Science Daily: Pharmacology News

AUGUST 5, 2024

Seeds, twigs, and insect parts found under two miles of ice confirm Greenland's ice sheet melted in the recent past, the first direct evidence that the center -- not just the edges -- of the two-mile-deep ice melted away in the recent geological past. The new research indicates that the giant ice sheet is more fragile than scientists had realized until the last few years -- and reveals increased risk of sea-level catastrophe in a warmer future.

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Research 145

ASPET

AUGUST 5, 2024

Proinflammatory cytokines, elevated during inflammation caused by infection and/or autoimmune disorders, result in reduced clearance of drugs eliminated primarily by cytochrome P450 enzymes (CYPs). However, the effect of cytokines on hepatic drug transporter expression or activity has not been well-studied. Here, using plated human hepatocytes (PHHs; n=3 lots), we investigated the effect of interleukin (IL)-6, IL-1β, tumor necrosis factor-α (TNF-α), and interferon- (IFN-), on the

Pharmacogenetics 100

Pharmacogenetics Pharmacokinetics Drugs 100

Science Daily: Pharmacology News

AUGUST 5, 2024

With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome. GROVER treats human DNA as a text, learning its rules and context to draw functional information about the DNA sequences.

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DNA Research 132

ASPET

AUGUST 5, 2024

Cannabinoid and opioid receptor activities can be modulated by a variety of posttranslational mechanisms including the formation of interacting complexes. This study examines the involvement of endogenous and exogenous chaperones in modulating the abundance and activity of cannabinoid CB 1 receptor (CB 1 R), delta opioid receptor (DOR), and CB 1 R-DOR interacting complexes.

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Small Molecule Regulations Treatment 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

AUGUST 5, 2024

Scientists from across academic disciplines are extremely concerned about climate change. Many of them have already changed their own lifestyles or engaged in advocacy and protest, with even more being willing to do so in future. This is evident from a large-scale survey of scientists from all over the world.

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Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 -- Botanicals like turmeric, green tea and black cohosh may seem benign, but their overuse is being increasingly linked to liver injury. New research suggests that 7% of U.S. adults are using at least one of the six leading.

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Research 111

Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 (HeathDay News) -- A new antimicrobial compound can effectively clear “flesh-eating” bacterial infections in mice, a new study shows.The compound could be the first in an entirely new class of antibiotics, which could prove inv.

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Doctors 111

Science Daily: Pharmacology News

AUGUST 5, 2024

Scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of a large-animal model. New material comprises peptides, proteins and polysaccharides that mimic the microstructure of natural cartilage. Within six months, researchers observed new cartilage growth.

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Research 111

BioPharma Drive: Drug Pricing

AUGUST 5, 2024

For years, many manufacturers have assumed that pre-market physician education was not strictly necessary unless their brand was the first to market or had a novel mechanism of action. With the advent of precision medicine, however, ongoing disease state education has become increasingly critical.

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Disease Marketing 104

Science Daily: Pharmacology News

AUGUST 5, 2024

The Pyramid of Djoser, the oldest of Egypt's iconic pyramids, may have been built with the help of a unique hydraulic lift system, according to researchers. A new study suggests that water may have been able to flow into two shafts located inside the pyramid itself, where that water could have been used to help raise and lower a float used to carry the building stones.

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Research 112

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 5, 2024

MONDAY, Aug 5, 2024 -- Folks worried about bird flu, salmonella and other foodborne illnesses have a simple solution at hand – simply use a cooking thermometer to make sure food is well-cooked.But only about 1 in 4 Americans (27%) use one either “.

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Science Daily: Pharmacology News

AUGUST 5, 2024

New findings on how sharks achieve drag reduction could inspire the design of riblets for more efficient aircraft and boats. In their investigation of great white shark denticles, researchers found that ridge height and spacing play crucial roles in drag reduction at different swimming speeds. Higher middle ridges aid sharks in efficient cruising at slower speeds, while the lower side ridges become more critical for drag reduction during high-speed hunting bursts.

Research 111

Research 111

Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 -- Three out of four police officers have experienced at least one concussion, increasing their risk of mental health issues, a new study suggests. About 74% of Ohio law enforcement officers had suffered one or more head.

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Science Daily: Pharmacology News

AUGUST 5, 2024

A groundbreaking study has revealed that red dwarf stars can produce stellar flares that carry far-ultraviolet (far-UV) radiation levels much higher than previously believed.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 -- Many people with disabilities aren’t getting the exercise they need because fitness centers don’t offer adaptive equipment or staff trained in helping the disabled, a new review finds.There are few efforts by most commercial.

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Science Daily: Pharmacology News

AUGUST 5, 2024

Understanding neutrino interactions is crucial for obtaining a complete picture of particle physics and the universe. To date, neutrino interaction cross sections have not been measured at high energy above some hundred gigaelectronvolts at particle colliders. Now, researchers have obtained the first direct observation of electron and muon neutrino interactions in the Teraelectronvolt range at CERN's Large Hadron Collider, using the FASER detector.

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Research 104

Drugs.com

AUGUST 5, 2024

MONDAY, Aug 5, 2024 -- Millions of Americans use the opioid-like herbal supplement known as kratom, but evidence of its dangers continue to mount.The U.S. Food and Drug Administration has issued another alert for consumers to stay away from one.

