Drug Discovery World

FEBRUARY 26, 2024

The global ADME toxicology testing market is predicted to generate a revenue of $19.21 billion by 2030, with a growth rate of 10.2%. Factors such as an increased need to check late-stage drug failures with the adoption of more appropriate toxicity testing methods by pharmaceutical companies are expected to aid revenue generation for the market. The predictions are made by ResearchAndMarkets.com in a new market report entitled ‘ADME Toxicology Testing Market Size, Share & Trends Analysis Repo

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Chemical Biology and Drug Design

FEBRUARY 26, 2024

Methyltransferase METTL3-mediated maturation of miR-4654 promotes high glucose-induced apoptosis, oxidative stress, and viability inhibition in lens epithelial cells via decreasing SOD2. Abstract N6-methyladenosine (m 6 A) modification has been reported to have roles in modulating the development of diabetic cataract (DC). Methyltransferase-like 3 (METTL3) is a critical m 6 A methyltransferase involving in m 6 A modification activation.

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RNA Regulations Therapies Research 100

Drug Discovery World

FEBRUARY 26, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. In a breakthrough for advanced therapies, this week saw the FDA approve the first ever cell therapy for solid tumour cancers, but there were other significant developments in the cell and gene therapy space.

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FDA Approval Therapies FDA Drugs 130

Chemical Biology and Drug Design

FEBRUARY 26, 2024

Cinnamaldehyde can enhance cell viability and inhibit cell apoptosis of H9C2 cardiomyocytes induced by oxygen-glucose deprivation/reoxygenation. The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model.

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DNA Treatment Disease Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 26, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. In a breakthrough for advanced therapies, this week saw the FDA approve the first ever cell therapy for solid tumour cancers, but there were other significant developments in the cell and gene therapy space.

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FDA Approval Therapies FDA Drugs 130

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- In a finding that suggests sooner is better than later, a new trial shows that giving advanced treatment early to Crohn’s patients can dramatically improve their gut health.About 80% of those who got therapy with an.

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Therapies Trials Treatment 116

Science Daily: Pharmacology News

FEBRUARY 26, 2024

Among the vast expanse of Antarctica lies the Thwaites Glacier, the world's widest glacier measuring about 80 miles on the western edge of the continent. Despite its size, the massive landform is losing about 50 billion tons of ice more than it is receiving in snowfall, which places it in a precarious position in respect to its stability. Accelerating ice loss has been observed since the 1970s, but it is unclear when this significant melting initiated -- until now.

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BioPharma Drive: Drug Pricing

FEBRUARY 26, 2024

Zealand shares rose by more than one-third on the data, which provide further evidence so-called incretin drugs could help treat people with the liver disease.

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Trials Drugs Disease 117

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Of course grief can ravage your mind, but science shows it can also weaken your body, leaving you open to illness. “As humans, we are strongly motivated to seek out social bonds that are warm, dependable, friendly and.

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Science 105

Drug Patent Watch

FEBRUARY 26, 2024

Switching pharmaceutical excipients, the inactive components used in drug formulations, can have significant implications for both production costs and market appeal. These components, while not contributing directly to the therapeutic… The post Cost-Cut Without Compromise: Navigating Excipient Switching in Pharma appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceuticals Production Marketing Drugs 105

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Comedian Amy Schumer has disclosed that she has been diagnosed with Cushing's syndrome, a condition that arises when there is too much cortisol in the body.In an interview published Friday in the News Not.

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SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

[Vienna, Feb 26 2024] — Leptospirosis is a globally distributed infectious disease that affects both animals and humans. While the infection is endemic in tropical regions, its incidence seems to increase in temperate regions.

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Disease 91

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Women might need a lot fewer daily steps to lower their risk of heart failure than they think, a new study suggests.The usual recommendation is that people get 10,000 steps a day, but women ages 63 and older actually gain.

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SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

RIVERSIDE, Calif. — Vapers are susceptible to infection by SARS-CoV-2, the virus that spreads COVID-19 and continues to infect people around the world, a University of California, Riverside, study has found. Credit: Talbot lab, UC Riverside. RIVERSIDE, Calif.

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Virus 91

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Pulse oximeters, devices that measure your blood's oxygen levels, are known to work less accurately in Black patients. Now, new research suggests faulty readings might also be worsening the care of Black people who battle.

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Research 97

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

The 7th World Conference on Targeting Phage Therapy 2024, two-day event dedicated to advancing the field of phage research and therapy will be hosted at Corinthia Palace Malta on June 20-21.

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Therapies Clinical Trials Research Trials 89

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Pulse oximeters, devices that measure your blood's oxygen levels, are known to work less accurately in Black patients. Now, new research suggests faulty readings might also be worsening the care of Black people who battle.

