Science Daily: Pharmacology News
AUGUST 2, 2024
A new study suggests that Earth's natural forces could substantially reduce Antarctica's impact on rising sea levels, but only if carbon emissions are swiftly reduced in the coming decades. By the same token, if emissions continue on the current trajectory, Antarctic ice loss could lead to more future sea level rise than previously thought.
ASPET
AUGUST 2, 2024
Primaquine and tafenoquine are the only approved drugs that can achieve a radical cure for Plasmodium vivax malaria but are contraindicated in patients who are deficient in glucose 6-phosphate dehydrogenase (G6PDd) due to risk of severe hemolysis from reactive oxygen species (ROS) generated by redox cycling of drug metabolites. 5-hydroxyprimaquine and its quinone-imine cause robust redox cycling in red blood cells (RBCs), but are so labile as to not be detected in blood or urine.
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Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- Two new studies show how eager Americans are to obtain either safe, legitimate versions of Ozempic or counterfeit and potentially dangerous forms of the diabetes/weight-loss drug.One study found U.S. prescriptions and.
ASPET
AUGUST 2, 2024
Warfarin, with its narrow therapeutic range, requires the understanding of various influencing factors for personalized medication. Vascular senescence, marked by vascular stiffening and endothelial dysfunction, has an unclear effect on the efficacy and safety of warfarin. Based on previous studies, we hypothesized that vascular senescence increases the risk of bleeding during warfarin therapy.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
AUGUST 2, 2024
Adaptimmune’s Tecelra is the first TCR cell therapy to reach market and, at $727,000, is also the priciest cellular medicine for cancer in the U.S.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- Mpox cases have soared by 160% in Africa this year, as a lack of both vaccines and treatments hamper efforts to slow the spread of the virus.In a report released by the Africa Centers for Disease Control and Prevention on.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- Too many women don’t know a key warning sign of endometrial cancer, the most common cancer of the female reproductive organs, a new study shows.More than one-third (37%) of women surveyed did not know that postmenopausal b.
Perficient: Drug Development
AUGUST 2, 2024
Imagine a world where your business can effortlessly keep pace with technological advancements and continuously changing customer expectations. The ability to swiftly develop new technology products and applications is crucial to staying competitive. However, relying solely on in-house development capabilities is not always feasible for many organizations.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- Fish oil supplements might help high-risk seniors stave off Alzheimer’s disease, a new study finds.Older people with a higher genetic risk of Alzheimer’s experienced slower breakdown of their brain’s nerve cells if they took.
Science Daily: Pharmacology News
AUGUST 2, 2024
Physicists have discovered two new ways to improve organic semiconductors. They found a way to remove more electrons from the material than previously possible and used unexpected properties in an environment known as the non-equilibrium state, boosting its performance for use in electronic devices.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- Background checks alone might not be enough to reduce shooting deaths in the United States, a new study warns.States that require gun permits, rather than relying solely on universal background checks, have firearm murder.
Quanticate
AUGUST 2, 2024
Real-world evidence (RWE) is changing clinical drug development, bridging the gap between controlled clinical trial environments and the complexities of everyday patient experiences. By using Real-World Data (RWD) from various sources like electronic health records (EHRs), insurance claims, and digital health tools, researchers can gather valuable insights into how drugs work in a wide range of populations.
Science Daily: Pharmacology News
AUGUST 2, 2024
The rising earth beneath the Antarctic Ice Sheet will likely become a major factor in future sea level rise, a new study suggests.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- People can offset hours spent sitting around with minutes of active exercise each week, a new study claims.Folks who are sedentary for eight or more hours daily can lower their overall risk of death – and especially their r.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
AUGUST 2, 2024
The origins of life remain a major mystery. How were complex molecules able to form and remain intact for prolonged periods without disintegrating? A team has demonstrated a mechanism that could have enabled the first RNA molecules to stabilize in the primordial soup. When two RNA strands combine, their stability and lifespan increase significantly.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- Experts have long suspected it, but a new study confirms that folks who vape and smoke tobacco face higher risks for lung cancer than if they'd done either alone.“From a public health perspective, we have always been c.
Science Daily: Pharmacology News
AUGUST 2, 2024
Shifts in the Earth's continental plates that drove long-term changes in sea level set the stage for the evolution of the earliest animals on Earth, a study suggests.
