Thu.Feb 08, 2024

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Scandinavia's first farmers slaughtered the hunter-gatherer population, study finds

Science Daily: Pharmacology News

Following the arrival of the first farmers in Scandinavia 5,900 years ago, the hunter-gatherer population was wiped out within a few generations, according to a new study. The results, which are contrary to prevailing opinion, are based on DNA analysis of skeletons and teeth found in what is now Denmark.

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Viagra, Cialis May Help Reduce Alzheimer's Risk

Drugs.com

THURSDAY, Feb. 8, 2023 -- Could drugs that give a boost to men's sexual performance help them stave off Alzheimer's disease?That's the main finding from a study suggesting that erectile dysfunction meds like Cialis, Levitra and Viagra might lower.

Disease 119
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Ice cores provide first documentation of rapid Antarctic ice loss in the past

Science Daily: Pharmacology News

Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.

Research 139
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BioNTech partners with Autolus to boost cell therapy manufacturing

BioPharma Drive: Drug Pricing

The German biotech will invest $200 million in Autolus — funds that, along with a $50 million fee, will give it licensing opportunities and access to supply infrastructure.

Therapies 112
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Combining materials may support unique superconductivity for quantum computing

Science Daily: Pharmacology News

A new fusion of materials, each with special electrical properties, has all the components required for a unique type of superconductivity that could provide the basis for more robust quantum computing.

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Prescriptions aren’t one-way tickets: how to stop what we started

On Medicine

Funded by the National Institute for Health and Care Research (NIHR), the CHARMER team have worked with healthcare professionals and older people, a patient group undoubtedly under-served by clinical research, to develop an approach to support geriatricians (hospital doctors who care for older people) and pharmacists to undertake more proactive deprescribing with older people whilst they are in hospital.

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More Trending

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eBook: Reveal Cell Function With Single-Cell Resolution

Drug Target Review

This eBook introduces a new approach to the analysis of immune cell function. Providing single-cell resolution that reveals the heterogeneity of immune cell populations, these workflows combine an innovative application of microfluidics technology with single-cell format flow cytometry of living cells. Get ready to discover how Xdrop DE50 droplets can be used to encapsulate individual immune cells and deliver them for incubation, analysis, and retrieval.

Research 105
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Dr. Anthony Fauci to Publish Memoir 'On Call' in June

Drugs.com

THURSDAY, Feb. 8, 2024 -- Dr. Anthony Fauci, who helped Americans navigate the HIV/AIDS epidemic and the COVID-19 pandemic, will reflect on his career in a memoir set for release this summer. His publisher, Viking, announced that the book, titled.

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Investigating the intratumoural microbiome in young-onset CRC patients

Drug Target Review

Researchers from the Cleveland Clinic have identified changes in tumour-related bacteria, which have revealed possible new strategies to tackle the increase of young-onset colorectal cancer (CRC), which refers to CRC incidence in patients under 50 years old. CRC is one of the leading causes of cancer related mortality worldwide, with some of its risk factors being obesity, red meat consumption, alcohol and tobacco. 1 Despite this condition being easy to surgically treat and target with chemother

Disease 105
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Composable vs. Headless – The Ultimate Commerce Battle Royale?

Perficient: Drug Development

The Celtics vs. The Lakers, Boston Red Sox vs. New York Yankees, Frazier vs. Ali. I think all of us have our favorite epic rivalries that stick with us. But what makes rivalries so engaging? Some say it’s the bragging rights, some say it’s the passion, and others say it’s because rivalries tend to bring out the best in each competitor. I tend to lean towards all the above as being the catalyst for why we find them so engaging.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Designing a Better Probiotic. CRISPR Hubris?

PLOS: DNA Science

Every morning I pop a Pearl probiotic. I try hard not to drop it, for the tiny, slippery yellow sphere bounces, is impossible to pick up, and cats love to bat them into unreachable domains. A probiotic is, technically speaking, a population of live microorganisms that confers health benefits on the multicellular organism that they inhabit – such as a human.

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Your Brain Finds Ways to Compensate Against Age-Related Decline

Drugs.com

THURSDAY, Feb. 8, 2024 -- No one's brain is as sharp at 60 as it was at 20. However, new research supports the notion that folk's brains can make subtle adjustments with age to compensate for that decline.A team of British researchers has found.

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Greenhouse gas repurposed

Science Daily: Pharmacology News

Cutting-edge research converted waste carbon dioxide into a potential precursor for chemicals and carbon-free fuel.

Research 112
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Head Position May Be Key to Better Clot Removal After Stroke

Drugs.com

THURSDAY, Feb. 8, 2024 -- The position in bed of stroke victims' heads could influence how well they’ll fare in upcoming surgery to remove a blood clot from their brain, a new study finds.Hospital beds for stroke patients are typically set up to.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Low voice pitch increases standing among strangers

Science Daily: Pharmacology News

If you're looking for a long-term relationship or to boost your social status, lower your pitch, according to researchers studying the effects of voice pitch on social perceptions. They found that lower voice pitch makes women and men sound more attractive to potential long-term partners, and lower voice pitch in males makes the individual sound more formidable and prestigious among other men.

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Americans Have One Trusted Source for Info on COVID Vaccines

Drugs.com

THURSDAY, Feb. 8, 2024 -- A doctor or nurse might be the only person capable of convincing a vaccine-hesitant person to get the COVID jab, a new study shows.

