Tue.Dec 12, 2023

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The Inflation Reduction Act Is Not Impacting Pharma R&D – Yet

Forbes: Drug Truths

Entitled "Pharmaceutical innovation and the Inflation Reduction Act: What can we learn from the first half of 2023", this policy brief examines whether "the IRA has ha.

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Tome Biosciences debuts with $213M and a new way to edit the genome

BioPharma Drive: Drug Pricing

Based on the work of MIT scientists, the well-funded startup is developing ways to insert large sizes of genetic material anywhere in the genome without damaging or breaking DNA.

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How a drought led to the rise of skateboarding in 1970s California

Science Daily: Pharmacology News

Why did professional skateboarding arise in southern California in the 1970s? Was it a coincidence, or was it a perfect storm of multiple factors? It's fairly well-known that a drought in southern California in the mid-1970s led to a ban on filling backyard swimming pools, and these empty pools became playgrounds for freestyle skateboarders in the greater Los Angeles area.

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FTC, in unusual move, leads Sanofi to terminate a drug research deal

BioPharma Drive: Drug Pricing

Just before clearing Pfizer’s buyout of Seagen, the regulator threatened to block Sanofi’s licensing deal with Maze Therapeutics, a challenge the biotech called ‘‘unprecedented.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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10 achondroplasia facts to note

Antidote

Achondroplasia, a term meaning “without cartilage formation,” is a genetic disorder leading to disproportionate short stature. Sometimes called achondroplastic dwarfism or ACH , this condition has few treatment options and no known cure. However, individuals diagnosed with this condition can typically lead fulfilling, healthy lives with proper management.

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The future of lymphoma treatment

Drug Target Review

How does Araris’ linker technology platform enable improved development of ADCs? Our technology platform allows for a one-step, easy to use method to efficiently conjugate a molecule to any off-the-shelf antibody. We use hydrophilic linkers, which prevent ADC aggregation and generate highly stable ADCs, in combination with a unique attachment site on the antibody to create ADCs that retain pharmacokinetic properties similar to the original unconjugated antibody.

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More Trending

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Saying 'No' to a Holiday Invite May Be Easier Than You Think

Drugs.com

TUESDAY, Dec. 12, 2023 -- Saying “no” to a holiday invite might feel unforgivably rude, but people often overestimate the social consequences of turning down an invitation, psychologists report.More than three out of four people (77%) say.

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Archaeologists unearth one of earliest known frame saddles

Science Daily: Pharmacology News

Recovered from looters, a new archaeological discovery from a cave in western Mongolia could change the story of the evolving relationship between humans and horses around the world.

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Using Marijuana While Pregnant Raises Complications Risk

Drugs.com

TUESDAY, Dec. 12, 2023 -- Marijuana use by expecting moms is associated with unhealthy pregnancy outcomes, especially low birth weight babies, a new study finds. Further, heavier weed use is associated with higher risks for the pregnancy, the.

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Hallmark quantum behavior in bouncing droplets

Science Daily: Pharmacology News

In a study that could help fill some holes in quantum theory, the team recreated a 'quantum bomb tester' in a classical droplet test.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Half of Diabetes Patients on Ozempic, Mounjaro Stop Using the Meds

Drugs.com

TUESDAY, Dec. 12, 2023 -- Many Americans battling diabetes are turning to a new class of injected drugs that includes blockbusters like Ozempic (semaglutide) and Mounjaro (tirzepatide).But a new study finds half of patients who use these "second.

Drugs 102
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The silent killer gets louder as high blood pressure risks trend upward

SCIENMAG: Medicine & Health

Research from Tokyo Medical and Dental University (TDMU) warns that rates of urgent dialysis and death are on the rise over the last decade in people hospitalized for acute high blood pressure.

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Is Violence a Risk With Your New Romantic Partner? Watch for These Warning Signs

Drugs.com

TUESDAY, Dec. 12, 2023 -- Many women and men begin new relationships never dreaming they could later be enmeshed in a cycle of intimate partner violence.Now, a new study finds there are early behavioral warning signs from a partner that suggest the.

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Sanford Burnham Prebys elects Lori Moore to its Board of Trustees

SCIENMAG: Medicine & Health

Sanford Burnham Prebys today announced that Lori Moore will join the Institute’s Board of Trustees. Credit: Lori Moore Sanford Burnham Prebys today announced that Lori Moore will join the Institute’s Board of Trustees.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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14-inch spacecraft delivers new details about 'hot Jupiters'

Science Daily: Pharmacology News

The Colorado Ultraviolet Transit Experiment (CUTE) spacecraft is about the size of a cereal box. It has also recorded incredibly detailed measurements of the atmospheres of planets hundreds of light-years from Earth.

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Tat-heat shock protein 10 ameliorates age-related phenotypes in the hippocampus

SCIENMAG: Medicine & Health

“Mitochondrial dysfunction is a major cellular change observed in the hippocampus during aging.” Credit: Jung et al. “Mitochondrial dysfunction is a major cellular change observed in the hippocampus during aging.

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Surprising Data on Employer-PBM Rebate Pass-Through Arrangements in 2023 (rerun)

Drug Channels

This week, I’m rerunning some popular posts while I prepare for Friday’s Drug Channels Outlook 2024 live video webinar. Click here to see the original post from August 2023. Something to consider while you review today's rerun: The Lower Costs, More Transparency Act (H.R. 5378) , which the U.S. House of Representatives passed yesterday, contains new PBM rebate disclosure requirements, but no mandates for rebate pass-through.

