Thu.Nov 30, 2023

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Scientists build tiny biological robots from human cells

Science Daily: Pharmacology News

Scientists have created tiny moving biological robots from human tracheal cells that can encourage the growth of neurons across artificial 'wounds' in the lab. Using patients' own cells could permit growth of Anthrobots that assist healing and regeneration in the future with no nead for immune suppression.

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Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries [Drug Discovery and Translational Medicine]

ASPET

Deployment of the tear gas agent 2-chlorobenzalmalononitrile (CS) for riot control has significantly increased in recent years. The effects of CS have been believed to be transient and benign. However, CS induces severe pain, blepharospasm, lachrymation, airway obstruction, and skin blisters, and with frequent injuries and hospitalizations have been reported following exposure.

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Lost brain function restored in mice after stroke

Science Daily: Pharmacology News

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

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Protective Activity of Novel Hydrophilic Synthetic Neurosteroids on Organophosphate Status Epilepticus-induced Chronic Epileptic Seizures, Non-Convulsive Discharges, High-Frequency Oscillations and Electrographic Ictal Biomarkers [Neuropharmacology]

ASPET

Nerve agents and organophosphates (OP) are neurotoxic chemicals that induce acute seizures, status epilepticus (SE), and mortality. Long-term neurological and neurodegenerative effects manifest months to years after OP exposure. Current benzodiazepine anticonvulsants are ineffective in preventing such long-term neurobehavioral and neuropathological changes.

Disease 100
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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What to know about colon cancer stages

Antidote

Despite the fact that colorectal cancer cases have been declining in the United States since the mid-1980s, it is still the third most common cancer diagnosed each year excluding skin cancer. Often shortened to colon cancer, colorectal cancer occurs when cells in the colon and/or the rectum begin to grow uncontrollably and eventually spread to other parts of the body.

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A murine model of vesicant-induced Acute Lung Injury [Toxicology]

ASPET

Burn injuries including those caused by chemicals can result in systemic effects and acute lung injury (ALI). Cutaneous exposure to Lewisite, a warfare and chemical burn agent, also causes ALI. To overcome the limitations in conducting direct research on Lewisite-induced ALI in a laboratory setting, an animal model was developed using phenylarsine oxide (PAO) as a surrogate for lewisite.

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Biotech Consolidation: Not Really Happening

LifeSciVC

After the bursting of the pandemic biotech bubble, talk of industry consolidation was ubiquitous. The sector had pushed out too many IPOs during the go-go years, leading to too many public biotech companies, with sub-scale enterprises, and wasteful crowding in lots of therapeutic categories. And too many inexperienced management teams leading those newly-minted public companies.

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Why Cats Sniff Each Other’s Butts

PLOS: DNA Science

Anyone who lives with more than one member of Felis catus knows that our beloved felines love to smell each other’s anal regions. Now a research team from the Department of Evolution and Ecology and Genome Center University of California, Davis, explains why, with their cataloging of the microbiomes of domestic cat anal glands. The bacterial members of the microbiome produce and release organic compounds that affect the behavior of another cat.

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Five Predictions for the Biopharma and Biotech Industries in 2024

PPD

As we approach the end of 2023, it’s time to reflect on the past 12 months and how advances in drug development shaped the pharma and biotech industries. These shifts are a prelude to further change and progress in the clinical trial landscape in 2024. This year, the U.S. Food and Drug Administration (FDA) has approved 47 new molecular entities for therapeutic use, already exceeding last year’s progress, which yielded 37 novel drug approvals.

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EPA to Require Removal of All Lead Pipes From U.S. Water System

Drugs.com

THURSDAY, Nov. 30, 2023 (Healthday News) -- The U.S. Environmental Protection Agency announced Thursday that it plans to require the removal of all lead pipes from the country's water systems.The proposed rule, an ambitious effort that will cost up.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Women in Stem with Andrea Pfeifer

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I’ve been involved in STEM for my entire academic and professional career. From an early age, I’ve been passionate about finding cures for difficult-to-treat diseases. After earning a PhD in toxicology from the University of Würzburg in Germany, I started my professional career as a cancer research scientist in the Human Carcinogenesis branch of the National Cancer Institute (USA).