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Breaking through barriers

SCIENMAG: Medicine & Health

Researchers from Tokyo Medical and Dental University (TMDU) overcome scientific roadblocks and develop a model to assess the biology of the human placental barrier Credit: Department of Diagnostic and Therapeutic Systems Engineering, TMDU Researchers from Tokyo Medical and Dental University (TMDU) overcome scientific roadblocks and develop a model to assess the biology of the human […]

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Adding Blood Thinners to Clot-Busting Meds Won't Improve Stroke Outcomes: Study

Drugs.com

THURSDAY, Feb. 8, 2024 -- Adding blood thinners to clot-busting drugs does not improve outcomes for stroke patients, a new study claims.Doctors had hoped that combining the two types of medications would improve treatment of stroke, as a similar.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Researchers uncover genetic factors for severe Lassa fever

Broad Institute

Researchers uncover genetic factors for severe Lassa fever By Allessandra DiCorato February 8, 2024 Breadcrumb Home Researchers uncover genetic factors for severe Lassa fever New findings from an international collaboration pave the way for studies of highly infectious diseases in Africa such as Ebola. By Allessandra DiCorato February 8, 2024 Credit: NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland Scanning electron image of the Lassa virus budding off a cell.

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CRISPR 101: Off-Target Effects

addgene Blog

“Off-target effects” a vague catch-all term for unintended consequences in an experiment. For CRISPR work, this often means DNA cleavage at unanticipated sites. While off-target effects are nearly impossible to eliminate, it ’ s essential to understand them in order to design the most specific assays possible. In this blog, we will discuss when off-targets can be an issue in CRISPR, how to predict and minimize them, and ways to control for and quantify them when they can’t be avoided.

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Gene editing biotech Metagenomi pulls off nearly $94M IPO

BioPharma Drive: Drug Pricing

The company is one of three preclinical biotechs to successfully go public since last summer, but it pulled in significantly less than others who’ve debuted with more advanced medicines.

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Predicting psychosis before it occurs

SCIENMAG: Medicine & Health

The onset of psychosis can be predicted before it occurs, using a machine-learning tool which can classify MRI brain scans into those who are healthy and those at risk of a psychotic episode.

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Spiral-shaped lens provides clear vision at a range of distances and lighting conditions

Science Daily: Pharmacology News

Researchers have developed a spiral-shaped lens that maintains clear focus at different distances in varying light conditions. The new lens works much like progressive lenses used for vision correction but without the distortions typically seen with those lenses. It could help advance contact lens technologies, intraocular implants for cataracts and miniaturized imaging systems.

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What They Said – FDA Press Releases in 2023

Eye on FDA

Less is more? Every so often is it worthwhile to look back at FDA to see what they had to say in a given year, and in addition, how they said it. One might not think that a large agency would vary much in terms of volume or style from year to year, but that is not the case. How Many? This year the agency issued 190 releases, which is a substantial cutback from recent years in terms of sheer numbers.

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Neurona raises another $120 million for brain disease cell therapies

BioPharma Drive: Drug Pricing

The company’s haul is the latest sign brain drugs are recapturing the interest of investors after years of being passed over for other areas of research.

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CDC Investigating Illness Outbreak on Luxury Cruise Ship

Drugs.com

Thursday, Feb. 8, 2024 -- The U.S. Centers of Disease Control and Prevention is investigating an outbreak of gastrointestinal illness aboard a luxury cruise ship that sailed out of San Francisco on Wednesday. More than 150 people on the Queen.

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Pharma CEOs, pressed by Senate panel, refuse to commit to price cuts

BioPharma Drive: Drug Pricing

Forced into testifying by Senate HELP chair Bernie Sanders, the heads of Bristol Myers Squibb, J&J and Merck largely avoided major missteps.

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Which pharmaceutical companies have the most SPCs in Estonia?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Estonia. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Estonia? appeared first on DrugPatentWatch - Make Better Decisions.

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Building the Disease Biology Generative AI Platform for Pharma R&D

BenchSci

Earlier this month, I traveled across North America and the UK to meet our 340 team members. Every year in January, we kick off the year with our “Roadshow”, where I meet our team in person and share our accomplishments and learning from the previous year and where we are going next. This year, you could feel even more excitement in the room than in previous years as we are accelerating our efforts to integrate even more Generative AI (GenAI) capabilities into our ASCEND Platform.

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New patent for Genentech Inc drug GAVRETO

Drug Patent Watch

Annual Drug Patent Expirations for GAVRETO Gavreto is a drug marketed by Genentech Inc and is included in one NDA. It is available from one supplier. There are two patents… The post New patent for Genentech Inc drug GAVRETO appeared first on DrugPatentWatch - Make Better Decisions.

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Integration of GWAS and functional data

Broad Institute

Integration of GWAS and functional data By Rose Circeo February 8, 2024 Breadcrumb Home Integration of GWAS and functional data The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for biostatistics,

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New patent for Gilead Sciences drug VEKLURY

Drug Patent Watch

Annual Drug Patent Expirations for VEKLURY Veklury is a drug marketed by Gilead Sciences Inc and is included in one NDA. It is available from one supplier. There are thirteen… The post New patent for Gilead Sciences drug VEKLURY appeared first on DrugPatentWatch - Make Better Decisions.

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Webinar: Assessing Cognition Impairment Using Driving Simulators in Clinical Trials

Alta Sciences

Webinar: Assessing Cognition Impairment Using Driving Simulators in Clinical Trials pmjackson Thu, 02/08/2024 - 21:18 Over 20,000 FDA-approved drugs are currently on the market, and many contain psychoactive or sedative pharmaceutical ingredients that can alter the ability to operate a motor vehicle, making reducing the incidence of motor vehicle accidents (MVAs) caused by drug-impaired driving a public health priority.