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New ‘atherosclerosis atlas’ sheds light on heart attacks, strokes

SCIENMAG: Medicine & Health

University of Virginia School of Medicine researchers have created an “atlas of atherosclerosis” that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes and coronary artery disease.

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Heart Attacks Spike During Holidays: Tips to Protect Yourself

Drugs.com

TUESDAY, Dec. 12, 2023 -- Late December is typically a time when holiday stress and winter weather can collide, creating a perfect recipe for a rise in heart attacks and stroke.Luckily, one expert has some advice on how to dodge the danger.“When.

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New study explores ways to reduce inflammation and preserve bone health with prunes

SCIENMAG: Medicine & Health

A new study published in The Journal of Nutrition shows daily consumption of prunes may reduce inflammation markers connected to bone signaling pathways and reduce the effects of bone loss among postmenopausal women.

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AstraZeneca to acquire vaccine maker Icosavax for up to $1.1B

BioPharma Drive: Drug Pricing

The deal signals the pharma company’s continuing interest in vaccine development and hands it a combination shot aimed at two respiratory viruses.

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Potential of forsythiae fructus in mitigating chemotherapy-induced gastrointestinal inflammation and nausea

SCIENMAG: Medicine & Health

Chemotherapy-induced nausea and vomiting (CINV) are among the most prevalent and distressing side effects faced by patients undergoing antineoplastic treatments. This condition can lead to complications such as dehydration, metabolic imbalances, anorexia and weakened physical stamina.

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Bristol Myers pays SystImmune $800M and adds to pharma’s ‘ADC’ deal spree

BioPharma Drive: Drug Pricing

The lucrative alliance, potentially worth more than $8 billion, continues a run of dealmaking for a class of cancer drugs that’s surged in popularity in recent years.

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Noisy Holiday Toys Are No Gift to a Child's Hearing

Drugs.com

TUESDAY, Dec. 12, 2023 -- Parents moaning over the noise from a new Christmas toy is a time-honored holiday tradition.But noisy playthings can do long-lasting damage to a child’s hearing, the American Academy of Audiology (AAA) is warning.

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This Japanese 'dragon' terrorized ancient seas

Science Daily: Pharmacology News

Researchers have described a Japanese mosasaur the size of a great white shark that terrorized Pacific seas 72 million years ago. The mosasaur was named for the place where it was found, Wakayama Prefecture. Researchers call it the Wakayama Soryu, which means blue dragon.

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Firearm Access Drives High Rate of U.S. Gun Deaths, International Study Finds

Drugs.com

TUESDAY, Dec. 11, 2023 -- Gun advocates often claim that mental illness is the driving force behind mass shootings in the United States.But new research argues that gun violence is more likely driven by the massive numbers of firearms available.

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New AI-powered algorithm could better assess people’s risk of common heart condition

SCIENMAG: Medicine & Health

LA JOLLA, CA—A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure.

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Decentralized Clinical Trials in 2024: A Look Ahead

Crucial Data Solutions

Decentralized clinical trials (DCTs) are growing. We may not be seeing the deep and widespread adoption of decentralized approaches some. The post Decentralized Clinical Trials in 2024: A Look Ahead appeared first on Crucial Data Solutions.

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New patent for Azurity drug EPRONTIA

Drug Patent Watch

Annual Drug Patent Expirations for EPRONTIA Eprontia is a drug marketed by Azurity and is included in one NDA. It is available from one supplier. There are two patents protecting… The post New patent for Azurity drug EPRONTIA appeared first on DrugPatentWatch - Make Better Decisions.

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Look What the Cat Dragged In: FDA’s Draft Guidance on Urinary Tract Health Claims for Cat Food

FDA Law Blog: Biosimilars

By Sophia R. Gaulkin & Riëtte van Laack — On November 30, FDA’s Center for Veterinary Medicine (CVM) released a draft guidance , “Using Relative Supersaturation to Support ‘Urinary Tract Health’ Claims for Adult Maintenance Cat Food,” to provide recommendations for how pet food companies manufacturers can use relative supersaturation (RSS) methodology to support urinary tract health (UTH) claims for certain adult maintenance cat food.

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New patent for Hisamitsu drug SECUADO

Drug Patent Watch

Annual Drug Patent Expirations for SECUADO Secuado is a drug marketed by Hisamitsu and is included in one NDA. It is available from one supplier. There are five patents protecting… The post New patent for Hisamitsu drug SECUADO appeared first on DrugPatentWatch - Make Better Decisions.

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ChatGPT Performs Well as 'Partner' in Diagnosing Patients

Drugs.com

TUESDAY, Dec. 12, 2023 -- Doctor's brains are great decision-makers, but even the smartest physicians might be well-served with a little diagnostic help from ChatGPT, a new study suggests. The main benefit comes from a thinking process known as.

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New patent expiration for Mylan Speciality drug DYMISTA

Drug Patent Watch

Annual Drug Patent Expirations for DYMISTA Dymista is a drug marketed by Mylan Speciality Lp and is included in one NDA. It is available from two suppliers. There are four… The post New patent expiration for Mylan Speciality drug DYMISTA appeared first on DrugPatentWatch - Make Better Decisions.

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Quality Resolutions

DS in Pharmatics

There are no holidays or time off when it comes to complying with regulations. Companies always need to be ready to meet the latest standards. With that in mind, new FDA programs are sure to keep pharmaceutical companies of all sizes busy in the year ahead. Here’s how to get through.