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FDA Drugs 104

LifeSciVC

AUGUST 5, 2024

By Peter Tummino, CSO of Nimbus Therapeutics, as part of the From The Trenches feature of LifeSciVC “Over the next five to 10 years, our goal is to become a company that’s leading the world in personalized medicines, a company that is leading the world in productivity, a company with a value of over $100 billion, a company that has five to 10 products on the market …., a company with the strongest pipeline in the entire industry.

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Molecular Biology Production Small Molecule Drug Development 90

Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 -- Women who use a breast pump to store milk for their infant tend to breastfeed 21 weeks longer, on average, compared to moms who don't use the devices, new research finds.Breast pumps have gained wide use among busy new moms.

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Research 98

Science Daily: Pharmacology News

AUGUST 5, 2024

Computational modeling shows that plate tectonics weren't necessary for early continents.

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Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 -- The U.S. heart transplant list for children isn’t accurately ranking the sickest kids highest, making it more likely they may die while waiting for a donor heart, a new study claims. Some very sick children were.

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Covalent Modifiers

AUGUST 5, 2024

Thatikonda, V., Lyu, H., Jurado, S. et al. Nat Cancer (2024). [link] Combination approaches are needed to strengthen and extend the clinical response to KRASG12C inhibitors (KRASG12Ci). Here, we assessed the antitumor responses of KRASG12C mutant lung and colorectal cancer models to combination treatment with a SOS1 inhibitor (SOS1i), BI-3406, plus the KRASG12C inhibitor, adagrasib.

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Treatment 69

Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 -- Folks who rub their forehead and complain that a complex problem is making their brain hurt aren’t overstating things, a new review suggests.Mental exertion appears to be associated with unpleasant feelings in many s.

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Perficient: Drug Development

AUGUST 5, 2024

In the modern digital landscape, efficient collaboration and streamlined workflows are proven elements of successful project management. Integrating GitHub repositories with Azure Storage proves to be a robust solution for the management of project files in the cloud. Whether you’re a developer, a project manager, or a technology enthusiast, understanding how to push files from a GitHub repository to an Azure Storage container can significantly enhance your productivity and simplify your d

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Production 69

BioPharma Drive: Drug Pricing

AUGUST 5, 2024

The decision makes Bristol the latest pharma to pull back on research into a type of cancer immunotherapy that’s drawn significant investment in recent years.

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Drugs Research 70

Perficient: Drug Development

AUGUST 5, 2024

Benefits of Utilizing Path Assistant in Salesforce In today’s fast-paced business environment, efficiency and consistency are key to success. Salesforce’s Path Assistant in Lightning Experience is designed to enhance user productivity and streamline workflows by visually guiding teams through critical stages of processes. This tool not only simplifies navigation but also ensures that best practices are followed consistently across Sales and Service Processes.

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Production 52

BioPharma Drive: Drug Pricing

AUGUST 5, 2024

All doses of the in-demand GLP-1 medicines are now available in the U.S., Lilly said ahead of reporting second quarter earnings later this week.

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Drug Patent Watch

AUGUST 5, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Drugs Marketing 52

Conversations in Drug Development Trends

AUGUST 5, 2024

Role at Worldwide: Associate Director of Project Management/Global Project Lead Joined Worldwide: September 2016 LinkedIn: Margo A Smith Get to Know Margo through this Q&A What attracted you to Worldwide and what keeps you here? What attracted me to Worldwide was its stellar reputation in the CNS research community. And it really motivated me to join Worldwide.

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Clinical Trials Trials Disease Marketing 52

Drugs.com

AUGUST 5, 2024

MONDAY, Aug. 5, 2024 -- Depression can lower a woman’s chances of surviving breast cancer, a new study reports.Women with breast cancer and depression are more than three times as likely to die as women without either condition, researchers f.

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Research 52

Drug Patent Watch

AUGUST 5, 2024

OPANA ER (oxymorphone hydrochloride) Endo pharms Patent: 8,114,383 Expiration: Aug 8, 2024 See More … For more information on how […] Source

Drugs 52

Drugs 52

thought leadership

AUGUST 5, 2024

In pharmacovigilance, recognizing and responding to safety signals quickly can be crucial for patient safety. A "signal" in pharmacovigilance refers to a hypothesis, supported by evidence, of a new or known adverse event that may be caused by a drug. Here are ten areas of signal detection in pharmacovigilance to monitor that require immediate attention to ensure effective identification and mitigation of potential risks.

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Drugs 40

Drug Patent Watch

AUGUST 5, 2024

In the rapidly evolving landscape of pharmaceutical research and development, artificial intelligence (AI) has emerged as a game-changing tool.

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Pharmaceuticals Research Drugs 52

PPD

AUGUST 5, 2024

Pulmonary arterial hypertension (PAH) is a progressive and fatal lung disease that is caused or influenced by multiple factors. Historically, the available drugs and U.S. Food and Drug Administration (FDA)-approved therapies for treating PAH were primarily vasodilators, designed to overcome the imbalance between vasoactive and vasodilator mediators and to restore endothelial cell function.

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