Tue.Oct 01, 2024

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Stronger together: miniature robots in convoy for endoscopic surgery

Science Daily: Pharmacology News

Miniature robots on the millimeter scale often lack the strength to transport instruments for endoscopic microsurgery through the body. Scientists are now combining several millimeter-sized TrainBots into one unit and equipping them with improved 'feet'. For the first time, the team was able to perform an electric surgical procedure on a bile duct obstruction experimentally with a robotic convoy.

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Kailera Therapeutics emerges from stealth with $400M for obesity drugs

BioPharma Drive: Drug Pricing

The company’s official launch comes five months after major investors such as Atlas Venture and Bain Capital filed a Shanghai stock exchange filing for a biotech named “Hercules CM NewCo.

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Research in 4 continents links outdoor air pollution to differences in children's brains

Science Daily: Pharmacology News

A research team systematically analyzed 40 empirical studies, the majority of which had found that outdoor air pollution is associated with differences in children's brains. These differences include volumes of white matter, which is associated with cognitive function, connections throughout the brain and even early markers for Alzheimer's.

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The top biopharma conferences in 2025

BioPharma Drive: Drug Pricing

Medical meetings often feature important clinical trial results, making them barometers of biotech and pharma companies' research progress. Here’s a list of conferences to watch in 2025.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Airborne plastic chemical levels shock researchers

Science Daily: Pharmacology News

A new study documents how Southern Californians are chronically being exposed to toxic airborne chemicals called plasticizers, including one that's been banned from children's items and beauty products.

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GLP-1 Weight-Loss Meds Could Interfere With Endoscopy, Colonoscopy

Drugs.com

TUESDAY, Oct. 1, 2024 -- Food left in the stomach or stool left in the bowel can impede a doctor's ability to successfully perform an endoscopy or colonoscopy.Now, research finds this scenario is more likely if the patient is taking popular new.

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California Bans 6 Artificial Dyes in Foods Served at Public Schools

Drugs.com

TUESDAY, Oct. 1, 2024 -- A new law just passed in California makes it the first state to tell public schools they may no longer serve foods that contain six artificial dyes linked to health and behavior problems among children.Gov. Gavin Newsom.

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Calculating the Regulatory Review Period for Patent Term Extension: A Comprehensive Guide

Drug Patent Watch

In the complex world of intellectual property and pharmaceutical development, understanding the intricacies of patent term extension (PTE) is crucial for innovators and businesses alike. One of the most critical aspects of PTE is calculating the regulatory review period, which can significantly impact the lifespan and profitability of a patented product.

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Scientists discover planet orbiting closest single star to our Sun

Science Daily: Pharmacology News

Astronomers have discovered an exoplanet orbiting Barnard's star, the closest single star to our Sun. On this newly discovered exoplanet, which has at least half the mass of Venus, a year lasts just over three Earth days. The team's observations also hint at the existence of three more exoplanet candidates, in various orbits around the star.

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When Do Drug Patents Expire: Understanding the Lifecycle of Pharmaceutical Innovations

Drug Patent Watch

Have you ever wondered why some medications seem to cost an arm and a leg, while others are surprisingly affordable? The answer often lies in the complex world of drug patents. Let’s dive into the fascinating realm of pharmaceutical intellectual property and explore when drug patents expire. Drug patents are a crucial aspect of the pharmaceutical industry.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Carbon dioxide and hydrogen peroxide on Pluto's moon Charon

Science Daily: Pharmacology News

Astronomers have detected carbon dioxide and hydrogen peroxide on the frozen surface of Pluto's largest moon, Charon, using observations from the James Webb Space Telescope. These discoveries add to Charon's known chemical inventory, previously identified by ground- and space-based observations, that includes water ice, ammonia-bearing species and the organic materials responsible for Charon's gray and red coloration.

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COVID Shot Lowers Your Odds for COVID-linked Heart Trouble

Drugs.com

TUESDAY, Oct. 1, 2024 -- While rare, heart-related side effects sometimes follow a COVID-19 vaccine shot, new research shows that's more than offset by heart-healthy benefits.Folks who are fully vaccinated are significantly less likely to develop.

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Using antimatter to detect nuclear radiation

Science Daily: Pharmacology News

Discerning whether a nuclear reactor is being used to also create material for nuclear weapons is difficult, but capturing and analyzing antimatter particles has shown promise for monitoring what specific nuclear reactor operations are occurring, even from hundreds of miles away. Researchers have developed a detector that exploits Cherenkov radiation, sensing antineutrinos and characterizing their energy profiles from miles away as a way of monitoring activity at nuclear reactors.

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How are prescription drug prices determined?

Drug Patent Watch

In the world of healthcare, few topics spark as much debate and confusion as prescription drug pricing. Have you ever wondered why that little pill in your medicine cabinet costs so much? Let’s dive into the intricate world of pharmaceutical economics and uncover the factors that determine the price tags on our prescriptions.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Feet first: AI reveals how infants connect with their world

Science Daily: Pharmacology News

Researchers explored how infants act purposefully by attaching a colorful mobile to their foot and tracking movements with a Vicon 3D motion capture system. The study tested AI's ability to detect changes in infant movement patterns. Findings showed that AI techniques, especially the deep learning model 2D-CapsNet, effectively classified different stages of behavior.

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Outbreak of Ebola-Like Marburg Virus in Rwanda Has Killed 8 People

Drugs.com

TUESDAY, Oct. 1, 2024 -- A rare, highly contagious Ebola-like virus has claimed eight lives in Rwanda, and U.S. health officials are closely monitoring the outbreak.Marburg virus causes a rare hemorrhagic fever that has no authorized vaccine or.