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Research 96

Science Daily: Pharmacology News

FEBRUARY 26, 2024

Ultraviolet-laser processing is a promising technique for developing intricate microstructures, enabling complex alignment of muscle cells, required for building life-like biohybrid actuators. Compared to traditional complex methods, this innovative technique enables easy and quick fabrication of microstructures with intricate patterns for achieving different muscle cell arrangements, paving the way for biohybrid actuators capable of complex, flexible movements.

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Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- U.S. poison center calls related to psilocybin “magic mushrooms” among youth skyrocketed after U.S. cities and states began decriminalizing the hallucinogen, a new study shows.Psilocybin-related calls among teens ages.

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Drugs 96

NIOSH Science Blog: Drugs

FEBRUARY 26, 2024

The American Journal of Public Health recently published a special supplement with 15 articles focusing on health worker mental health. As part of this special issue, our article Protecting the Mental Health and Well-being of the Nation’s Health Workforce summarizes the scope of the issue and prevention efforts underway at the Centers for Disease Control and Prevention (CDC) and the National Institute for Occupational Safety and Health (NIOSH).

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Disease 86

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

The mechanisms by which antidepressants and other emotion-focused medications work could be reconsidered due to an important new breakthrough in the understanding of how the gut communicates with the brain.

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Collaborative Drug

FEBRUARY 26, 2024

New LogP and LogD Models The models used for calculating the LogP and LogD scores based on the chemical structures registered in a Vault have been updated with an extended set of training data. The values for LogP and LogD in CDD Vault might change based on these updated models. (For example, the dataset used in the new LogD models was increased considerably by incorporating data aggregated from ChEMBL by Wang et al. (2023, ChEMBL) and by reviewing and adding new data from PubChem.

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SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

Your liver plays a vital role in your metabolism, the biological process which converts food into energy. We know that being overweight can negatively affect metabolic activity, but not exactly how. To better understand this, researchers compared the livers of mice which were a typical weight with mice which were obese.

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Research 86

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- The asthma medication Xolair has proved its prowess against food allergies, with new research showing the medication substantially lowers the chances of severe reactions in patients.Data published Sunday.

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Drugs Research 85

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

In a study in today’s (Monday Feb. 26) Nature Human Behavior, scientists delve into the world of chemical neuromodulators in the human brain, specifically dopamine and serotonin, to reveal their role in social behavior. Credit: Clayton Metz/Virginia Tech In a study in today’s (Monday Feb.

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Science Daily: Pharmacology News

FEBRUARY 26, 2024

A new record for electrical energy generation from CIGS solar cells has been reached. Scientists have achieved a 23.64 percent efficiency.

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SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

Black carbon is the most dangerous air pollutant you’ve never heard of. Its two main sources, diesel exhaust and wood smoke from wildfires and household heating, produce ultrafine air particles that are up to 25 times more of a health hazard per unit compared to other types of particulate matter.

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Science Daily: Pharmacology News

FEBRUARY 26, 2024

Striped marlin are some of the fastest animals on the planet and one of the ocean's top predators. When hunting in groups, individual marlin will take turns attacking schools of prey fish one at a time. Now a new study helps to explain how they might coordinate this turn-taking style of attack on their prey to avoid injuring each other. The key, according to the new work, is rapid color changes.

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SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

As the years add up, it’s common to notice slight changes in our ability to remember and think. Older people who have more marked changes than their peers can be diagnosed with mild cognitive impairment (MCI). Currently, we can’t easily predict which of these patients will develop Alzheimer’s disease and which will not.

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Disease 80

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Many younger children could be permanently damaging their hearing by blasting loud music on their earbuds and headphones, a new report finds.Two in three parents say that their child between the ages of 5 and 12 regularly.

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SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

In the face of increasing temperatures globally, a new Monash-led study of 1.2 million births in Sydney over two decades has shown a strong association between the risk of pre-term birth and exposure to extreme hot temperatures in the third trimester of pregnancy.

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Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Junk food increases people’s risk of colon cancer, as well as alcohol, lack of exercise and obesity.Unfortunately, many Americans don’t know about these risk factors for colon cancer, a new survey has found.Colon and.

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SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited. Another mystery is the regulation of cytochrome P450 enzymes (CYPs) in the central nervous system.

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Disease Pharmaceuticals Regulations Treatment 75

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Polycythemia vera is a rare form of blood cancer with few good treatment options, but that may soon change based on the results of a new clinical trial. An injected experimental drug called rusfertide appears effective in.

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Clinical Trials Drugs Trials Treatment 69