Drug Discovery World

SEPTEMBER 16, 2024

NKGen Biotech has announced promising early interim data from the Phase I cohort trial of troculeucel, its cryopreserved autologous enhanced natural killer (NK) cell therapy for moderate Alzheimer’s disease. Early independent review of the Phase I data shows that after only three months treatment with a dose of six billion cells per treatment, the three patients in the Phase I cohort had no drug-related adverse reactions.

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Chemical Biology and Drug Design

SEPTEMBER 16, 2024

This study identified MAPK9 as the directly binding target of baicalein by the DNA-programmed affinity labeling method and tested the binding affinity as 89.7 nM by surface plasmon resonance. Baicalein stabilized MAPK9 to induce apoptosis in hepatocarcinoma cells, which would be helpful to understand and use baicalein in hepatocarcinoma therapy. ABSTRACT Hepatocellular carcinoma (HCC) is a significant global health concern.

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Drug Discovery World

SEPTEMBER 16, 2024

A new study has demonstrated that the frequency of second primary malignancies (SPMs) is no higher with CAR-T cell therapies than with previous standard-of-care strategies. The authors found that T cell malignancies represented a small minority of adverse events at just 1.5%. The paper ‘ Second primary malignancies after CAR T-cell therapy: A systematic review and meta-analysis of 5,517 lymphoma and myeloma patients’ was published in the journal Clinical Cancer Research.

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Science Daily: Pharmacology News

SEPTEMBER 16, 2024

Astronomers have used the NASA/ESA James Webb Space Telescope to confirm that supermassive black holes can starve their host galaxies of the fuel they need to form new stars.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 16, 2024

In this webinar on 30 September, from 3-4PM BST, hosted by DDW and sponsored by ApconiX, you will hear from Dr Isaac Klein, Chief Scientific Officer at Dewpoint Therapeutics, Dr Sam Clark, CEO of Terran Biosciences, and Professor Ruth Roberts, Co-founder and Director of Safety Science at ApconiX. Dr Klein shares how Dewpoint applies insights into the subcellular organisation of biochemical processes into membrane-less compartments to discover novel drug targets and revolutionary drugs for diseas

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Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- People should prepare for the fall cold and flu season by getting the updated influenza and COVID-19 vaccinations, an infectious diseases expert says.“When my patients ask me if they should be getting a COVID vaccine this y.

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Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. In a new decades-long study, veterans with diabetes.

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Disease Research 113

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

New research examines thousands of years of Arctic sled dog ancestry and reveals when and how Siberian and Alaskan sled dogs' DNA mixed.

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DNA Research 115

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Tiny puffs from asthma inhalers could be causing big climate problems for Mother Earth, a new study warns.Each inhaler dose contains some of the most potent greenhouse gases known, and they are adding up, researchers.

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Research 113

NIOSH Science Blog: Drugs

SEPTEMBER 16, 2024

As part of Fungal Disease Awareness Week, we are highlighting fungal diseases that can affect workers. Coccidioidomycosis (Valley fever), blastomycosis, and histoplasmosis are fungal diseases caused by fungi that live in the environment in certain regions. Infections are caused by breathing in fungal spores that get into the air. Some jobs and work activities that disturb soil in areas where the fungi live can release fungal spores into the air and put workers at higher risk.

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Disease 96

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Vaping may look cool when you're young, but it appears to be dulling the brains of college students, a new study warns.College students who vape have lower cognitive function scores than those who don't, researchers.

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Science Daily: Pharmacology News

SEPTEMBER 16, 2024

Researchers follow the dramatic changes that occur in the brain throughout the course of pregnancy.

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Research 107

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 (Healthday News) -- In a disclosure that can't eliminate the possibility that bird flu may have spread from one human to another for the first time, U.S. health officials have reported that a person who lived with a Missouri.

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BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Results for Pfizer’s ponsegromab looked promising, while BioNTech and Instil Bio capitalized on momentum surrounding a kind of bispecific antibody.

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Drugs 85

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept 16, 2024 -- A decade of patient follow-up finds a combo of two immunotherapy drugs can greatly extend survival for people with advanced melanomas.In 2011, a diagnosis of advanced, metastatic melanoma typically meant death within 6.5.

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Drugs 105

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

An experiment tested six generative large language models against students in an online introductory biomedical and health informatics course. The models scored higher than as many as three quarters of the real-world students in the class.

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Research 83

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Newfangled designs intended to make football helmets more protective have overlooked one key component, a new study suggests.Nearly a third of concussions in pro football involve impacts to the facemask, a part of the.

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BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

There’s no doubt that AI and GenAI can speed up pharmaceutical innovation. But before organizations can jump into the future, it’s crucial to understand the benefits – and the risks – of advanced technology.

