Thu.May 09, 2024

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A fragment of human brain, mapped in exquisite detail

Science Daily: Pharmacology News

Researchers have created the largest synaptic-resolution, 3D reconstruction of a piece of human brain to date, showing in vivid detail each cell and its web of neural connections in a piece of human temporal cortex about half the size of a rice grain.

Research 133
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Americans Got Drug-Resistant Infections After Stem Cell Treatments in Mexico

Drugs.com

THURSDAY, May 9, 2024 -- Antibiotic-resistant meningitis or severe, long-lasting joint infections: That's what three U.S. "medical tourists" brought home after seeking out unapproved stem cell treatments in Mexico, according to a new report.The.

Treatment 118
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Liberals and conservatives differ on climate change beliefs--but are relatively united in taking action

Science Daily: Pharmacology News

The division between liberals and conservatives on both climate-change beliefs and related policy support is long-standing. However, the results of a newly released global experiment show that despite these differences, the two camps actually align when it comes to taking certain actions to combat climate change.

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Can Zinc Really Shorten a Cold?

Drugs.com

THURSDAY, May 9, 2024 -- Every cold and flu season, folks are flooded with ads for zinc lozenges, sprays and syrups that promise to shorten their sniffles.Zinc might indeed reduce the duration of common cold symptoms by about two days, a new.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Generative AI that imitates human motion

Science Daily: Pharmacology News

Walking and running is notoriously difficult to recreate in robots. Now, a group of researchers has overcome some of these challenges by creating an innovative method that employs central pattern generators -- neural circuits located in the spinal cord that generate rhythmic patterns of muscle activity -- with deep reinforcement learning. The method not only imitates walking and running motions but also generates movements for frequencies where motion data is absent, enables smooth transition mo

Research 115
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Handling Not Allowed Reflection Method in Sitecore

Perficient: Drug Development

Recently, to meet project requirements, we customized and expanded the functionality of the “General Link” feature by incorporating a new “Telephone Link” feature. Everything was working correctly on our local project instance, but we got the below-listed error when the changes were deployed on the higher environment. Exception: Sitecore.Exceptions.AccessDeniedException Message: Calling Fieldtypes.ExtendedGeneralLink.ExtendedGeneralLinkForm.OnModeChange method through ref

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2D all-organic perovskites: potential use in 2D electronics

Science Daily: Pharmacology News

Perovskites are among the most researched topics in materials science. Recently, a research team has solved an age-old challenge to synthesize all-organic two-dimensional perovskites, extending the field into the exciting realm of 2D materials. This breakthrough opens up a new field of 2D all-organic perovskites, which holds promise for both fundamental science and potential applications.

Science 99
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More Than 200 Insulin Pump Users Injured After App Causes Malfunction

Drugs.com

THURSDAY, May 9, 2024 -- The U.S. Food and Drug Administration has issued a Class 1 recall -- its most urgent kind -- for an IOS app linked to a specific kind of insulin pump used by people with diabetes.The recall notice, which the FDA says is a.

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Astrophysicists discover a novel method for hunting the first stars

Science Daily: Pharmacology News

A recent study has discovered a novel method for detecting the first-generations stars, known as Population III (Pop III) stars, which have never been directly detected. These potential discoveries about Pop III stars hold the promise of unlocking the secrets of the universe's origin and providing a deeper understanding of the remarkable journey from the primordial cosmos to the world we inhabit today.

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Stomach-Zapping Procedure Lowers Appetite to Help With Weight Loss

Drugs.com

THURSDAY, May 9, 2024 -- An experimental procedure could reduce levels of a hunger-triggering hormone by burning part of a person’s stomach lining, a new study reports.In the procedure, doctors snake a tube down the patient’s throat with a tiny.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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New Rhizobia-diatom symbiosis solves long-standing marine mystery

Science Daily: Pharmacology News

Scientists have discovered a new partnership between a marine diatom and a bacterium that can account for a large share of nitrogen fixation in vast regions of the ocean. The newly-discovered bacterial symbiont is closely related to the nitrogen-fixing Rhizobia which live in partnership with many crop plants and may open up new avenues to engineer nitrogen-fixing plants.

