Wed.Aug 07, 2024

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Scientists lay out revolutionary method to warm Mars

Science Daily: Pharmacology News

Ever since we learned that the surface of planet Mars is cold and dead, people have wondered if there is a way to make it friendlier to life. The newly proposed method is over 5,000 times more efficient than previous schemes to globally warm Mars, representing a significant leap forward in our ability to modify the Martian environment.

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Cost Keeps Many Who Need Them From Getting New Weight-Loss Meds

Drugs.com

WEDNESDAY, Aug. 7, 2024 (HealthDay news) -- Medicare and Medicaid patients are less likely to get cutting-edge weight-loss drugs than people with private insurance are, a new study finds.Medicaid accounted for less than 10% of semaglutide (Ozempic.

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3D-printed blood vessels bring artificial organs closer to reality

Science Daily: Pharmacology News

Lab-grown organs are a long-time 'holy grail' of organ engineering that has yet to be achieved, but new research has brought that goal a big step closer to reality using a new 3D-printing method called co-SWIFT. co-SWIFT prints branching networks of double-layered vessels that are infused with smooth muscle cells and endothelial cells into living human cardiac tissue, and can even replicate patient-specific vascular structures,indicating that it could one day be used for personalized medicine.

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Novo shares tumble on lower-than-expected obesity drug sales

BioPharma Drive: Drug Pricing

Quarterly revenue from Ozempic and Wegovy missed Wall Street estimates by about 9%, concerning some analysts and causing a stock sell-off costing the Danish drugmaker tens of billions in market value.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Processing traumatic memories during sleep leads to changes in the brain associated with improvement in PTSD symptoms

Science Daily: Pharmacology News

Currently, the first-choice treatment for PTSD is exposure-based psychotherapy, where therapists help rewire the emotions associated with the traumatic memory in the patient's brain, shifting from fear and arousal to a more neutral response. However, up to 50% of patients fail to respond well to this treatment. In a new study scientists showed for the first time that reactivating therapeutically-altered memories during sleep leads to more brain activity related to memory processing, which is ass

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Amgen talks obesity drug ‘differentiation’; Servier brain cancer drug approved by FDA

BioPharma Drive: Drug Pricing

Executives at Amgen had few updates on their drug MariTide, but defended what they see as the once-monthly shot’s competitive profile.

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EPA Bans Vegetable Pesticide That Can Harm Fetuses

Drugs.com

WEDNESDAY, Aug. 7, 2024 -- In an historic move, the Environmental Protection Agency on Tuesday banned the use of a pesticide that can harm fetuses.Known as dimethyl tetrachloroterephthalate (DCPA or Dacthal), the weedkiller is used on a variety of.

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Do smells prime our gut to fight off infection?

Science Daily: Pharmacology News

In nematodes and humans, mitochondrial stress in the nervous system initiates a whole-body response that is most pronounced in the gut. A recent study showed that in nematodes, the odor of a pathogen triggers the nervous system to broadcast this response to the rest of the organism, prepping mitochondria in intestinal cells to fight a bacterial infection.

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Red Cross Issues Blood Shortage Alert as Summer Heat Cuts Donations

Drugs.com

WEDNESDAY, Aug. 7, 2024 -- This summer's blistering temperatures have helped prompt an emergency blood shortage, the American Red Cross has warned.Heat waves affected almost 100 blood drives last month, either by hurting turnout or forcing the.

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Social rank may determine if animals live fast, die young

Science Daily: Pharmacology News

Social rank may determine whether animals prioritize immediate fitness over long-term health, according to a study. Researchers studied macaques on a Thai island and found that the animals' unusual habit of washing their food is in fact based on social rank. Dominant monkeys quickly brush their food on their fur before eating it, along with mouthfuls of tooth-degrading sand, while lower-ranked monkeys obsessively wash their food in the surf.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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More Than 1 in 4 Americans Over 50 Are Now Caregivers

Drugs.com

WEDNESDAY, Aug. 7, 2024 -- More than 1 in 4 Americans 50 or older are now caregivers, looking after at least one family member or friend who has a health problem or disability, a new poll has found.In all, 30% of all people in their 50s and early.

