Chemical Biology and Drug Design

FEBRUARY 26, 2024

Methyltransferase METTL3-mediated maturation of miR-4654 promotes high glucose-induced apoptosis, oxidative stress, and viability inhibition in lens epithelial cells via decreasing SOD2. Abstract N6-methyladenosine (m 6 A) modification has been reported to have roles in modulating the development of diabetic cataract (DC). Methyltransferase-like 3 (METTL3) is a critical m 6 A methyltransferase involving in m 6 A modification activation.

RNA 100

RNA Regulations Therapies Research 100

ASPET

FEBRUARY 26, 2024

While agonists of mu (MOR) and kappa (KOR) opioid receptors have analgesic effects, they produce euphoria and dysphoria, respectively. Other side effects include respiratory depression and addiction for MOR agonists and sedation for KOR agonists. We reported that 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-{[4'-(2'-cyanopyridyl)]carboxamido}cmorphinan (NCP) displayed potent KOR full agonist and MOR partial agonist activities (58%) with 6.5x KOR-over-MOR selectivity in vitro

Drugs 100

Drugs 100

Chemical Biology and Drug Design

FEBRUARY 26, 2024

Cinnamaldehyde can enhance cell viability and inhibit cell apoptosis of H9C2 cardiomyocytes induced by oxygen-glucose deprivation/reoxygenation. The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model.

DNA 100

DNA Treatment Disease Research 100

ASPET

FEBRUARY 26, 2024

The farnesoid X receptor (FXR) is a nuclear receptor that controls bile acid, lipid, and cholesterol metabolism. FXR-targeted drugs have shown promise in late-stage clinical trials for non-alcoholic steatohepatitis. Herein, we used clinical results from our first non-steroidal FXR agonist, Px-102 (4-[2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl] benzoic acid), to develop cilofexor, a potent, non-steroidal FXR agonist with a more manageable safety p

Disease 100

Disease Treatment Clinical Trials Clinical Development 100

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Science Daily: Pharmacology News

FEBRUARY 26, 2024

Among the vast expanse of Antarctica lies the Thwaites Glacier, the world's widest glacier measuring about 80 miles on the western edge of the continent. Despite its size, the massive landform is losing about 50 billion tons of ice more than it is receiving in snowfall, which places it in a precarious position in respect to its stability. Accelerating ice loss has been observed since the 1970s, but it is unclear when this significant melting initiated -- until now.

118

118

ASPET

FEBRUARY 26, 2024

Panobinostat is a potent pan-HDAC inhibitor that has been tested in multiple studies for the treatment of brain tumors. There have been contrasting views surrounding its efficacy for the treatment of tumors in the CNS following systemic administration when examined in different models or species. We conducted experiments using three different mouse strains or genotypes to have a more comprehensive understanding of the systemic as well as the CNS distributional kinetics of panobinostat.

Metabolic Stability 100

Metabolic Stability Pharmacokinetics Pharmacogenetics Treatment 100

ASPET

FEBRUARY 26, 2024

The number of opioid overdose deaths has increased significantly over the past decade. The life-threatening effect of opioids is hypoventilation that can be reversed by the µ-opioid receptor (MOR) antagonist naloxone; however, because of the very short duration of action of naloxone, re-emergence of MOR agonist-induced hypoventilation can occur, requiring additional doses of naloxone.

Laboratories 100

Laboratories 100

BioPharma Drive: Drug Pricing

FEBRUARY 26, 2024

Zealand shares rose by more than one-third on the data, which provide further evidence so-called incretin drugs could help treat people with the liver disease.

Trials 119

Trials Drugs Disease 119

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Of course grief can ravage your mind, but science shows it can also weaken your body, leaving you open to illness. “As humans, we are strongly motivated to seek out social bonds that are warm, dependable, friendly and.

Science 105

Science 105

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

[Vienna, Feb 26 2024] — Leptospirosis is a globally distributed infectious disease that affects both animals and humans. While the infection is endemic in tropical regions, its incidence seems to increase in temperate regions.

Disease 91

Disease 91

Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Comedian Amy Schumer has disclosed that she has been diagnosed with Cushing's syndrome, a condition that arises when there is too much cortisol in the body.In an interview published Friday in the News Not.

105

105

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

RIVERSIDE, Calif. — Vapers are susceptible to infection by SARS-CoV-2, the virus that spreads COVID-19 and continues to infect people around the world, a University of California, Riverside, study has found. Credit: Talbot lab, UC Riverside. RIVERSIDE, Calif.

Virus 91

Virus 91

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Women might need a lot fewer daily steps to lower their risk of heart failure than they think, a new study suggests.The usual recommendation is that people get 10,000 steps a day, but women ages 63 and older actually gain.

105

105

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

The 7th World Conference on Targeting Phage Therapy 2024, two-day event dedicated to advancing the field of phage research and therapy will be hosted at Corinthia Palace Malta on June 20-21.

Therapies 89

Therapies Clinical Trials Research Trials 89

Advertisement

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

NIOSH Science Blog: Drugs

FEBRUARY 26, 2024

The American Journal of Public Health recently published a special supplement with 15 articles focusing on health worker mental health. As part of this special issue, our article Protecting the Mental Health and Well-being of the Nation’s Health Workforce summarizes the scope of the issue and prevention efforts underway at the Centers for Disease Control and Prevention (CDC) and the National Institute for Occupational Safety and Health (NIOSH).