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Colon Cancer Cases Rising Sharply Among Children, Teens

Drugs.com

THURSDAY, May 9, 2024 -- Colon cancer steadily increased among young people in the United States over the past two decades, with tweens enduring the most dramatic leap in cancer rates, a new study says.The rate of colon cancer grew 500% among kids.

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A better way to control shape-shifting soft robots

Science Daily: Pharmacology News

A new machine-learning technique can train and control a reconfigurable soft robot that can dynamically change its shape to complete a task. The researchers also built a simulator that can evaluate control algorithms for shape-shifting soft robots.

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Neuropathy Nerve Damage Often Goes Undiagnosed

Drugs.com

THURSDAY, May 9, 2024 — Though it is a widespread disorder, neuropathy often goes undiagnosed, new research shows, leaving many people at risk of falls, infection and even amputation.Neuropathy is nerve damage that causes numbness and pain in.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Squeezed by neighbors, planet glows with molten lava

Science Daily: Pharmacology News

Astrophysicists discovered that an exoplanet is covered with so many active volcanoes that seen from a distance it would take on a fiery, glowing-red hue.

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Tobacco Plus Weed in Pregnancy Could Be Lethal Combo for Baby

Drugs.com

THURSDAY, May 9, 2024 -- Smoking cigarettes while pregnant has long been known to harm the fetus, but new research shows things get even worse when marijuana is in the mix.The study by a team at Oregon Health & Science University (OSHU) in.

Science 98
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Takeda targets ‘efficiency’ in restructuring, pipeline cuts

BioPharma Drive: Drug Pricing

The company is discontinuing an array of early drug programs, including several in oncology, as it prioritizes investment in six late-stage assets.

Drugs 95
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More Data Suggests 'Ultraprocessed' Foods Can Shorten Your Life

Drugs.com

THURSDAY, May 9, 2024 -- People who eat large amounts of ultra-processed foods have a slightly higher risk of premature death than those who mostly shun the industrially produced eats, a new 30-year study says.Those who ate the most ultra-processed.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis

Covalent Modifiers

Martin K. Himmelbauer, Bekim Bajrami, Rebecca Basile, Andrew Capacci, TeYu Chen, Colin K. Choi, Rab Gilfillan, Felix Gonzalez-Lopez de Turiso, Chungang Gu, Marc Hoemberger, Douglas S. Johnson, J. Howard Jones, Ekta Kadakia, Melissa Kirkland, Edward Y. Lin, Ying Liu, Bin Ma, Tom Magee, Srinivasa Mantena, Isaac E. Marx, Claire M. Metrick, Michael Mingueneau, Paramasivam Murugan, Cathy A.

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Solving Access Barriers in Biomarker Testing: 5 Tips for Manufacturers

Drug Channels

Today’s guest post comes from Hannah Baxter, Associate Partner at The Dedham Group; Jen Klarer, Partner, Head of Cell & Gene Therapy at The Dedham Group; and Carolyn Zele, Advisor, Solution Consulting at MMIT. The authors discuss the access barriers facing patients who need biomarker testing. They discuss five ways manufacturers can prevent these barriers from affecting patients.

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Novo taps another Flagship startup in search for next obesity drugs

BioPharma Drive: Drug Pricing

The deal with Metaphore Biotechnologies is the third to emerge from a Flagship alliance that’s meant to boost the Danish drugmaker’s pipeline of weight loss medicines.

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Integrating pharmacogenetics data: a new lens for target prioritisation

The Open Targets Blog

In December 2023, we introduced the pharmacogenetics widget in the Open Targets Platform, which brings in data from PharmGKB on the influence of genetic variation on drug responses. PharmGKB is a rich knowledge base of curated annotations and information about gene-drug-disease relationships, including drug pathways and clinical guidelines as well as the genotype-phenotype associations highlighted in our first version of the widget.

