or uterine cancer , is a condition that approximately 66,000 individuals are diagnosed with annually, and instances rise roughly 2% in the United States each year. Because it is often caught early, a person’s prognosis is typically good — but it is still a disheartening diagnosis that significantly impacts the lives of those who experience it.

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How 3D human tissue models are transforming drug discovery

Drug Target Review

What specific limitations in mirroring diseases in humans are commonly observed when using animal models for preclinical research? The standard animal model paradigm for drug discovery does not translate well to effects in patients for a number of reasons. For one, animal models require disease induction, either genetic or surgical modifications, diet, or application of a disease inducing agent or toxin, yet this is nothing like how diseases progress in humans, which typically take years to deve

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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FDA Can’t Reclassify Its Way Out of Reviewing 100,000 LDT Submissions

FDA Law Blog: Biosimilars

By Steven J. Gonzalez & Allyson B. Mullen — On January 31, 2024, FDA announced its intent to initiate the reclassification process for most in vitro diagnostic (IVD) products that are currently class III (high risk) into class II (moderate risk). Most of these reclassified tests will supposedly be infectious disease and companion diagnostic IVDs.

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Biotech in 2024: Opportunities, Trends & Challenges

Fierce BioTech

The annual J.P. Morgan Healthcare Conference is a key date in the industry calendar that is always met with reflection and anticipation. | In this exclusive interview, ICON Biotech President Chris Smyth paints a picture of the operating environment facing biotechs in 2024.

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More Trending

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Brain drug developer Alto Neuroscience prices $129M IPO

BioPharma Drive: Drug Pricing

The California biotech is the third this year to go public, following stock offerings from CG Oncology and Arrivent Biopharma.

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Why Some Folks Get COVID and Others Never Do

Drugs.com

FRIDAY, Feb. 2, 2024 (HealthDay News) -- Everyone knows someone who gets COVID-19 repeatedly, and they probably also have that annoying friend who's never had the illness. What gives? According to new research, over the long-term it's probably.

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Gene-editing offers hope for people with hereditary disorder

Science Daily: Pharmacology News

A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher.

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Neighborhood Gyms Can Be a Lifeline for Stroke Survivors

Drugs.com

FRIDAY, Feb. 2, 2024 -- Exercise is crucial to recovering from a stroke, helping victims regain lost physical and mental function.And stroke survivors are more likely to remain physically active -- or even exercise more than before -- if they have.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation

Covalent Modifiers

Seong Ho Hong, Anand Divakaran, Akane Osa, Oscar W. Huang, Ingrid E. Wertz, and Daniel K. Nomura ACS Chemical Biology 2024 DOI: [link] Targeted protein degradation with proteolysis targeting chimeras (PROTACs) is a powerful therapeutic modality for eliminating disease-causing proteins through targeted ubiquitination and proteasome-mediated degradation.

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'Whole Blood' Transfusions Might Save More Lives

Drugs.com

FRIDAY, Feb. 2, 2024 -- Patients who are bleeding out have a better chance of surviving if they’re given whole blood transfusions, a new study shows.Traditionally, patients with significant bleeding are given transfusions of specific blood.

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Why are people climate change deniers?

Science Daily: Pharmacology News

Do climate change deniers bend the facts to avoid having to modify their environmentally harmful behavior? Researchers ran an online experiment involving 4,000 US adults, and found no evidence to support this idea. The authors of the study were themselves surprised by the results. Whether they are good or bad news for the fight against global heating remains to be seen.

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CDC Warns That 'Gas Station Heroin' May Contain Synthetic Pot

Drugs.com

FRIDAY, Feb. 2, 2024 -- It's known by the street name "gas station heroin," but a new government report finds the highly addictive supplement Neptune's Fix may also contain synthetic pot.The product has already been linked to seizures, brain.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New Report: How GoodRx Improves the Economics of Healthcare

Drug Channels

Today’s guest post comes from Divya Iyer, SVP of Go-to-Market Strategy at GoodRx. Divya shares highlights from GoodRx’s new research report: The GoodRx Effect: How GoodRx Improves the Economics of Healthcare. She highlights how GoodRx’s integrated pharma copay cards help to improve medication access, therapy adherence, and overall health outcomes. Click here to download the full report and learn more about partnering with GoodRx to drive patient access for your brand.

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Women Are More Prone to Autoimmune Disorders Than Men, and Scientists May Know Why

Drugs.com

FRIDAY, Feb. 2, 2024 -- Women are much more prone than men to develop autoimmune diseases like rheumatoid arthritis, multiple sclerosis and lupus.Now, researchers have come up with a potential explanation for that -- one that's rooted in genes that.

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Gene editing precisely repairs immune cells

SCIENMAG: Medicine & Health

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in “Science Immunology.” Credit: Elijah D. Lowenstein and Xun Li, K.