Disease 95
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New study uses genetic data to support use of thiazide diuretics for kidney stone prevention

SCIENMAG: Medicine & Health

Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for kidney stone prevention because they reduce the excretion of urinary calcium.

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More Evidence That Regular Mammograms Save Lives

Drugs.com

THURSDAY, Nov. 30, 2023 -- A woman who gets her regular mammograms as scheduled is much less likely to die from breast cancer than if she skips screenings, a new study shows.Women with breast cancer who underwent all her scheduled mammograms had a.

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Early rhythm control, lifestyle modification and more tailored stroke risk assessment are top goals in managing atrial fibrillation

SCIENMAG: Medicine & Health

The American College of Cardiology (ACC) and the American Heart Association (AHA), along with several other leading medical associations, have issued a new guideline for preventing and optimally managing atrial fibrillation (AFib). The guideline was jointly published today in the Journal of the American College of Cardiology and Circulation.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The waxy surface protecting plants might hold the key to developing stronger crops

Science Daily: Pharmacology News

Researchers have discovered that the waxy protective barrier around plants might play a role in sending chemical signals to other plants and insects.

Research 104
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EU/EEA: HIV diagnoses rise for the first time in a decade

SCIENMAG: Medicine & Health

Across the 30 countries of the European Union and European Economic Area (EU/EEA), 22,995 new HIV diagnoses were reported in 2022. Almost every second new HIV diagnosis (49%, n=11,103) was among migrants, i.e. among people who were not born in in the country they were diagnosed in. born abroad from the country of their diagnosis.

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Climate: Why disinformation is so persistent

Science Daily: Pharmacology News

Melting of glaciers, rising sea levels, extreme heat waves: the consequences of climate change are more visible than ever, and the scientific community has confirmed that humans are responsible. Yet studies show that a third of the population still doubts or disputes these facts. The cause is disinformation spread by certain vested interests. To try and prevent this phenomenon, a team has developed and tested six psychological interventions on nearly 7,000 participants from twelve countries.

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Odette Tomescu-Hatto appointed Institut Pasteur Executive Vice-President, International Affairs

SCIENMAG: Medicine & Health

Dr. Odette Tomescu-Hatto has been appointed Executive Vice-President, International Affairs at the Institut Pasteur, with effect from January 2024. Credit: © Institut Pasteur – François Gardy Dr. Odette Tomescu-Hatto has been appointed Executive Vice-President, International Affairs at the Institut Pasteur, with effect from January 2024.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Durable plastic pollution easily, cleanly degrades with new catalyst

Science Daily: Pharmacology News

Found in fishing nets, carpet, clothing, Nylon-6 is a major contributor to plastic pollution, including ocean pollution. Now, chemists have developed a new catalyst that quickly, cleanly and completely breaks down Nylon-6 in a matter of minutes -- without generating harmful byproducts. Even better: The process does not require toxic solvents, expensive materials or extreme conditions, making it practical for everyday applications.

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George Demetri, MD, of Dana-Farber earns Lifetime Achievement Award in Medicine from Stanford University School of Medicine

SCIENMAG: Medicine & Health

Boston – George Demetri, MD, director of the Sarcoma Center at Dana-Farber Cancer Institute, is being awarded the prestigious J.E. Wallace Sterling Lifetime Achievement Award in Medicine from the Stanford Medicine Alumni Association (SMAA).

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Discovery of planet too big for its sun throws off solar system formation models

Science Daily: Pharmacology News

The discovery of a planet that is far too massive for its sun is calling into question what was previously understood about the formation of planets and their solar systems.

