Fri.Aug 02, 2024

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Link between global warming and rising sea levels

Science Daily: Pharmacology News

A new study suggests that Earth's natural forces could substantially reduce Antarctica's impact on rising sea levels, but only if carbon emissions are swiftly reduced in the coming decades. By the same token, if emissions continue on the current trajectory, Antarctic ice loss could lead to more future sea level rise than previously thought.

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First-of-its-kind cell therapy approved by FDA for rare soft tissue cancer

BioPharma Drive: Drug Pricing

Adaptimmune’s Tecelra is the first TCR cell therapy to reach market and, at $727,000, is also the priciest cellular medicine for cancer in the U.S.

Therapies 294
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How the rising earth in Antarctica will impact future sea level rise

Science Daily: Pharmacology News

The rising earth beneath the Antarctic Ice Sheet will likely become a major factor in future sea level rise, a new study suggests.

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Legit Ozempic Sales Soar While Counterfeits Put Patients in Danger

Drugs.com

FRIDAY, Aug. 2, 2024 -- Two new studies show how eager Americans are to obtain either safe, legitimate versions of Ozempic or counterfeit and potentially dangerous forms of the diabetes/weight-loss drug.One study found U.S. prescriptions and.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Scientists pin down the origins of the moon's tenuous atmosphere

Science Daily: Pharmacology News

Scientists say they have identified the main process that formed the moon's atmosphere and continues to sustain it today. The team reports that the lunar atmosphere is primarily a product of 'impact vaporization.

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Fossil shows how penguins' wings evolved

Science Daily: Pharmacology News

A tiny fossil penguin plays a huge role in the evolutionary history of the bird, an international study shows.

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Many Women Don't Know This Warning Sign of Endometrial Cancer

Drugs.com

FRIDAY, Aug. 2, 2024 -- Too many women don’t know a key warning sign of endometrial cancer, the most common cancer of the female reproductive organs, a new study shows.More than one-third (37%) of women surveyed did not know that postmenopausal b.

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Solving the doping problem: Enhancing performance in organic semiconductors

Science Daily: Pharmacology News

Physicists have discovered two new ways to improve organic semiconductors. They found a way to remove more electrons from the material than previously possible and used unexpected properties in an environment known as the non-equilibrium state, boosting its performance for use in electronic devices.

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Fish Oil Might Help High-Risk Older Adults Avoid Alzheimer's

Drugs.com

FRIDAY, Aug. 2, 2024 -- Fish oil supplements might help high-risk seniors stave off Alzheimer’s disease, a new study finds.Older people with a higher genetic risk of Alzheimer’s experienced slower breakdown of their brain’s nerve cells if they took.

Disease 264
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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What gave the first molecules their stability?

Science Daily: Pharmacology News

The origins of life remain a major mystery. How were complex molecules able to form and remain intact for prolonged periods without disintegrating? A team has demonstrated a mechanism that could have enabled the first RNA molecules to stabilize in the primordial soup. When two RNA strands combine, their stability and lifespan increase significantly.

RNA 294
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Background Checks Not Enough to Lower Gun Homicide Rates: Study

Drugs.com

FRIDAY, Aug. 2, 2024 -- Background checks alone might not be enough to reduce shooting deaths in the United States, a new study warns.States that require gun permits, rather than relying solely on universal background checks, have firearm murder.

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Sea level changes shaped early life on Earth, fossil study reveals

Science Daily: Pharmacology News

Shifts in the Earth's continental plates that drove long-term changes in sea level set the stage for the evolution of the earliest animals on Earth, a study suggests.

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Sit a Lot? Exercise Might Offset the Damage to Your Health

Drugs.com

FRIDAY, Aug. 2, 2024 -- People can offset hours spent sitting around with minutes of active exercise each week, a new study claims.Folks who are sedentary for eight or more hours daily can lower their overall risk of death – and especially their r.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Graph neural networks for identifying protein-reactive compounds

Covalent Modifiers

Victor Hugo Cano Gil and Christopher N. Rowley Digital Discovery , 2024 [link] The identification of protein-reactive electrophilic compounds is critical to the design of new covalent modifier drugs, screening for toxic compounds, and the exclusion of reactive compounds from high throughput screening. In this work, we employ traditional and graph machine learning (ML) algorithms to classify molecules being reactive towards proteins or nonreactive.

