Wed.Jan 31, 2024

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Claims that AI will “revolutionise pharma R&D” are (almost entirely) hype

DrugBaron

This month’s announcement that Alphabet’s Isomorphic Labs, led by the talented and charismatic Deepmind co-founder Demis Hassabis, had inked discovery collaboration deals with both Lilly and Novartis was just the latest indication that AI-enabled pharma R&D was ready for the big time. Billions of dollars have been invested in companies promising to “revolutionise pharma R&D” through the application of artificial intelligence – but it is now clear that global pharma companies, and not ju

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Trees struggle to 'breathe' as climate warms

Science Daily: Pharmacology News

Trees are struggling to sequester heat-trapping carbon dioxide (CO2) in warmer, drier climates, meaning that they may no longer serve as a solution for offsetting humanity's carbon footprint as the planet continues to warm, according to a new study.

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Chemotherapeutics Loaded Poly(Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment [Chemotherapy, Antibiotics, and Gene Therapy]

ASPET

Chemophotothermal therapy is an emerging treatment for metastatic and drug resistant cancer anomalies. Among various photothermal agents tested, polydopamine provides an excellent biocompatible alternative that can be used to develop novel drug delivery carriers for cancer treatment. This study explores the synthesis of starch encapsulated, polydopamine coated core-shell nanoparticles, in a one pot synthesis approach and by surfactant free approach.

Treatment 100
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Exposure to even moderate levels of radon linked to increased risk of stroke

Science Daily: Pharmacology News

Radon is the second leading cause of lung cancer. Now a new study has found exposure to this invisible, odorless gas is also linked to an increased risk of stroke. The study, which examined exposures in middle age to older female participants, found an increased risk of stroke among those exposed to high and even moderate concentrations of the gas compared to those exposed to the lowest concentrations.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Lucanthone, a Potential PPT1 inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation and Slows the Growth of Temozolomide-Resistant Gliomas in Vivo [Chemotherapy, Antibiotics, and Gene Therapy]

ASPET

Glioblastoma (GBM) is the most frequently diagnosed primary CNS tumor in adults. Despite the standard of care therapy which includes surgical resection, temozolomide chemotherapy, radiation and the newly added tumor treating fields, median survival remains only ~20 months. Unfortunately, GBM has a ~100% recurrence rate, but after recurrence there are no FDA-approved therapies to limit tumor growth and enhance patient survival, as these tumors are resistant to TMZ.

Therapies 100
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Engineering viruses to kill deadly pathogens

Science Daily: Pharmacology News

Antimicrobial resistance is an urgent and growing global crisis. Researchers are exploring phages, viruses that infect bacteria, as a possible solution. In the new study, researchers successfully modified DNA from four types of phages to kill a deadly pathogen. The process can also be used to produce more phage variants for further exploration.

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More Trending

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Six Million U.S. Women Became Pregnant Due to Rape, Coercion in Their Lifetimes: Study

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- Becoming pregnant as a result of sexual violence is disturbingly common in the United States, a new study reveals.Nearly 6 million U.S. women have become pregnant as a result of rape or sexual coercion, researchers.

Research 105
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Neanderthals and humans lived side by side in Northern Europe 45,000 years ago

Science Daily: Pharmacology News

Archaeologists have debated whether Neanderthals or modern humans made stone tools that are found at sites across northern Europe and date from about 40,000 years ago. A new excavation at one site in Germany turned up 45,000-year-old bone fragments that, when analyzed for mitochondrial DNA, proved to be from Homo sapiens. This is the earliest evidence that modern humans overlapped with Neanderthals in northwest Europe, thousands of years before Neanderthals went extinct.

DNA 110
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New CMS pilot to test payment scheme for pricey sickle cell gene therapies

BioPharma Drive: Drug Pricing

The agency is planning a pilot program across states to help sickle cell patients access treatments like the newly approved Casgevy and Lyfgenia.

Therapies 113
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Unprecedented ocean heating shows risks of a world 3°C warmer

Science Daily: Pharmacology News

New research examines the causes of the record-breaking ocean temperatures witnessed in 2023.

Research 143
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Biogen quits Aduhelm, handing back rights to original developer

BioPharma Drive: Drug Pricing

The decision to discontinue the controversial drug closes a tumultuous three-year saga that brought significant upheaval to the company.

Drugs 116
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Source rocks of the first real continents

Science Daily: Pharmacology News

Geoscientists have uncovered a missing link in the enigmatic story of how the continents developed- - a revised origin story that doesn't require the start of plate tectonics or any external factor to explain their formation. Instead, the findings rely solely on internal geological forces that occurred within oceanic plateaus that formed during the first few hundred million years of Earth's history.

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Journey Science : How Journey Science is Transforming Data Science and Customer Experience

Perficient: Drug Development

Computer Science, Data Science, Journey Science. Computer Science: The Here and Now In the beginning, Computer Science was abstract. The theoretical concepts of Boole, Turing, Babbage, and Lovelace quickly gave way to real-life innovations. Their focus was ambitious but simple: Change the world by making our lives more efficient and less error-prone, relying on machines to do repetitive tasks humans were less suited to.

Science 98
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Harrison’s Superhero Story

KIF1A

“Harrison is the most amazing little boy who makes us all so proud everyday. He is very determined and independent, he loves school, absolutely loves the outdoors, and has a wonderful brother and sister who support him at all times.” A message from Harrison’s family: Harrison was a very fussy upset baby, we had no idea why and went through many problem solving options with doctors.

Doctors 98
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Breast Cancer Gene Test May Lead to Worse Care for Black Patients

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- A common genetic test to determine treatment options for breast cancer could be leading some Black patients to forego chemotherapy that might have helped them, a new study says.The test appears to underestimate the.