Covalent Modifiers
AUGUST 2, 2024
Victor Hugo Cano Gil and Christopher N. Rowley Digital Discovery , 2024 [link] The identification of protein-reactive electrophilic compounds is critical to the design of new covalent modifier drugs, screening for toxic compounds, and the exclusion of reactive compounds from high throughput screening. In this work, we employ traditional and graph machine learning (ML) algorithms to classify molecules being reactive towards proteins or nonreactive.
Science Daily: Pharmacology News
AUGUST 2, 2024
A tiny fossil penguin plays a huge role in the evolutionary history of the bird, an international study shows.
BioPharma Drive: Drug Pricing
AUGUST 2, 2024
The one-time drug developer is pivoting to cancer research. Elsewhere, Neurocrine reported a strong quarter and venBio raised half a billion dollars for biotech investing.
Perficient: Drug Development
AUGUST 2, 2024
In IBM Sterling OMS, Exception Handling is the procedure for managing deviations from the normal order processing flow – including incorrect pricing, missing information, inventory issues, stock shortages, payment issues, or shipping errors – which require immediate attention to preserve service quality and operational continuity. Retail businesses manage order processing and exception handling through manual entries and semi-automated systems.
BioPharma Drive: Drug Pricing
AUGUST 2, 2024
A special committee of the board said the proposal offers no premium to 23andMe’s stock price and, with a lack of committed financing, is “insufficient.
Agency IQ
AUGUST 2, 2024
By Alexander Gaffney, MS, RAC In this ongoing feature, AgencyIQ looks at public data to determine what the FDA is likely to do in the months ahead, including key deadlines, meetings, events, planned regulations, comment periods and more. The goal: To allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts. Fill out the form to read the full article.
Perficient: Drug Development
AUGUST 2, 2024
What went wrong on July 19, 2024? On July 19, 2024, the cybersecurity company CrowdStrike made a mass update to its CrowdStrike Falcon sensor on millions of computers worldwide. These updates are used to help identifying new threats and improve its cyberattack prevention capabilities. This upgrade proved to be a big mistake, causing a major crash on Windows systems everywhere.
Agency IQ
AUGUST 2, 2024
By Scott Stephens, MPA Welcome to AgencyIQ’s monthly roundup of EU chemical sector activities. This recurring feature compiles information from across EU agencies and institutions to deliver an overview of chemicals-related regulatory actions likely to happen in the month ahead, including planned legislation, consultations, webinars, meetings, and more.
Drug Patent Watch
AUGUST 2, 2024
Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.
Agency IQ
AUGUST 2, 2024
By Laura DiAngelo, MPH In late July 2024, the Department of Health and Human Services (HHS) announced a new Assistant Secretary for Technology Policy, elevating what has historically been an office within the Centers for Medicare and Medicaid Services to lead HHS-wide artificial intelligence and technology policy work. Simultaneously, the National Institute for Standards and Technology (NIST) is releasing new guidance, while FDA is previewing future work.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug. 2, 2024 -- Hospitalization for a heart-related emergency can have profound effects on a person’s mental health, a new study finds.People hospitalized for heart attack, stroke or other heart-related illnesses were 83% more likely to be d.
Agency IQ
AUGUST 2, 2024
By Sebastian Godoy, MPH , Kirsten Messmer, PhD, RAC, Corey Jaseph, MS, RAC , Kari Oakes In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more. Fill out the form to read the full article.
Drugs.com
AUGUST 2, 2024
FRIDAY, Aug 2. 2024 -- Mass shootings and other traumatic events hit community members hard, with those closest to the incident often experiencing post-traumatic stress disorder (PTSD) even years later, new research shows. "Outcomes of mass.
Drug Channels
AUGUST 2, 2024
Today’s guest post comes from Stacey Little, Senior Vice President of Business Development and Marketing at AssistRx. Stacey provides five crucial questions to help life science companies evaluate providers of patient support programs (PSPs). To learn more, register for AssistRx's free three-part webinar series: Ahead of the Curve: Considerations for your 2025 Patient Support Program.
Agency IQ
AUGUST 2, 2024
What We Expect the FDA to do in August and September 2024 In this ongoing feature, AgencyIQ looks at public data to determine what the FDA is likely to do in the months ahead, including key deadlines, meetings, events, planned regulations, comment periods and more. The goal: To allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts.
Drug Patent Watch
AUGUST 2, 2024
This chart shows the drugs with the most patents in Ireland. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.
Agency IQ
AUGUST 2, 2024
What we expect European regulators to do in August and September 2024 In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more. Given the expansive and complex European life sciences regulatory landscape, we’ll be including updates from key E.U. and national regulators.
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