Early Impact Of The Inflation Reduction Act On Drug Discovery
Forbes: Drug Truths
MARCH 6, 2024
There is another aspect of this provision of the IRA that is starting to be felt – "the small molecule penalty"
Wed.Mar 06, 2024
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FDA Warns of Toxic Lead in Cinnamon Products
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- The U.S. Food and Drug Administration issued a health advisory Wednesday warning consumers that six brands of ground cinnamon are tainted with lead. The FDA urged folks to throw away and not buy the following brands of.
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Schizophrenia and aging may share a common biological basis
Broad Institute
MARCH 6, 2024
Schizophrenia and aging may share a common biological basis By Allessandra DiCorato March 6, 2024 Breadcrumb Home Schizophrenia and aging may share a common biological basis Tightly synchronized genetic changes in two types of brain cells may underlie cognitive impairment in both conditions, offering potential therapeutic clues. By Allessandra DiCorato March 6, 2024 Credit: Ricardo Job-Reese, Broad Communications A new study of aging and schizophrenia reveals synchronized gene expression in astr
Computational analysis followed by in vitro studies to explore cytokines (TNF??, IL?6 and IL?1?) inhibition potential of the new natural molecule polonilignan
Chemical Biology and Drug Design
MARCH 6, 2024
Computational analysis and in vitro studies corroborated the cytokines (TNF-α, IL-6 and IL-1β) inhibition potential of the new natural molecule polonilignan. Abstract Targeting pro-inflammatory cytokines and their production is found to be of therapeutic benefit for the regulation of inflammation in various chronic autoimmune diseases. Our continued efforts to discover small molecular-weight pro-inflammatory cytokine inhibitors resulted in identifying a novel natural lignan molecule named poloni
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Humanization of SLCO2B1 in rats increases rCYP3A1 protein expression but not the metabolism of erlotinib to OSI-420 [Metabolism, Transport, and Pharmacogenetics]
ASPET
MARCH 6, 2024
The organic anion transporting polypeptide (OATP) 2B1 (gene name SLCO2B1 ) is an uptake transporter that facilitates cellular accumulation of its substrates. In order to assess the in vivo relevance of the transporter, we applied SLCO2B1 +/+ knock-in and Slco2b1 -/- knock-out rats. A first pharmacological phenotyping with the OATP2B1 substrate-drug atorvastatin revealed reduced hepatic content and increased expression of rCYP3A1 in the humanized animals.
Sinking land increases risk for thousands of coastal residents by 2050
Science Daily: Pharmacology News
MARCH 6, 2024
A new study provides a new comprehensive look at the potential for flooding in a combined 32 cities along the Atlantic, Pacific, and Gulf coasts. It predicts as many as 500,000 people will be affected by flooding alongside 1 in 35 privately owned properties within the next three decades, and it highlights the racial and socioeconomic demographics of those potentially affected.
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Astronomers spot oldest 'dead' galaxy yet observed
Science Daily: Pharmacology News
MARCH 6, 2024
A galaxy that suddenly stopped forming new stars more than 13 billion years ago has been observed by astronomers. Using the James Webb Space Telescope, astronomers have spotted a 'dead' galaxy when the universe was just 700 million years old, the oldest such galaxy ever observed.
Wegovy, Ozempic Use Could Complicate Your Surgery
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- Weight-loss drugs like Wegovy and Ozempic can increase a person’s risk of throwing up during surgery while under anesthesia, a new study reports. People are typically asked to fast prior to surgery because general.
Nanodevices can produce energy from evaporating tap or seawater
Science Daily: Pharmacology News
MARCH 6, 2024
Researchers have discovered that nanoscale devices harnessing the hydroelectric effect can harvest electricity from the evaporation of fluids with higher ion concentrations than purified water, revealing a vast untapped energy potential.
Co-founder of Company Behind Deadly 2012 Meningitis Outbreak Gets Up to 15 Years in Prison
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- Barry Cadden, co-founder of a specialty compounding pharmacy behind a deadly meningitis outbreak in 2012, has been handed a prison sentence of 10 to 15 years in Michigan for involuntary manslaughter.On Tuesday, Cadden.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Healable cathode could unlock potential of solid-state lithium-sulfur batteries
Science Daily: Pharmacology News
MARCH 6, 2024
Engineers developed a cathode material for lithium-sulfur (Li-S) batteries that is healable and highly conductive, overcoming longstanding challenges of traditional sulfur cathodes. The advance holds promise for bringing more energy dense and low-cost Li-S batteries closer to market.
FDA Clears First OTC Continuous Blood Glucose Monitor
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- The U.S. Food and Drug Administration on Tuesday approved the country's first continuous glucose monitor for type 2 diabetes.The new Dexcom Stelo Glucose Biosensor System, which will be available by summer, is intended.
Bee-2-Bee influencing: Bees master complex tasks through social interaction
Science Daily: Pharmacology News
MARCH 6, 2024
Bumblebees successfully learned a two-step puzzle box task through social observation. This task was too complex for individual bees to learn on their own. Observing trained demonstrator bees performing the first unrewarded step was crucial for successful social learning. Individual bees failed to solve the puzzle without previous demonstration, despite extensive exposure.
Drug-Emitting Vaginal Ring Safely Protects Pregnant Women From HIV
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- A vaginal ring that emits the antiviral dapivirine has passed safety trials and could shield vulnerable women against HIV infection during pregnancy, a new trial shows."We now have data on the ring’s safety during all.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Genetic mutation in a quarter of all Labradors hard-wires them for obesity
Science Daily: Pharmacology News
MARCH 6, 2024
New research finds around a quarter of Labrador retriever dogs face a double-whammy of feeling hungry all the time and burning fewer calories due to a genetic mutation.