Drugs 189
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Smoking & Vaping Together Raise Lung Cancer Risks Even Higher

Drugs.com

FRIDAY, Aug. 2, 2024 -- Experts have long suspected it, but a new study confirms that folks who vape and smoke tobacco face higher risks for lung cancer than if they'd done either alone.“From a public health perspective, we have always been c.

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Vir retreats from infectious disease; Vertex shelves two drugs for AATD

BioPharma Drive: Drug Pricing

The one-time drug developer is pivoting to cancer research. Elsewhere, Neurocrine reported a strong quarter and venBio raised half a billion dollars for biotech investing.

Disease 164
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Mental Health Risks Rise in Months After Heart Attack

Drugs.com

FRIDAY, Aug. 2, 2024 -- Hospitalization for a heart-related emergency can have profound effects on a person’s mental health, a new study finds.People hospitalized for heart attack, stroke or other heart-related illnesses were 83% more likely to be d.

Hospitals 130
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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23andMe board rejects CEO Wojcicki’s take-private proposal

BioPharma Drive: Drug Pricing

A special committee of the board said the proposal offers no premium to 23andMe’s stock price and, with a lack of committed financing, is “insufficient.

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PTSD of Mass Shootings Can Haunt Community Members for Years

Drugs.com

FRIDAY, Aug 2. 2024 -- Mass shootings and other traumatic events hit community members hard, with those closest to the incident often experiencing post-traumatic stress disorder (PTSD) even years later, new research shows. "Outcomes of mass.

Research 130
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Perficient Included In Forrester’s Modern Application Development Services Landscape, Q3 2024

Perficient: Drug Development

Imagine a world where your business can effortlessly keep pace with technological advancements and continuously changing customer expectations. The ability to swiftly develop new technology products and applications is crucial to staying competitive. However, relying solely on in-house development capabilities is not always feasible for many organizations.

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Does Lifting Weights 'Close to Failure' Really Build Muscle?

Drugs.com

FRIDAY, Aug. 2, 2024 -- A popular tactic among weight lifters is “training to failure” -- pushing yourself to the point where you can’t do a single more rep.That might help a person grow bigger muscles, but won’t necessarily increase their overall s.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Real-World Evidence in Clinical Drug Development

Quanticate

Real-world evidence (RWE) is changing clinical drug development, bridging the gap between controlled clinical trial environments and the complexities of everyday patient experiences. By using Real-World Data (RWD) from various sources like electronic health records (EHRs), insurance claims, and digital health tools, researchers can gather valuable insights into how drugs work in a wide range of populations.

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Primaquine-5,6-orthoquinone is directly hemolytic to older G6PD deficient RBCs in a humanized mouse model. [Toxicology]

ASPET

Primaquine and tafenoquine are the only approved drugs that can achieve a radical cure for Plasmodium vivax malaria but are contraindicated in patients who are deficient in glucose 6-phosphate dehydrogenase (G6PDd) due to risk of severe hemolysis from reactive oxygen species (ROS) generated by redox cycling of drug metabolites. 5-hydroxyprimaquine and its quinone-imine cause robust redox cycling in red blood cells (RBCs), but are so labile as to not be detected in blood or urine.

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Automated Resolution of IBM Sterling OMS Exceptions

Perficient: Drug Development

In IBM Sterling OMS, Exception Handling is the procedure for managing deviations from the normal order processing flow – including incorrect pricing, missing information, inventory issues, stock shortages, payment issues, or shipping errors – which require immediate attention to preserve service quality and operational continuity. Retail businesses manage order processing and exception handling through manual entries and semi-automated systems.

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Effect of vascular senescence on the efficacy and safety of warfarin: insights from rat models and a prospective cohort study [Cardiovascular]

ASPET

Warfarin, with its narrow therapeutic range, requires the understanding of various influencing factors for personalized medication. Vascular senescence, marked by vascular stiffening and endothelial dysfunction, has an unclear effect on the efficacy and safety of warfarin. Based on previous studies, we hypothesized that vascular senescence increases the risk of bleeding during warfarin therapy.

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What We Expect the FDA to do in August and September 2024

Agency IQ

By Alexander Gaffney, MS, RAC In this ongoing feature, AgencyIQ looks at public data to determine what the FDA is likely to do in the months ahead, including key deadlines, meetings, events, planned regulations, comment periods and more. The goal: To allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts. Fill out the form to read the full article.

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