Drug Discovery World

APRIL 24, 2024

Evotec and Variant Bio have announced a collaboration agreement to identify a best-in-class treatment for diseases caused by fibrosis. Despite the chronic nature of fibrotic conditions, widespread impact on various organs, and substantial disease burden, there is currently no curative treatment for these conditions. The strategic partnership will combine Variant Bio’s genomic discovery capabilities and VB-Inference platform with Evotec’s knowledge of antifibrotic drug discovery.

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Treatment Small Molecule Clinical Development Disease 130

Science Daily: Pharmacology News

APRIL 24, 2024

Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.

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Research 140

Drug Discovery World

APRIL 24, 2024

The European Federation of Pharmaceutical Industries and Associations (EFPIA) has supported the use of artificial intelligence (AI) to deliver benefit for patients, life science companies and society, in response to the EU Artificial Intelligence (AI) Act. The AI Act, which bans certain AI applications that it feels threaten citizens’ rights, was approved in the European Parliament in March 2024.

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Pharma R&D Government Regulations Drug Development 130

Science Daily: Pharmacology News

APRIL 24, 2024

People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.

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Drugs 127

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

APRIL 24, 2024

Join DDW for this exclusive free event, ‘ rAAV genome sequencing with Oxford Nanopore uncovers transgene integrity and packaging impurities ’. The event will be supported by Oxford Nanopore Technologies. The event will feature experts Daniel Jachimowicz, Senior Bioscience Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden, and Bastian Schiffthaler, Senior Data Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden.

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DNA Packaging Virus International 130

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Long-term daily use of aspirin has been known to prevent colon cancer, but up to now it’s been unclear why that is.Now, researchers think they understand how aspirin acts against colon cancer, a new study says.Aspirin.

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Science Research 124

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- A budget-busting 3.6 million Medicare recipients could now be eligible for coverage of the weight-loss drug Wegovy, a new KFF analysis says.That’s because the U.S. Food and Drug Administration has approved the use of.

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Drugs 119

Science Daily: Pharmacology News

APRIL 24, 2024

Researchers have invented a new optical element that brings us one step closer to mixing the real and virtual worlds in an ordinary pair of eyeglasses using high-definition 3D holographic images.

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Research 120

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Many people with tough-to-treat depression may be trying psilocybin, the active ingredient in magic mushrooms, as an alternative to antidepressants.Thinking that it's a "natural" drug, folks might assume it comes.

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Drugs 116

Science Daily: Pharmacology News

APRIL 24, 2024

Researchers have found a way to super-charge the 'engine' of sustainable fuel generation -- by giving the materials a little twist. The researchers are developing low-cost light-harvesting semiconductors that power devices for converting water into clean hydrogen fuel, using just the power of the sun. These semiconducting materials, known as copper oxides, are cheap, abundant and non-toxic, but their performance does not come close to silicon, which dominates the semiconductor market.

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Engineering Marketing Research 112

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

APRIL 24, 2024

An expanded partnership with OpenAI is helping Moderna embed custom-built AI chatbots in a wide range of research and business processes.

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Research 123

Science Daily: Pharmacology News

APRIL 24, 2024

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

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DNA Regulations Research 107

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- New Jersey native Lisa Pisano was staring down the end of her days.The 54-year-old had heart failure and end-stage kidney disease, but several chronic medical conditions excluded her as a candidate for heart and kidney.

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Disease 105

Science Daily: Pharmacology News

APRIL 24, 2024

Researchers have grown diamonds under conditions of 1 atmosphere pressure and at 1025 degrees Celsius using a liquid metal alloy composed of gallium, iron, nickel, and silicon, thus breaking the existing paradigm. The discovery of this new growth method opens many possibilities for further basic science studies and for scaling up the growth of diamonds in new ways.

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Science Research 107

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- The percentage of married American women under the age of 50 who are infertile rose between 2011 and 2019, new government statistics show.Data from the National Survey of Family Growth show that "the percentage of.

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Government 105

Science Daily: Pharmacology News

APRIL 24, 2024

Estuaries -- where freshwater rivers meet the salty sea -- are great locations for birdwatching and kayaking. In these areas, waters containing different salt concentrations mix and may be sources of sustainable, 'blue' osmotic energy. Researchers report creating a semipermeable membrane that harvests osmotic energy from salt gradients and converts it to electricity.