Free COVID Test Orders to End on March 8
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- Americans will not be able to order free at-home COVID tests after Friday, U.S. health officials announced Tuesday.Households across the country have been able to order four free rapid antigen tests.
Missing disease-related gene identified in generalized pustular psoriasis
SCIENMAG: Medicine & Health
MARCH 6, 2024
A team from Nagoya University in Japan has identified previously unidentified gene variants that are associated with the development of generalized pustular psoriasis (GPP). The team’s findings, published in the Journal of the American Academy of Dermatology, offer hope for improving diagnosis and therapy.
Many Can't Access Mental Health Services that Save Money, Keep People Out of Jail
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- When it comes to giving at-risk Americans access to the mental health services they need, prevention is far better than detention, new research confirms.However, a majority of the 950 U.S. counties surveyed in the report.
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Making quantum bits fly
Science Daily: Pharmacology News
MARCH 6, 2024
Physicists are developing a method that could enable the stable exchange of information in quantum computers. In the leading role: photons that make quantum bits 'fly'.
Breastfeeding After COVID Booster Passes Protective Antibodies to Baby
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- There's more evidence bolstering the health effects of both breastfeeding and the COVID booster shot: Vaccinated, breastfeeding moms appear to pass COVID-fighting antibodies to their infants. That's important, since.
GELATIN-Free Medicines: Which Drugs Contain GELATIN?
Drug Patent Watch
MARCH 6, 2024
GELATIN-Free Medicines, 2024 is part of DrugPatentWatch’s deep library of business intelligence on biopharmaceutical drugs. Buy Gelatin-Free Medicines on Amazon This guide is designed to provide information for healthcare providers to… The post GELATIN-Free Medicines: Which Drugs Contain GELATIN? appeared first on DrugPatentWatch - Make Better Decisions.
Iron Gathers in Brain After Concussions
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- Folks who've suffered a concussion and then develop headaches show iron accumulation in their brains, new research discovers.Excess brain iron stores are a hallmark of damage, noted a team led by Simona Nikolova, of the.
Revealing a hidden threat: Researchers show viral infections pose early heart risks
SCIENMAG: Medicine & Health
MARCH 6, 2024
In a potentially game-changing development, scientists with the Fralin Biomedical Research Institute at VTC have revealed a new understanding of sometimes fatal viral infections that affect the heart.
Dirty Air Increasingly Affects Minority Communities
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- Air pollution harms the health of everyone exposed to it, but a new study says communities of color are disproportionately harmed by dirty air.Smog causes nearly 8 times higher childhood asthma rates and 1.3 times higher.
Impact of COVID on people with epilepsy: higher rate of deaths and hospital admissions
SCIENMAG: Medicine & Health
MARCH 6, 2024
SWANSEA UNIVERSITY NEWS RELEASE Credit: Swansea University SWANSEA UNIVERSITY NEWS RELEASE 06 March 2024 Impact of COVID on people with epilepsy: higher rate of deaths and hospitalisations, new research shows People with epilepsy had a higher risk of being hospitalised with COVID and of dying from COVID during the first 15 months of […]
Some Women Escape the Mental Health Effects of Menopause: Study
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- Menopause is thought to trigger mood changes among women, with changes in female hormone levels contributing to anxiety, depression and stress.However, a new study says some women are at more risk than others for.
Higher BMI is significantly associated with worse mental health, especially in women, per study of middle-aged and older adults which adjusted for lifestyle and demographic factors
SCIENMAG: Medicine & Health
MARCH 6, 2024
Higher BMI is significantly associated with worse mental health, especially in women, per study of middle-aged and older adults which adjusted for lifestyle and demographic factors Credit: Teona Smith, Pexels, CC0 ([link] Higher BMI is significantly associated with worse mental health, especially in women, per study of middle-aged and older adults which adjusted for lifestyle […]
Regenxbio data suggest ‘niche’ in Duchenne gene therapy
BioPharma Drive: Drug Pricing
MARCH 6, 2024
Study results showed early signs of promise in Duchenne patients who are currently ineligible to receive Sarepta’s Elevidys, triggering a stock surge.
This injectable hydrogel mitigates damage to the right ventricle of the heart
SCIENMAG: Medicine & Health
MARCH 6, 2024
An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journal of the American College of Cardiology: Basic to Translational Science.
Sionna raises another $182M to challenge Vertex in cystic fibrosis
BioPharma Drive: Drug Pricing
MARCH 6, 2024
Incubated by RA Capital and backed by a wide array of investors, the startup is developing drugs that work differently than Vertex’s market-leading medicines.
Do some electric fish sense the world through comrades' auras?
Science Daily: Pharmacology News
MARCH 6, 2024
It would be a game-changer if all members of a basketball team could see out of each other's eyes in addition to their own. Biologists have found evidence that this kind of collective sensing occurs in close-knit groups of African weakly electric fish, also known as elephantnose fish. This instantaneous sharing of sensory intelligence could help the fish locate food, friends and foes.
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D
Covalent Modifiers
MARCH 6, 2024
Qinheng Zheng, Ziyang Zhang, Keelan Z. Guiley & Kevan M. Shokat Nat Chem Biol 2024 [link] K-Ras is the most commonly mutated oncogene in human cancer. The recently approved non-small cell lung cancer drugs sotorasib and adagrasib covalently capture an acquired cysteine in K-Ras-G12C mutation and lock it in a signaling-incompetent state. However, covalent inhibition of G12D, the most frequent K-Ras mutation particularly prevalent in pancreatic ductal adenocarcinoma, has remained elusive due t
Gilead bets on ‘trispecifics’ in latest cancer drug deal
BioPharma Drive: Drug Pricing
MARCH 6, 2024
A small partnership with Merus adds to Gilead’s string of cancer dealmaking, which, so far, has not paid off for the large biotech.
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