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Royalty Pharma pays startup $525M for stake in Sanofi MS drug

BioPharma Drive: Drug Pricing

The deal gives the company milestone payments and royalties to a medicine, frexalimab, that Sanofi licensed from biotech ImmuNext and expects to be a future blockbuster.

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Year of the Camelid: Antibody Style

addgene Blog

The UN General Assembly has declared 2024 the International Year of Camelids. The declaration is intended to raise awareness of the economic and cultural importance of these animals to human populations around the world. Here at Addgene, we love camelids too, though not just for the reasons the UN describes. In honor of the Camelid family, I wanted to take a moment to revisit some of the ways these animals have impacted humans through biomedical research.

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Has Spring Sprouted New Growth in Immuno-Oncology?

LifeSciVC

By Jonathan Montagu, CEO of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC As Boston’s weather has started its turn from the frigid darkness that is a northeast winter to the longer days and lighter conditions of spring, the city is brimming with all the hallmarks that make this season what it is. It’s impossible to not feel a sense of optimism this time of year, and I can’t help but be struck by undeniable parallelism of this same sense of optimism that’s been palpa

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How Long Does Marijuana THC Linger in Breast Milk?

Drugs.com

THURSDAY, May 9, 2024 -- New mothers who like to smoke marijuana might wind up exposing their babies to THC through their own breast milk, a new study says.

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Tackling Mental Health Challenges in the Public Safety Sector: Implementing and Evaluating Mental Health Programs

NIOSH Science Blog: Drugs

Public safety sector workers including firefighters (structural and wildland), law enforcement officers, emergency medical services (EMS) clinicians, and corrections personnel are at a high risk of occupational exposure to traumatic events and stress. As such, mental health programs are critical for addressing the unique challenges these workers face.

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Genomic Interpretation, seqr and Matchmaker Exchange

Broad Institute

Genomic Interpretation, seqr and Matchmaker Exchange By Rose Circeo May 9, 2024 Breadcrumb Home Genomic Interpretation, seqr and Matchmaker Exchange The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tool

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Perficient Atlanta: Making a Community Impact in 2024

Perficient: Drug Development

Perficient’s Giving ERG was established in 2021 , as a way for employees to bond over philanthropy and inspire generosity. Shortly after, in September 2022, a group of liaisons was formed in Atlanta so we could start to give back to our local community in person. Since then, the Atlanta liaisons have grown to a team of 8, planning frequent events from volunteering at animal shelters, cooking meals for the unhoused, hosting food, toy and clothing donation drives, and everything in between!

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How to build your AI-enabled drug discovery program

Fierce BioTech

How to build your AI-enabled drug discovery program This whitepaper offers a thorough guide to incorporating AI into current drug discovery initiatives, highlighting the need for strategic planning, collaborative cross-functional teamwork, and the cultivation of trust. It outlines practical steps for embracing AI, including the evaluation of data infrastructure and the selection of appropriate AI tools. jkarimi Thu, 05/09/2024 - 13:57 This whitepaper offers a thorough guide to incorporating AI i

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The Significance of Universal Design for Learning in Education

Perficient: Drug Development

In the mosaic of education, diversity is the common thread that weaves through every classroom. Students come with unique backgrounds, abilities, and learning styles. Recognizing and embracing this diversity is essential for creating inclusive learning environments where all students can thrive. Universal Design for Learning (UDL) offers a transformative approach to education by providing a framework that addresses the diverse needs of learners.

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Eating Disorders Common in People With Type 1 Diabetes

Drugs.com

THURSDAY, May 9, 2024 -- One in every four people age 16 or older with type 1 diabetes may be struggling with an eating disorder, a new review of data on the subject finds.Type 1 diabetes is an autoimmune disorder in which the body attacks its own.

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Embracing Inclusivity: Education Accessibility in the Universal Design Series -1

Perficient: Drug Development

Welcome to the inaugural installment of our Universal Design Series, where we embark on a journey to explore the vital intersection of Inclusivity for Learning in Education Accessibility. In this series, we’ll delve into the principles, practices, and significance of Universal Design in creating inclusive learning environments that cater to the diverse needs of all students.