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First noninvasive method to continually measure true blood pressure

Science Daily: Pharmacology News

The new device uses sound waves to gather blood pressure data from blood vessels, monitoring the response with ultrasound. The new technique, called resonance sonomanometry, holds the promise to enable better vital-sign monitoring at home, in hospitals, and possibly even in remote locations.

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Six scientists named as new core institute members at Broad

Broad Institute

Six scientists named as new core institute members at Broad By Corie Lok August 7, 2024 Breadcrumb Home Six scientists named as new core institute members at Broad As leaders in their fields, the new core members have also all demonstrated deep commitment to the community and intellectual life at Broad. By Broad Communications August 7, 2024 Gad Getz, Anna Greka, Evan Macosko (top row, left to right); Nir Hacohen, Ben Neale, Pardis Sabeti (bottom row, left to right) have been named new core inst

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Drug Approved to Fight Rare Cancer That Hits Young Adults

Drugs.com

WEDNESDAY, Aug. 7, 2024 -- A new immunotherapy is now available to treat a rare soft tissue cancer that most frequently occurs in young men.The U.S. Food and Drug Administration has granted accelerated approval to Tecelra (afamitresgene.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Most existing heat wave indices fail to capture heat wave severity

Science Daily: Pharmacology News

Even though climate change is bringing more frequent and severe heat waves, there is no standard, global way to measure heat-wave severity, and existing indices have different thresholds for defining dangerous heat-stress conditions. Researchers report that five out of six existing heat-wave indices were unable to capture the severity and spatial distribution of recent lethal heat waves in India, Spain, and the USA.

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Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy

Broad Institute

Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy By Allessandra DiCorato August 7, 2024 Breadcrumb Home Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy The method could accelerate the development of more effective adeno-associated viruses (AAVs). By Allessandra DiCorato August 7, 2024 Credit: Susanna Hamilton, Broad Communications Related news How one lab uses machine learning to solve a key gene t

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Glimpse into the nanoworld: Microscope reveals tiniest cell processes

Science Daily: Pharmacology News

What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers have succeeded in developing a microscope with resolutions better than five nanometers (five billionths of a meter). This is roughly equivalent to the width of a hair split into 10,000 strands.

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Tecelra Approved to Fight Rare Cancer That Hits Young Adults

Drugs.com

WEDNESDAY, Aug. 7, 2024 -- A new immunotherapy is now available to treat a rare soft tissue cancer that most frequently occurs in young men. The U.S. Food and Drug Administration has granted accelerated approval to Tecelra (afamitresgene.

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Giant prehistoric flying reptile took off using similar method to bats, study finds

Science Daily: Pharmacology News

The pterosaur likely used all four limbs to propel itself in the air, as seen in bats today, researchers have found.

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Madrigal’s MASH drug launch gets off to a fast start

BioPharma Drive: Drug Pricing

U.S. sales of the medicine, Rezdiffra, were more than triple analysts’ expectations, encouraging Madrigal to market it in Europe without a partner.

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Your best friend from high school? Here's why their genes mattered

Science Daily: Pharmacology News

The genetic makeup of adolescent peers may have long-term consequences for individual risk of drug and alcohol use disorders, depression and anxiety, a groundbreaking study has found.

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Shaping drug development success: how does artwork play a role?

Drug Target Review

The pharmaceutical industry is undergoing a major shift towards the development of breakthrough medicines and advanced therapies. This continued innovation highlights the complexity of the drug development process, particularly as the field is highly regulated by health authorities around the world. While the entire lifecycle of the development process must be carefully navigated, and as the life sciences sector develops, there will be more significant investment in the preclinical stage, spec

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Another Attack on the Carve-Out: Novartis Seeks a TRO Enjoining ENTRESTO Generic

FDA Law Blog: Biosimilars

By Sara W. Koblitz — Increasingly the subject of induced infringement litigation, the viability of the carve-out has been questioned for several years now. But recently, a new challenge was filed in the District Court for the District of Columbia questioning whether modifications to labeling as a result of patent protections—beyond the mere omission of language—are permissible under the section viii carve-out requirements.

