Wed.Jun 26, 2024

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First case of Down syndrome in Neanderthals documented in new study

Science Daily: Pharmacology News

A new study documents the first case of Down syndrome in Neanderthals and reveals that they were capable of providing altruistic care and support for a vulnerable member of their social group.

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Women with a common hormonal disorder have few good treatment options. Could GLP-1 drugs help?

BioPharma Drive: Drug Pricing

Obesity drugs like Wegovy are proving useful in many other diseases. Polycystic ovary syndrome, a chronic condition that can cause infertility, may be one.

Treatment 122
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Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Science Daily: Pharmacology News

Engineers have developed a pill that releases microscopic robots, or microrobots, into the colon to treat inflammatory bowel disease (IBD). The experimental treatment, given orally, has shown success in mice. It significantly reduced IBD symptoms and promoted the healing of damaged colon tissue without causing toxic side effects.

Disease 122
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First-of-its-kind Intellia data suggest CRISPR drug could be given more than once

BioPharma Drive: Drug Pricing

The findings provide early proof that multiple doses of a gene editing medicine can be safely administered with additive effects, overcoming a key constraint of the complex therapies.

Therapies 111
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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How do our memories last a lifetime? New study offers a biological explanation

Science Daily: Pharmacology News

A new study by a team of international researchers has uncovered a biological explanation for long-term memories. It centers on the discovery of the role of a molecule, KIBRA, that serves as a 'glue' to other molecules, thereby solidifying memory formation.

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CDC Warns of Rising Threat of Dengue This Summer

Drugs.com

WEDNESDAY, June 26, 2024 -- A federal health advisory warning of a heightened risk of dengue fever infections in the United States was issued on Tuesday.The alert was prompted by an unexpectedly high number of dengue fever cases reported across the.

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Drug-Resistant Fungi Found in Commercial Flower Bulbs, Compost, Soil

Drugs.com

WEDNESDAY, June 26, 2024 -- A tough-to-treat, drug-resistant fungal infection may be as close as your local garden center, new research shows.Investigators at the University of Georgia (UGA) in Athens found high levels of multidrug-resistant fungi.

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Playing youth sports linked to better mental health in adults

Science Daily: Pharmacology News

Adults who continuously played organized sports through their youth have fewer symptoms of anxiety and depression than those who never played or those who dropped out, a new study finds. And those who dropped out of sports had poorer mental health than those who never played at all.

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Exposure to Plastics Chemical BPA May Raise Diabetes Risk

Drugs.com

WEDNESDAY, June 26, 2024 -- A common plastics chemical might increase a person’s risk of diabetes, a new study warns.People fed small doses of Bisphonol A (BPA) developed significantly worse insulin sensitivity within a four-day period, researchers.

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Almonds, pottery, wood help date famed Kyrenia shipwreck

Science Daily: Pharmacology News

Researchers have identified the likeliest timeline of the famous Hellenistic-era Kyrenia shipwreck, discovered and recovered off the north coast of Cyprus in the 1960s.

Research 103
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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PreSTAR: a New Template for Pre Submissions and 513(g) Requests for Information

FDA Law Blog: Biosimilars

By Lisa M. Baumhardt, Senior Medical Device Regulation Expert & Adrienne R. Lenz, Principal Medical Device Regulation Expert — FDA recently released a new eSTAR template for device pre-submissions and 513(g) Requests for Information, referred to as PreSTAR. A pre-submission provides the submitter an opportunity to obtain FDA feedback prior to a planned medical device premarket submission.

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Cortisol Might Play Role in Tough-to-Treat Diabetes

Drugs.com

WEDNESDAY, June 26, 2024 -- The stress hormone cortisol appears to play a role in tough-to-treat type 2 diabetes, a new study finds.About 1 in 4 people (24%) with tough-to-treat type 2 diabetes have elevated cortisol levels, researchers.

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Iceland's volcano eruptions may last decades

Science Daily: Pharmacology News

Scientists predict from geochemical data that Iceland is entering a new volcanic era that will last for decades, possibly centuries. Under an hour's drive from the country's capital city, the ongoing eruptions pose considerable risks for economic disruption, and they leave evacuated communities uncertain of a possible return.

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New Insights Into How Microbiome Helps Cause Type 2 Diabetes

Drugs.com

WEDNESDAY, June 26, 2024 -- A person’s gut microbiome appears to increase their risk of developing type 2 diabetes, researchers claim.Specific strains of gut microbes are more commonly found in people with type 2 diabetes, and these strains seem to.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Shocked quartz reveals evidence of historical cosmic airburst

Science Daily: Pharmacology News

Researchers continue to expand the case for the Younger Dryas Impact hypothesis. The idea proposes that a fragmented comet smashed into the Earth's atmosphere 12,800 years ago, causing a widespread climatic shift that, among other things, led to the abrupt reversal of the Earth's warming trend and into an anomalous near-glacial period called the Younger Dryas.

Research 100
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Anxiety Tied to Doubling of Parkinson's Risk

Drugs.com

WEDNESDAY, June 26, 2024 -- Anxiety could be an early warning sign of Parkinson's disease, a new study finds.People with anxiety have at least double the risk of developing Parkinson’s compared to those without the mood disorder, results s.