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Women in Stem with Dr Sara Sangha

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? As a female undergraduate student studying pharmaceutical sciences, one of the biggest challenges was not having enough female leaders as mentors. Even today, women make up only 34 percent of the STEM workforce, with men drastically outnumbering women in STEM college majors.

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Could Eating Kimchi Each Day Help Folks Stay Slim?

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- It's been a staple at Korean dinner tables for centuries, and the fermented veggie concoction known as kimchi is increasingly familiar to Americans. Now, Korean researchers say a few servings of the spicy food each day.

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GSK sales of RSV vaccine stay strong, beating forecast

BioPharma Drive: Drug Pricing

The British drugmaker reported Arexvy sales of about $1.5 billion for 2023, higher than the range it had previously predicted for the year.

Vaccine 110
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Tomato Juice May Help Kill Off the Typhoid Bacteria

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- The bacteria behind typhoid, a major killer of children in the developing world, could be vulnerable to something as simple as tomato juice, new research suggests.Typhoid is caused by the Salmonella Typhi bacterium, and.

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University of Oklahoma research advances understanding of a deadly disease that affects premature babies

SCIENMAG: Medicine & Health

In the past year, three researchers at the University of Oklahoma College of Medicine at OU Health Sciences have earned more than $5 million in grant money to study causes and potential treatments for necrotizing enterocolitis, a deadly intestinal disease that primarily affects infants born prematurely.

Disease 92
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Just a Small Boost in Fitness Cuts Men's Prostate Cancer Risk

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- Even small increases in a man’s cardio fitness can significantly reduce his risk of developing prostate cancer, researchers report.An annual increase in aerobic fitness of 3% or more is linked to a 35% lower risk of.

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Bright galaxies put dark matter to the test

Science Daily: Pharmacology News

The earliest galaxies are thought to have formed as the gravitational pull of dark matter, which has been impossible to study directly, slowly drew in enough hydrogen and helium to ignite stars. But astrophysicists now show that after the Big Bang, hydrogen and helium gas bounced at supersonic speeds off dense, slowly moving clumps of cold dark matter.

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Autoimmune disease and pregnancy

SCIENMAG: Medicine & Health

SEATTLE – For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes.

Disease 87
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New and highly infectious E. coli strain resistant to powerful antibiotics

Science Daily: Pharmacology News

A new type of E. coli that is both highly infectious and resistant to some antibiotics has been discovered. The newly identified mutation of antibiotic-resistant E. coli is described in a new article. The team suggests that some existing antibiotics called carbapenems will be ineffective against the bacteria.

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After big shocks such as the pandemic lockdowns and the invasion of Ukraine, happiness levels may return to normal in as little as 2-3 weeks, per sentiment analysis of tweets in ten countries

SCIENMAG: Medicine & Health

After big shocks such as the pandemic lockdowns and the invasion of Ukraine, happiness levels may return to normal in as little as 2-3 weeks, per sentiment analysis of tweets in ten countries Credit: AbsolutVision, Pixabay, CC0 ([link] After big shocks such as the pandemic lockdowns and the invasion of Ukraine, happiness levels may return […]

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Archaeological evidence of seasonal vitamin D deficiency discovered

Science Daily: Pharmacology News

Rickets ran rife in children following the Industrial Revolution, but new research has found factory work and polluted cities aren't entirely to blame for the period's vitamin D deficiencies.

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Non-invasive wearable devices might be able to predict preterm birth by monitoring changes in maternal heart rate variability

SCIENMAG: Medicine & Health

Non-invasive wearable devices might be able to predict preterm birth by monitoring changes in maternal heart rate variability Credit: WHOOP, CC-BY 4.

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Biogen Is Dropping Controversial Alzheimer's Drug Aduhelm

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- Biogen, maker of the Alzheimer's medicine Aduhelm, announced Wednesday that it would "discontinue the development and commercialization" of the controversial drug.

Drugs 72
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Lupus Research Alliance 2023 Dr. William E. Paul Distinguished Innovator Award granted to Yale School of Medicine Researcher Akiko Iwasaki, Ph.D.

SCIENMAG: Medicine & Health

NEW YORK, NY – January 31. The Lupus Research Alliance (LRA) is pleased to grant the 2023 Dr. William E. Paul Distinguished Innovator Award (DIA) to Akiko Iwasaki, Ph.D., Sterling Professor of Immunobiology at the Yale School of Medicine. Dr.

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Elon Musk Says First Human Has Received Neuralink Brain Implant

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- Elon Musk, co-founder of Neuralink, said this week that the company placed the first brain implant in a human over the weekend.In a statement posted on X, the platform formerly known as Twitter that is now owned by.

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New patent for Abbvie drug RESTASIS

Drug Patent Watch

Annual Drug Patent Expirations for RESTASIS Restasis is a drug marketed by Abbvie and is included in one NDA. It is available from four suppliers. There are ten patents protecting… The post New patent for Abbvie drug RESTASIS appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 64
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Folks Often Hide Infectious Illness at Work, Socializing

Drugs.com

WEDNESDAY, Jan. 31, 2024 -- A disturbing number of people sick with an infectious disease conceal their illness to avoid missing work, travel or social events, new research reveals.About three in four people (75%) had either hidden an infectious.

Disease 75
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New patent for Pharmacyclics Llc drug IMBRUVICA

Drug Patent Watch

Annual Drug Patent Expirations for IMBRUVICA Imbruvica is a drug marketed by Pharmacyclics Llc and is included in three NDAs. It is available from one supplier. There are forty-one patents… The post New patent for Pharmacyclics Llc drug IMBRUVICA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 64