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Mass General-developed brain care score (BCS) is a scientifically validated way to assess current health habits and risk to future brain health

SCIENMAG: Medicine & Health

BOSTON – Individuals can improve their brain care and reduce their risk of developing brain diseases such as dementia and stroke by focusing on a list of 12 steps covering modifiable physical, lifestyle, and social-emotional components of health.

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Twin research indicates that that a vegan diet improves cardiovascular health

Science Daily: Pharmacology News

A recent trial of identical twins comparing vegan and omnivore diets found that a vegan diet improves overall cardiovascular health.

Research 104
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Center for BrainHealth publishes new model to predict improvement in brain health

SCIENMAG: Medicine & Health

As part of its ongoing quest to advance better brain health and performance, new research led by Center for BrainHealth at The University of Texas at Dallas investigated neural biomarkers associated with improvements on a brain health index.

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New Clues to What Might Drive Tinnitus

Drugs.com

THURSDAY, Nov. 30, 2023 -- Tinnitus, or "ringing in the ears," affects up to 1 in every 10 people and can be disabling for some.Now, scientists at the Massachusetts Ear and Eye Infirmary believe they may have discovered a key cause of the.

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Inoculation against diseased fields

Science Daily: Pharmacology News

Farmland often harbors a multitude of pathogens which attack plants and reduce yields. A research team has now shown that inoculating the soil with mycorrhizal fungi can help maintain or even improve yields without the use of additional fertilizers or pesticides. In a large-scale field trial, plant yield increased by up to 40 percent.

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Could an Overactive Thyroid Harm the Aging Brain?

Drugs.com

THURSDAY, Nov. 30, 2023 -- Elevated levels of thyroid hormone appear to harm the aging brain, increasing seniors’ risk of dementia or other cognitive disorders, a new study finds.High levels of thyroid hormone -- a condition called thyrotoxicosis.

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A mixed origin made maize successful

Science Daily: Pharmacology News

Maize is one of the world's most widely grown crops. It is used for both human and animal foods and holds great cultural significance, especially for indigenous peoples in the Americas. Yet despite its importance, the origins of the grain have been hotly debated for more than a century. Now new research shows that all modern maize descends from a hybrid created just over 5000 years ago in central Mexico, thousands of years after the plant was first domesticated.

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Day Cares Aren't COVID 'Super Spreaders,' Study Finds

Drugs.com

THURSDAY, Nov. 30, 2023 (Healthday News) -- Parents should worry less about whether their young child could catch COVID while in daycare, and worry more about them being infected at home once a family member falls ill, new research suggests. In.

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Build a tube handling system that works for you in 2 easy steps

sptlabtech

Recognizing that laboratories have diverse requirements, we believe in abandoning a one-size-fits-all approach when it comes to tube handling. As an integral part of your research, tube handling systems must be able to address your specific needs to deliver maximum value. With our BioMicroLab XL systems , not only can you select a base unit depending on your rack capacity needs, but you have the freedom to add on modules that provide the exact functionality you need.

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Rocky planets can form in extreme environments

Science Daily: Pharmacology News

Astronomers have provided the first observation of water and other molecules in the highly irradiated inner, rocky-planet-forming regions of a disk in one of the most extreme environments in our galaxy. These results suggest that the conditions for terrestrial planet formation can occur in a possible broader range of environments than previously thought.

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How Direct-to-Consumer Rx Platforms Help Patient Support Programs Succeed

Drug Channels

Today’s guest post comes from Josh Bliss, Head of Pharma Solutions at SingleCare. Josh outlines manufacturers’ challenge when educating and informing patients about patient support programs. He then describes the SingleCare prescription discount card and Pharma Solutions , which provides manufacturers with a platform to reach patients. Click here to learn how manufacturers can advertise patient support programs at the point of purchase.

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‘Bone biographies’ reveal lives of medieval England’s common people – and illuminate early benefits system

SCIENMAG: Medicine & Health

A series of ‘bone biographies’ created by a major research project tell the stories of medieval Cambridge residents as recorded on their skeletons, illuminating everyday lives during the era of Black Death and its aftermath.