Disease 89

Disease 89

Science Daily: Pharmacology News

FEBRUARY 26, 2024

Ultraviolet-laser processing is a promising technique for developing intricate microstructures, enabling complex alignment of muscle cells, required for building life-like biohybrid actuators. Compared to traditional complex methods, this innovative technique enables easy and quick fabrication of microstructures with intricate patterns for achieving different muscle cell arrangements, paving the way for biohybrid actuators capable of complex, flexible movements.

98

98

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

The mechanisms by which antidepressants and other emotion-focused medications work could be reconsidered due to an important new breakthrough in the understanding of how the gut communicates with the brain.

86

86

Drug Patent Watch

FEBRUARY 26, 2024

Switching pharmaceutical excipients, the inactive components used in drug formulations, can have significant implications for both production costs and market appeal. These components, while not contributing directly to the therapeutic… The post Cost-Cut Without Compromise: Navigating Excipient Switching in Pharma appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceuticals 82

Pharmaceuticals Production Marketing Drugs 82

Advertisement

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

Your liver plays a vital role in your metabolism, the biological process which converts food into energy. We know that being overweight can negatively affect metabolic activity, but not exactly how. To better understand this, researchers compared the livers of mice which were a typical weight with mice which were obese.

Research 86

Research 86

Collaborative Drug

FEBRUARY 26, 2024

New LogP and LogD Models The models used for calculating the LogP and LogD scores based on the chemical structures registered in a Vault have been updated with an extended set of training data. The values for LogP and LogD in CDD Vault might change based on these updated models. (For example, the dataset used in the new LogD models was increased considerably by incorporating data aggregated from ChEMBL by Wang et al. (2023, ChEMBL) and by reviewing and adding new data from PubChem.

81

81

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

In a study in today’s (Monday Feb. 26) Nature Human Behavior, scientists delve into the world of chemical neuromodulators in the human brain, specifically dopamine and serotonin, to reveal their role in social behavior. Credit: Clayton Metz/Virginia Tech In a study in today’s (Monday Feb.

86

86

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Pulse oximeters, devices that measure your blood's oxygen levels, are known to work less accurately in Black patients. Now, new research suggests faulty readings might also be worsening the care of Black people who battle.

Research 97

Research 97

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

Black carbon is the most dangerous air pollutant you’ve never heard of. Its two main sources, diesel exhaust and wood smoke from wildfires and household heating, produce ultrafine air particles that are up to 25 times more of a health hazard per unit compared to other types of particulate matter.

84

84

Science Daily: Pharmacology News

FEBRUARY 26, 2024

A new record for electrical energy generation from CIGS solar cells has been reached. Scientists have achieved a 23.64 percent efficiency.

95

95

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

As the years add up, it’s common to notice slight changes in our ability to remember and think. Older people who have more marked changes than their peers can be diagnosed with mild cognitive impairment (MCI). Currently, we can’t easily predict which of these patients will develop Alzheimer’s disease and which will not.

Disease 80

Disease 80

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Pulse oximeters, devices that measure your blood's oxygen levels, are known to work less accurately in Black patients. Now, new research suggests faulty readings might also be worsening the care of Black people who battle.

Research 96

Research 96

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

In the face of increasing temperatures globally, a new Monash-led study of 1.2 million births in Sydney over two decades has shown a strong association between the risk of pre-term birth and exposure to extreme hot temperatures in the third trimester of pregnancy.

77

77

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- U.S. poison center calls related to psilocybin “magic mushrooms” among youth skyrocketed after U.S. cities and states began decriminalizing the hallucinogen, a new study shows.Psilocybin-related calls among teens ages.

Drugs 96

Drugs 96

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited. Another mystery is the regulation of cytochrome P450 enzymes (CYPs) in the central nervous system.

Disease 75

Disease Pharmaceuticals Regulations Treatment 75

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- The asthma medication Xolair has proved its prowess against food allergies, with new research showing the medication substantially lowers the chances of severe reactions in patients.Data published Sunday.

Drugs 85

Drugs Research 85

Science Daily: Pharmacology News

FEBRUARY 26, 2024

Striped marlin are some of the fastest animals on the planet and one of the ocean's top predators. When hunting in groups, individual marlin will take turns attacking schools of prey fish one at a time. Now a new study helps to explain how they might coordinate this turn-taking style of attack on their prey to avoid injuring each other. The key, according to the new work, is rapid color changes.

81

81

Drugs.com

FEBRUARY 26, 2024

MONDAY, Feb. 26, 2024 -- Polycythemia vera is a rare form of blood cancer with few good treatment options, but that may soon change based on the results of a new clinical trial. An injected experimental drug called rusfertide appears effective in.

Clinical Trials 69

Clinical Trials Drugs Trials Treatment 69

Perficient: Drug Development

FEBRUARY 26, 2024

Introduction To Pipeline Templates In today’s agile software development landscape, teams rely heavily on robust workflows called “pipelines” to automate tasks and enhance productivity. For DevOps teams who were historically familiar with Microsoft’s Azure DevOps CICD Automation platform, one of the most powerful functionalities rolled out by the platform that allowed teams to drastically speed up the pipeline development process was: “ YAML Templates “ YAML temp

Government 69

Government Compliance Production Regulations 69