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Future Leaders of Tomorrow: Insights from a Conversation with BenchSci's CEO

BenchSci

This blog was guest-authored by Krish Mendapara, Naina Kumar, and Tehseen Dahya who partnered with BenchSci for a 7-week placement through our ongoing partnership with The Knowledge Society.

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How Does Imaging Support the Development of New Therapeutics?: A Focus on ADC and Radioisotope Therapy

Fierce BioTech

How Does Imaging Support the Development of New Therapeutics?: A Focus on ADC and Radioisotope Therapy pesurya Wed, 08/07/2024 - 11:14 Wed, 10/16/2024 - 14:00 Resource Type Webinar Promotion Start Fri, 08/16/2024 - 11:17 Promotion End Sun, 02/16/2025 - 11:00 Duration 60 Minutes Medical imaging is critical in clinical trials, serving as a key component in assessing treatment efficacy and safety.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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The Unfiltered Truth about AI & Pharma Marketing

Fierce BioTech

The Unfiltered Truth about AI & Pharma Marketing dwunderlin Wed, 08/07/2024 - 12:04 Wed, 09/04/2024 - 14:00 Resource Type Webinar Chris Cullmann Doug Barr Promotion Start Thu, 08/08/2024 - 15:00 Promotion End Sat, 02/08/2025 - 15:00 Duration 60 Minutes You need to know where artificial intelligence disrupts the pharmaceutical marketing norms. How whole-team integration with AI integration can radically shift your advertising dynamics and redefine market leadership.

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New patent expiration for Endo Pharms drug OPANA ER

Drug Patent Watch

Annual Drug Patent Expirations for OPANA+ER Opana Er is a drug marketed by Endo Pharms and is included in two NDAs. There are five patents protecting this drug and six Paragraph IV challenges.

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Enhancing Clinical Trials: The Power of Contact Center Services

PPD

Clinical trials are the backbone of medical research, enabling the development of new treatments and therapies that can improve patient outcomes. However, conducting successful clinical trials requires efficient communication and coordination among various stakeholders. This is where contact center services play a vital role. In this blog, we will delve into the world of clinical trial contact center services and explore how they enhance the entire trial process, from recruitment to post-trial f

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Gestational Diabetes Won't Raise Women's Odds for Breast Cancer

Drugs.com

WEDNESDAY, Aug. 8, 2024 -- About 14% of women will develop diabetes while pregnant, a condition known as gestational diabetes. It's linked with obesity and older age, and the number of cases is growing although they usually resolve by the time of.

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Overcoming Formulation Challenges in Generic Drug Development: A Case Study

Drug Patent Watch

Introduction Generic drug development is a crucial aspect of the pharmaceutical industry, as it provides access to affordable medications for […] Source

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Miscarriages in Horses Offer Insights to Help Prevent Human Miscarriages

Drugs.com

WEDNESDAY, Aug. 7, 2024 (HeathDay News) -- Researchers are gleaning important insights into miscarriages in women from an longtime four-legged friend: horses.It shouldn't come as a surprise, since female horses have long pregnancies (11 months) and.

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Suspension dosed drug patent expirations by year

Drug Patent Watch

This chart shows the patent expirations for suspension dosed drugs over the next decade. The term of drug patents varies.

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Feel Judged by Your Doctor? You Might Not Be Imagining It

Drugs.com

WEDNESDAY, Aug. 7, 2024 -- It’s tough to open up to a doctor, even though it’s vital if patients want the best care for what ails them.Why the reticence? People worry they’ll be judged by their doctor if they share mistaken beliefs or false ideas.

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