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Climate scientists express their views on possible future climate scenarios in a new study

Science Daily: Pharmacology News

A new survey of climate experts reveals that a majority believes the Earth to be headed for a rise in global temperatures far higher than the 2015 Paris Agreement targets of 1.5 to well-below 2 degrees Celsius. It also shows that two-thirds of respondents believe we may succeed in achieving net zero CO2 emissions during the second half of this century.

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Helene's Aftermath: How to Safely Enter, Clean Flood-Damaged Homes

Drugs.com

TUESDAY, Oct. 1, 2024 -- Following the historic destruction of Hurricane Helene, many Americans must now return to their mangled homes and begin the heartbreaking task of clean-up.After making landfall in Florida near Tallahassee as a ferocious.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Neuroscientists spark shelter-seeking response by reactivating memory circuit

Science Daily: Pharmacology News

Using a sophisticated brain-imaging system, neuroscientists say they have successfully reactivated a specific memory circuit in mice, causing them to seek out shelter when no shelter is actually present.

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Could a Cheek Swab Predict When You Might Die?

Drugs.com

TUESDAY, Oct. 1, 2024 -- A new test called CheekAge, based on a quick swab of cells in the mouth, might someday be used to predict how long a person has to live, developers report.The test tracks what are known as epigenetics: The way in which a.

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Deep brain stimulation instantly improves arm and hand function post-brain injury

Science Daily: Pharmacology News

Deep brain stimulation may provide immediate improvement in arm and hand strength and function weakened by traumatic brain injury or stroke.

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U.S. Breast Cancer Deaths Keep Declining, Though Disparities Remain

Drugs.com

TUESDAY, Oct. 1, 2024 -- While women overall are less likely to die of breast cancer now, some alarming disparities remain, a new American Cancer Society (ACS) analysis warns.Death rates for American Indian and Alaska Native women haven't changed.

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Sourcing the Key Starting Materials (KSMs) for pharmaceutical Active Pharmaceutical Ingredients (APIs)

Drug Patent Watch

To find Key Starting Materials (KSMs) for pharmaceutical Active Pharmaceutical Ingredients (APIs), you can follow these steps: Remember that the availability and sourcing of KSMs can vary depending on the specific API and regulatory requirements in different countries. It’s essential to ensure that any KSMs used in pharmaceutical manufacturing meet the necessary quality and regulatory standards.

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Drug Industry Taking Bigger Role in Clinical Cancer Trials

Drugs.com

TUESDAY, Oct. 1, 2024 -- Clinical trials sponsored by Big Pharma enrolled eight times as many patients as U.S.-government trials did between 2018 and 2022, new research shows.The study -- conducted by researchers at Fred Hutch Cancer Center in.

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5 FDA decisions to watch in the fourth quarter

BioPharma Drive: Drug Pricing

Over the next three months, the agency could approve a rival to a fast-selling Pfizer heart drug, a much-debated lung cancer medicine and an addition to Vertex's dominant cystic fibrosis business.

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Bogus 'Conversion Therapy' Leads to Higher Risk of Mental Illness for LGBT People

Drugs.com

TUESDAY, Oct. 1, 2024 -- Besides being useless in altering a person's sexuality or gender identity, so-called "conversion therapy" or "conversion practice" can greatly raise the odds that an LGBT person experiences mental health issues, new.

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Women in STEM with Gilda Ascione

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? Since I was a child, I always wanted to be a doctor. From a scientific point of view, I liked the possibility of studying and learning about the human body, its vital functions, how it gets sick, and how to treat it. From a human point of view, I have always considered doctors’ work as a sort of mission for the good of others.

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Outpatient CAR-T Cancer Therapy Can Be Safe, Effective

Drugs.com

TUESDAY, Oct. 1, 2024 -- Patients with a fast-spreading blood cancer respond well to outpatient treatment with CAR-T therapy, the largest study examining its use in a community setting has found.CAR-T is shorthand for chimeric antigen receptor.

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IGM lays off staff in autoimmune pivot; Metsera ramps up obesity drug supply

BioPharma Drive: Drug Pricing

IGM is the latest biotech to focus on the potential for T cell engagers to treat inflammatory conditions. Elsewhere, Metsera signed a manufacturing deal and UCB started a first-of-its-kind trial.

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Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells

Covalent Modifiers

Njomen, E., Hayward, R.E., DeMeester, K.E. et al. Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells. Nat. Chem. (2024). [link] Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with broadly reactive probes.

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Vanda-lay Litigation Industries, Inc.: Taking Stock of Vanda Pharmaceuticals, Inc.’s Big Bets on Petitioning and Litigation Against FDA and the Federal Government

FDA Law Blog: Biosimilars

By Kurt R. Karst — If you monitor Regulations.gov dockets and litigation dockets on PACER like we do, then you know that one company name—more than any other over the past several years—pops up: Vanda Pharmaceuticals, Inc. But unlike the fictitious Vandelay Industries of Seinfeld that George Costanza claims to have been interviewed for as a latex salesman, Vanda Pharmaceuticals, Inc.

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Fireside Chat - Racial Disparities in Cancer Research and Outcomes

Broad Institute

Fireside Chat - Racial Disparities in Cancer Research and Outcomes By Rose Circeo October 1, 2024 Breadcrumb Home Fireside Chat - Racial Disparities in Cancer Research and Outcomes Join Equity in Biomedicine and Women At Broad for a fireside chat between Dr. Nyasha Chambwe and our very own Dr. Alicia Martin to discuss Racial Disparities in Cancer Research and Outcomes.

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CVS to lay off 2,900 employees amid reports of strategic review

BioPharma Drive: Drug Pricing

As CVS pursues a massive cost-cutting plan — and reportedly considers a potential breakup of its businesses — the healthcare behemoth has decided to cut 1% of its workforce.

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