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Research 106

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Anne Helms is one busy mom, constantly juggling the demands of working from home with parenting two young children.Despite that whirl of activity, Helms says she often feels isolated and lonely.“I work from home full.

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Perficient: Drug Development

APRIL 24, 2024

Uncovering the Challenge: Relying on Spreadsheets for Portfolio Analysis A leading wealth and asset management firm recently sought our financial services expertise for a critical challenge. Relying on complex spreadsheets for portfolio analysis, the firm faced operational hurdles due to immense computing demands. The Perficient Approach: Transforming Operations through Strategic Consulting Our team embraced the challenge, conducting a meticulous two-week analysis to uncover the root issue: a cu

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Production 103

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Nearly 40% of Americans live where the air is polluted enough to harm them, a new report warns.In the American Lung Association's “State of the Air” report, released Wednesday, the number of people living with.

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Science Daily: Pharmacology News

APRIL 24, 2024

Hydrologists predict human-induced underground fluid fluxes to rise with climate change mitigation strategies like carbon sequestration.

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Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Bits of inactive bird flu virus have been discovered in samples of pasteurized milk from across the United States, health officials said Tuesday, although they stressed the viral fragments don't threaten humans.

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Virus 104

Science Daily: Pharmacology News

APRIL 24, 2024

New research has highlighted the profound link between dietary choices and brain health.

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Research 141

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Black and Hispanic Americans are gaining a better understanding of CPR, with a growing number expressing confidence they could use it to save a life, a new survey finds.About 44% of Black Americans now feel confident.

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Science Daily: Pharmacology News

APRIL 24, 2024

Researchers explain the genomic and developmental basis of the patagium, the thin skin membrane that allows some mammalian species to soar through the air.

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Research 106

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- America’s mental health woes essentially serve as an annual economic downturn for the nation, a new study says.Mental illness costs the U.S. economy $282 billion every year, equivalent to the average economic.

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Science Daily: Pharmacology News

APRIL 24, 2024

While ESA's satellite INTEGRAL was observing the sky, it spotted a burst of gamma-rays -- high-energy photons -- coming from the nearby galaxy M82. Only a few hours later, ESA's XMM-Newton X-ray space telescope searched for an afterglow from the explosion but found none. An international team realized that the burst must have been an extra-galactic flare from a magnetar, a young neutron star with an exceptionally strong magnetic field.

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International 98

BioPharma Drive: Drug Pricing

APRIL 24, 2024

Growing demand has convinced Biogen that it's worth expanding the sales force around Leqembi by 30%.

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Drugs 126

Science Daily: Pharmacology News

APRIL 24, 2024

A new national survey finds a broad majority of parents experience isolation, loneliness and burnout from the demands of parenthood, with many feeling a lack of support in fulfilling that role.

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BioPharma Drive: Drug Pricing

APRIL 24, 2024

The mRNA vaccine maker, which has lost most of its value since early 2021, is undergoing an “organizational redesign” that will involve the elimination of 150 positions.

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Vaccine 70

Science Daily: Pharmacology News

APRIL 24, 2024

In a significant development in the field of superconductivity, researchers have successfully achieved robust superconductivity in high magnetic fields using a newly created one-dimensional (1D) system. This breakthrough offers a promising pathway to achieving superconductivity in the quantum Hall regime, a longstanding challenge in condensed matter physics.

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Research 87

BioPharma Drive: Drug Pricing

APRIL 24, 2024

While the company is eager to diversify, CEO Chris Viehbacher said that in the near-term any dealmaking would likely focus on collaborations and early-stage assets.

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Science Daily: Pharmacology News

APRIL 24, 2024

Oncorhynchus rastrosus, a giant species of salmon that lived in the North American Pacific Northwest a few million years ago, sported a pair of front teeth that projected out from the sides of its mouth like tusks, according to a new study.

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BioPharma Drive: Drug Pricing

APRIL 24, 2024

First quarter sales of Zurzuvae doubled consensus estimates, though analysts are skeptical whether the better-than-expected launch will continue.

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Drugs 76

FDA Law Blog: Biosimilars

APRIL 24, 2024

By Allyson B. Mullen & Jeffrey N. Gibbs — We’ve been hearing for quite some time that a Final LDT Rule would likely be coming this spring, before May 1. This timing has been attributed to FDA’s desire to avoid having the rule being overturned by Congress under the Congressional Review Act. Of course, if a new administration takes over next year, the rule’s future would be questionable, even without congressional action.

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