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Ancient Greeks Seldom Hit by Dementia, Suggesting It's a Modern Malady

Drugs.com

FRIDAY, Feb. 2, 2024 -- Dementia seems like a disorder that’s always haunted the human race.But this form of severe memory loss is actually a modern malady, if classical Greek and Roman physicians are to be believed.A new analysis of ancient.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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HMSOM researchers: Data shows clinical trials becoming more inclusive

SCIENMAG: Medicine & Health

Clinical trials and medical research have been historically lacking in diversity among all groups. Credit: Hackensack Meridian Health Clinical trials and medical research have been historically lacking in diversity among all groups.

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Latest COVID Vaccine Shields Against Current Dominant Strain

Drugs.com

FRIDAY, Feb. 2, 2024 -- In some good news for those folks who rolled up their sleeves for the latest COVID vaccine last fall, new government research shows the updated shots halve the chances of getting a symptomatic infection.“Everything from.

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Clinique partners with Icahn School of Medicine at Mount Sinai to establish the Mount Sinai-Clinique Healthy Skin Dermatology Center

SCIENMAG: Medicine & Health

New York, NY (February 2, 2024) – Clinique and Icahn School of Medicine at Mount Sinai today announced a philanthropic partnership to establish the Mount Sinai-Clinique Healthy Skin Dermatology Center.

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Dermatologists' Group Offers Latest Guidance on Acne

Drugs.com

FRIDAY, Feb. 2, 2024 -- It might take a combination of treatments to rein in problem acne in teens and adults, updated guidelines from the American Academy of Dermatology (AAD) suggest.The guidelines on the all-too-common condition (acne affects.

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Welch Foundation supports Johnson-Winters’ TB research

SCIENMAG: Medicine & Health

With a $300,000 grant, the Welch Foundation is supporting University of Texas at Arlington research into why some types of Mycobacterium tuberculosis (Mtb), the bacteria that causes the lung disease tuberculosis (TB), do not respond to treatments.

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Scientists Spot Brain Cells That Prepare You to Speak

Drugs.com

FRIDAY, Feb. 2, 2024 -- Advanced brain recording techniques have revealed how neurons in the human brain work together to produce speech.The recordings provide a detailed map of how people think about what words they want to say and then speak them.

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Neptune-like exoplanets can be cloudy or clear

Science Daily: Pharmacology News

Astronomers have shown new atmospheric detail in a set of 15 exoplanets similar to Neptune. While none could support humanity, a better understanding of their behavior might help us to understand why we don't have a small Neptune, while most solar systems seem to feature a planet of this class.

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Stroke Recovery Could Depend on Where You Live

Drugs.com

FRIDAY, Feb. 2, 2024 -- For stroke survivors, the relative affluence of their neighborhood could be a factor in how well and how soon they recover, new research shows.Compared to Americans living in better-off locales, those living in areas plagued.

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Arch, a prolific biotech creator, is raising $3B for startup investing

BioPharma Drive: Drug Pricing

A regulatory filing shows the firm is putting together a new multibillion-dollar fund, roughly two years after raising a similar amount.

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Dental Group Says Lead Aprons No Longer Needed for X-Rays

Drugs.com

FRIDAY, Feb. 2, 2024 -- The heavy lead apron dentists drape over you during dental X-rays may soon be a thing of the past.

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Which pharmaceutical drugs have the most drug patents in Peru?

Drug Patent Watch

This chart shows the drugs with the most patents in Peru. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.… The post Which pharmaceutical drugs have the most drug patents in Peru? appeared first on DrugPatentWatch - Make Better Decisions.

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Americans Have Mixed Feelings on Tech, AI in Health Care: Poll

Drugs.com

FRIDAY, Feb. 2, 2024 -- Americans are cautiously optimistic that AI will be able to improve the health care they receive, a new Cleveland Clinic survey finds.About three out of five Americans believe that AI will lead to better heart care, and.

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New patent for Abbvie drug UBRELVY

Drug Patent Watch

Annual Drug Patent Expirations for UBRELVY Ubrelvy is a drug marketed by Abbvie and is included in one NDA. It is available from one supplier. There are six patents protecting… The post New patent for Abbvie drug UBRELVY appeared first on DrugPatentWatch - Make Better Decisions.

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What we expect the EPA to do in February

Agency IQ

In this returning feature, AgencyIQ looks at public data to determine what the Environmental Protection Agency is planning to do in the month ahead, including deadlines, meetings, events, planned regulations, comment periods, and more. Fill out the form to read the full article.

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New patent for Mayne Pharma drug ANNOVERA

Drug Patent Watch

Annual Drug Patent Expirations for ANNOVERA Annovera is a drug marketed by Mayne Pharma and is included in one NDA. It is available from one supplier. There are seven patents… The post New patent for Mayne Pharma drug ANNOVERA appeared first on DrugPatentWatch - Make Better Decisions.

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