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A Guide to CDISC ADaM Standards in 2024

Quanticate

Clinical Data Interchange Standards Consortium (CDISC) defines and manages industry level data standards that are widely used during the analysis, reporting and the regulatory submission of clinical data. There are three key CDISC standards which are vital for efficient data processing and analysis of clinical trial data known as CDASH , SDTM and ADaM.

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Could Mom's Smartphone Use Affect Baby's Language Development?

Drugs.com

WEDNESDAY, June 26, 2024 -- Mothers tend to speak less to infants when they’re on their smartphones, a new study finds.Moms talked 16% less to their babies when they were fiddling with their phone, researchers found.Shorter 1- to 2-minute intervals.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Future risk of coral bleaching set to intensify globally

Science Daily: Pharmacology News

Researchers have projected future marine heatwaves will cause coral reefs to be at severe risk of bleaching for longer periods than previously seen.

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Study Finds Multivitamins Won't Help You Live Longer

Drugs.com

WEDNESDAY, June 26, 2024 -- A full third of American adults take multivitamins, despite prior studies suggesting they do little to boost health.Now, a study involving almost 400,000 people finds zero benefit from multivitamin use in helping folks.

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Researchers address ocean paradox with 55 gallons of fluorescent dye

Science Daily: Pharmacology News

Researchers have directly measured cold, deep water upwelling via turbulent mixing along the slope of a submarine canyon in the Atlantic Ocean.

Research 102
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Novo nixes trial of blood pressure drug it bought in deal worth $1.3B

BioPharma Drive: Drug Pricing

The failure of a Phase 3 trial led the Wegovy maker to take an accounting charge that will hit its operating profit growth this year.

Trials 96
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Solar technology: Innovative light-harvesting system works very efficiently

Science Daily: Pharmacology News

Researchers are reporting progress on the road to more efficient utilization of solar energy: They have developed an innovative light-harvesting system.

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What is the market forecast for Ozempic?

Drug Patent Watch

This is an example from the DrugPatentWatch AI Research Assistant, which is available with DrugPatentWatch subscriptions. The DrugPatentWatch AI Research Assistantuses sophisticated AI algorithms to understand and process your questions, delivering precise answers. It goes beyond simple keyword matching, comprehending the intent and context of questions to provide meaningful and relevant responses.

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Simple new process stores CO2 in concrete without compromising strength

Science Daily: Pharmacology News

By using carbonated -- rather than still -- water during the concrete manufacturing process, a team of engineers has discovered a new way to store carbon dioxide (CO2) in the ubiquitous construction material.

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The Double-Edged Sword: Opportunities and Challenges in China’s Patent Litigation System

Drug Patent Watch

Introduction In the rapidly evolving landscape of pharmaceutical patent disputes in China, injunctive relief has emerged as a critical tool for patent holders. This legal remedy, which aims to halt infringement activities swiftly, plays a pivotal role in protecting intellectual property (IP) rights and fostering innovation.

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Precision instrument bolsters efforts to find elusive dark energy

Science Daily: Pharmacology News

Dark energy -- a mysterious force pushing the universe apart at an ever-increasing rate -- was discovered 26 years ago, and ever since, scientists have been searching for a new and exotic particle causing the expansion. Physicists combined an optical lattice with an atom interferometer to hold atoms in place for up to 70 seconds -- a record for an atom interferometer -- allowing them to more precisely test for deviations from the accepted theory of gravity that could be caused by dark energy par

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Brain Health

Broad Institute

Brain Health By Maria Nemchuk June 26, 2024 Breadcrumb Home Brain Health The Program in Brain Health at the Broad Institute is characterizing the genetic and mechanistic basis of health and disease in the human brain. Our goal is to turn emerging biological findings into new diagnostic and therapeutic approaches that could benefit the hundreds of millions of people around the world living with these conditions.

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For healthy adults, taking multivitamins daily is not associated with a lower risk of early death

Science Daily: Pharmacology News

A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin use and lower risk of early death.

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The Opportunities and Challenges of Improving Health Equity with Expert Daniel Perez

H1 Blog

The pursuit of health equity has many obstacles. Achieving a state where everyone has fair and equitable access to healthcare is a massive endeavor with many stakeholders. It requires addressing historical and modern injustices associated with economic and social factors to eliminate preventable health disparities. With such a complex model, understanding all the pieces requires an expert perspective.

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Pillars of creation star in new visualization from NASA's Hubble and Webb telescopes

Science Daily: Pharmacology News

Made famous in 1995 by NASA's Hubble Space Telescope, the Pillars of Creation in the heart of the Eagle Nebula have captured imaginations worldwide with their arresting, ethereal beauty. Now, NASA has released a new 3D visualization of these towering celestial structures using data from NASA's Hubble and James Webb space telescopes. This is the most comprehensive and detailed multiwavelength movie yet of these star-birthing clouds.

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Zealand hauls in $1B off obesity drug data; Curie.bio zeroes in on Series A’s

BioPharma Drive: Drug Pricing

Zealand capitalized on a stock surge following the release of early study results. Elsewhere, U.S. regulators rejected an AbbVie medicine and another well-funded AI drug discovery startup emerged.

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Mechanical computer relies on kirigami cubes, not electronics

Science Daily: Pharmacology News

Researchers have developed a kirigami-inspired mechanical computer that uses a complex structure of rigid, interconnected polymer cubes to store, retrieve and erase data without relying on electronic components. The system also includes a reversible feature that allows users to control when data editing is permitted and when data should be locked in place.