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Pharmaceuticals 74

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- People with rare genetic variants linked to degenerative brain disorders like Parkinson’s disease are at increased risk of developing ALS, a new study finds.Further, having these genetic variants increases the risk of a p.

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Disease 84

Antidote

SEPTEMBER 16, 2024

Receiving a Parkinson’s diagnosis is a life-altering event that nearly 1 million people in the United States have experienced. Parkinson’s disease symptoms can vary from person to person. Receiving a diagnosis often requires several steps. In this blog, we’ll be sharing more details about the disease and discussing opportunities for individuals to get involved in Parkinson’s research.

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Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- For the first time, scientists have detected microscopic microplastics lodged in the human brain.Researchers in Germany and Brazil say that 8 out of 15 autopsied adults had microplastics detected within their brain's smell.

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BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Warner Biddle and Christi Shaw, two prominent former executives at Gilead’s CAR-T division, will try to turn around an autoimmune cell therapy developer that’s lost most of its value since raising $319 million in a February IPO.

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Therapies 69

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

If seabirds can catch avian flu by stealing food from infectious birds, it gives scientists a clue where to monitor for outbreaks among these vulnerable birds.

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FDA Law Blog: Biosimilars

SEPTEMBER 16, 2024

By Mark I. Schwartz — FDA recently published a Federal Register (FR) Notice [ Docket No. FDA-2024-N-3945 ] announcing the publication of a draft strategy document, for public comment, outlining specific actions FDA plans to take to facilitate the use of innovative manufacturing technologies. This FR Notice and draft strategy document are part of FDA’s commitment under the Prescription Drug User Fee Act (PDUFA) Reauthorization Performance Goals and Procedures for Fiscal Years 2023-2027 (PDUFA VII

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Drug Patent Watch

SEPTEMBER 16, 2024

In the high-stakes world of pharmaceuticals, where innovation meets profit, a little-known regulatory program called REMS (Risk Evaluation and Mitigation Strategy) has become a powerful tool for brand-name drug manufacturers to fend off generic competition.

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Perficient: Drug Development

SEPTEMBER 16, 2024

What is SEO? SEO (Search Engine Optimization) refers to the practice of optimizing websites and content to rank higher in search engine results pages It involves improving on-page and off-page factors to drive organic traffic to your website Why is SEO Important? Increases visibility : Higher rankings lead to increased visibility, helping your target audience find your site.

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Drug Target Review

SEPTEMBER 16, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? First of all, thank you so much for having me. Drug Target Review’s commitment to highlighting diverse experiences resonates deeply with me, and I’m honoured to be a part of this conversation. My love for science truly began at home.

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New Drug Approvals

SEPTEMBER 16, 2024

Atilotrelvir, BDBM622370, GST-HG171 2850365-55-6, ALIGOS THERAPEUTICS, INC 511.5 C 24 H 32 F 3 N 5 O 4 (1 S ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[(2 S )-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]spiro[2-azabicyclo[2.2.1]heptane-5,1′-cyclopropane]-3-carboxamide Spiro[2-azabicyclo[2.2.1]heptane-5,1′-cyclopropane]-3-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-2-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]bu

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Production 57

BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Applying a systems thinking approach can create improvements in scientific integrity, operational feasibility and scalability.

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Perficient: Drug Development

SEPTEMBER 16, 2024

The Winter ’25 Salesforce release is rolling out between September and October 2024, bringing exciting updates and new features designed to enhance developer productivity. From adding advanced AI features to boosting platform capabilities, this release is packed with valuable tools for Salesforce developers. Let’s explore some of the key updates. Pic Courtsey: Salesforce Apex Improvements Preventing Collection Modification During Iteration In previous Apex versions, developers could modify a set

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Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- With implications for research around postpartum depression and other health issues, scientists have tracked the changes pregnancy brings to the female brain. These changes weren't subtle: Big shifts in what's known as the.

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Perficient: Drug Development

SEPTEMBER 16, 2024

In the rapidly evolving healthcare landscape, technology and assistive devices have emerged as critical components in making healthcare more accessible for individuals with physical disabilities. In this installment of the UX in Universal Design Series , we will explore how these innovations improve the usability of health systems, enhance patient experiences, and foster more inclusive care environments.

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Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Many parents worry that their kids aren’t popular enough, or that they aren’t making the right friends, a new survey finds.About 1 in 5 parents say their child aged 6 to 12 has no friends or not enough friends, according to.

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Perficient: Drug Development

SEPTEMBER 16, 2024

AI has arrived in the ever-evolving world of software development and staying ahead means embracing tools that can boost productivity and streamline workflows. GitHub Copilot, an AI-powered coding assistant developed by GitHub and OpenAI, has been turning heads since its debut. Integrated seamlessly with Visual Studio Code (VS Code), Copilot is more than just an autocomplete tool—it’s like having a coding partner who’s always ready to help.

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